Published online Jan 7, 2008. doi: 10.3748/wjg.14.81
Revised: September 22, 2007
Published online: January 7, 2008
AIM: To investigate the effects of fib sealant on hemostasis and liver regeneration and intra-abdominal adhesions in an experimental liver injury.
METHODS: Thirty-six Wistar rats were randomly divided into primary suture group (n = 15), fib sealant group (n = 15) and control group (n = 6). A wedge resection was performed on the left lobe of the liver. In primary suture group, liver was sutured using polypropylene material, while fib glue was administrated on the liver surface in fib sealant group.
RESULTS: More intra-abdominal adhesions were observed in the primary suture group compared to the fib sealant group on 3rd (2.50 ± 0.5 vs 0.25 ± 0.5, P = 0.015), 10th (2.75 ± 0.5 vs 0.50 ± 0.6, P = 0.06) and 20th (1.75 ± 0.5 vs 0.70 ± 0.5, P = 0.015) postoperative days. Histopathological scores were better in the fib sealant group in comparison with the primary suture group on 3rd (8.75 ± 0.5 vs 6.75 ± 0.5, P = 0.006), 10th (7.50 ± 1.0 vs 5.5 ± 0.6, P = 0.021) and 20th (6.40 ± 1.7 vs 3.20 ± 1.6, P = 0.025) postoperative days.
CONCLUSION: Out data suggest that fib sealant is preferred over primary suture in appropriate cases including liver trauma since it causes less intra-abdominal adhesions while allowing shorter hemostasis time as assessed in experimental liver trauma.