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For: Civelli O, Reinscheid RK, Zhang Y, Wang Z, Fredriksson R, Schiöth HB. G protein-coupled receptor deorphanizations. Annu Rev Pharmacol Toxicol 2013;53:127-46. [PMID: 23020293 DOI: 10.1146/annurev-pharmtox-010611-134548] [Cited by in Crossref: 111] [Cited by in F6Publishing: 113] [Article Influence: 11.1] [Reference Citation Analysis]
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2 Lee JW, Huang BX, Kwon H, Rashid MA, Kharebava G, Desai A, Patnaik S, Marugan J, Kim HY. Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function. Nat Commun 2016;7:13123. [PMID: 27759003 DOI: 10.1038/ncomms13123] [Cited by in Crossref: 70] [Cited by in F6Publishing: 71] [Article Influence: 11.7] [Reference Citation Analysis]
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6 Toll L, Bruchas MR, Calo' G, Cox BM, Zaveri NT. Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems. Pharmacol Rev 2016;68:419-57. [PMID: 26956246 DOI: 10.1124/pr.114.009209] [Cited by in Crossref: 147] [Cited by in F6Publishing: 135] [Article Influence: 24.5] [Reference Citation Analysis]
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8 Caruso V, Le Grevés M, Shirazi Fard S, Haitina T, Olszewski PK, Alsiö J, Schiöth HB, Fredriksson R. The Orphan G Protein-Coupled Receptor Gene GPR178 Is Evolutionary Conserved and Altered in Response to Acute Changes in Food Intake. PLoS One 2015;10:e0122061. [PMID: 26047506 DOI: 10.1371/journal.pone.0122061] [Cited by in Crossref: 1] [Article Influence: 0.1] [Reference Citation Analysis]
9 Kolar GR, Grote SM, Yosten GL. Targeting orphan G protein-coupled receptors for the treatment of diabetes and its complications: C-peptide and GPR146. J Intern Med 2017;281:25-40. [PMID: 27306986 DOI: 10.1111/joim.12528] [Cited by in Crossref: 14] [Cited by in F6Publishing: 13] [Article Influence: 2.3] [Reference Citation Analysis]
10 Ngo T, Ilatovskiy AV, Stewart AG, Coleman JL, McRobb FM, Riek RP, Graham RM, Abagyan R, Kufareva I, Smith NJ. Orphan receptor ligand discovery by pickpocketing pharmacological neighbors. Nat Chem Biol 2017;13:235-42. [PMID: 27992882 DOI: 10.1038/nchembio.2266] [Cited by in Crossref: 33] [Cited by in F6Publishing: 29] [Article Influence: 5.5] [Reference Citation Analysis]
11 Moniri NH. Free-fatty acid receptor-4 (GPR120): Cellular and molecular function and its role in metabolic disorders. Biochem Pharmacol 2016;110-111:1-15. [PMID: 26827942 DOI: 10.1016/j.bcp.2016.01.021] [Cited by in Crossref: 60] [Cited by in F6Publishing: 52] [Article Influence: 10.0] [Reference Citation Analysis]
12 Gilissen J, Geubelle P, Dupuis N, Laschet C, Pirotte B, Hanson J. Forskolin-free cAMP assay for Gi-coupled receptors. Biochem Pharmacol 2015;98:381-91. [PMID: 26386312 DOI: 10.1016/j.bcp.2015.09.010] [Cited by in Crossref: 21] [Cited by in F6Publishing: 21] [Article Influence: 3.0] [Reference Citation Analysis]
13 Rønnekleiv OK, Fang Y, Zhang C, Nestor CC, Mao P, Kelly MJ. Research resource: Gene profiling of G protein-coupled receptors in the arcuate nucleus of the female. Mol Endocrinol 2014;28:1362-80. [PMID: 24933249 DOI: 10.1210/me.2014-1103] [Cited by in Crossref: 15] [Cited by in F6Publishing: 15] [Article Influence: 1.9] [Reference Citation Analysis]
