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For: Nollet M, Gaillard P, Minier F, Tanti A, Belzung C, Leman S. Activation of orexin neurons in dorsomedial/perifornical hypothalamus and antidepressant reversal in a rodent model of depression. Neuropharmacology 2011;61:336-46. [PMID: 21530551 DOI: 10.1016/j.neuropharm.2011.04.022] [Cited by in Crossref: 70] [Cited by in F6Publishing: 69] [Article Influence: 6.4] [Reference Citation Analysis]
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15 Sargin D. The role of the orexin system in stress response. Neuropharmacology 2019;154:68-78. [PMID: 30266600 DOI: 10.1016/j.neuropharm.2018.09.034] [Cited by in Crossref: 26] [Cited by in F6Publishing: 24] [Article Influence: 6.5] [Reference Citation Analysis]
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17 Han D, Shi Y, Han F. The effects of orexin-A and orexin receptors on anxiety- and depression-related behaviors in a male rat model of post-traumatic stress disorder. J Comp Neurol 2022;530:592-606. [PMID: 34387361 DOI: 10.1002/cne.25231] [Reference Citation Analysis]
18 Connor KM, Ceesay P, Hutzelmann J, Snavely D, Krystal AD, Trivedi MH, Thase M, Lines C, Herring WJ, Michelson D. Phase II Proof-of-Concept Trial of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Major Depressive Disorder. Int J Neuropsychopharmacol 2017;20:613-8. [PMID: 28582570 DOI: 10.1093/ijnp/pyx033] [Cited by in Crossref: 10] [Cited by in F6Publishing: 6] [Article Influence: 2.5] [Reference Citation Analysis]
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20 Summers CH, Yaeger JDW, Staton CD, Arendt DH, Summers TR. Orexin/hypocretin receptor modulation of anxiolytic and antidepressive responses during social stress and decision-making: Potential for therapy. Brain Res 2020;1731:146085. [PMID: 30590027 DOI: 10.1016/j.brainres.2018.12.036] [Cited by in Crossref: 15] [Cited by in F6Publishing: 13] [Article Influence: 3.8] [Reference Citation Analysis]
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22 Sonawane S, Khanolkar V, Namavari A, Chaudhary S, Gandhi S, Tibrewal S, Jassim SH, Shaheen B, Hallak J, Horner JH, Newcomb M, Sarkar J, Jain S. Ocular surface extracellular DNA and nuclease activity imbalance: a new paradigm for inflammation in dry eye disease. Invest Ophthalmol Vis Sci 2012;53:8253-63. [PMID: 23169882 DOI: 10.1167/iovs.12-10430] [Cited by in Crossref: 48] [Cited by in F6Publishing: 49] [Article Influence: 4.8] [Reference Citation Analysis]
23 Davies M, Jacobs A, Brody DL, Friess SH. Delayed Hypoxemia after Traumatic Brain Injury Exacerbates Long-Term Behavioral Deficits. J Neurotrauma 2018;35:790-801. [PMID: 29149808 DOI: 10.1089/neu.2017.5354] [Cited by in Crossref: 14] [Cited by in F6Publishing: 14] [Article Influence: 3.5] [Reference Citation Analysis]
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25 Sanna MD, Ghelardini C, Galeotti N. Effect of amitriptyline treatment on neurofilament-H protein in an experimental model of depression. Brain Research Bulletin 2017;128:1-6. [DOI: 10.1016/j.brainresbull.2016.11.001] [Cited by in Crossref: 9] [Cited by in F6Publishing: 7] [Article Influence: 1.8] [Reference Citation Analysis]
26 Mavanji V, Pomonis B, Kotz CM. Orexin, serotonin, and energy balance. WIREs Mech Dis 2022;14:e1536. [PMID: 35023323 DOI: 10.1002/wsbm.1536] [Reference Citation Analysis]
