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For: Marti-Solano M, Crilly SE, Malinverni D, Munk C, Harris M, Pearce A, Quon T, Mackenzie AE, Wang X, Peng J, Tobin AB, Ladds G, Milligan G, Gloriam DE, Puthenveedu MA, Babu MM. Combinatorial expression of GPCR isoforms affects signalling and drug responses. Nature 2020;587:650-6. [PMID: 33149304 DOI: 10.1038/s41586-020-2888-2] [Cited by in Crossref: 17] [Cited by in F6Publishing: 10] [Article Influence: 8.5] [Reference Citation Analysis]
Number Citing Articles
1 Jensen SB, Thodberg S, Parween S, Moses ME, Hansen CC, Thomsen J, Sletfjerding MB, Knudsen C, Del Giudice R, Lund PM, Castaño PR, Bustamante YG, Velazquez MNR, Jørgensen FS, Pandey AV, Laursen T, Møller BL, Hatzakis NS. Biased cytochrome P450-mediated metabolism via small-molecule ligands binding P450 oxidoreductase. Nat Commun 2021;12:2260. [PMID: 33859207 DOI: 10.1038/s41467-021-22562-w] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 2.0] [Reference Citation Analysis]
2 Kumar GA, Puthenveedu MA. Diversity and specificity in location-based signaling outputs of neuronal GPCRs. Current Opinion in Neurobiology 2022;76:102601. [DOI: 10.1016/j.conb.2022.102601] [Reference Citation Analysis]
3 Kooistra AJ, Mordalski S, Pándy-Szekeres G, Esguerra M, Mamyrbekov A, Munk C, Keserű GM, Gloriam DE. GPCRdb in 2021: integrating GPCR sequence, structure and function. Nucleic Acids Res 2021;49:D335-43. [PMID: 33270898 DOI: 10.1093/nar/gkaa1080] [Cited by in Crossref: 19] [Cited by in F6Publishing: 23] [Article Influence: 19.0] [Reference Citation Analysis]
4 Herbrechter R, Hube N, Buchholz R, Reiner A. Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data. Cell Mol Life Sci 2021;78:5605-30. [PMID: 34100982 DOI: 10.1007/s00018-021-03865-z] [Cited by in F6Publishing: 2] [Reference Citation Analysis]
5 Matic M, Singh G, Carli F, Oliveira Rosa N, Miglionico P, Magni L, Gutkind JS, Russell RB, Inoue A, Raimondi F. PRECOGx: exploring GPCR signaling mechanisms with deep protein representations. Nucleic Acids Res 2022:gkac426. [PMID: 35639758 DOI: 10.1093/nar/gkac426] [Reference Citation Analysis]
6 Pearce A, Redfern-nichols T, Harris M, Poyner DR, Wigglesworth M, Ladds G. Determining the Effects of Differential Expression of GRKs and β-arrestins on CLR-RAMP Agonist Bias. Front Physiol 2022;13:840763. [DOI: 10.3389/fphys.2022.840763] [Reference Citation Analysis]
7 Liang J, Kruijssen DLH, Verschuuren ACJ, Voesenek BJB, Benavides FFW, Sáez Gonzalez M, Ruiter M, Wierenga CJ. Axonal CB1 Receptors Mediate Inhibitory Bouton Formation via cAMP Increase and PKA. J Neurosci 2021;41:8279-96. [PMID: 34413209 DOI: 10.1523/JNEUROSCI.0851-21.2021] [Reference Citation Analysis]
8 Schihada H, Klompstra TM, Humphrys LJ, Cervenka I, Dadvar S, Kolb P, Ruas JL, Schulte G. Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and mediate intracellular pathway bias. J Biol Chem 2022;:102328. [PMID: 35933013 DOI: 10.1016/j.jbc.2022.102328] [Reference Citation Analysis]
9 Sente A, Desai R, Naydenova K, Malinauskas T, Jounaidi Y, Miehling J, Zhou X, Masiulis S, Hardwick SW, Chirgadze DY, Miller KW, Aricescu AR. Differential assembly diversifies GABAA receptor structures and signalling. Nature 2022. [PMID: 35355020 DOI: 10.1038/s41586-022-04517-3] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 2.0] [Reference Citation Analysis]
10 Leysen H, Walter D, Christiaenssen B, Vandoren R, Harputluoğlu İ, Van Loon N, Maudsley S. GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between Health and Disease. Int J Mol Sci 2021;22:13387. [PMID: 34948182 DOI: 10.3390/ijms222413387] [Reference Citation Analysis]