14 Ren Z, Chen L, Wang Y, Wei X, Zeng S, Zheng Y, Gao C, Liu H. Activation of the Omega-3 Fatty Acid Receptor GPR120 Protects against Focal Cerebral Ischemic Injury by Preventing Inflammation and Apoptosis in Mice. J Immunol 2019;202:747-59. [PMID: 30598514 DOI: 10.4049/jimmunol.1800637] [Cited by in Crossref: 21] [Cited by in F6Publishing: 21] [Article Influence: 5.3] [Reference Citation Analysis]
15 Black JB, Premont RT, Daaka Y. Feedback regulation of G protein-coupled receptor signaling by GRKs and arrestins. Semin Cell Dev Biol 2016;50:95-104. [PMID: 26773211 DOI: 10.1016/j.semcdb.2015.12.015] [Cited by in Crossref: 29] [Cited by in F6Publishing: 27] [Article Influence: 4.8] [Reference Citation Analysis]
16 Ward RJ, Milligan G. Structural and biophysical characterisation of G protein-coupled receptor ligand binding using resonance energy transfer and fluorescent labelling techniques. Biochim Biophys Acta 2014;1838:3-14. [PMID: 23590995 DOI: 10.1016/j.bbamem.2013.04.007] [Cited by in Crossref: 25] [Cited by in F6Publishing: 23] [Article Influence: 2.8] [Reference Citation Analysis]
17 Freyd T, Warszycki D, Mordalski S, Bojarski AJ, Sylte I, Gabrielsen M. Ligand-guided homology modelling of the GABAB2 subunit of the GABAB receptor. PLoS One 2017;12:e0173889. [PMID: 28323850 DOI: 10.1371/journal.pone.0173889] [Cited by in Crossref: 12] [Cited by in F6Publishing: 9] [Article Influence: 2.4] [Reference Citation Analysis]
18 Fisher GW, Fuhrman MH, Adler SA, Szent-gyorgyi C, Waggoner AS, Jarvik JW. Self-Checking Cell-Based Assays for GPCR Desensitization and Resensitization. J Biomol Screen 2014;19:1220-6. [DOI: 10.1177/1087057114534299] [Cited by in Crossref: 24] [Cited by in F6Publishing: 23] [Article Influence: 3.0] [Reference Citation Analysis]
19 Fricker LD. Carboxypeptidase E and the Identification of Novel Neuropeptides as Potential Therapeutic Targets. Adv Pharmacol 2018;82:85-102. [PMID: 29413529 DOI: 10.1016/bs.apha.2017.09.001] [Cited by in Crossref: 10] [Cited by in F6Publishing: 7] [Article Influence: 2.0] [Reference Citation Analysis]
20 Gavioli EC, Holanda VAD, Calo G, Ruzza C. Nociceptin/orphanin FQ receptor system blockade as an innovative strategy for increasing resilience to stress. Peptides 2021;141:170548. [PMID: 33862163 DOI: 10.1016/j.peptides.2021.170548] [Reference Citation Analysis]
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22 Alavi MS, Karimi G, Roohbakhsh A. The role of orphan G protein-coupled receptors in the pathophysiology of multiple sclerosis: A review. Life Sci 2019;224:33-40. [PMID: 30904492 DOI: 10.1016/j.lfs.2019.03.045] [Cited by in Crossref: 5] [Cited by in F6Publishing: 4] [Article Influence: 1.7] [Reference Citation Analysis]
23 Dunkel A, Steinhaus M, Kotthoff M, Nowak B, Krautwurst D, Schieberle P, Hofmann T. Nature's chemical signatures in human olfaction: a foodborne perspective for future biotechnology. Angew Chem Int Ed Engl 2014;53:7124-43. [PMID: 24939725 DOI: 10.1002/anie.201309508] [Cited by in Crossref: 245] [Cited by in F6Publishing: 185] [Article Influence: 30.6] [Reference Citation Analysis]
