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For: Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C, Richardson JA, Williams SC, Xiong Y, Kisanuki Y. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell. 1999;98:437-451. [PMID: 10481909 DOI: 10.1016/s0092-8674(00)81973-x] [Cited by in Crossref: 2090] [Cited by in F6Publishing: 750] [Article Influence: 90.9] [Reference Citation Analysis]
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12 Herring WJ, Connor KM, Snyder E, Snavely DB, Zhang Y, Hutzelmann J, Matzura-Wolfe D, Benca RM, Krystal AD, Walsh JK, Lines C, Roth T, Michelson D. Suvorexant in Patients with Insomnia: Pooled Analyses of Three-Month Data from Phase-3 Randomized Controlled Clinical Trials. J Clin Sleep Med 2016;12:1215-25. [PMID: 27397664 DOI: 10.5664/jcsm.6116] [Cited by in Crossref: 30] [Cited by in F6Publishing: 26] [Article Influence: 5.0] [Reference Citation Analysis]
13 Sharf R, Guarnieri DJ, Taylor JR, DiLeone RJ. Orexin mediates morphine place preference, but not morphine-induced hyperactivity or sensitization. Brain Res 2010;1317:24-32. [PMID: 20034477 DOI: 10.1016/j.brainres.2009.12.035] [Cited by in Crossref: 69] [Cited by in F6Publishing: 74] [Article Influence: 5.3] [Reference Citation Analysis]
14 Hasegawa E, Maejima T, Yoshida T, Masseck OA, Herlitze S, Yoshioka M, Sakurai T, Mieda M. Serotonin neurons in the dorsal raphe mediate the anticataplectic action of orexin neurons by reducing amygdala activity. Proc Natl Acad Sci U S A 2017;114:E3526-35. [PMID: 28396432 DOI: 10.1073/pnas.1614552114] [Cited by in Crossref: 43] [Cited by in F6Publishing: 38] [Article Influence: 8.6] [Reference Citation Analysis]
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16 Desarnaud F, Murillo-Rodriguez E, Lin L, Xu M, Gerashchenko D, Shiromani SN, Nishino S, Mignot E, Shiromani PJ. The diurnal rhythm of hypocretin in young and old F344 rats. Sleep 2004;27:851-6. [PMID: 15453542 DOI: 10.1093/sleep/27.5.851] [Cited by in Crossref: 65] [Cited by in F6Publishing: 58] [Article Influence: 3.6] [Reference Citation Analysis]
17 Mignot E, Lin L, Rogers W, Honda Y, Qiu X, Lin X, Okun M, Hohjoh H, Miki T, Hsu S, Leffell M, Grumet F, Fernandez-Vina M, Honda M, Risch N. Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am J Hum Genet 2001;68:686-99. [PMID: 11179016 DOI: 10.1086/318799] [Cited by in Crossref: 397] [Cited by in F6Publishing: 307] [Article Influence: 18.9] [Reference Citation Analysis]
18 Williams RH, Burdakov D. Hypothalamic orexins/hypocretins as regulators of breathing. Expert Rev Mol Med 2008;10:e28. [PMID: 18828950 DOI: 10.1017/S1462399408000823] [Cited by in Crossref: 59] [Cited by in F6Publishing: 24] [Article Influence: 4.2] [Reference Citation Analysis]
19 Sikder D, Kodadek T. The neurohormone orexin stimulates hypoxia-inducible factor-1 activity. Genes Dev 2007;21:2995-3005. [PMID: 18006690 DOI: 10.1101/gad.1584307] [Cited by in Crossref: 43] [Cited by in F6Publishing: 41] [Article Influence: 2.9] [Reference Citation Analysis]
