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World J Gastroenterol. Feb 14, 2011; 17(6): 717-726
Published online Feb 14, 2011. doi: 10.3748/wjg.v17.i6.717
Published online Feb 14, 2011. doi: 10.3748/wjg.v17.i6.717
Glutamine depletion induces murine neonatal melena with increased apoptosis of the intestinal epithelium
Takayuki Motoki, Yoshio Naomoto, Yasuhiro Shirakawa, Tomoki Yamatsuji, Junji Matsuoka, Munenori Takaoka, Yasuhiro Fujiwara, Noriaki Tanaka, Toshiyoshi Fujiwara, Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 2-5-1, Shikata-cho, Okayama, 700-8558, Japan
Yoshio Naomoto, Department of General Surgery, Kawasaki Medical School Kawasaki Hospital, 2-1-80, Nakasange, Kita-ku, Okayama, 700-8505, Japan
Junji Hoshiba, Department of Animal Resources, Advanced Science Research Center, Okayama University, 2-5-1, Shikata-cho, Okayama, 700-8558, Japan
Yasuko Tomono, Division of Molecular and Cell Biology, Shigei Medical Research Institute, 2117 Yamada, Okayama, 701-0202, Japan
Hiroshi Tsuchita, Food Technology Research Institute, Meiji Dairies Corporation, 540 Naruda, Odawara, Kanagawa, 250-0862, Japan
Mehmet Gunduz, Hitoshi Nagatsuka, Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 2-5-1, Shikata-cho, Okayama, 700-8558, Japan
Author contributions: Motoki T, Naomoto Y, Matsuoka J, Yamatsuji T, Shirakawa Y, Takaoka M and Tanaka N conceived and designed the study; Motoki T, Naomoto Y, Nagatsuka H and Fujiwara T conducted the study; Hoshiba J produced the feeding bottles; Tsuchita H synthesized the milk; Tomono Y performed the Western blotting; Motoki T and Fujiwara Y statistically analyzed the data; Motoki T, Naomoto Y, Matsuoka J, Yamatsuji T, Shirakawa Y, Takaoka M and Gunduz M wrote the manuscript; all authors were responsible for data interpretation.
Supported by The trust accounts of the Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
Correspondence to: Yoshio Naomoto, MD, PhD, Professor of Department of General Surgery, Kawasaki Medical School Kawasaki Hospital, 2-1-80, Nakasange, Kita-ku, Okayama, 700-8505, Japan. ynaomoto@med.kawasaki-m.ac.jp
Telephone: +81-86-2252111 Fax: +81-86-2328343
Received: June 20, 2010
Revised: September 17, 2010
Accepted: September 24, 2010
Published online: February 14, 2011
Revised: September 17, 2010
Accepted: September 24, 2010
Published online: February 14, 2011
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