11 Ramms DJ, Raimondi F, Arang N, Herberg FW, Taylor SS, Gutkind JS. Gαs-Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant Gαs-PKA Signaling. Pharmacol Rev 2021;73:155-97. [PMID: 34663687 DOI: 10.1124/pharmrev.120.000269] [Reference Citation Analysis]
12 Divorty N, Jenkins L, Ganguly A, Butcher AJ, Hudson BD, Schulz S, Tobin AB, Nicklin SA, Milligan G. Agonist-induced phosphorylation of orthologues of the orphan receptor GPR35 functions as an activation sensor. J Biol Chem 2022;298:101655. [PMID: 35101446 DOI: 10.1016/j.jbc.2022.101655] [Cited by in Crossref: 3] [Cited by in F6Publishing: 2] [Article Influence: 3.0] [Reference Citation Analysis]
13 Tichy AM, So WL, Gerrard EJ, Janovjak H. Structure-guided optimization of light-activated chimeric G-protein-coupled receptors. Structure 2022:S0969-2126(22)00139-3. [PMID: 35588733 DOI: 10.1016/j.str.2022.04.012] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 2.0] [Reference Citation Analysis]
14 Somogyi AA, Musolino ST, Barratt DT. New pharmacological perspectives and therapeutic options for opioids: Differences matter. Anaesth Intensive Care 2022;:310057X211063891. [PMID: 35112584 DOI: 10.1177/0310057X211063891] [Reference Citation Analysis]
15 Raines R, Mcknight I, White H, Legg K, Lee C, Li W, Lee PHU, Shim JW. Drug-Targeted Genomes: Mutability of Ion Channels and GPCRs. Biomedicines 2022;10:594. [DOI: 10.3390/biomedicines10030594] [Reference Citation Analysis]
16 van Gastel J, Leysen H, Boddaert J, Vangenechten L, Luttrell LM, Martin B, Maudsley S. Aging-related modifications to G protein-coupled receptor signaling diversity. Pharmacol Ther 2021;223:107793. [PMID: 33316288 DOI: 10.1016/j.pharmthera.2020.107793] [Cited by in Crossref: 1] [Article Influence: 0.5] [Reference Citation Analysis]
17 Lengger B, Hoch-Schneider EE, Jensen CN, Jakočiu Nas T, Petersen AA, Frimurer TM, Jensen ED, Jensen MK. Serotonin G Protein-Coupled Receptor-Based Biosensing Modalities in Yeast. ACS Sens 2022;7:1323-35. [PMID: 35452231 DOI: 10.1021/acssensors.1c02061] [Reference Citation Analysis]
18 Zhang CY, Xiao X, Zhang Z, Hu Z, Li M. An alternative splicing hypothesis for neuropathology of schizophrenia: evidence from studies on historical candidate genes and multi-omics data. Mol Psychiatry 2021. [PMID: 33686213 DOI: 10.1038/s41380-021-01037-w] [Cited by in Crossref: 7] [Cited by in F6Publishing: 4] [Article Influence: 7.0] [Reference Citation Analysis]
19 Torrens-Fontanals M, Stepniewski TM, Gloriam DE, Selent J. Structural dynamics bridge the gap between the genetic and functional levels of GPCRs. Curr Opin Struct Biol 2021;69:150-9. [PMID: 34052782 DOI: 10.1016/j.sbi.2021.04.005] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
20 Wright CJ, Smith CWJ, Jiggins CD. Alternative splicing as a source of phenotypic diversity. Nat Rev Genet 2022. [PMID: 35821097 DOI: 10.1038/s41576-022-00514-4] [Cited by in Crossref: 1] [Article Influence: 1.0] [Reference Citation Analysis]
21 Mckay K, Hamilton NB, Remington JM, Schneebeli ST, Li J. Essential Dynamics Ensemble Docking for Structure-Based GPCR Drug Discovery. Front Mol Biosci 2022;9:879212. [DOI: 10.3389/fmolb.2022.879212] [Reference Citation Analysis]
22 Lin LC, Quon T, Engberg S, Mackenzie AE, Tobin AB, Milligan G. G Protein-Coupled Receptor GPR35 Suppresses Lipid Accumulation in Hepatocytes. ACS Pharmacol Transl Sci 2021;4:1835-48. [PMID: 34927014 DOI: 10.1021/acsptsci.1c00224] [Reference Citation Analysis]
