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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2015; 21(6): 1814-1820
Published online Feb 14, 2015. doi: 10.3748/wjg.v21.i6.1814
Published online Feb 14, 2015. doi: 10.3748/wjg.v21.i6.1814
Overexpression of Csk-binding protein decreases growth, invasion, and migration of esophageal carcinoma cells by controlling Src activation
Dong Zhou, Yu-Min Li, Gansu Provincial Key Laboratory of Digestive System Tumors, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China
Peng Dong, Department of Cardiology, Aviation General Hospital, Beijing 100012, China
Fa-Cai Guo, An-Ping Zhang, Run-Ze Song, Ya-Min Zhang, Zhi-Yong Li, Dong Yuan, Chuan Yang, Department of Vascular Surgery, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China
Author contributions: Zhou D and Dong P contributed to the work equally and should be regarded as co-first authors; Zhou D and Li YM designed the research; Zhou D, Dong P, Guo FC and Zhang AP performed the research; Zhang YM, Li ZY, Yuan D and Yang C analyzed data; Zhou D and Dong P wrote the paper.
Supported by Gansu Provincial Natural Science Foundation, No. 1308RJZA188; and the Fundamental Research Funds for the Central Universities, No. lzujbky-2011-T03-16.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yu-Min Li, PhD, Professor, Gansu Provincial Key Laboratory of Digestive System Tumors, Lanzhou University Second Hospital, 82 Cuiyingmen, Lanzhou 730030, Gansu Province, China. 13919951166@139.com
Telephone: +86-931-8942935
Received: May 24, 2014
Peer-review started: May 24, 2014
First decision: July 15, 2014
Revised: October 20, 2014
Accepted: December 19, 2014
Article in press: December 22, 2014
Published online: February 14, 2015
Processing time: 263 Days and 6.7 Hours
Peer-review started: May 24, 2014
First decision: July 15, 2014
Revised: October 20, 2014
Accepted: December 19, 2014
Article in press: December 22, 2014
Published online: February 14, 2015
Processing time: 263 Days and 6.7 Hours
Core Tip
Core tip: Csk-binding protein (CBP) is a ubiquitously expressed transmembrane protein and functions as a suppressor of Src-mediated tumor progression by promoting the inactivation of Src. Here, we established a CBP overexpressing esophageal carcinoma cell line (TE-1) and found that the overexpression of CBP significantly decreased the proliferation, invasion, and migration of TE-1 cells, accompanied by decreased activation of Src. These results indicate that CBP may decrease the metastasis of esophageal carcinoma by inhibiting the activation of Src. Targeting the CBP gene may be an alternative strategy for the development of therapies for esophageal carcinoma.