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For: Hiesinger K, Dar'in D, Proschak E, Krasavin M. Spirocyclic Scaffolds in Medicinal Chemistry. J Med Chem 2021;64:150-83. [PMID: 33381970 DOI: 10.1021/acs.jmedchem.0c01473] [Cited by in Crossref: 15] [Cited by in F6Publishing: 12] [Article Influence: 7.5] [Reference Citation Analysis]
Number Citing Articles
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2 Raji Reddy C, Kolgave DH, Ajaykumar U, Ramesh R. Copper(II)-catalyzed oxidative ipso-annulation of N-arylpropiolamides and biaryl ynones with 1,3-diketones: construction of diketoalkyl spiro-trienones. Org Biomol Chem 2022;20:6879-89. [PMID: 35972321 DOI: 10.1039/d2ob01282k] [Reference Citation Analysis]
3 Leśniak RK, Nichols RJ, Schonemann M, Zhao J, Gajera CR, Lam G, Nguyen KC, Langston JW, Smith M, Montine TJ. Discovery of azaspirocyclic 1H-3,4,5-Trisubstitued pyrazoles as novel G2019S-LRRK2 selective kinase inhibitors. Eur J Med Chem 2022;242:114693. [PMID: 36049274 DOI: 10.1016/j.ejmech.2022.114693] [Reference Citation Analysis]
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6 Xu Y, Shen Y, Du C, Liu L, Wu H, Ji Q. Spiro[benzoxazine-piperidin]-one derivatives as chitin synthase inhibitors and antifungal agents: Design, synthesis and biological evaluation. European Journal of Medicinal Chemistry 2022. [DOI: 10.1016/j.ejmech.2022.114723] [Reference Citation Analysis]
7 Lukin A, Chudinov M, Vedekhina T, Rogacheva E, Kraeva L, Bakulina O, Krasavin M. Exploration of Spirocyclic Derivatives of Ciprofloxacin as Antibacterial Agents. Molecules 2022;27:4864. [DOI: 10.3390/molecules27154864] [Reference Citation Analysis]
8 Cihan-Üstündağ G, Acar Ç, Naesens L, Erköse-Genç G, Şatana D. Synthesis of new N-(3-oxo-1-thia-4-azaspiro[4.5]decan-4-yl)pyridine-3-carboxamide derivatives and evaluation of their anti-influenza virus and antitubercular activities. Arch Pharm (Weinheim) 2022;:e2200224. [PMID: 35849096 DOI: 10.1002/ardp.202200224] [Reference Citation Analysis]
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11 Kumura K, Umemura E, Hirai Y, Ajito K. Discovery of Novel Lincomycin Derivatives Effective against Resistant Streptococcus pneumoniae and Streptococcus pyogenes Possessing ErmB Gene. J Synth Org Chem Jpn 2022;80:676-90. [DOI: 10.5059/yukigoseikyokaishi.80.676] [Reference Citation Analysis]
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13 Meanwell NA, Loiseleur O. Applications of Isosteres of Piperazine in the Design of Biologically Active Compounds: Part 1. J Agric Food Chem . [DOI: 10.1021/acs.jafc.2c00726] [Cited by in F6Publishing: 1] [Reference Citation Analysis]
14 Hu Y, Zhang S, Yu X, Feng X, Yamaguchi M, Bao M. Spirocarbocycle Synthesis from Chloromethylarenes via Transition-Metal-Catalyzed Allylative Dearomatization and Ring Closure Metathesis. J Org Chem 2022. [PMID: 35658456 DOI: 10.1021/acs.joc.2c00651] [Reference Citation Analysis]
15 Sedenkova KN, Andriasov KS, Eremenko MG, Grishin YK, Alferova VA, Baranova AA, Zefirov NA, Zefirova ON, Zarubaev VV, Gracheva YA, Milaeva ER, Averina EB. Bicyclic Isoxazoline Derivatives: Synthesis and Evaluation of Biological Activity. Molecules 2022;27:3546. [PMID: 35684482 DOI: 10.3390/molecules27113546] [Reference Citation Analysis]
16 Shirokova VV, Smirnov AY, Zaitseva ER, Baleeva NS, Mikhaylov AА, Baranov MS. Synthesis of julolidine derivatives via SnCl4-promoted spirocyclization of (1-alkyltetrahydroquinolin-8-yl)methylidene-1H-imidazol-5(4H)-ones. Chem Heterocycl Comp. [DOI: 10.1007/s10593-022-03080-z] [Reference Citation Analysis]
