Brief Article
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World J Gastroenterol. May 7, 2012; 18(17): 2067-2075
Published online May 7, 2012. doi: 10.3748/wjg.v18.i17.2067
Efficacy and safety profile of LCR35 complete freeze-dried culture in irritable bowel syndrome: A randomized, double-blind study
Michel Dapoigny, Thierry Piche, Philippe Ducrotte, Bernard Lunaud, Jean-Michel Cardot, Annick Bernalier-Donadille
Michel Dapoigny, Médecine Digestive, Centre Hospitalier Universitaire (CHU) Estaing, CHU Clermont-Ferrand, Clermont Université, Inserm UMR 766, 63001 F-Clermont-Ferrand, France
Thierry Piche, Department of Gastroenterology and Inserm 576, Hôpital de l’Archet 2, 06202 Nice, Cedex 3, France
Philippe Ducrotte, Department of Hepatogastroenterology and Nutrition, Hôpital Charles Nicolle, Inserm UMR 1073, 76031 Rouen, Cedex, France
Bernard Lunaud, Department of Gastroenterology, Centre République, 63000 Clermont-Ferrand, France
Jean-Michel Cardot, Biopharmacy Department, Faculty of Pharmacy, 63000 Clermont-Ferrand, France
Annick Bernalier-Donadille, UR454 Microbiology Division, Institut National de la Recherche Agronomique, Research Centre of Clermont-Ferrand-Theix, 63122 Saint Genès-Champanelle, France
Author contributions: Dapoigny M was the coordinator-investigator of the study; Piche T, Ducrotte P and Lunaud B were co-investigators; Cardot JM was the scientific advisor for statistical issues; Bernalier-Donadille A was responsible for the analysis of faeces samples; all authors critically reviewed the manuscript and approved the final version.
Supported by Laboratoires Lyocentre
Correspondence to: Michel Dapoigny, MD, PhD, Médecine Digestive, Centre Hospitalier Universitaire (CHU) Estaing, CHU Clermont-Ferrand, Clermont Université, Inserm UMR 766, 63001 F-Clermont-Ferrand, France. mdapoigny@chu-clermontferrand.fr
Telephone: +33-4-73750523 Fax: +33-4-73750524
Received: July 16, 2011
Revised: January 22, 2012
Accepted: April 13, 2012
Published online: May 7, 2012
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