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For: Johansson A, Löfberg C, Antonsson M, von Unge S, Hayes MA, Judkins R, Ploj K, Benthem L, Lindén D, Brodin P, Wennerberg M, Fredenwall M, Li L, Persson J, Bergman R, Pettersen A, Gennemark P, Hogner A. Discovery of (3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone (AZD1979), a Melanin Concentrating Hormone Receptor 1 (MCHr1) Antagonist with Favorable Physicochemical Properties. J Med Chem 2016;59:2497-511. [PMID: 26741166 DOI: 10.1021/acs.jmedchem.5b01654] [Cited by in Crossref: 37] [Cited by in F6Publishing: 27] [Article Influence: 6.2] [Reference Citation Analysis]
Number Citing Articles
1 Johansson A. Evolution of physicochemical properties of melanin concentrating hormone receptor 1 (MCHr1) antagonists. Bioorg Med Chem Lett 2016;26:4559-64. [PMID: 27595423 DOI: 10.1016/j.bmcl.2016.08.072] [Cited by in Crossref: 6] [Cited by in F6Publishing: 5] [Article Influence: 1.0] [Reference Citation Analysis]
2 Abdildinova A, Gong YD. Current Parallel Solid-Phase Synthesis of Drug-like Oxadiazole and Thiadiazole Derivatives for Combinatorial Chemistry. ACS Comb Sci 2018;20:309-29. [PMID: 29714475 DOI: 10.1021/acscombsci.8b00044] [Cited by in Crossref: 16] [Cited by in F6Publishing: 9] [Article Influence: 4.0] [Reference Citation Analysis]
3 Tyler JL, Noble A, Aggarwal VK. Strain‐Release Driven Spirocyclization of Azabicyclo[1.1.0]butyl Ketones. Angew Chem 2021;133:11930-5. [DOI: 10.1002/ange.202102754] [Cited by in Crossref: 2] [Cited by in F6Publishing: 1] [Article Influence: 2.0] [Reference Citation Analysis]
4 Hiesinger K, Dar'in D, Proschak E, Krasavin M. Spirocyclic Scaffolds in Medicinal Chemistry. J Med Chem 2021;64:150-83. [PMID: 33381970 DOI: 10.1021/acs.jmedchem.0c01473] [Cited by in Crossref: 15] [Cited by in F6Publishing: 12] [Article Influence: 7.5] [Reference Citation Analysis]
5 Babalola BA, Adetobi TE, Akinsuyi OS, Adebisi OA, Folajimi EO. Computational Study of the Therapeutic Potential of Novel Heterocyclic Derivatives against SARS-CoV-2. COVID 2021;1:757-74. [DOI: 10.3390/covid1040061] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
6 Kawata Y, Okuda S, Hotta N, Igawa H, Takahashi M, Ikoma M, Kasai S, Ando A, Satomi Y, Nishida M, Nakayama M, Yamamoto S, Nagisa Y, Takekawa S. A novel and selective melanin-concentrating hormone receptor 1 antagonist ameliorates obesity and hepatic steatosis in diet-induced obese rodent models. Eur J Pharmacol 2017;796:45-53. [PMID: 27986627 DOI: 10.1016/j.ejphar.2016.12.018] [Cited by in Crossref: 13] [Cited by in F6Publishing: 11] [Article Influence: 2.2] [Reference Citation Analysis]
7 Gennemark P, Trägårdh M, Lindén D, Ploj K, Johansson A, Turnbull A, Carlsson B, Antonsson M. Translational Modeling to Guide Study Design and Dose Choice in Obesity Exemplified by AZD1979, a Melanin-concentrating Hormone Receptor 1 Antagonist. CPT Pharmacometrics Syst Pharmacol 2017;6:458-68. [PMID: 28556607 DOI: 10.1002/psp4.12199] [Cited by in Crossref: 3] [Cited by in F6Publishing: 2] [Article Influence: 0.6] [Reference Citation Analysis]
8 Toselli F, Fredenwall M, Svensson P, Li XQ, Johansson A, Weidolf L, Hayes MA. Oxetane Substrates of Human Microsomal Epoxide Hydrolase. Drug Metab Dispos 2017;45:966-73. [PMID: 28600384 DOI: 10.1124/dmd.117.076489] [Cited by in Crossref: 8] [Cited by in F6Publishing: 7] [Article Influence: 1.6] [Reference Citation Analysis]