17 O'Dowd H, Manske JL, Freedman SA, Cochran JE. Ketoreductase-Catalyzed Access to Axially Chiral 2,6-Disubstituted Spiro[3.3]heptane Derivatives. Org Lett 2022. [PMID: 35486487 DOI: 10.1021/acs.orglett.2c01378] [Reference Citation Analysis]
18 Caló FP, Zimmer A, Bistoni G, Fürstner A. From Serendipity to Rational Design: Heteroleptic Dirhodium Amidate Complexes for Diastereodivergent Asymmetric Cyclopropanation. J Am Chem Soc 2022. [PMID: 35420801 DOI: 10.1021/jacs.2c02258] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
19 Ivanov DS, Zaitseva ER, Smirnov AY, Rustamova DA, Mikhaylov AA, Sycheva MA, Gluschenko DA, Baleeva NS, Baranov MS. Chemodivergent Spirocyclization of 2‐Sec‐Aminobenzilidene Imidazolones: Lewis Versus Brønsted Acids Catalysis. Adv Synth Catal 2022;364:1587-95. [DOI: 10.1002/adsc.202200109] [Reference Citation Analysis]
20 Wu H, Du C, Xu Y, Liu L, Zhou X, Ji Q. Design, synthesis, and biological evaluation of novel spiro[pyrrolidine-2,3′-quinolin]-2′-one derivatives as potential chitin synthase inhibitors and antifungal agents. European Journal of Medicinal Chemistry 2022;233:114208. [DOI: 10.1016/j.ejmech.2022.114208] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
21 Warghude PK, Bhowmick A, Bhat RG. Direct Access to Spirooxindole Dihydropyrrole Fused Pyrazolones and Bis-Spiropyrazolone Derivatives. Tetrahedron Letters 2022. [DOI: 10.1016/j.tetlet.2022.153791] [Reference Citation Analysis]
22 Batista VF, Pinto DCGA, Silva AMS. Recent in vivo advances of spirocyclic scaffolds for drug discovery. Expert Opin Drug Discov 2022;:1-16. [PMID: 35333138 DOI: 10.1080/17460441.2022.2055544] [Reference Citation Analysis]
23 Das P, Carter C, Shaheen G, Hamme AT 2nd. Bromo-lactamization of isoxazole via neighboring group participation: toward spiro-isoxazoline γ- and δ-lactams. RSC Adv 2022;12:9628-36. [PMID: 35424956 DOI: 10.1039/d2ra01070d] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
24 He X, Zhao Y, Zhang Z, Shen X. Tuning the Reactivity of Alkoxyl Radicals from Cyclization to 1,2-Silyl Transfer: Stereoselective Synthesis of β-Substituted Cycloalcohols. Org Lett . [DOI: 10.1021/acs.orglett.2c00428] [Cited by in Crossref: 4] [Article Influence: 4.0] [Reference Citation Analysis]
25 Peil S, Gutiérrez González A, Leutzsch M, Fürstner A. C-H Insertion via Ruthenium Catalyzed gem-Hydrogenation of 1,3-Enynes. J Am Chem Soc 2022. [PMID: 35170941 DOI: 10.1021/jacs.1c13446] [Cited by in Crossref: 8] [Cited by in F6Publishing: 3] [Article Influence: 8.0] [Reference Citation Analysis]
26 Peshkov AA, Makhmet A, Bakulina O, Kanov E, Gainetdinov R, Peshkov VA, Dar’in D, Krasavin M. A General Approach to Spirocyclic Piperidines via Castagnoli–Cushman Chemistry. Synthesis 2022;54:2604-15. [DOI: 10.1055/s-0040-1719878] [Reference Citation Analysis]
27 Yang T, Cui X, Tang M, Qi W, Zhu Z, Shi M, Yang L, Pei H, Zhang W, Xie L, Xu Y, Yang Z, Chen L. Identification of a Novel 2,8-Diazaspiro[4.5]decan-1-one Derivative as a Potent and Selective Dual TYK2/JAK1 Inhibitor for the Treatment of Inflammatory Bowel Disease. J Med Chem 2022. [PMID: 35113547 DOI: 10.1021/acs.jmedchem.1c01137] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
28 Vepreva A, Kantin G, Krasavin M, Dar’in D. A General Way to Spiro-Annulated 2-Benzoxepines via Rh2(esp)2-Catalyzed [5+2] Cycloaddition of Diazo Arylidene Succinimides to Ketones. Synthesis. [DOI: 10.1055/s-0037-1610790] [Cited by in Crossref: 2] [Cited by in F6Publishing: 1] [Article Influence: 2.0] [Reference Citation Analysis]
