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World J Gastroenterol. Aug 14, 2012; 18(30): 4051-4058
Published online Aug 14, 2012. doi: 10.3748/wjg.v18.i30.4051
Published online Aug 14, 2012. doi: 10.3748/wjg.v18.i30.4051
Human papilloma virus 16 E6 oncoprotein associated with p53 inactivation in colorectal cancer
Tan-Hsia Chen, Shu-Hau Chang, Wen-Wei Sung, Ya-Wen Cheng, Huei Lee, Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan, China
Tan-Hsia Chen, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan, China
Chi-Chou Huang, Kun-Tu Yeh, Shih-Wen Chang, School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan, China
Chi-Chou Huang, Shih-Wen Chang, Department of Surgery, Chung Shan Medical University Hospital, Taichung 402, Taiwan, China
Kun-Tu Yeh, Department of Pathology, Changhua Christian Hospital, Changhua 500, Taiwan, China
Ya-Wen Cheng, Huei Lee, Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan, China
Ya-Wen Cheng, Huei Lee, PhD Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, 115, Taiwan, China
Author contributions: Chen TH, Huang CC, Cheng YW, Lee H contributed equally to this work; Cheng YW, Lee H designed the study and wrote the paper; Cheng YW, Chen TH, Huang CC, Yeh KT and Chang SH conceived the experiments, wrote the paper, and prepared the figures; Huang CC and Yeh KT collected the colorectal tumor samples; Sung WW performed the p21 and Mdm2 mRNA detection; and all authors gave final approval for the manuscript to be submitted for publication.
Supported by Grants from the National Science Council of Taiwan, China, No. 99-2628-B-040-002-MY3 and No. 97-2314-B-040-027-MY3
Correspondence to: Huei Lee, Professor, PhD Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, 12F., No.3, Sec. 4, Bade Rd., Nangang Dist., Taipei 115, Taiwan, China. hl@tmu.edu.tw
Telephone: +886-4-24759400 Fax: +886-4-24720407
Received: January 30, 2012
Revised: March 31, 2012
Accepted: April 9, 2012
Published online: August 14, 2012
Revised: March 31, 2012
Accepted: April 9, 2012
Published online: August 14, 2012
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