27 James MH, Campbell EJ, Dayas CV. Role of the Orexin/Hypocretin System in Stress-Related Psychiatric Disorders. Curr Top Behav Neurosci 2017;33:197-219. [PMID: 28083790 DOI: 10.1007/7854_2016_56] [Cited by in Crossref: 55] [Cited by in F6Publishing: 55] [Article Influence: 11.0] [Reference Citation Analysis]
28 Demin KA, Kolesnikova TO, Galstyan DS, Krotova NA, Ilyin NP, Derzhavina KA, Levchenko NA, Strekalova T, de Abreu MS, Petersen EV, Seredinskaya M, Cherneyko YV, Kositsyn YM, Sorokin DV, Zabegalov KN, Mor MS, Efimova EV, Kalueff AV. Modulation of behavioral and neurochemical responses of adult zebrafish by fluoxetine, eicosapentaenoic acid and lipopolysaccharide in the prolonged chronic unpredictable stress model. Sci Rep 2021;11:14289. [PMID: 34253753 DOI: 10.1038/s41598-021-92422-6] [Reference Citation Analysis]
29 Heifetz A, Barker O, Morris GB, Law RJ, Slack M, Biggin PC. Toward an understanding of agonist binding to human Orexin-1 and Orexin-2 receptors with G-protein-coupled receptor modeling and site-directed mutagenesis. Biochemistry 2013;52:8246-60. [PMID: 24144388 DOI: 10.1021/bi401119m] [Cited by in Crossref: 26] [Cited by in F6Publishing: 24] [Article Influence: 2.9] [Reference Citation Analysis]
30 Kátai Z, Ádori C, Kitka T, Vas S, Kalmár L, Kostyalik D, Tóthfalusi L, Palkovits M, Bagdy G. Acute escitalopram treatment inhibits REM sleep rebound and activation of MCH-expressing neurons in the lateral hypothalamus after long term selective REM sleep deprivation. Psychopharmacology 2013;228:439-49. [DOI: 10.1007/s00213-013-3046-4] [Cited by in Crossref: 12] [Cited by in F6Publishing: 12] [Article Influence: 1.3] [Reference Citation Analysis]
31 Demin KA, Lakstygal AM, Krotova NA, Masharsky A, Tagawa N, Chernysh MV, Ilyin NP, Taranov AS, Galstyan DS, Derzhavina KA, Levchenko NA, Kolesnikova TO, Mor MS, Vasyutina ML, Efimova EV, Katolikova N, Prjibelski AD, Gainetdinov RR, de Abreu MS, Amstislavskaya TG, Strekalova T, Kalueff AV. Understanding complex dynamics of behavioral, neurochemical and transcriptomic changes induced by prolonged chronic unpredictable stress in zebrafish. Sci Rep 2020;10:19981. [PMID: 33203921 DOI: 10.1038/s41598-020-75855-3] [Cited by in Crossref: 2] [Cited by in F6Publishing: 1] [Article Influence: 1.0] [Reference Citation Analysis]
32 Nollet M, Leman S. Role of Orexin in the Pathophysiology of Depression: Potential for Pharmacological Intervention. CNS Drugs 2013;27:411-22. [DOI: 10.1007/s40263-013-0064-z] [Cited by in Crossref: 53] [Cited by in F6Publishing: 46] [Article Influence: 5.9] [Reference Citation Analysis]
33 Li SB, Jones JR, de Lecea L. Hypocretins, Neural Systems, Physiology, and Psychiatric Disorders. Curr Psychiatry Rep 2016;18:7. [PMID: 26733323 DOI: 10.1007/s11920-015-0639-0] [Cited by in Crossref: 33] [Cited by in F6Publishing: 32] [Article Influence: 5.5] [Reference Citation Analysis]
34 Li T, Xu W, Ouyang J, Lu X, Sherchan P, Lenahan C, Irio G, Zhang JH, Zhao J, Zhang Y, Tang J. Orexin A alleviates neuroinflammation via OXR2/CaMKKβ/AMPK signaling pathway after ICH in mice. J Neuroinflammation 2020;17:187. [PMID: 32539736 DOI: 10.1186/s12974-020-01841-1] [Cited by in Crossref: 8] [Cited by in F6Publishing: 8] [Article Influence: 4.0] [Reference Citation Analysis]
