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For: Sakurai T, Mieda M. Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal. Trends Pharmacol Sci 2011;32:451-62. [PMID: 21565412 DOI: 10.1016/j.tips.2011.03.007] [Cited by in Crossref: 139] [Cited by in F6Publishing: 136] [Article Influence: 12.6] [Reference Citation Analysis]
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6 Heydendael W, Sengupta A, Bhatnagar S. Putative genes mediating the effects of orexins in the posterior paraventricular thalamus on neuroendocrine and behavioral adaptations to repeated stress. Brain Res Bull 2012;89:203-10. [PMID: 22982687 DOI: 10.1016/j.brainresbull.2012.09.002] [Cited by in Crossref: 11] [Cited by in F6Publishing: 12] [Article Influence: 1.1] [Reference Citation Analysis]
7 Vazquez-DeRose J, Schwartz MD, Nguyen AT, Warrier DR, Gulati S, Mathew TK, Neylan TC, Kilduff TS. Hypocretin/orexin antagonism enhances sleep-related adenosine and GABA neurotransmission in rat basal forebrain. Brain Struct Funct 2016;221:923-40. [PMID: 25431268 DOI: 10.1007/s00429-014-0946-y] [Cited by in Crossref: 13] [Cited by in F6Publishing: 17] [Article Influence: 1.6] [Reference Citation Analysis]
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9 Roecker AJ, Mercer SP, Schreier JD, Cox CD, Fraley ME, Steen JT, Lemaire W, Bruno JG, Harrell CM, Garson SL, Gotter AL, Fox SV, Stevens J, Tannenbaum PL, Prueksaritanont T, Cabalu TD, Cui D, Stellabott J, Hartman GD, Young SD, Winrow CJ, Renger JJ, Coleman PJ. Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia. ChemMedChem 2014;9:311-22. [PMID: 24376006 DOI: 10.1002/cmdc.201300447] [Cited by in Crossref: 48] [Cited by in F6Publishing: 39] [Article Influence: 5.3] [Reference Citation Analysis]
10 Iigaya K, Horiuchi J, Mcdowall LM, Lam ACB, Sediqi Y, Polson JW, Carrive P, Dampney RAL. Blockade of orexin receptors with Almorexant reduces cardiorespiratory responses evoked from the hypothalamus but not baro- or chemoreceptor reflex responses. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2012;303:R1011-22. [DOI: 10.1152/ajpregu.00263.2012] [Cited by in Crossref: 22] [Cited by in F6Publishing: 24] [Article Influence: 2.2] [Reference Citation Analysis]
11 Lynch KS, O'Connell LA, Louder MIM, Balakrishnan CN, Fischer EK. Understanding the Loss of Maternal Care in Avian Brood Parasites Using Preoptic Area Transcriptome Comparisons in Brood Parasitic and Non-parasitic Blackbirds. G3 (Bethesda) 2019;9:1075-84. [PMID: 30760540 DOI: 10.1534/g3.118.200992] [Cited by in Crossref: 1] [Cited by in F6Publishing: 2] [Article Influence: 0.3] [Reference Citation Analysis]
12 Yi SS, Chung SH, Kim PS. Sharing Pathological Mechanisms of Insomnia and Osteoporosis, and a New Perspective on Safe Drug Choice. J Menopausal Med 2018;24:143-9. [PMID: 30671405 DOI: 10.6118/jmm.2018.24.3.143] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 0.3] [Reference Citation Analysis]
13 Carvajal F, Alcaraz-iborra M, Lerma-cabrera JM, Valor LM, de la Fuente L, Sanchez-amate MDC, Cubero I. Orexin receptor 1 signaling contributes to ethanol binge-like drinking: Pharmacological and molecular evidence. Behavioural Brain Research 2015;287:230-7. [DOI: 10.1016/j.bbr.2015.03.046] [Cited by in Crossref: 14] [Cited by in F6Publishing: 13] [Article Influence: 2.0] [Reference Citation Analysis]
14 Jaeger WC, Seeber RM, Eidne KA, Pfleger KD. Molecular determinants of orexin receptor-arrestin-ubiquitin complex formation. Br J Pharmacol 2014;171:364-74. [PMID: 24206104 DOI: 10.1111/bph.12481] [Cited by in Crossref: 13] [Cited by in F6Publishing: 11] [Article Influence: 1.6] [Reference Citation Analysis]
