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World J Gastroenterol. Jan 21, 2011; 17(3): 300-312
Published online Jan 21, 2011. doi: 10.3748/wjg.v17.i3.300
Published online Jan 21, 2011. doi: 10.3748/wjg.v17.i3.300
Hepatocellular carcinoma xenograft supports HCV replication: A mouse model for evaluating antivirals
Sidhartha Hazari, Partha K Chandra, Bret Poat, Feyza Gunduz, Tong Wu, Srikanta Dash, Department of Pathology and Laboratory Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, United States
Henry J Hefler, Feyza Gunduz, Luis A Balart, Srikanta Dash, Department of Gastroenterology and Hepatology, Tulane University Health Sciences Center, New Orleans, LA 70112, United States
Tara Ooms, Department of Comparative Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, United States
Author contributions: Hazari S performed the majority of the experiments, acquisition and analysis of data, and participated in design of the study; Hefler HJ performed some animal experiments and helped in the antiviral studies; Chandra PK performed the real time RT-PCR and RPA; Poat B and Gunduz F performed biochemical assays and tumor cell inoculation of SCID mice; Ooms T performed the intrasplenic injection of S3-GFP cells into SCID-NOD mice and gave valuable suggestions on animal handling and care during the whole study; Wu T performed the histological evaluation of subcutaneous and liver tumors, and took all the histological images; Balart LA provided valuable suggestions and edited the manuscript; Dash S conceptualized and designed the study, evaluated the overall results, and wrote the manuscript.
Supported by Funds received from the National Cancer Institute (CA127481, CA129776), Geyer Foundation, New York, Louisiana Cancer Research Consortium and Tulane Cancer Center
Correspondence to: Srikanta Dash, PhD, Professor, Department of Pathology and Laboratory Medicine and Gastroenterology and Hepatology, Tulane University Health Sciences Center, 1430 Tulane Ave., SL-79, New Orleans, LA 70112, United States. sdash@tulane.edu
Telephone: +1-504-9882519 Fax: +1-504-9887389
Received: June 9, 2010
Revised: August 3, 2010
Accepted: August 10, 2010
Published online: January 21, 2011
Revised: August 3, 2010
Accepted: August 10, 2010
Published online: January 21, 2011
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