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25 Lin YF, Xu X, Cape A, Li S, Li XJ. Huntingtin-associated protein-1 deficiency in orexin-producing neurons impairs neuronal process extension and leads to abnormal behavior in mice. J Biol Chem 2010;285:15941-9. [PMID: 20304926 DOI: 10.1074/jbc.M110.107318] [Cited by in Crossref: 25] [Cited by in F6Publishing: 16] [Article Influence: 2.1] [Reference Citation Analysis]
26 Nishino S, Okuro M, Kotorii N, Anegawa E, Ishimaru Y, Matsumura M, Kanbayashi T. Hypocretin/orexin and narcolepsy: new basic and clinical insights. Acta Physiol (Oxf) 2010;198:209-22. [PMID: 19555382 DOI: 10.1111/j.1748-1716.2009.02012.x] [Cited by in Crossref: 39] [Cited by in F6Publishing: 30] [Article Influence: 3.0] [Reference Citation Analysis]
27 Tyree SM, Borniger JC, de Lecea L. Hypocretin as a Hub for Arousal and Motivation. Front Neurol 2018;9:413. [PMID: 29928253 DOI: 10.3389/fneur.2018.00413] [Cited by in Crossref: 37] [Cited by in F6Publishing: 28] [Article Influence: 9.3] [Reference Citation Analysis]
28 Satoh A, Brace CS, Ben-Josef G, West T, Wozniak DF, Holtzman DM, Herzog ED, Imai S. SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus. J Neurosci 2010;30:10220-32. [PMID: 20668205 DOI: 10.1523/JNEUROSCI.1385-10.2010] [Cited by in Crossref: 150] [Cited by in F6Publishing: 91] [Article Influence: 12.5] [Reference Citation Analysis]
29 Cun Y, Tang L, Yan J, He C, Li Y, Hu Z, Xia J. Orexin A attenuates the sleep-promoting effect of adenosine in the lateral hypothalamus of rats. Neurosci Bull 2014;30:877-86. [PMID: 24898402 DOI: 10.1007/s12264-013-1442-8] [Cited by in Crossref: 20] [Cited by in F6Publishing: 18] [Article Influence: 2.5] [Reference Citation Analysis]
30 Thompson MD, Sakurai T, Rainero I, Maj MC, Kukkonen JP. Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics. Pharmaceuticals (Basel) 2017;10:E79. [PMID: 28991183 DOI: 10.3390/ph10040079] [Cited by in Crossref: 25] [Cited by in F6Publishing: 23] [Article Influence: 5.0] [Reference Citation Analysis]
31 Fadel J, Burk JA. Orexin/hypocretin modulation of the basal forebrain cholinergic system: Role in attention. Brain Res 2010;1314:112-23. [PMID: 19699722 DOI: 10.1016/j.brainres.2009.08.046] [Cited by in Crossref: 56] [Cited by in F6Publishing: 58] [Article Influence: 4.3] [Reference Citation Analysis]
32 Wu MF, Nienhuis R, Maidment N, Lam HA, Siegel JM. Role of the hypocretin (orexin) receptor 2 (Hcrt-r2) in the regulation of hypocretin level and cataplexy. J Neurosci 2011;31:6305-10. [PMID: 21525270 DOI: 10.1523/JNEUROSCI.0365-11.2011] [Cited by in Crossref: 13] [Cited by in F6Publishing: 9] [Article Influence: 1.2] [Reference Citation Analysis]
33 Equihua AC, De La Herrán-Arita AK, Drucker-Colin R. Orexin receptor antagonists as therapeutic agents for insomnia. Front Pharmacol 2013;4:163. [PMID: 24416019 DOI: 10.3389/fphar.2013.00163] [Cited by in Crossref: 27] [Cited by in F6Publishing: 21] [Article Influence: 3.0] [Reference Citation Analysis]
34 Siebold C, Hansen BE, Wyer JR, Harlos K, Esnouf RE, Svejgaard A, Bell JI, Strominger JL, Jones EY, Fugger L. Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy. Proc Natl Acad Sci U S A 2004;101:1999-2004. [PMID: 14769912 DOI: 10.1073/pnas.0308458100] [Cited by in Crossref: 103] [Cited by in F6Publishing: 89] [Article Influence: 5.7] [Reference Citation Analysis]