15 Gupta PR, Prabhavalkar K. Combination therapy with neuropeptides for the treatment of anxiety disorder. Neuropeptides 2021;86:102127. [PMID: 33607407 DOI: 10.1016/j.npep.2021.102127] [Reference Citation Analysis]
16 Furutani N, Hondo M, Kageyama H, Tsujino N, Mieda M, Yanagisawa M, Shioda S, Sakurai T. Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness states. PLoS One 2013;8:e62391. [PMID: 23620827 DOI: 10.1371/journal.pone.0062391] [Cited by in Crossref: 49] [Cited by in F6Publishing: 46] [Article Influence: 5.4] [Reference Citation Analysis]
17 Dale NC, Hoyer D, Jacobson LH, Pfleger KDG, Johnstone EKM. Orexin Signaling: A Complex, Multifaceted Process. Front Cell Neurosci 2022;16:812359. [DOI: 10.3389/fncel.2022.812359] [Reference Citation Analysis]
18 Panula P, Nuutinen S. The histaminergic network in the brain: basic organization and role in disease. Nat Rev Neurosci 2013;14:472-87. [DOI: 10.1038/nrn3526] [Cited by in Crossref: 179] [Cited by in F6Publishing: 168] [Article Influence: 19.9] [Reference Citation Analysis]
19 Nonogaki K. Serotonin conflict in sleep-feeding. Vitam Horm 2012;89:223-39. [PMID: 22640616 DOI: 10.1016/B978-0-12-394623-2.00012-3] [Cited by in Crossref: 6] [Cited by in F6Publishing: 3] [Article Influence: 0.6] [Reference Citation Analysis]
20 Jalewa J, Wong-lin K, Mcginnity TM, Prasad G, Hölscher C. Increased number of orexin/hypocretin neurons with high and prolonged external stress-induced depression. Behavioural Brain Research 2014;272:196-204. [DOI: 10.1016/j.bbr.2014.05.030] [Cited by in Crossref: 41] [Cited by in F6Publishing: 32] [Article Influence: 5.1] [Reference Citation Analysis]
21 Hunt NJ, Waters KA, Rodriguez ML, Machaalani R. Decreased orexin (hypocretin) immunoreactivity in the hypothalamus and pontine nuclei in sudden infant death syndrome. Acta Neuropathol 2015;130:185-98. [PMID: 25953524 DOI: 10.1007/s00401-015-1437-9] [Cited by in Crossref: 23] [Cited by in F6Publishing: 18] [Article Influence: 3.3] [Reference Citation Analysis]
22 Öz P, Gökalp HK, Göver T, Uzbay T. Dose-dependent and opposite effects of orexin A on prepulse inhibition response in sleep-deprived and non-sleep-deprived rats. Behav Brain Res 2018;346:73-9. [PMID: 29237551 DOI: 10.1016/j.bbr.2017.12.002] [Cited by in Crossref: 3] [Cited by in F6Publishing: 3] [Article Influence: 0.6] [Reference Citation Analysis]
23 Kakizaki M, Tsuneoka Y, Takase K, Kim SJ, Choi J, Ikkyu A, Abe M, Sakimura K, Yanagisawa M, Funato H. Differential Roles of Each Orexin Receptor Signaling in Obesity. iScience 2019;20:1-13. [PMID: 31546102 DOI: 10.1016/j.isci.2019.09.003] [Cited by in Crossref: 13] [Cited by in F6Publishing: 12] [Article Influence: 4.3] [Reference Citation Analysis]
24 Feillet CA, Bainier C, Mateo M, Blancas-velázquez A, Salaberry NL, Ripperger JA, Albrecht U, Mendoza J. Rev-erbα modulates the hypothalamic orexinergic system to influence pleasurable feeding behaviour in mice: Food-reward in clock mutants. Addiction Biology 2017;22:411-22. [DOI: 10.1111/adb.12339] [Cited by in Crossref: 21] [Cited by in F6Publishing: 21] [Article Influence: 3.0] [Reference Citation Analysis]
25 Yamamoto K, Motokawa K, Yoshizaki T, Yano T, Hirano H, Ohara Y, Shirobe M, Inagaki H, Awata S, Shinkai S, Watanabe Y. Association of Dietary Variety and Appetite with Sleep Quality in Urban-Dwelling Older Japanese Adults. J Nutr Health Aging 2020;24:152-9. [PMID: 32003404 DOI: 10.1007/s12603-019-1297-4] [Cited by in Crossref: 5] [Cited by in F6Publishing: 4] [Article Influence: 2.5] [Reference Citation Analysis]
