N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized, placebo-controlled pilot study

doi:10.3748/wjg.14.2851

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May 14, 2008 (publication date) through Nov 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 14, 2008; 14(18): 2851-2857
Published online May 14, 2008. doi: 10.3748/wjg.14.2851

N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized, placebo-controlled pilot study

Luis G Guijarro, Jose Mate, Javier P Gisbert, Jose Luis Perez-Calle, Ignacio Marín-Jimenez, Encarna Arriaza, Tomás Olleros, Mario Delgado, Maria S Castillejo, David Prieto-Merino, Venancio Gonzalez Lara, Amado Salvador Peña

Luis G Guijarro, Mario Delgado, Maria S Castillejo, David Prieto-Merino, Department of Biochemistry and Molecular Biology, CIBERehd, Alcalá University, Alcalá de Henares, Madrid, Spain

Jose Mate, Javier P Gisbert, Gastroenterology Unit, CIBERehd La Princesa University Hospital, Autonomous University, Madrid, Spain

Jose Luis Perez-Calle, Ignacio Marín-Jimenez, Venancio Gonzalez Lara, Gastroenterology Unit, Gregorio Marañón University Hospital, Complutense University, Madrid, Spain

Encarna Arriaza, Tomás Olleros, Group Farmasierra SL., Ctra N-II Km 26.200, San Sebastián de los Reyes, Madrid, Spain

Amado Salvador Peña, Laboratory of Immunogenetics, Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands

Author contributions: Guijarro LG designed the study, carried out the statistical analysis and wrote the first draft of the manuscript; Mate J compiled the data patients; Gisbert JP helped write and correct the paper; Perez-Calle JL compiled the data patients; Marín-Jimenez I compiled the data patients; Arriaza E organized patient data; Olleros T organized patient data; Delgado M did ELISA assays; Castillejo MS did ELISA assays and GSH measurement; Prieto-Merino D carried out statistical data; Gonzalez Lara V compiled the data patients; Peña AS helped write, corrected and supervised the organization process.

Correspondence to: Luis G Guijarro, PhD, Unidad de Toxicología Molecular Hepática, Department de Bioquímica & Biología Molecular, Universidad de Alcalá, E-28871, Alcalá de Henares, Spain. luis.gonzalez@uah.es

Telephone: +34-918854865

Fax: +34-918854585

Received: January 31, 2007
Revised: March 23, 2008
Published online: May 14, 2008

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