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World J Gastroenterol. Apr 21, 2012; 18(15): 1732-1744
Published online Apr 21, 2012. doi: 10.3748/wjg.v18.i15.1732
Published online Apr 21, 2012. doi: 10.3748/wjg.v18.i15.1732
Macrophage secretory products induce an inflammatory phenotype in hepatocytes
Michelle Melino, Victoria L Gadd, Gene V Walker, Richard Skoien, Helen D Barrie, Dinesh Jothimani, Andrew D Clouston, Julie R Jonsson, Elizabeth E Powell, Centre for Liver Disease Research, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Brisbane 4102, Queensland, Australia
Richard Skoien, Leigh Horsfall, Elizabeth E Powell, Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane 4102, Queensland, Australia
Alun Jones, Matthew J Sweet, Institute for Molecular Bioscience and Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane 4072, Queensland, Australia
Gethin P Thomas, Diamantina Institute, The University of Queensland, Brisbane 4102, Queensland, Australia
Author contributions: Powell EE, Jonsson JR and Clouston AD conceived the study; Powell EE, Jonsson JR, Melino M and Clouston AD designed the study; Melino M, Powell EE, Jonsson JR and Clouston AD wrote the manuscript and gave final approval; Melino M, Gadd VL, Walker GV, Skoien R, Barrie HD and Jothimani D performed the laboratory analyses, analysed and interpreted the results and approved the manuscript; Horsfall L recruited patients and processed and managed the clinical data; Jones A designed, performed, analysed and interpreted the HPLC/MS/MS experiments; Thomas GP designed, analysed and interpreted the microarray experiments and contributed to the writing of the manuscript; Melino M performed the microarray experiments; Sweet MJ contributed to the design of the study and writing, and approval of the manuscript.
Supported by The National Health and Medical Research Council of Australia, No. APP1003108; the Queensland Government’s Smart State Health and Medical Research Fund; The Princess Alexandra Hospital Research and Development Foundation and The Sasakawa Foundation (Royal Children’s Hospital, Brisbane); an Unrestricted Education Grant from MSD (to Powell EE); a Lions Medical Research Foundation Senior Research Fellowship (to Thomas GP)
Correspondence to: Elizabeth Powell, Professor, Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Woolloongabba 4102, Queensland, Australia. e.powell@uq.edu.au
Telephone: +61-7-32402035 Fax: +61-7-32402337
Received: June 23, 2011
Revised: September 20, 2011
Accepted: September 27, 2011
Published online: April 21, 2012
Revised: September 20, 2011
Accepted: September 27, 2011
Published online: April 21, 2012
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