Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome

doi:10.3748/wjg.15.6068

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Dec 28, 2009 (publication date) through May 1, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2009; 15(48): 6068-6074
Published online Dec 28, 2009. doi: 10.3748/wjg.15.6068

Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome

Kajsa Kajander, Eveliina Myllyluoma, Sinikka Kyrönpalo, Martin Rasmussen, Pentti Sipponen, Ismo Mattila, Tuulikki Seppänen-Laakso, Heikki Vapaatalo, Matej Orešič, Riitta Korpela

Kajsa Kajander, Eveliina Myllyluoma, Heikki Vapaatalo, Riitta Korpela, Institute of Biomedicine, Pharmacology, University of Helsinki, FI-00014, Helsinki, Finland

Kajsa Kajander, Eveliina Myllyluoma, Riitta Korpela, Valio Ltd, Research Centre, FI-00039, Helsinki, Finland

Sinikka Kyrönpalo, Martin Rasmussen, Tampere Health Centre and Department of Medicine, Tampere City Hospital, FI-33100, Tampere, Finland

Pentti Sipponen, Department of Pathology, Jorvi Hospital, Helsinki University Central Hospital, FI-02740, Espoo, Finland

Ismo Mattila, Tuulikki Seppänen-Laakso, Matej Orešič, VTT Technical Research Centre of Finland, FI-02044, Espoo, Finland

Riitta Korpela, Foundation for Nutrition Research, FI-00390, Helsinki, Finland

Author contributions: Kajander K, Myllyluoma E, Kyrönpalo S, Rasmussen M, Sipponen P, Vapaatalo H and Korpela R designed the study protocol; Rasmussen M acted as principal investigator; Kajander K, Myllyluoma E, Kyrönpalo S, Rasmussen M and Sipponen P recruited the subjects and collected the clinical samples; Mattila I, Seppänen-Laakso T and Orešič M performed the metabolomic analyses and bioinformatics; Kajander K wrote the paper with support from all the other authors.

Supported by Valio Ltd and the Finnish Funding Agency for Technology and Innovation (TEKES); the preparation of this manuscript was funded in part by the Academy of Finland

Correspondence to: Riitta Korpela, PhD, Professor, Institute of Biomedicine, Pharmacology, University of Helsinki, PO Box 63, FI-00014, Helsinki, Finland. riitta.korpela@valio.fi

Telephone: +358-10381-3026 Fax: +358-10381-3019

Received: May 20, 2009
Revised: November 2, 2009
Accepted: November 9, 2009
Published online: December 28, 2009

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