Gastric antisecretory and antiulcer activity of bovine hemoglobin

doi:10.3748/wjg.v19.i21.3291

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 7, 2013; 19(21): 3291-3299
Published online Jun 7, 2013. doi: 10.3748/wjg.v19.i21.3291

Gastric antisecretory and antiulcer activity of bovine hemoglobin

Abdulrahman K Al Asmari, Saud Al Omani, Ibrahim Elfaki, Mohammad Tariq, Ahmed Al Malki, Saeed Al Asmary

Abdulrahman K Al Asmari, Ibrahim Elfaki, Mohammad Tariq, Research Center, Prince Sultan Military Medical City, Riyadh 11159, Saudi Arabia

Saud Al Omani, Department of Surgery, Prince Sultan Military Medical City, Riyadh 11159, Saudi Arabia

Ahmed Al Malki, Department of Gastroenterology, Prince Sultan Military Medical City, Riyadh 11159, Saudi Arabia

Saeed Al Asmary, Family and Community Medicine, Prince Sultan Military Medical City, Riyadh 11159, Saudi Arabia

Author contributions: Al Asmari AK designed the study, performed some experiments and assisted in the drafting of the manuscript; Elfaki I performed some experiments and collected the data; Al Malki A analyzed and interpreted the data; Tariq M critically reviewed the manuscript; Al Omani S and Al Asmary S supervised the study, assisted in analysis of the data and drafting the manuscript.

Correspondence to: Dr. Abdulrahman K Al Asmari, Research Center, Prince Sultan Military Medical City, PO Box 7897 (775-S), Riyadh 11159, Saudi Arabia. abdulrahman.alasmari@gmail.com

Telephone: +966-1-4777714 Fax: +966-1-4786601

Received: December 30, 2012
Revised: March 9, 2013
Accepted: April 13, 2013
Published online: June 7, 2013
Processing time: 155 Days and 20.3 Hours

Core Tip

Core tip: In the recent years the treatment strategies for gastric ulcer diseases have significantly changed, mirroring the revolution in the understanding of its pathogenesis. Improved oxygenation in critically ischemic gastric mucosa has emerged as a method of choice to accelerate epithelization of erosive and ulcerative defects. Bovine hemoglobin (B-Hb) has been used in a wide range of applications including restoration of tissue oxygenation in ischemic condition. Our data show that B-Hb has significant anti-gastric acid secretory and gastroprotective activity. Further studies are warranted to determine the role of B-Hb in prophylaxis/treatment of gastric ulcer disease.