Basic Study
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World J Gastroenterol. May 7, 2022; 28(17): 1798-1813
Published online May 7, 2022. doi: 10.3748/wjg.v28.i17.1798
Sirtuin1 attenuates acute liver failure by reducing reactive oxygen species via hypoxia inducible factor 1α
Pan Cao, Qian Chen, Chun-Xia Shi, Lu-Wen Wang, Zuo-Jiong Gong
Pan Cao, Qian Chen, Chun-Xia Shi, Lu-Wen Wang, Zuo-Jiong Gong, Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Author contributions: Cao P and Gong ZJ designed the study; Cao P, Chen Q and Shi CX performed most of the experiments and wrote the article; Wang LW analyzed the data; All authors approved the final version of the article.
Supported by National Natural Science Foundation of China, No. 82070609.
Institutional review board statement: This study was approved by the Institutional Review Board of Renmin Hospital of Wuhan University.
Institutional animal care and use committee statement: All animal operations were reviewed and approved by the Institutional Animal Care and Use Committee of Renmin Hospital of Wuhan University (Approval No. WDRY2021-K016), and were conducted in accordance with the established International Guiding Principles for Animal Research.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zuo-Jiong Gong, PhD, Full Professor, Department of Infectious Diseases, Renmin Hospital of Wuhan University, No. 238 Jiefang Road, Wuhan 430060, Hubei Province, China. zjgong@163.com
Received: October 28, 2021
Peer-review started: October 28, 2021
First decision: December 12, 2021
Revised: December 21, 2021
Accepted: March 25, 2022
Article in press: March 25, 2022
Published online: May 7, 2022
Processing time: 182 Days and 19.3 Hours
Core Tip

Core Tip: Hypoxia inducible factor 1α (HIF-1α) is a transcription factor that regulates oxygen homeostasis. Under hypoxic conditions, HIF-1α translocates to the nucleus and binds to β-subunits, resulting in transcription of target genes. In acute liver failure, HIF-1α contributes to early liver cell necrosis. The activation of Sirtuin1 (Sirt1) will result in a powerful antioxidant defense system. This study examined the influence of Sirt1-mediated pathways on HIF-1α expression in vivo and in vitro, explored the relationship between Sirt1 and HIF-1α, and further explored its potential mechanism.