26 Nakamachi T, Shibata H, Sakashita A, Iinuma N, Wada K, Konno N, Matsuda K. Orexin A enhances locomotor activity and induces anxiogenic-like action in the goldfish, Carassius auratus. Hormones and Behavior 2014;66:317-23. [DOI: 10.1016/j.yhbeh.2014.06.004] [Cited by in Crossref: 22] [Cited by in F6Publishing: 20] [Article Influence: 2.8] [Reference Citation Analysis]
27 Ni P, Tian Y, Gu X, Yang L, Wei J, Wang Y, Zhao L, Zhang Y, Zhang C, Li L, Tang X, Ma X, Hu X, Li T. Plasma neuropeptides as circulating biomarkers of multifactorial schizophrenia. Compr Psychiatry 2019;94:152114. [PMID: 31401216 DOI: 10.1016/j.comppsych.2019.152114] [Reference Citation Analysis]
28 Burgess CR, Scammell TE. Narcolepsy: neural mechanisms of sleepiness and cataplexy. J Neurosci 2012;32:12305-11. [PMID: 22956821 DOI: 10.1523/JNEUROSCI.2630-12.2012] [Cited by in Crossref: 82] [Cited by in F6Publishing: 35] [Article Influence: 8.2] [Reference Citation Analysis]
29 Black SW, Morairty SR, Fisher SP, Chen TM, Warrier DR, Kilduff TS. Almorexant promotes sleep and exacerbates cataplexy in a murine model of narcolepsy. Sleep 2013;36:325-36. [PMID: 23449602 DOI: 10.5665/sleep.2442] [Cited by in F6Publishing: 1] [Reference Citation Analysis]
30 Abdallah K, Artola A, Monconduit L, Dallel R, Luccarini P. Bilateral descending hypothalamic projections to the spinal trigeminal nucleus caudalis in rats. PLoS One 2013;8:e73022. [PMID: 23951340 DOI: 10.1371/journal.pone.0073022] [Cited by in Crossref: 28] [Cited by in F6Publishing: 27] [Article Influence: 3.1] [Reference Citation Analysis]
31 Luppi AI, Spindler LRB, Menon DK, Stamatakis EA. The Inert Brain: Explaining Neural Inertia as Post-anaesthetic Sleep Inertia. Front Neurosci 2021;15:643871. [PMID: 33737863 DOI: 10.3389/fnins.2021.643871] [Reference Citation Analysis]
32 Rhyne DN, Anderson SL. Suvorexant in insomnia: efficacy, safety and place in therapy. Ther Adv Drug Saf 2015;6:189-95. [PMID: 26478806 DOI: 10.1177/2042098615595359] [Cited by in Crossref: 35] [Cited by in F6Publishing: 25] [Article Influence: 5.0] [Reference Citation Analysis]
33 Sani TP, Bond RL, Marshall CR, Hardy CJD, Russell LL, Moore KM, Slattery CF, Paterson RW, Woollacott IOC, Wendi IP, Crutch SJ, Schott JM, Rohrer JD, Eriksson SH, Dijk DJ, Warren JD. Sleep symptoms in syndromes of frontotemporal dementia and Alzheimer's disease: A proof-of-principle behavioural study. eNeurologicalSci 2019;17:100212. [PMID: 31828228 DOI: 10.1016/j.ensci.2019.100212] [Cited by in Crossref: 4] [Cited by in F6Publishing: 4] [Article Influence: 1.3] [Reference Citation Analysis]
34 Xu TR, Ward RJ, Pediani JD, Milligan G. Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation. J Biol Chem 2012;287:14937-49. [PMID: 22389503 DOI: 10.1074/jbc.M111.334300] [Cited by in Crossref: 17] [Cited by in F6Publishing: 5] [Article Influence: 1.7] [Reference Citation Analysis]
35 Willie JT, Lim MM, Bennett RE, Azarion AA, Schwetye KE, Brody DL. Controlled cortical impact traumatic brain injury acutely disrupts wakefulness and extracellular orexin dynamics as determined by intracerebral microdialysis in mice. J Neurotrauma 2012;29:1908-21. [PMID: 22607167 DOI: 10.1089/neu.2012.2404] [Cited by in Crossref: 44] [Cited by in F6Publishing: 37] [Article Influence: 4.9] [Reference Citation Analysis]
36 Eyigor O, Minbay Z, Kafa IM. Glutamate and Orexin Neurons. Sleep Hormones. Elsevier; 2012. pp. 209-22. [DOI: 10.1016/b978-0-12-394623-2.00011-1] [Cited by in Crossref: 15] [Cited by in F6Publishing: 5] [Article Influence: 1.5] [Reference Citation Analysis]
37 Bettica P, Squassante L, Groeger JA, Gennery B, Winsky-Sommerer R, Dijk DJ. Differential effects of a dual orexin receptor antagonist (SB-649868) and zolpidem on sleep initiation and consolidation, SWS, REM sleep, and EEG power spectra in a model of situational insomnia. Neuropsychopharmacology 2012;37:1224-33. [PMID: 22237311 DOI: 10.1038/npp.2011.310] [Cited by in Crossref: 59] [Cited by in F6Publishing: 59] [Article Influence: 5.9] [Reference Citation Analysis]