24 Grönbladh A, Hallberg M. [(35)S]GTPγS autoradiography for studies of opioid receptor functionality. Methods Mol Biol 2015;1230:169-76. [PMID: 25293324 DOI: 10.1007/978-1-4939-1708-2_13] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 0.1] [Reference Citation Analysis]
25 Harden TK. Enigmatic GPCR finds a stimulating drug. Sci Signal 2013;6:pe34. [PMID: 24150253 DOI: 10.1126/scisignal.2004755] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 0.2] [Reference Citation Analysis]
26 Schöneberg T, Meister J, Knierim AB, Schulz A. The G protein-coupled receptor GPR34 - The past 20 years of a grownup. Pharmacol Ther 2018;189:71-88. [PMID: 29684466 DOI: 10.1016/j.pharmthera.2018.04.008] [Cited by in Crossref: 13] [Cited by in F6Publishing: 11] [Article Influence: 3.3] [Reference Citation Analysis]
27 Wang K, Zheng Y, Yang Y, Wang J, Li B, Wei F, Zhao H, Ren X. Nociceptin Receptor Is Overexpressed in Non-small Cell Lung Cancer and Predicts Poor Prognosis. Front Oncol 2019;9:235. [PMID: 31024840 DOI: 10.3389/fonc.2019.00235] [Cited by in Crossref: 3] [Cited by in F6Publishing: 2] [Article Influence: 1.0] [Reference Citation Analysis]
28 Fricker LD, Devi LA. Orphan neuropeptides and receptors: Novel therapeutic targets. Pharmacol Ther 2018;185:26-33. [PMID: 29174650 DOI: 10.1016/j.pharmthera.2017.11.006] [Cited by in Crossref: 12] [Cited by in F6Publishing: 12] [Article Influence: 2.4] [Reference Citation Analysis]
29 Xiao C, Liu N, Province H, Piñol RA, Gavrilova O, Reitman ML. BRS3 in both MC4R- and SIM1-expressing neurons regulates energy homeostasis in mice. Mol Metab 2020;36:100969. [PMID: 32229422 DOI: 10.1016/j.molmet.2020.02.012] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 2.0] [Reference Citation Analysis]
30 Hoque M, Ali S, Hoda M. Current status of G-protein coupled receptors as potential targets against type 2 diabetes mellitus. International Journal of Biological Macromolecules 2018;118:2237-44. [DOI: 10.1016/j.ijbiomac.2018.07.091] [Cited by in Crossref: 5] [Cited by in F6Publishing: 4] [Article Influence: 1.3] [Reference Citation Analysis]
31 Krishnan A, Schiöth HB. The role of G protein-coupled receptors in the early evolution of neurotransmission and the nervous system. J Exp Biol 2015;218:562-71. [PMID: 25696819 DOI: 10.1242/jeb.110312] [Cited by in Crossref: 48] [Cited by in F6Publishing: 36] [Article Influence: 6.9] [Reference Citation Analysis]
32 Malfacini D, Caló G. Pharmacological Assays for Investigating the NOP Receptor. Handb Exp Pharmacol 2019;254:69-89. [PMID: 30725284 DOI: 10.1007/164_2018_200] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 0.3] [Reference Citation Analysis]
33 Ngo T, Kufareva I, Coleman JLj, Graham RM, Abagyan R, Smith NJ. Identifying ligands at orphan GPCRs: current status using structure-based approaches. Br J Pharmacol 2016;173:2934-51. [PMID: 26837045 DOI: 10.1111/bph.13452] [Cited by in Crossref: 39] [Cited by in F6Publishing: 33] [Article Influence: 6.5] [Reference Citation Analysis]
34 Chidambaram H, Chinnathambi S. G-Protein Coupled Receptors and Tau-different Roles in Alzheimer’s Disease. Neuroscience 2020;438:198-214. [DOI: 10.1016/j.neuroscience.2020.04.019] [Cited by in Crossref: 9] [Cited by in F6Publishing: 7] [Article Influence: 4.5] [Reference Citation Analysis]
