Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer

doi:10.3748/wjg.v18.i45.6577

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 7, 2012; 18(45): 6577-6586
Published online Dec 7, 2012. doi: 10.3748/wjg.v18.i45.6577

Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer

Yasutaka Sukawa, Hiroyuki Yamamoto, Katsuhiko Nosho, Hiroaki Kunimoto, Hiromu Suzuki, Yasushi Adachi, Mayumi Nakazawa, Takayuki Nobuoka, Mariko Kawayama, Masashi Mikami, Takashi Matsuno, Tadashi Hasegawa, Koichi Hirata, Kohzoh Imai, Yasuhisa Shinomura

Yasutaka Sukawa, Hiroyuki Yamamoto, Katsuhiko Nosho, Hiroaki Kunimoto, Hiromu Suzuki, Yasushi Adachi, Mayumi Nakazawa, Yasuhisa Shinomura, First Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo 60-8543, Japan

Hiromu Suzuki, Department of Molecular Biology, Sapporo Medical University School of Medicine, Sapporo 60-8543, Japan

Takayuki Nobuoka, Koichi Hirata, First Department of Surgery, Sapporo Medical University School of Medicine, Sapporo 60-8543, Japan

Mariko Kawayama, Masashi Mikami, Department of Gastroenterology, JR Sapporo Hospital, Sapporo 60-8543, Japan

Takashi Matsuno, Department of Surgery, Sapporo Gekakinen Hospital, Sapporo 60-8543, Japan

Tadashi Hasegawa, Department of Surgical Pathology, Sapporo Medical University Hospital, Sapporo 60-8543, Japan

Kohzoh Imai, Division of Cancer Research, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan

Author contributions: Sukawa Y and Yamamoto H designed the research, performed experiments, analyzed the data and wrote the manuscript; Nosho K, Suzuki H and Adachi Y analyzed the data; Kunimoto H and Nakazawa M performed experiments; Nobuoka T, Kawayama M, Mikami M, Matuno T, Hasegawa T and Hirata K provided the collection of the human material and analyzed the data; and Imai K and Shinomura Y edited the manuscript.

Supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan, to Yamamoto H and Shinomura Y

Correspondence to: Hiroyuki Yamamoto, MD, FJSIM, PhD, First Department of Internal Medicine, Sapporo Medical University School of Medicine, S-1 W-16 Chuo-ku, Sapporo 60-8543, Japan. h-yama@sapmed.ac.jp

Telephone: +81-11-6112111 Fax: +81-11-6112282

Received: June 18, 2012
Revised: August 21, 2012
Accepted: August 25, 2012
Published online: December 7, 2012

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