9 Ahmad S, Washburn WN, Hernandez AS, Bisaha S, Ngu K, Wang W, Pelleymounter MA, Longhi D, Flynn N, Azzara AV, Rohrbach K, Devenny J, Rooney S, Thomas M, Glick S, Godonis H, Harvey S, Zhang H, Gemzik B, Janovitz EB, Huang C, Zhang L, Robl JA, Murphy BJ. Synthesis and Antiobesity Properties of 6-(4-Chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2- d ]pyrimidin-4(3 H )-one (BMS-814580): A Highly Efficacious Melanin Concentrating Hormone Receptor 1 (MCHR1) Inhibitor. J Med Chem 2016;59:8848-58. [DOI: 10.1021/acs.jmedchem.6b00676] [Cited by in Crossref: 2] [Cited by in F6Publishing: 1] [Article Influence: 0.3] [Reference Citation Analysis]
10 Pancholi AK, Iacobini GP, Clarkson GJ, Porter DW, Shipman M. Synthesis of 4,5-Diazaspiro[2.3]hexanes and 1,2-Diazaspiro[3.3]heptanes as Hexahydropyridazine Analogues. J Org Chem 2018;83:491-8. [PMID: 29183129 DOI: 10.1021/acs.joc.7b02622] [Cited by in Crossref: 5] [Cited by in F6Publishing: 1] [Article Influence: 1.3] [Reference Citation Analysis]
11 Izu K, Tokoro Y, Oyama T. Curing acceleration of cyanate ester resin by a phenolic compound having a tertiary amino group at the ortho-position. Polym J 2020;52:1245-52. [DOI: 10.1038/s41428-020-0380-3] [Cited by in Crossref: 3] [Cited by in F6Publishing: 2] [Article Influence: 1.5] [Reference Citation Analysis]
12 Degorce SL, Bodnarchuk MS, Scott JS. Lowering Lipophilicity by Adding Carbon: AzaSpiroHeptanes, a logD Lowering Twist. ACS Med Chem Lett 2019;10:1198-204. [PMID: 31417667 DOI: 10.1021/acsmedchemlett.9b00248] [Cited by in Crossref: 14] [Cited by in F6Publishing: 7] [Article Influence: 4.7] [Reference Citation Analysis]
13 Tyler JL, Noble A, Aggarwal VK. Strain-Release Driven Spirocyclization of Azabicyclo[1.1.0]butyl Ketones. Angew Chem Int Ed Engl 2021;60:11824-9. [PMID: 33754432 DOI: 10.1002/anie.202102754] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
14 Bochevarov AD, Watson MA, Greenwood JR, Philipp DM. Multiconformation, Density Functional Theory-Based p Ka Prediction in Application to Large, Flexible Organic Molecules with Diverse Functional Groups. J Chem Theory Comput 2016;12:6001-19. [DOI: 10.1021/acs.jctc.6b00805] [Cited by in Crossref: 66] [Cited by in F6Publishing: 61] [Article Influence: 11.0] [Reference Citation Analysis]
15 Golden M, Legg D, Milne D, Bharadwaj M. A, Deepthi K, Gopal M, Dokka N, Nambiar S, Ramachandra P, Santhosh U, Sharma P, Sridharan R, Sulur M, Linderberg M, Nilsson A, Sohlberg R, Kremers J, Oliver S, Patra D. The Development of a Manufacturing Route to an MCHr1 Antagonist. Org Process Res Dev 2016;20:675-82. [DOI: 10.1021/acs.oprd.6b00006] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 0.2] [Reference Citation Analysis]
16 Parmar DR, Rayani RH, Vala AG, Kusurkar RV, Manvar RK, Talukdar SN, Preeti, Zunjar V, Battula S, Soni JY. Design, Synthesis, In Silico Studies and In Vitro Anticancer Activity of 3‐(4‐Methoxyphenyl)azetidine Derivatives. ChemistrySelect 2020;5:14296-302. [DOI: 10.1002/slct.202003654] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 0.5] [Reference Citation Analysis]