29 Mills LR, Gygi D, Ludwig JR, Simmons EM, Wisniewski SR, Kim J, Chirik PJ. Cobalt-Catalyzed C(sp 2 )–C(sp 3 ) Suzuki–Miyaura Cross-Coupling Enabled by Well-Defined Precatalysts with L,X-Type Ligands. ACS Catal 2022;12:1905-18. [DOI: 10.1021/acscatal.1c05586] [Cited by in Crossref: 1] [Article Influence: 1.0] [Reference Citation Analysis]
30 Pan Y, Ren W, Zhang Z, Luo F, Hou X, Li X, Yang Y, Wang Y. Tandem 1,6-addition/cyclopropanation/rearrangement reaction of vinylogous para -quinone methides with 3-chlorooxindoles: construction of vicinal quaternary carbon centers. Org Chem Front . [DOI: 10.1039/d2qo00471b] [Reference Citation Analysis]
31 Budeev A, Kantin G, Dar'in D, Krasavin M. Ugi reaction-derived 1H-pyrrol-2(5H)-ones proved as valid precursors to a new class of heterocyclic α-diazocarbonyl compounds. Tetrahedron Letters 2022;89:153598. [DOI: 10.1016/j.tetlet.2021.153598] [Reference Citation Analysis]
32 Revillo Imbernon J, Jacquemard C, Bret G, Marcou G, Kellenberger E. Comprehensive analysis of commercial fragment libraries. RSC Med Chem . [DOI: 10.1039/d1md00363a] [Reference Citation Analysis]
33 Wang M, Zhang J, Wang H, Ma B, Dai H. Construction of Aza-spiro[4,5]indole Scaffolds via Rhodium-Catalyzed Regioselective C(4)—H Activation of Indole . Acta Chimica Sinica 2022;80:277. [DOI: 10.6023/a21120588] [Reference Citation Analysis]
34 Deng Y, Sun S, Wang Y, Jia P, Li W, Wang K, Yan W. Asymmetric Synthesis of Chiral α ‐CF 2 H Spiro[Indoline‐3,3′‐Thiophene] via Phase‐Transfer Catalyzed Sulfa‐Michael/Michael Domino Reaction. Adv Synth Catal. [DOI: 10.1002/adsc.202101320] [Reference Citation Analysis]
35 Bavo F, de-Jong H, Petersen J, Falk-Petersen CB, Löffler R, Sparrow E, Rostrup F, Eliasen JN, Wilhelmsen KS, Barslund K, Bundgaard C, Nielsen B, Kristiansen U, Wellendorph P, Bogdanov Y, Frølund B. Structure-Activity Studies of 3,9-Diazaspiro[5.5]undecane-Based γ-Aminobutyric Acid Type A Receptor Antagonists with Immunomodulatory Effect. J Med Chem 2021;64:17795-812. [PMID: 34908407 DOI: 10.1021/acs.jmedchem.1c00290] [Reference Citation Analysis]
36 Harmata AS, Spiller TE, Sowden MJ, Stephenson CRJ. Photochemical Formal (4 + 2)-Cycloaddition of Imine-Substituted Bicyclo[1.1.1]pentanes and Alkenes. J Am Chem Soc 2021;143:21223-8. [PMID: 34902245 DOI: 10.1021/jacs.1c10541] [Reference Citation Analysis]
37 Soklou KE, Marzag H, Vallée B, Routier S, Plé K. Synthesis of Heterospirocycles through Gold‐(I) Catalysis: Useful Building Blocks for Medicinal Chemistry. Adv Synth Catal 2022;364:218-24. [DOI: 10.1002/adsc.202101080] [Cited by in Crossref: 1] [Article Influence: 1.0] [Reference Citation Analysis]
38 Zhao Y, Wang X, Yao R, Li C, Xu Z, Zhang L, Han G, Hou J, Liu Y, Song Y. Iron‐Catalyzed Alkene Trifluoromethylation in Tandem with Phenol Dearomatizing Spirocyclization: Regioselective Construction of Trifluoromethylated Spirocarbocycles. Adv Synth Catal 2022;364:637-42. [DOI: 10.1002/adsc.202101201] [Reference Citation Analysis]
39 Peng Y, Huo X, Luo Y, Wu L, Zhang W. Enantio- and Diastereodivergent Synthesis of Spirocycles through Dual-Metal-Catalyzed [3+2] Annulation of 2-Vinyloxiranes with Nucleophilic Dipoles. Angew Chem Int Ed Engl 2021;60:24941-9. [PMID: 34532948 DOI: 10.1002/anie.202111842] [Reference Citation Analysis]
40 Tyler JL, Noble A, Aggarwal VK. Strain-Release-Driven Friedel-Crafts Spirocyclization of Azabicyclo[1.1.0]butanes. Angew Chem Int Ed Engl 2021. [PMID: 34780681 DOI: 10.1002/anie.202114235] [Reference Citation Analysis]
41 Xu Y, Yu C, Zhang X, Fan X. Synthesis of Indolyl-Tethered Spiro[cyclobutane-1,1'-indenes] through Cascade Reactions of 1-(Pyridin-2-yl)-1H-indoles with Alkynyl Cyclobutanols. Org Lett 2021;23:8510-5. [PMID: 34652921 DOI: 10.1021/acs.orglett.1c03200] [Reference Citation Analysis]