35 Henderson F, Vialou V, El Mestikawy S, Fabre V. Effects of Social Defeat Stress on Sleep in Mice. Front Behav Neurosci 2017;11:227. [PMID: 29234278 DOI: 10.3389/fnbeh.2017.00227] [Cited by in Crossref: 19] [Cited by in F6Publishing: 16] [Article Influence: 3.8] [Reference Citation Analysis]
36 Dimatelis JJ, Mtintsilana A, Naidoo V, Stein DJ, Russell VA. Chronic light exposure alters serotonergic and orexinergic systems in the rat brain and reverses maternal separation-induced increase in orexin receptors in the prefrontal cortex. Metab Brain Dis 2018;33:433-41. [DOI: 10.1007/s11011-017-0123-0] [Cited by in Crossref: 1] [Cited by in F6Publishing: 1] [Article Influence: 0.2] [Reference Citation Analysis]
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38 Chen X, Wang H, Lin Z, Li S, Li Y, Bergen HT, Vrontakis ME, Kirouac GJ. Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks. Brain Struct Funct 2014;219:2103-18. [PMID: 23955372 DOI: 10.1007/s00429-013-0626-3] [Cited by in Crossref: 26] [Cited by in F6Publishing: 35] [Article Influence: 2.9] [Reference Citation Analysis]
39 Lungwitz EA, Molosh A, Johnson PL, Harvey BP, Dirks RC, Dietrich A, Minick P, Shekhar A, Truitt WA. Orexin-A induces anxiety-like behavior through interactions with glutamatergic receptors in the bed nucleus of the stria terminalis of rats. Physiol Behav 2012;107:726-32. [PMID: 22652097 DOI: 10.1016/j.physbeh.2012.05.019] [Cited by in Crossref: 68] [Cited by in F6Publishing: 69] [Article Influence: 6.8] [Reference Citation Analysis]
40 Roch C, Bergamini G, Steiner MA, Clozel M. Nonclinical pharmacology of daridorexant: a new dual orexin receptor antagonist for the treatment of insomnia. Psychopharmacology (Berl) 2021;238:2693-708. [PMID: 34415378 DOI: 10.1007/s00213-021-05954-0] [Reference Citation Analysis]
41 Yi LT, Li J, Geng D, Liu BB, Fu Y, Tu JQ, Liu Y, Weng LJ. Essential oil of Perilla frutescens-induced change in hippocampal expression of brain-derived neurotrophic factor in chronic unpredictable mild stress in mice. J Ethnopharmacol 2013;147:245-53. [PMID: 23506995 DOI: 10.1016/j.jep.2013.03.015] [Cited by in Crossref: 24] [Cited by in F6Publishing: 25] [Article Influence: 2.7] [Reference Citation Analysis]
42 Murillo-Rodríguez E, Millán-Aldaco D, Arankowsky-Sandoval G, Yamamoto T, Pertwee RG, Parker L, Mechoulam R. Assessing the treatment of cannabidiolic acid methyl ester: a stable synthetic analogue of cannabidiolic acid on c-Fos and NeuN expression in the hypothalamus of rats. J Cannabis Res 2021;3:31. [PMID: 34253253 DOI: 10.1186/s42238-021-00081-1] [Reference Citation Analysis]
43 Moorman DE. The hypocretin/orexin system as a target for excessive motivation in alcohol use disorders. Psychopharmacology (Berl) 2018;235:1663-80. [PMID: 29508004 DOI: 10.1007/s00213-018-4871-2] [Cited by in Crossref: 12] [Cited by in F6Publishing: 12] [Article Influence: 3.0] [Reference Citation Analysis]
44 Fitch TE, Benvenga MJ, Jesudason CD, Zink C, Vandergriff AB, Menezes MM, Schober DA, Rorick-Kehn LM. LSN2424100: a novel, potent orexin-2 receptor antagonist with selectivity over orexin-1 receptors and activity in an animal model predictive of antidepressant-like efficacy. Front Neurosci 2014;8:5. [PMID: 24478625 DOI: 10.3389/fnins.2014.00005] [Cited by in Crossref: 17] [Cited by in F6Publishing: 15] [Article Influence: 2.1] [Reference Citation Analysis]