17 Meanwell NA. Improving Drug Design: An Update on Recent Applications of Efficiency Metrics, Strategies for Replacing Problematic Elements, and Compounds in Nontraditional Drug Space. Chem Res Toxicol 2016;29:564-616. [DOI: 10.1021/acs.chemrestox.6b00043] [Cited by in Crossref: 102] [Cited by in F6Publishing: 84] [Article Influence: 17.0] [Reference Citation Analysis]
18 Cheng R, Mori W, Ma L, Alhouayek M, Hatori A, Zhang Y, Ogasawara D, Yuan G, Chen Z, Zhang X, Shi H, Yamasaki T, Xie L, Kumata K, Fujinaga M, Nagai Y, Minamimoto T, Svensson M, Wang L, Du Y, Ondrechen MJ, Vasdev N, Cravatt BF, Fowler C, Zhang MR, Liang SH. In Vitro and in Vivo Evaluation of 11C-Labeled Azetidinecarboxylates for Imaging Monoacylglycerol Lipase by PET Imaging Studies. J Med Chem 2018;61:2278-91. [PMID: 29481079 DOI: 10.1021/acs.jmedchem.7b01400] [Cited by in Crossref: 25] [Cited by in F6Publishing: 21] [Article Influence: 6.3] [Reference Citation Analysis]
19 Gregson CHU, Noble A, Aggarwal VK. Divergent, Strain-Release Reactions of Azabicyclo[1.1.0]butyl Carbinols: Semipinacol or Spiroepoxy Azetidine Formation. Angew Chem Int Ed Engl 2021;60:7360-5. [PMID: 33555105 DOI: 10.1002/anie.202100583] [Cited by in Crossref: 7] [Cited by in F6Publishing: 6] [Article Influence: 7.0] [Reference Citation Analysis]
20 Ploj K, Benthem L, Kakol-Palm D, Gennemark P, Andersson L, Bjursell M, Börjesson J, Kärrberg L, Månsson M, Antonsson M, Johansson A, Iverson S, Carlsson B, Turnbull A, Lindén D. Effects of a novel potent melanin-concentrating hormone receptor 1 antagonist, AZD1979, on body weight homeostasis in mice and dogs. Br J Pharmacol 2016;173:2739-51. [PMID: 27400775 DOI: 10.1111/bph.13548] [Cited by in Crossref: 11] [Cited by in F6Publishing: 9] [Article Influence: 1.8] [Reference Citation Analysis]
21 Toselli F, Fredenwall M, Svensson P, Li X, Johansson A, Weidolf L, Hayes MA. Hip To Be Square: Oxetanes as Design Elements To Alter Metabolic Pathways. J Med Chem 2019;62:7383-99. [DOI: 10.1021/acs.jmedchem.9b00030] [Cited by in Crossref: 11] [Cited by in F6Publishing: 10] [Article Influence: 3.7] [Reference Citation Analysis]
22 Li XQ, Grönberg G, Bangur EH, Hayes MA, Castagnoli N Jr, Weidolf L. Metabolism of Strained Rings: Glutathione S-transferase-Catalyzed Formation of a Glutathione-Conjugated Spiro-azetidine without Prior Bioactivation. Drug Metab Dispos 2019;47:1247-56. [PMID: 31492694 DOI: 10.1124/dmd.119.088658] [Cited by in Crossref: 9] [Cited by in F6Publishing: 8] [Article Influence: 3.0] [Reference Citation Analysis]
23 Boutin JA, Jullian M, Frankiewicz L, Galibert M, Gloanec P, Le Diguarher T, Dupuis P, Ko A, Ripoll L, Bertrand M, Pecquery A, Ferry G, Puget K. MCH-R1 Antagonist GPS18169, a Pseudopeptide, Is a Peripheral Anti-Obesity Agent in Mice. Molecules 2021;26:1291. [PMID: 33673598 DOI: 10.3390/molecules26051291] [Reference Citation Analysis]
24 Yan L, Deng M, Chen A, Li Y, Zhang W, Du Z, Dong C, Meunier B, Chen H. Synthesis of N-pyrimidin[1,3,4]oxadiazoles and N-pyrimidin[1,3,4]-thiadiazoles from 1,3,4-oxadiazol-2-amines and 1,3,4-thiadiazol-2-amines via Pd-catalyzed heteroarylamination. Tetrahedron Letters 2019;60:1359-62. [DOI: 10.1016/j.tetlet.2019.04.022] [Cited by in Crossref: 6] [Cited by in F6Publishing: 1] [Article Influence: 2.0] [Reference Citation Analysis]
25 Schaller D, Hagenow S, Alpert G, Naß A, Schulz R, Bermudez M, Stark H, Wolber G. Systematic Data Mining Reveals Synergistic H3R/MCHR1 Ligands. ACS Med Chem Lett 2017;8:648-53. [PMID: 28626527 DOI: 10.1021/acsmedchemlett.7b00118] [Cited by in Crossref: 6] [Cited by in F6Publishing: 4] [Article Influence: 1.2] [Reference Citation Analysis]