42 Li L, Liu T, Zhang X, Hou X, Dong H, Li X, Ren W, Wang Y. Catalyst-free and atom-economical 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines: Facile synthesis of isoquinoline-fused spirocycles. Green Synthesis and Catalysis 2021. [DOI: 10.1016/j.gresc.2021.11.005] [Reference Citation Analysis]
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44 Simlandy AK, Lyu MY, Brown MK. Catalytic Arylboration of Spirocyclic Cyclobutenes: Rapid Access to Highly Substituted Spiro[3.n]alkanes. ACS Catal 2021;11:12815-20. [PMID: 35464106 DOI: 10.1021/acscatal.1c03491] [Cited by in Crossref: 6] [Cited by in F6Publishing: 1] [Article Influence: 6.0] [Reference Citation Analysis]
45 Chen Z, Zhang H, Zhou SF, Cui X. Metal-Free Sulfonylative Spirocyclization of Indolyl-ynones via Insertion of Sulfur Dioxide: Access to Sulfonated Spiro[cyclopentenone-1,3'-indoles]. Org Lett 2021;23:7992-5. [PMID: 34581591 DOI: 10.1021/acs.orglett.1c02999] [Cited by in Crossref: 1] [Article Influence: 1.0] [Reference Citation Analysis]
46 Askey HE, Grayson JD, Tibbetts JD, Turner-Dore JC, Holmes JM, Kociok-Kohn G, Wrigley GL, Cresswell AJ. Photocatalytic Hydroaminoalkylation of Styrenes with Unprotected Primary Alkylamines. J Am Chem Soc 2021;143:15936-45. [PMID: 34543004 DOI: 10.1021/jacs.1c07401] [Cited by in Crossref: 1] [Article Influence: 1.0] [Reference Citation Analysis]
47 Zhao AX, Horsfall LE, Hulme AN. New Methods for the Synthesis of Spirocyclic Cephalosporin Analogues. Molecules 2021;26:6035. [PMID: 34641579 DOI: 10.3390/molecules26196035] [Reference Citation Analysis]
48 Nayebzadeh B, Amiri K, Khosravi H, Mirzaei S, Rominger F, Dar'in D, Krasavin M, Bijanzadeh HR, Balalaie S. Synthesis of Spiro[chromene-imidazo[1,2-a]pyridin]-3'-imines via 6-exo-dig Cyclization Reaction. J Org Chem 2021;86:13693-701. [PMID: 34529434 DOI: 10.1021/acs.joc.1c01789] [Reference Citation Analysis]
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51 Silvestri IP, Colbon PJJ. The Growing Importance of Chirality in 3D Chemical Space Exploration and Modern Drug Discovery Approaches for Hit-ID: Topical Innovations. ACS Med Chem Lett 2021;12:1220-9. [PMID: 34413951 DOI: 10.1021/acsmedchemlett.1c00251] [Cited by in Crossref: 6] [Cited by in F6Publishing: 3] [Article Influence: 6.0] [Reference Citation Analysis]
52 Zhang J, Wang M, Wang H, Xu H, Chen J, Guo Z, Ma B, Ban SR, Dai HX. Construction of 2-alkynyl aza-spiro[4,5]indole scaffolds via sequential C-H activations for modular click chemistry libraries. Chem Commun (Camb) 2021;57:8656-9. [PMID: 34373875 DOI: 10.1039/d1cc02798k] [Reference Citation Analysis]
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57 Hariri M, Darvish F, Mengue Me Ndong KP, Sechet N, Chacktas G, Boosaliki H, Tran Do ML, Mwande-Maguene G, Lebibi J, Burilov AR, Ayad T, Virieux D, Pirat JL. Gold-Catalyzed Access to Isophosphinoline 2-Oxides. J Org Chem 2021;86:7813-24. [PMID: 34009995 DOI: 10.1021/acs.joc.1c00648] [Reference Citation Analysis]
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59 Murray PRD, Bussink WMM, Davies GHM, van der Mei FW, Antropow AH, Edwards JT, D'Agostino LA, Ellis JM, Hamann LG, Romanov-Michailidis F, Knowles RR. Intermolecular Crossed [2 + 2] Cycloaddition Promoted by Visible-Light Triplet Photosensitization: Expedient Access to Polysubstituted 2-Oxaspiro[3.3]heptanes. J Am Chem Soc 2021;143:4055-63. [PMID: 33666086 DOI: 10.1021/jacs.1c01173] [Cited by in Crossref: 4] [Article Influence: 4.0] [Reference Citation Analysis]
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