35 Yu X, Ma Y, Harding EC, Yustos R, Vyssotski AL, Franks NP, Wisden W. Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness. Sleep 2019;42:zsz031. [PMID: 30722053 DOI: 10.1093/sleep/zsz031] [Cited by in Crossref: 7] [Cited by in F6Publishing: 7] [Article Influence: 3.5] [Reference Citation Analysis]
36 Mizrahi-Kliger AD, Feldmann LK, Kühn AA, Bergman H. Etiologies of insomnia in Parkinson's disease - Lessons from human studies and animal models. Exp Neurol 2022;350:113976. [PMID: 35026228 DOI: 10.1016/j.expneurol.2022.113976] [Reference Citation Analysis]
37 St Louis EK, Videnovic A. Sleep Neurology's Toolkit at the Crossroads: Challenges and Opportunities in Neurotherapeutics Lost and Found in Translation. Neurotherapeutics 2021;18:1-5. [PMID: 33821447 DOI: 10.1007/s13311-021-01032-7] [Reference Citation Analysis]
38 Stettner GM, Kubin L. Antagonism of orexin receptors in the posterior hypothalamus reduces hypoglossal and cardiorespiratory excitation from the perifornical hypothalamus. J Appl Physiol (1985) 2013;114:119-30. [PMID: 23104701 DOI: 10.1152/japplphysiol.00965.2012] [Cited by in Crossref: 10] [Cited by in F6Publishing: 10] [Article Influence: 1.0] [Reference Citation Analysis]
39 Kohlmeier KA, Watanabe S, Tyler CJ, Burlet S, Leonard CS. Dual orexin actions on dorsal raphe and laterodorsal tegmentum neurons: noisy cation current activation and selective enhancement of Ca2+ transients mediated by L-type calcium channels. J Neurophysiol 2008;100:2265-81. [PMID: 18667550 DOI: 10.1152/jn.01388.2007] [Cited by in Crossref: 59] [Cited by in F6Publishing: 65] [Article Influence: 4.2] [Reference Citation Analysis]
40 Kawashima M, Lin L, Tanaka S, Jennum P, Knudsen S, Nevsimalova S, Plazzi G, Mignot E. Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy. Sleep 2010;33:869-74. [PMID: 20614846 DOI: 10.1093/sleep/33.7.869] [Cited by in Crossref: 89] [Cited by in F6Publishing: 79] [Article Influence: 7.4] [Reference Citation Analysis]
41 Boutrel B, Cannella N, de Lecea L. The role of hypocretin in driving arousal and goal-oriented behaviors. Brain Res 2010;1314:103-11. [PMID: 19948148 DOI: 10.1016/j.brainres.2009.11.054] [Cited by in Crossref: 84] [Cited by in F6Publishing: 86] [Article Influence: 6.5] [Reference Citation Analysis]
42 Venner A, Todd WD, Fraigne J, Bowrey H, Eban-Rothschild A, Kaur S, Anaclet C. Newly identified sleep-wake and circadian circuits as potential therapeutic targets. Sleep 2019;42:zsz023. [PMID: 30722061 DOI: 10.1093/sleep/zsz023] [Cited by in Crossref: 8] [Cited by in F6Publishing: 6] [Article Influence: 4.0] [Reference Citation Analysis]
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44 Kotz CM, Perez-Leighton CE, Teske JA, Billington CJ. Spontaneous Physical Activity Defends Against Obesity. Curr Obes Rep 2017;6:362-70. [PMID: 29101738 DOI: 10.1007/s13679-017-0288-1] [Cited by in Crossref: 17] [Cited by in F6Publishing: 14] [Article Influence: 4.3] [Reference Citation Analysis]
45 Cason AM, Smith RJ, Tahsili-Fahadan P, Moorman DE, Sartor GC, Aston-Jones G. Role of orexin/hypocretin in reward-seeking and addiction: implications for obesity. Physiol Behav 2010;100:419-28. [PMID: 20338186 DOI: 10.1016/j.physbeh.2010.03.009] [Cited by in Crossref: 155] [Cited by in F6Publishing: 150] [Article Influence: 12.9] [Reference Citation Analysis]
