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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 21, 2018; 24(3): 360-370
Published online Jan 21, 2018. doi: 10.3748/wjg.v24.i3.360
Published online Jan 21, 2018. doi: 10.3748/wjg.v24.i3.360
Hypoxia preconditioning protects Ca2+-ATPase activation of intestinal mucosal cells against R/I injury in a rat liver transplantation model
Zhi-Peng Ji, Department of General Surgery, the Second Hospital of Shandong University, Jinan 250033, Shandong Province, China
Yuan-Xin Li, Zhuo-Nan Zhuang, Department of Gastrointestinal Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China
Bao-Xu Shi, Department of Neurology, People’s Hospital of Rizhaolanshan, Rizhao 276800, Shandong Province, China
Jing-Yan Yang, Department of Pathology, the Second Hospital of Shandong University, Jinan 250033, Shandong Province, China
Sen Guo, Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan 250033, Shandong Province, China
Xiao-Zhou Xu, Ke-Sen Xu, Hai-Lin Li, Department of Hepatobiliary Surgery, the Second Hospital of Shandong University, Shandong University, Jinan 250033, Shandong Province, China
Author contributions: Ji ZP and Li HL designed the research and drafted and revised the paper; Ji ZP and Zhuang ZN performed the research; Shi BX, Guo S, Xu XZ and Zhuang ZN searched the literature and analysed the data; Xu KS and Li HL revised the paper and approved the final version; Yang JY provided technical assistance with pathology analysis.
Supported by The Second Hospital of Shandong University Youth Foundation, No. Y2013010033.
Institutional review board statement: The study was reviewed and approved by The Second Hospital of Shandong University Institutional Review Board.
Conflict-of-interest statement: We declare that there are no conflicts of interest to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hai-Lin Li, MD, PhD, Adjunct Professor, Department of Hepatobiliary Surgery, the Second Hospital of Shandong University, Shandong University, 247#, Beiyuan Street, Jinan 250033, Shandong Province, China. lehaln01@163.com
Telephone: +86-531-82169203 Fax: +86-531-82169243
Received: October 17, 2017
Peer-review started: October 17, 2017
First decision: October 31, 2017
Revised: November 7, 2017
Accepted: November 27, 2017
Article in press: November 27, 2017
Published online: January 21, 2018
Peer-review started: October 17, 2017
First decision: October 31, 2017
Revised: November 7, 2017
Accepted: November 27, 2017
Article in press: November 27, 2017
Published online: January 21, 2018
Core Tip
Core tip: Ischaemia/reperfusion (I/R) injury affects the recovery of postoperative bowel function in liver transplantation. In our research, hypoxia-induced HIF-1α expression could protect mitochondrial function and Ca2+-ATPase activity against I/R injury to reduce the apoptosis and pathological damage to intestinal cells. Therefore, we suggest that hypoxic preconditioning therapy could improve the tolerance of small intestinal mucosal cell to hypoxia in rat autologous orthotopic liver transplantation.