38 Nobunaga M, Obukuro K, Kurauchi Y, Hisatsune A, Seki T, Tsutsui M, Katsuki H. High fat diet induces specific pathological changes in hypothalamic orexin neurons in mice. Neurochem Int 2014;78:61-6. [PMID: 25195718 DOI: 10.1016/j.neuint.2014.09.002] [Cited by in Crossref: 27] [Cited by in F6Publishing: 19] [Article Influence: 3.4] [Reference Citation Analysis]
39 Liu M, Min T, Zhang H, Liu Y, Wang Z. Pharmacological Characteristics of Porcine Orexin 2 Receptor and Mutants. Front Endocrinol (Lausanne) 2020;11:132. [PMID: 32296386 DOI: 10.3389/fendo.2020.00132] [Reference Citation Analysis]
40 Matzeu A, Martin-Fardon R. Cocaine-Seeking Behavior Induced by Orexin A Administration in the Posterior Paraventricular Nucleus of the Thalamus Is Not Long-Lasting: Neuroadaptation of the Orexin System During Cocaine Abstinence. Front Behav Neurosci 2021;15:620868. [PMID: 33708078 DOI: 10.3389/fnbeh.2021.620868] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
41 Azeez IA, Del Gallo F, Cristino L, Bentivoglio M. Daily Fluctuation of Orexin Neuron Activity and Wiring: The Challenge of "Chronoconnectivity". Front Pharmacol 2018;9:1061. [PMID: 30319410 DOI: 10.3389/fphar.2018.01061] [Cited by in Crossref: 24] [Cited by in F6Publishing: 18] [Article Influence: 6.0] [Reference Citation Analysis]
42 Sakurai T. Roles of orexins in the regulation of body weight homeostasis. Obesity Research & Clinical Practice 2014;8:e414-20. [DOI: 10.1016/j.orcp.2013.12.001] [Cited by in Crossref: 27] [Cited by in F6Publishing: 25] [Article Influence: 3.4] [Reference Citation Analysis]
43 Cengiz M, Karaj V, Kocabasoğlu N, Gozubatik-celik G, Dirican A, Bayoglu B. Orexin/hypocretin receptor, Orx 1 , gene variants are associated with major depressive disorder. International Journal of Psychiatry in Clinical Practice 2019;23:114-21. [DOI: 10.1080/13651501.2018.1551549] [Cited by in Crossref: 6] [Cited by in F6Publishing: 5] [Article Influence: 1.5] [Reference Citation Analysis]
44 Han Y, Yuan K, Zheng Y, Lu L. Orexin Receptor Antagonists as Emerging Treatments for Psychiatric Disorders. Neurosci Bull 2020;36:432-48. [PMID: 31782044 DOI: 10.1007/s12264-019-00447-9] [Cited by in Crossref: 14] [Cited by in F6Publishing: 11] [Article Influence: 4.7] [Reference Citation Analysis]
45 Joshi D, Sarkar D, Singh SK. Decreased expression of orexin 1 receptor in adult mice testes during alloxan-induced diabetes mellitus perturbs testicular steroidogenesis and glucose homeostasis. Biochemical and Biophysical Research Communications 2017;490:1346-54. [DOI: 10.1016/j.bbrc.2017.07.026] [Cited by in Crossref: 12] [Cited by in F6Publishing: 12] [Article Influence: 2.4] [Reference Citation Analysis]
46 Eban-Rothschild A, de Lecea L. Neuronal substrates for initiation, maintenance, and structural organization of sleep/wake states. F1000Res 2017;6:212. [PMID: 28357049 DOI: 10.12688/f1000research.9677.1] [Cited by in Crossref: 10] [Cited by in F6Publishing: 8] [Article Influence: 2.0] [Reference Citation Analysis]
47 Steiner MA, Gatfield J, Brisbare-Roch C, Dietrich H, Treiber A, Jenck F, Boss C. Discovery and characterization of ACT-335827, an orally available, brain penetrant orexin receptor type 1 selective antagonist. ChemMedChem 2013;8:898-903. [PMID: 23589487 DOI: 10.1002/cmdc.201300003] [Cited by in Crossref: 56] [Cited by in F6Publishing: 57] [Article Influence: 6.2] [Reference Citation Analysis]
