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World J Gastroenterol. Sep 14, 2011; 17(34): 3899-3911
Published online Sep 14, 2011. doi: 10.3748/wjg.v17.i34.3899
Published online Sep 14, 2011. doi: 10.3748/wjg.v17.i34.3899
Preclinical evaluation of azathioprine plus buthionine sulfoximine in the treatment of human hepatocarcinoma and colon carcinoma
Borja Hernández-Breijo, Sara Ramírez-Rubio, Eva P Cuevas, M Dolores Fernández-Moreno, Irene D Román, Luis G Guijarro, Molecular Hepatic Toxicology Unit, Biochemistry and Molecular Biology Department, University of Alcalá, Networked Biomedical Research Center of Hepatic and Digestive Diseases (CIBEREHD), Alcalá de Henares 28871, Spain
Jorge Monserrat, Medicine Department, University of Alcalá, Alcalá de Henares 28871, Spain
Diana Vara, Inés Díaz-Laviada, Neuroendocrinology of Cannabinoid/Vanilloid System Unit, Biochemistry and Molecular Biology Department, University of Alcalá, Alcalá de Henares 28871, Spain
Javier P Gisbert, Gastroenterology Unit, Hospital de la Princesa, Institute of Health Research Princesa, Networked Biomedical Research Center of Hepatic and Digestive Diseases (CIBEREHD), Madrid 28006, Spain
Author contributions: Hernández-Breijo B performed the majority of the in vitro and in vivo experiments; Monserrat J performed cytometry; Ramírez-Rubio S and Cuevas EP performed in vitro experiments; Vara D performed the in vivo experiments; Fernández-Moreno MD, Román ID performed analysis of glutathione levels and reviewed the manuscript; Díaz-Laviada I and Gisbert JP reviewed the manuscript; Guijarro LG designed the study and wrote the manuscript.
Supported by Grants from SAF2008-05355 and CCG07-UAH/BIO-2085
Correspondence to: Dr. Luis González Guijarro, Professor, Biochemistry and Molecular Biology Department, University of Alcalá, Alcalá de Henares 28871, Spain. luis_guijarro@telefonica.net
Telephone: +34-91-885-4865 Fax: +34-91-885-4585
Received: January 10, 2011
Revised: March 26, 2011
Accepted: April 2, 2011
Published online: September 14, 2011
Revised: March 26, 2011
Accepted: April 2, 2011
Published online: September 14, 2011
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