Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats

doi:10.3748/wjg.v18.i35.4866

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Sep 21, 2012 (publication date) through Dec 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Original Article

World J Gastroenterol. Sep 21, 2012; 18(35): 4866-4874
Published online Sep 21, 2012. doi: 10.3748/wjg.v18.i35.4866

Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats

Paula Esquivias, Antonio Morandeira, Alfredo Escartín, Carmelo Cebrián, Sonia Santander, Francisco Esteva, María Asunción García-González, Javier Ortego, Angel Lanas, Elena Piazuelo

Paula Esquivias, María Asunción García-González, Javier Ortego, Angel Lanas, Elena Piazuelo, CIBER Digestive and Hepatic Deseases, 08036 Barcelona, Spain

Antonio Morandeira, Alfredo Escartín, Service of Surgery, University Hospital “Lozano Blesa”, 50009 Zaragoza, Spain

Carmelo Cebrián, Javier Ortego, Service of Pathology, University Hospital “Lozano Blesa”, 50009 Zaragoza, Spain

Sonia Santander, Angel Lanas, Department of Medicine, University of Zaragoza, 50009 Zaragoza, Spain

Francisco Esteva, Service of Clinical Biochemistry, University Hospital “Lozano Blesa”, 50009 Zaragoza, Spain

María Asunción García-González, Angel Lanas, Elena Piazuelo, Aragon Health Science Institute, 50009 Zaragoza, Spain

Angel Lanas, Service of Gastroenterology, University Hospital “Lozano Blesa”, 50009 Zaragoza, Spain

Author contributions: Esquivias P wrote the manuscript; Morandeira A and Escartín A carried out all surgical procedures; Cebrián C and Ortego J performed histological analysis; Santander S, García-González MA and Esteva F were involved in all biochemical determinations and provided vital reagents and analytical tools; Lanas A and Piazuelo E were involved in the design of the study, statistical analysis and editing the manuscript.

Supported by Instituto de Salud Carlos III (CIBERehd); MF-tricyclic was supplied free of charge by Merck Frosst Canada Inc.

Correspondence to: Paula Esquivias, BSc, CIBER Digestive and Hepatic Deseases, Cardenal Goma s/n, 08036 Barcelona, Spain. pauesquivias@gmail.com

Telephone: +34-652-960252 Fax: +34-976-765478

Received: November 29, 2011
Revised: May 17, 2012
Accepted: June 15, 2012
Published online: September 21, 2012

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