45 Sheng Z, Santiago AM, Thomas MP, Routh VH. Metabolic regulation of lateral hypothalamic glucose-inhibited orexin neurons may influence midbrain reward neurocircuitry. Mol Cell Neurosci 2014;62:30-41. [PMID: 25107627 DOI: 10.1016/j.mcn.2014.08.001] [Cited by in Crossref: 64] [Cited by in F6Publishing: 62] [Article Influence: 8.0] [Reference Citation Analysis]
46 Farooq RK, Isingrini E, Tanti A, Le Guisquet AM, Arlicot N, Minier F, Leman S, Chalon S, Belzung C, Camus V. Is unpredictable chronic mild stress (UCMS) a reliable model to study depression-induced neuroinflammation? Behav Brain Res 2012;231:130-7. [PMID: 22465167 DOI: 10.1016/j.bbr.2012.03.020] [Cited by in Crossref: 99] [Cited by in F6Publishing: 96] [Article Influence: 9.9] [Reference Citation Analysis]
47 Hsu CW, Wang S. Changes in the Orexin System in Rats Exhibiting Learned Helplessness Behaviors. Brain Sci 2021;11:1634. [PMID: 34942932 DOI: 10.3390/brainsci11121634] [Reference Citation Analysis]
48 Arendt DH, Hassell J, Li H, Achua JK, Guarnieri DJ, Dileone RJ, Ronan PJ, Summers CH. Anxiolytic function of the orexin 2/hypocretin A receptor in the basolateral amygdala. Psychoneuroendocrinology 2014;40:17-26. [PMID: 24485472 DOI: 10.1016/j.psyneuen.2013.10.010] [Cited by in Crossref: 44] [Cited by in F6Publishing: 40] [Article Influence: 4.9] [Reference Citation Analysis]
49 Lu J, Huang ML, Li JH, Jin KY, Li HM, Mou TT, Fronczek R, Duan JF, Xu WJ, Swaab D, Bao AM. Changes of Hypocretin (Orexin) System in Schizophrenia: From Plasma to Brain. Schizophr Bull 2021;47:1310-9. [PMID: 33974073 DOI: 10.1093/schbul/sbab042] [Reference Citation Analysis]
50 Grafe LA, Bhatnagar S. Orexins and stress. Front Neuroendocrinol 2018;51:132-45. [PMID: 29932958 DOI: 10.1016/j.yfrne.2018.06.003] [Cited by in Crossref: 34] [Cited by in F6Publishing: 31] [Article Influence: 8.5] [Reference Citation Analysis]
51 Katzman MA, Katzman MP. Neurobiology of the Orexin System and Its Potential Role in the Regulation of Hedonic Tone. Brain Sciences 2022;12:150. [DOI: 10.3390/brainsci12020150] [Reference Citation Analysis]
52 Pałasz A, Lapray D, Peyron C, Rojczyk-Gołębiewska E, Skowronek R, Markowski G, Czajkowska B, Krzystanek M, Wiaderkiewicz R. Dual orexin receptor antagonists - promising agents in the treatment of sleep disorders. Int J Neuropsychopharmacol 2014;17:157-68. [PMID: 23702225 DOI: 10.1017/S1461145713000552] [Cited by in Crossref: 11] [Cited by in F6Publishing: 3] [Article Influence: 1.2] [Reference Citation Analysis]
53 Kim JS, Martin-Fardon R. Possible Role of CRF-Hcrt Interaction in the Infralimbic Cortex in the Emergence and Maintenance of Compulsive Alcohol-Seeking Behavior. Alcohol Clin Exp Res 2020;44:354-67. [PMID: 31840823 DOI: 10.1111/acer.14264] [Cited by in Crossref: 2] [Cited by in F6Publishing: 2] [Article Influence: 1.0] [Reference Citation Analysis]
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55 Weymann KB, Wood LJ, Zhu X, Marks DL. A role for orexin in cytotoxic chemotherapy-induced fatigue. Brain Behav Immun 2014;37:84-94. [PMID: 24216337 DOI: 10.1016/j.bbi.2013.11.003] [Cited by in Crossref: 33] [Cited by in F6Publishing: 36] [Article Influence: 3.7] [Reference Citation Analysis]
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