Original Article
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World J Gastroenterol. Oct 21, 2010; 16(39): 4932-4937
Published online Oct 21, 2010. doi: 10.3748/wjg.v16.i39.4932
HBx-induced reactive oxygen species activates hepatocellular carcinogenesis via dysregulation of PTEN/Akt pathway
Hye-Lin Ha, Dae-Yeul Yu
Hye-Lin Ha, Dae-Yeul Yu, Disease Model Research Laboratory, Aging Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Oun-dong, Yuseong-gu, Daejeon 305-806, South Korea; Department of Functional Genomics, University of Science and Technology, Yuseong-gu, Daejeon 305-333, South Korea
Author contributions: Ha HL and Yu DY designed the research; Ha HL performed the research; Ha HL and Yu DY wrote the paper.
Supported by The 21st century Frontier Program in the Functional Human Genome Project, No. HGM0200934; the International Collaboration Program of Science and Technology, No. FGM0600914; the Research Program for New Drug Target Discovery Grant from the Ministry of Education, Science & Technology, No. NBM3300711; and the KRIBB Research Initiative Program Grant, No. KGM3320911
Correspondence to: Dae-Yeul Yu, PhD, Principal Researcher and Professor, Disease Model Research Laboratory, Aging Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Oun-dong, Yuseong-gu, Daejeon 305-806, South Korea. dyyu10@kribb.re.kr
Telephone: +82-42-8604422 Fax: +82-42-8604609
Received: April 22, 2010
Revised: June 4, 2010
Accepted: June 11, 2010
Published online: October 21, 2010
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