35 Milligan G, Shimpukade B, Ulven T, Hudson BD. Complex Pharmacology of Free Fatty Acid Receptors. Chem Rev 2017;117:67-110. [PMID: 27299848 DOI: 10.1021/acs.chemrev.6b00056] [Cited by in Crossref: 117] [Cited by in F6Publishing: 109] [Article Influence: 19.5] [Reference Citation Analysis]
36 Jin C, Decker AM, Langston TL. Design, synthesis and pharmacological evaluation of 4-hydroxyphenylglycine and 4-hydroxyphenylglycinol derivatives as GPR88 agonists. Bioorg Med Chem 2017;25:805-12. [PMID: 27956039 DOI: 10.1016/j.bmc.2016.11.058] [Cited by in Crossref: 8] [Cited by in F6Publishing: 8] [Article Influence: 1.3] [Reference Citation Analysis]
37 Wang J, Chen MS, Wang RS, Hu JQ, Liu S, Wang YY, Xing XL, Zhang BW, Liu JM, Wang S. Current Advances in Structure-Function Relationships and Dose-Dependent Effects of Human Milk Oligosaccharides. J Agric Food Chem 2022. [PMID: 35593935 DOI: 10.1021/acs.jafc.2c01365] [Reference Citation Analysis]
38 Garcia VJ, Daur N, Temporal S, Schulz DJ, Bucher D. Neuropeptide receptor transcript expression levels and magnitude of ionic current responses show cell type-specific differences in a small motor circuit. J Neurosci 2015;35:6786-800. [PMID: 25926455 DOI: 10.1523/JNEUROSCI.0171-15.2015] [Cited by in Crossref: 25] [Cited by in F6Publishing: 20] [Article Influence: 3.6] [Reference Citation Analysis]
39 Di Liberto V, Mudò G, Garozzo R, Frinchi M, Fernandez-Dueñas V, Di Iorio P, Ciccarelli R, Caciagli F, Condorelli DF, Ciruela F, Belluardo N. The Guanine-Based Purinergic System: The Tale of An Orphan Neuromodulation. Front Pharmacol 2016;7:158. [PMID: 27378923 DOI: 10.3389/fphar.2016.00158] [Cited by in Crossref: 28] [Cited by in F6Publishing: 28] [Article Influence: 4.7] [Reference Citation Analysis]
40 Li S, Luo H, Lou R, Tian C, Miao C, Xia L, Pan C, Duan X, Dang T, Li H, Fan C, Tang P, Zhang Z, Liu Y, Li Y, Xu F, Zhang Y, Zhong G, Hu J, Shui W. Multiregional profiling of the brain transmembrane proteome uncovers novel regulators of depression. Sci Adv 2021;7:eabf0634. [PMID: 34290087 DOI: 10.1126/sciadv.abf0634] [Reference Citation Analysis]
41 Davis BH, Beasley TM, Amaral M, Szaflarski JP, Gaston T, Perry Grayson L, Standaert DG, Bebin EM, Limdi NA; UAB CBD Study Group (includes all the investigators involved in the UAB EAP CBD program). Pharmacogenetic Predictors of Cannabidiol Response and Tolerability in Treatment-Resistant Epilepsy. Clin Pharmacol Ther 2021;110:1368-80. [PMID: 34464454 DOI: 10.1002/cpt.2408] [Reference Citation Analysis]
42 Tian K, Xiao Q, Zhang X, Lan X, Zhao X, Wang Y, Li D, Yin H, Ye L, Zhu Q. Identification of two novel chicken GPR133 variants and their expression in different tissues. Funct Integr Genomics 2017;17:687-96. [DOI: 10.1007/s10142-017-0564-x] [Cited by in Crossref: 3] [Cited by in F6Publishing: 3] [Article Influence: 0.6] [Reference Citation Analysis]
43 Sisignano M, Bennett DL, Geisslinger G, Scholich K. TRP-channels as key integrators of lipid pathways in nociceptive neurons. Prog Lipid Res 2014;53:93-107. [PMID: 24287369 DOI: 10.1016/j.plipres.2013.11.002] [Cited by in Crossref: 41] [Cited by in F6Publishing: 37] [Article Influence: 4.6] [Reference Citation Analysis]