46 Latifi B, Adamantidis A, Bassetti C, Schmidt MH. Sleep-Wake Cycling and Energy Conservation: Role of Hypocretin and the Lateral Hypothalamus in Dynamic State-Dependent Resource Optimization. Front Neurol 2018;9:790. [PMID: 30344503 DOI: 10.3389/fneur.2018.00790] [Cited by in Crossref: 11] [Cited by in F6Publishing: 10] [Article Influence: 2.8] [Reference Citation Analysis]
47 Flores Á, Julià-Hernández M, Maldonado R, Berrendero F. Involvement of the orexin/hypocretin system in the pharmacological effects induced by Δ(9) -tetrahydrocannabinol. Br J Pharmacol 2016;173:1381-92. [PMID: 26799708 DOI: 10.1111/bph.13440] [Cited by in Crossref: 10] [Cited by in F6Publishing: 9] [Article Influence: 1.7] [Reference Citation Analysis]
48 Acuna-Goycolea C, van den Pol AN. Neuroendocrine proopiomelanocortin neurons are excited by hypocretin/orexin. J Neurosci 2009;29:1503-13. [PMID: 19193897 DOI: 10.1523/JNEUROSCI.5147-08.2009] [Cited by in Crossref: 39] [Cited by in F6Publishing: 22] [Article Influence: 3.0] [Reference Citation Analysis]
49 Sun Y, Tisdale RK, Kilduff TS. Hypocretin/Orexin Receptor Pharmacology and Sleep Phases. Front Neurol Neurosci 2021;45:22-37. [PMID: 34052813 DOI: 10.1159/000514963] [Cited by in Crossref: 2] [Cited by in F6Publishing: 1] [Article Influence: 2.0] [Reference Citation Analysis]
50 Sun Y, Blanco-Centurion C, Zou B, Bendell E, Shiromani PJ, Liu M. Amygdala GABA Neurons Project To vlPAG And mPFC. IBRO Rep 2019;6:132-6. [PMID: 31193158 DOI: 10.1016/j.ibror.2019.03.001] [Cited by in Crossref: 6] [Cited by in F6Publishing: 5] [Article Influence: 2.0] [Reference Citation Analysis]
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54 Baracchi F, Opp MR. Sleep-wake behavior and responses to sleep deprivation of mice lacking both interleukin-1 beta receptor 1 and tumor necrosis factor-alpha receptor 1. Brain Behav Immun 2008;22:982-93. [PMID: 18329246 DOI: 10.1016/j.bbi.2008.02.001] [Cited by in Crossref: 50] [Cited by in F6Publishing: 49] [Article Influence: 3.6] [Reference Citation Analysis]
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58 Kumar R. Approved and investigational uses of modafinil: an evidence-based review. Drugs. 2008;68:1803-1839. [PMID: 18729534 DOI: 10.2165/00003495-200868130-00003] [Cited by in Crossref: 156] [Cited by in F6Publishing: 116] [Article Influence: 12.0] [Reference Citation Analysis]
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60 Yi SS, Chung SH, Kim PS. Sharing Pathological Mechanisms of Insomnia and Osteoporosis, and a New Perspective on Safe Drug Choice. J Menopausal Med 2018;24:143-9. [PMID: 30671405 DOI: 10.6118/jmm.2018.24.3.143] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 0.3] [Reference Citation Analysis]
61 Miyagawa T, Honda M, Kawashima M, Shimada M, Tanaka S, Honda Y, Tokunaga K. Polymorphism located between CPT1B and CHKB, and HLA-DRB1*1501-DQB1*0602 haplotype confer susceptibility to CNS hypersomnias (essential hypersomnia). PLoS One 2009;4:e5394. [PMID: 19404393 DOI: 10.1371/journal.pone.0005394] [Cited by in Crossref: 24] [Cited by in F6Publishing: 19] [Article Influence: 1.8] [Reference Citation Analysis]
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