48 Nollet M, Leman S. Role of Orexin in the Pathophysiology of Depression: Potential for Pharmacological Intervention. CNS Drugs 2013;27:411-22. [DOI: 10.1007/s40263-013-0064-z] [Cited by in Crossref: 53] [Cited by in F6Publishing: 46] [Article Influence: 5.9] [Reference Citation Analysis]
49 Alò R, Avolio E, Mele M, Di Vito A, Canonaco M. Central amygdalar nucleus treated with orexin neuropeptides evoke differing feeding and grooming responses in the hamster. J Neurol Sci 2015;351:46-51. [PMID: 25732800 DOI: 10.1016/j.jns.2015.02.030] [Cited by in Crossref: 6] [Cited by in F6Publishing: 6] [Article Influence: 0.9] [Reference Citation Analysis]
50 Etori K, Saito YC, Tsujino N, Sakurai T. Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in mice. Front Neurosci 2014;8:8. [PMID: 24550770 DOI: 10.3389/fnins.2014.00008] [Cited by in Crossref: 27] [Cited by in F6Publishing: 27] [Article Influence: 3.4] [Reference Citation Analysis]
51 Carrive P. Orexin, Stress and Central Cardiovascular Control. A Link with Hypertension? Neurosci Biobehav Rev 2017;74:376-92. [PMID: 27477446 DOI: 10.1016/j.neubiorev.2016.06.044] [Cited by in Crossref: 13] [Cited by in F6Publishing: 13] [Article Influence: 2.2] [Reference Citation Analysis]
52 Caroleo M, Carbone EA, Primerano A, Foti D, Brunetti A, Segura-Garcia C. The role of hormonal, metabolic and inflammatory biomarkers on sleep and appetite in drug free patients with major depression: A systematic review. J Affect Disord 2019;250:249-59. [PMID: 30870775 DOI: 10.1016/j.jad.2019.03.015] [Cited by in Crossref: 11] [Cited by in F6Publishing: 6] [Article Influence: 3.7] [Reference Citation Analysis]
53 Yang L, Zou B, Xiong X, Pascual C, Xie J, Malik A, Xie J, Sakurai T, Xie XS. Hypocretin/orexin neurons contribute to hippocampus-dependent social memory and synaptic plasticity in mice. J Neurosci 2013;33:5275-84. [PMID: 23516292 DOI: 10.1523/JNEUROSCI.3200-12.2013] [Cited by in Crossref: 77] [Cited by in F6Publishing: 39] [Article Influence: 8.6] [Reference Citation Analysis]
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55 Colavito V, Tesoriero C, Wirtu AT, Grassi-zucconi G, Bentivoglio M. Limbic thalamus and state-dependent behavior: The paraventricular nucleus of the thalamic midline as a node in circadian timing and sleep/wake-regulatory networks. Neuroscience & Biobehavioral Reviews 2015;54:3-17. [DOI: 10.1016/j.neubiorev.2014.11.021] [Cited by in Crossref: 49] [Cited by in F6Publishing: 49] [Article Influence: 7.0] [Reference Citation Analysis]
56 Edalat P, Kavianpour M, Zarrabian S, Haghparast A. Role of orexin-1 and orexin-2 receptors in the CA1 region of hippocampus in the forced swim stress- and food deprivation-induced reinstatement of morphine seeking behaviors in rats. Brain Research Bulletin 2018;142:25-32. [DOI: 10.1016/j.brainresbull.2018.06.016] [Cited by in Crossref: 11] [Cited by in F6Publishing: 11] [Article Influence: 2.8] [Reference Citation Analysis]
57 Cristino L, Busetto G, Imperatore R, Ferrandino I, Palomba L, Silvestri C, Petrosino S, Orlando P, Bentivoglio M, Mackie K, Di Marzo V. Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons. Proc Natl Acad Sci U S A 2013;110:E2229-38. [PMID: 23630288 DOI: 10.1073/pnas.1219485110] [Cited by in Crossref: 97] [Cited by in F6Publishing: 96] [Article Influence: 10.8] [Reference Citation Analysis]
58 Xie X(. The Neuronal Circuit Between Nociceptin/Orphanin FQ and Hypocretins/Orexins Coordinately Modulates Stress-Induced Analgesia and Anxiety-Related Behavior. Nociceptin Opioid. Elsevier; 2015. pp. 295-321. [DOI: 10.1016/bs.vh.2014.11.004] [Cited by in Crossref: 3] [Cited by in F6Publishing: 2] [Article Influence: 0.4] [Reference Citation Analysis]
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