26 Colella M, Musci P, Cannillo D, Spennacchio M, Aramini A, Degennaro L, Luisi R. Development of a Continuous Flow Synthesis of 2-Substituted Azetines and 3-Substituted Azetidines by Using a Common Synthetic Precursor. J Org Chem 2021;86:13943-54. [PMID: 34291947 DOI: 10.1021/acs.joc.1c01297] [Reference Citation Analysis]
27 Parmar DR, Soni JY, Guduru R, Rayani RH, Kusurkar RV, Vala AG. Azetidines of pharmacological interest. Arch Pharm (Weinheim) 2021;:e2100062. [PMID: 34184778 DOI: 10.1002/ardp.202100062] [Reference Citation Analysis]
28 Gregson CHU, Noble A, Aggarwal VK. Divergent, Strain‐Release Reactions of Azabicyclo[1.1.0]butyl Carbinols: Semipinacol or Spiroepoxy Azetidine Formation. Angew Chem 2021;133:7436-41. [DOI: 10.1002/ange.202100583] [Cited by in Crossref: 4] [Cited by in F6Publishing: 1] [Article Influence: 4.0] [Reference Citation Analysis]
29 Brown DG, Boström J. Where Do Recent Small Molecule Clinical Development Candidates Come From? J Med Chem 2018;61:9442-68. [DOI: 10.1021/acs.jmedchem.8b00675] [Cited by in Crossref: 54] [Cited by in F6Publishing: 43] [Article Influence: 13.5] [Reference Citation Analysis]
30 Musci P, Colella M, Andresini M, Aramini A, Degennaro L, Luisi R. Flow technology enabled preparation of C3-heterosubstituted 1-azabicyclo[1.1.0]butanes and azetidines: accessing unexplored chemical space in strained heterocyclic chemistry. Chem Commun (Camb) 2022;58:6356-9. [PMID: 35536561 DOI: 10.1039/d2cc01641a] [Reference Citation Analysis]
31 Bauer MR, Di Fruscia P, Lucas SCC, Michaelides IN, Nelson JE, Storer RI, Whitehurst BC. Put a ring on it: application of small aliphatic rings in medicinal chemistry. RSC Med Chem 2021;12:448-71. [PMID: 33937776 DOI: 10.1039/d0md00370k] [Cited by in Crossref: 16] [Cited by in F6Publishing: 4] [Article Influence: 16.0] [Reference Citation Analysis]
32 Li J, Lu X, Xu Y, Wen J, Hou G, Liu L. Photoredox Catalysis Enables Decarboxylative Cyclization with Hypervalent Iodine(III) Reagents: Access to 2,5-Disubstituted 1,3,4-Oxadiazoles. Org Lett 2020;22:9621-6. [DOI: 10.1021/acs.orglett.0c03663] [Cited by in Crossref: 8] [Cited by in F6Publishing: 3] [Article Influence: 4.0] [Reference Citation Analysis]
33 Lei B, Wang X, Ma L, Jiao H, Zhu L, Li Z. DDQ-promoted direct C5-alkylation of oxazoles with alkylboronic acids via palladium-catalysed C–H bond activation. Org Biomol Chem 2017;15:6084-8. [DOI: 10.1039/c7ob01083d] [Cited by in Crossref: 12] [Article Influence: 2.4] [Reference Citation Analysis]
34 Li XQ, Hayes MA, Grönberg G, Berggren K, Castagnoli N Jr, Weidolf L. Discovery of a Novel Microsomal Epoxide Hydrolase-Catalyzed Hydration of a Spiro Oxetane. Drug Metab Dispos 2016;44:1341-8. [PMID: 27256986 DOI: 10.1124/dmd.116.071142] [Cited by in Crossref: 7] [Cited by in F6Publishing: 7] [Article Influence: 1.2] [Reference Citation Analysis]
35 Khojasteh SC, Driscoll JP, Jackson KD, Miller GP, Mitra K, Rietjens IMCM, Zhang D. Novel advances in biotransformation and bioactivation research-2019 year in review.. Drug Metab Rev 2020;52:333-65. [PMID: 32645275 DOI: 10.1080/03602532.2020.1772281] [Cited by in Crossref: 1] [Article Influence: 0.5] [Reference Citation Analysis]