23 Winfield I, Barkan K, Routledge S, Robertson NJ, Harris M, Jazayeri A, Simms J, Reynolds CA, Poyner DR, Ladds G. The Role of ICL1 and H8 in Class B1 GPCRs; Implications for Receptor Activation. Front Endocrinol 2022;12:792912. [DOI: 10.3389/fendo.2021.792912] [Reference Citation Analysis]
24 Sachdev S, Cabalteja CC, Cheloha RW. Strategies for targeting cell surface proteins using multivalent conjugates and chemical biology. Methods Cell Biol 2021;166:205-22. [PMID: 34752333 DOI: 10.1016/bs.mcb.2021.06.004] [Reference Citation Analysis]
25 Cong Z, Zhou F, Zhang C, Zou X, Zhang H, Wang Y, Zhou Q, Cai X, Liu Q, Li J, Shao L, Mao C, Wang X, Wu J, Xia T, Zhao LH, Jiang H, Zhang Y, Xu HE, Cheng X, Yang D, Wang MW. Constitutive signal bias mediated by the human GHRHR splice variant 1. Proc Natl Acad Sci U S A 2021;118:e2106606118. [PMID: 34599099 DOI: 10.1073/pnas.2106606118] [Reference Citation Analysis]
26 Narci K, Kahraman DC, Koyas A, Ersahin T, Tuncbag N, Atalay RC. Context dependent isoform specific PI3K inhibition confers drug resistance in hepatocellular carcinoma cells. BMC Cancer 2022;22:320. [PMID: 35331184 DOI: 10.1186/s12885-022-09357-y] [Cited by in Crossref: 2] [Article Influence: 2.0] [Reference Citation Analysis]
27 Tasma Z, Siow A, Harris PWR, Brimble MA, Hay DL, Walker CS. Characterisation of agonist signalling profiles and agonist-dependent antagonism at PACAP-responsive receptors: Implications for drug discovery. Br J Pharmacol 2021. [PMID: 34612509 DOI: 10.1111/bph.15700] [Reference Citation Analysis]
28 Johansen OS, Ma T, Gerhart-Hines Z. Leveraging GPCR signaling in thermogenic fat to counteract metabolic diseases. Mol Metab 2022;:101474. [PMID: 35339729 DOI: 10.1016/j.molmet.2022.101474] [Reference Citation Analysis]
29 Cong Z, Liang Y, Zhou Q, Darbalaei S, Zhao F, Feng W, Zhao L, Xu HE, Yang D, Wang M. Structural perspective of class B1 GPCR signaling. Trends in Pharmacological Sciences 2022. [DOI: 10.1016/j.tips.2022.01.002] [Cited by in Crossref: 3] [Cited by in F6Publishing: 1] [Article Influence: 3.0] [Reference Citation Analysis]
30 Liu Q, Aseer KR, Yao Q, Zhong X, Ghosh P, O’connell JF, Egan JM. Anti-Inflammatory and Pro-Autophagy Effects of the Cannabinoid Receptor CB2R: Possibility of Modulation in Type 1 Diabetes. Front Pharmacol 2022;12:809965. [DOI: 10.3389/fphar.2021.809965] [Reference Citation Analysis]
31 Muscato AJ, Walsh P, Pong S, Pupo A, Gross RJ, Christie AE, Hull JJ, Dickinson PS. Does Differential Receptor Distribution Underlie Variable Responses to a Neuropeptide in the Lobster Cardiac System? Int J Mol Sci 2021;22:8703. [PMID: 34445418 DOI: 10.3390/ijms22168703] [Reference Citation Analysis]
32 Karakulak T, Moch H, von Mering C, Kahraman A. Probing Isoform Switching Events in Various Cancer Types: Lessons From Pan-Cancer Studies. Front Mol Biosci 2021;8:726902. [PMID: 34888349 DOI: 10.3389/fmolb.2021.726902] [Reference Citation Analysis]
33 Denzinger K, Nguyen TN, Noonan T, Wolber G, Bermudez M. Biased Ligands Differentially Shape the Conformation of the Extracellular Loop Region in 5-HT2B Receptors. Int J Mol Sci 2020;21:E9728. [PMID: 33419260 DOI: 10.3390/ijms21249728] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 1.0] [Reference Citation Analysis]
34 Louadi Z, Elkjaer ML, Klug M, Lio CT, Fenn A, Illes Z, Bongiovanni D, Baumbach J, Kacprowski T, List M, Tsoy O. Functional enrichment of alternative splicing events with NEASE reveals insights into tissue identity and diseases. Genome Biol 2021;22:327. [PMID: 34857024 DOI: 10.1186/s13059-021-02538-1] [Reference Citation Analysis]