44 Bordano V, Kinsella GK, Cannito S, Dianzani C, Gigliotti CL, Stephens JC, Monge C, Bocca C, Rosa AC, Miglio G, Dianzani U, Findlay JB, Benetti E. G protein–coupled receptor 21 in macrophages: An in vitro study. European Journal of Pharmacology 2022. [DOI: 10.1016/j.ejphar.2022.175018] [Reference Citation Analysis]
45 Milligan G, Alvarez-Curto E, Watterson KR, Ulven T, Hudson BD. Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4. Br J Pharmacol 2015;172:3254-65. [PMID: 25131623 DOI: 10.1111/bph.12879] [Cited by in Crossref: 51] [Cited by in F6Publishing: 51] [Article Influence: 7.3] [Reference Citation Analysis]
46 Morri M, Sanchez-Romero I, Tichy AM, Kainrath S, Gerrard EJ, Hirschfeld PP, Schwarz J, Janovjak H. Optical functionalization of human Class A orphan G-protein-coupled receptors. Nat Commun 2018;9:1950. [PMID: 29769519 DOI: 10.1038/s41467-018-04342-1] [Cited by in Crossref: 17] [Cited by in F6Publishing: 15] [Article Influence: 4.3] [Reference Citation Analysis]
47 Xiao C, Reitman ML. Bombesin-Like Receptor 3: Physiology of a Functional Orphan. Trends Endocrinol Metab 2016;27:603-5. [PMID: 27055378 DOI: 10.1016/j.tem.2016.03.003] [Cited by in Crossref: 18] [Cited by in F6Publishing: 16] [Article Influence: 3.0] [Reference Citation Analysis]
48 Jékely G, Melzer S, Beets I, Kadow ICG, Koene J, Haddad S, Holden-Dye L. The long and the short of it - a perspective on peptidergic regulation of circuits and behaviour. J Exp Biol 2018;221:jeb166710. [PMID: 29439060 DOI: 10.1242/jeb.166710] [Cited by in Crossref: 42] [Cited by in F6Publishing: 36] [Article Influence: 10.5] [Reference Citation Analysis]
49 McCallum JE, Mackenzie AE, Divorty N, Clarke C, Delles C, Milligan G, Nicklin SA. G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation. J Vasc Res 2015;52:383-95. [PMID: 27064272 DOI: 10.1159/000444754] [Cited by in Crossref: 11] [Cited by in F6Publishing: 11] [Article Influence: 1.8] [Reference Citation Analysis]
50 Zhao C, Zhou J, Meng Y, Shi N, Wang X, Zhou M, Li G, Yang Y. DHA Sensor GPR120 in Host Defense Exhibits the Dual Characteristics of Regulating Dendritic Cell Function and Skewing the Balance of Th17/Tregs. Int J Biol Sci 2020;16:374-87. [PMID: 32015675 DOI: 10.7150/ijbs.39551] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 2.0] [Reference Citation Analysis]
51 Di Pizio A, Levit A, Slutzki M, Behrens M, Karaman R, Niv MY. Comparing Class A GPCRs to bitter taste receptors: Structural motifs, ligand interactions and agonist-to-antagonist ratios. Methods Cell Biol 2016;132:401-27. [PMID: 26928553 DOI: 10.1016/bs.mcb.2015.10.005] [Cited by in Crossref: 43] [Cited by in F6Publishing: 38] [Article Influence: 6.1] [Reference Citation Analysis]
52 Doi M, Murai I, Kunisue S, Setsu G, Uchio N, Tanaka R, Kobayashi S, Shimatani H, Hayashi H, Chao HW, Nakagawa Y, Takahashi Y, Hotta Y, Yasunaga J, Matsuoka M, Hastings MH, Kiyonari H, Okamura H. Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour. Nat Commun 2016;7:10583. [PMID: 26882873 DOI: 10.1038/ncomms10583] [Cited by in Crossref: 29] [Cited by in F6Publishing: 22] [Article Influence: 4.8] [Reference Citation Analysis]
