Meta-Analysis
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2017; 23(7): 1310-1318
Published online Feb 21, 2017. doi: 10.3748/wjg.v23.i7.1310
Prognostic value of circulating tumor cells in esophageal cancer
Hai-Tao Xu, Jing Miao, Jian-Wei Liu, Lian-Guo Zhang, Qing-Guang Zhang
Hai-Tao Xu, Jian-Wei Liu, Lian-Guo Zhang, Qing-Guang Zhang, Department of Thoracic Surgery, Affiliated Hospital of Binzhou Medical University, Binzhou 256603, Shandong Province, China
Jing Miao, Department of Neonatal Intensive Care Unit, Binzhou People’s Hospital, Binzhou 256603, Shandong Province, China
Author contributions: Xu HT and Miao J contributed equally to this work as co-first authors; Xu HT designed the research, analyzed the data and wrote the manuscript; Miao J designed the research, analyzed the data and wrote the manuscript; Liu JW performed the research and contributed analytical tools; Zhang LG performed the research; Zhang QG conceived and designed the research, and revised the manuscript as corresponding author.
Conflict-of-interest statement: The authors declare that this is no conflict of interest related to this study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Qing-Guang Zhang, MD, Department of Thoracic Surgery, Affiliated Hospital of Binzhou Medical University, No. 661, Huanghe Erlu, Binzhou 256603, Shandong Province, China. drzhangqingg@126.com
Telephone: +86-543-3258731 Fax: +86-543-3257792
Received: December 19, 2016
Peer-review started: December 21, 2016
First decision: January 10, 2017
Revised: January 20, 2017
Accepted: February 7, 2017
Article in press: February 8, 2017
Published online: February 21, 2017
Processing time: 62 Days and 22.5 Hours
Core Tip

Core tip: The clinical validity of circulating tumor cells (CTCs) is still controversial and inconclusive in patients with esophageal cancer. Our meta-analysis provides strong evidence that detection of CTCs in peripheral blood at baseline is an independent prognosticator of poor survival outcomes in esophageal cancer patients.