53 Tichy AM, Gerrard EJ, Sexton PM, Janovjak H. Light-activated chimeric GPCRs: limitations and opportunities. Curr Opin Struct Biol 2019;57:196-203. [PMID: 31207383 DOI: 10.1016/j.sbi.2019.05.006] [Cited by in Crossref: 12] [Cited by in F6Publishing: 10] [Article Influence: 4.0] [Reference Citation Analysis]
54 Dupuis N, Laschet C, Franssen D, Szpakowska M, Gilissen J, Geubelle P, Soni A, Parent AS, Pirotte B, Chevigné A, Twizere JC, Hanson J. Activation of the Orphan G Protein-Coupled Receptor GPR27 by Surrogate Ligands Promotes β-Arrestin 2 Recruitment. Mol Pharmacol 2017;91:595-608. [PMID: 28314853 DOI: 10.1124/mol.116.107714] [Cited by in Crossref: 16] [Cited by in F6Publishing: 14] [Article Influence: 3.2] [Reference Citation Analysis]
55 Hauser AS, Gloriam DE, Bräuner-Osborne H, Foster SR. Novel approaches leading towards peptide GPCR de-orphanisation. Br J Pharmacol 2020;177:961-8. [PMID: 31863461 DOI: 10.1111/bph.14950] [Cited by in Crossref: 9] [Cited by in F6Publishing: 6] [Article Influence: 4.5] [Reference Citation Analysis]
56 Ye N, Li B, Mao Q, Wold EA, Tian S, Allen JA, Zhou J. Orphan Receptor GPR88 as an Emerging Neurotherapeutic Target. ACS Chem Neurosci 2019;10:190-200. [PMID: 30540906 DOI: 10.1021/acschemneuro.8b00572] [Cited by in Crossref: 9] [Cited by in F6Publishing: 11] [Article Influence: 3.0] [Reference Citation Analysis]
57 Jin C, Decker AM, Harris DL, Blough BE. Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA: Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies. ACS Chem Neurosci 2016;7:1418-32. [PMID: 27499251 DOI: 10.1021/acschemneuro.6b00182] [Cited by in Crossref: 13] [Cited by in F6Publishing: 13] [Article Influence: 2.2] [Reference Citation Analysis]
58 De Francesco EM, Sotgia F, Clarke RB, Lisanti MP, Maggiolini M. G Protein-Coupled Receptors at the Crossroad between Physiologic and Pathologic Angiogenesis: Old Paradigms and Emerging Concepts. Int J Mol Sci 2017;18:E2713. [PMID: 29240722 DOI: 10.3390/ijms18122713] [Cited by in Crossref: 16] [Cited by in F6Publishing: 12] [Article Influence: 3.2] [Reference Citation Analysis]
59 Oishi A, Karamitri A, Gerbier R, Lahuna O, Ahmad R, Jockers R. Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions. Sci Rep 2017;7:8990. [PMID: 28827538 DOI: 10.1038/s41598-017-08996-7] [Cited by in Crossref: 14] [Cited by in F6Publishing: 12] [Article Influence: 2.8] [Reference Citation Analysis]
60 Semmens DC, Beets I, Rowe ML, Blowes LM, Oliveri P, Elphick MR. Discovery of sea urchin NGFFFamide receptor unites a bilaterian neuropeptide family. Open Biol 2015;5:150030. [PMID: 25904544 DOI: 10.1098/rsob.150030] [Cited by in Crossref: 31] [Cited by in F6Publishing: 22] [Article Influence: 5.2] [Reference Citation Analysis]
61 Xiao C, Piñol RA, Carlin JL, Li C, Deng C, Gavrilova O, Reitman ML. Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism. Mol Metab 2017;6:1540-50. [PMID: 29107299 DOI: 10.1016/j.molmet.2017.08.013] [Cited by in Crossref: 11] [Cited by in F6Publishing: 12] [Article Influence: 2.2] [Reference Citation Analysis]
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