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Sep 26, 2014 (publication date) through Jul 12, 2025
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World Journal of Methodology
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2222-0682
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
| For: | Kontoghiorghe CN, Andreou N, Constantinou K, Kontoghiorghes GJ. World health dilemmas: Orphan and rare diseases, orphan drugs and orphan patients. World J Methodol 2014; 4(3): 163-188 [PMID: 25332915 DOI: 10.5662/wjm.v4.i3.163] |
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| URL: | https://www.wjgnet.com/1007-9327/full/v4/i3/163.htm |
| Number | Citing Articles |
| 1 |
George Kontoghiorghes, Annita Kolnagou, Theodora Demetriou, Marina Neocleous, Christina Kontoghiorghe. New Era in the Treatment of Iron Deficiency Anaemia Using Trimaltol Iron and Other Lipophilic Iron Chelator Complexes: Historical Perspectives of Discovery and Future Applications. International Journal of Molecular Sciences 2021; 22(11): 5546 doi: 10.3390/ijms22115546
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| 2 |
David J Timson. Value of predictive bioinformatics in inherited metabolic diseases. World Journal of Medical Genetics 2015; 5(3): 46-51 doi: 10.5496/wjmg.v5.i3.46
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| 3 |
Davide Benedetto Tiz, Luana Bagnoli, Ornelio Rosati, Francesca Marini, Luca Sancineto, Claudio Santi. Top Selling (2026) Small Molecule Orphan Drugs: A Journey into Their Chemistry. International Journal of Molecular Sciences 2023; 24(2): 930 doi: 10.3390/ijms24020930
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| 4 |
Ekaterina V Makarova, Ivan S Krysanov, Tatiana P Valilyeva, Mikhail D Vasiliev, Rena A Zinchenko. Evaluation of orphan diseases global burden. European Journal of Translational Myology 2021; 31(2) doi: 10.4081/ejtm.2021.9610
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| 5 |
George J. Kontoghiorghes. Differences between the European Union and United States of America in Drug Regulatory Affairs Affect Global Patient Safety Standards and Public Health Awareness: The Case of Deferasirox and Other Iron Chelating Drugs. Medicines 2021; 8(7): 36 doi: 10.3390/medicines8070036
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| 6 |
Sara Rosenberg, Björn Södergård, Jessica Rosenholm, Jussi-Pekka Rauha. Sustainability challenges concerning the effects of high-priced drugs on the day-to-day operations of community pharmacies in Finland. European Journal of Pharmaceutical Sciences 2024; 199: 106816 doi: 10.1016/j.ejps.2024.106816
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| 7 |
Bander Balkhi, Asma Almuaither, Saeed Alqahtani. Cross-national comparative study of orphan drug policies in Saudi Arabia, the United States, and the European Union. Saudi Pharmaceutical Journal 2023; 31(9): 101738 doi: 10.1016/j.jsps.2023.101738
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| 8 |
George J. Kontoghiorghes, Annita Kolnagou, Stella Fetta, Christina N. Kontoghiorghe. Conventional and Unconventional Approaches for Innovative Drug Treatments in COVID-19: Looking Outside of Plato’s Cave. International Journal of Molecular Sciences 2021; 22(13): 7208 doi: 10.3390/ijms22137208
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| 9 |
Paloma López Villafranca. Communicating Rare Diseases and Disorders in the Digital Age. Advances in Medical Technologies and Clinical Practice 2020; : 200 doi: 10.4018/978-1-7998-2088-8.ch006
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| 10 |
Matthew K. Ito, Gerald F. Watts. Challenges in the Diagnosis and Treatment of Homozygous Familial Hypercholesterolemia. Drugs 2015; 75(15): 1715 doi: 10.1007/s40265-015-0466-y
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| 11 |
Yuna Horiuchi, Ryunosuke Ohkawa, Shao-Jui Lai, Azusa Yamazaki, Hayato Ikoma, Kouji Yano, Takahiro Kameda, Minoru Tozuka. Characterization of the cholesterol efflux of apolipoprotein E-containing high-density lipoprotein in THP-1 cells. Biological Chemistry 2019; 400(2): 209 doi: 10.1515/hsz-2018-0284
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| 12 |
Christina N Kontoghiorghe, George J Kontoghiorghes. New developments and controversies in iron metabolism and iron chelation therapy. World Journal of Methodology 2016; 6(1): 1-19 doi: 10.5662/wjm.v6.i1.1
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| 13 |
Inés Adriana Cismondi, Romina Kohan, Heather Adams, Mike Bond, Rachel Brown, Jonathan D. Cooper, Perla K. de Hidalgo, Sophia-Martha Kleine Holthaus, Sara E. Mole, Julia Mugnaini, Ana María Oller de Ramirez, Favio Pesaola, Gisela Rautenberg, Frances M. Platt, Inés Noher de Halac. Guidelines for incorporating scientific knowledge and practice on rare diseases into higher education: neuronal ceroid lipofuscinoses as a model disorder. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2015; 1852(10): 2316 doi: 10.1016/j.bbadis.2015.06.018
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| 14 |
Christina Kontoghiorghe, Annita Kolnagou, George Kontoghiorghes. Phytochelators Intended for Clinical Use in Iron Overload, Other Diseases of Iron Imbalance and Free Radical Pathology. Molecules 2015; 20(11): 20841 doi: 10.3390/molecules201119725
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| 15 |
George J. Kontoghiorghes, Annita Kolnagou, Christina N. Kontoghiorghe. Post COVID-19 Reflections and Questions: How Prepared Are We for the Next Pandemic?. International Journal of Molecular Sciences 2024; 25(2): 859 doi: 10.3390/ijms25020859
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| 16 |
George J. Kontoghiorghes. New Iron Metabolic Pathways and Chelation Targeting Strategies Affecting the Treatment of All Types and Stages of Cancer. International Journal of Molecular Sciences 2022; 23(22): 13990 doi: 10.3390/ijms232213990
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| 17 |
George J. Kontoghiorghes. Drug Selection and Posology, Optimal Therapies and Risk/Benefit Assessment in Medicine: The Paradigm of Iron-Chelating Drugs. International Journal of Molecular Sciences 2023; 24(23): 16749 doi: 10.3390/ijms242316749
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| 18 |
George J. Kontoghiorghes. New Insights into Aspirin’s Anticancer Activity: The Predominant Role of Its Iron-Chelating Antioxidant Metabolites. Antioxidants 2024; 14(1): 29 doi: 10.3390/antiox14010029
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| 19 |
George J. Kontoghiorghes. The Vital Role Played by Deferiprone in the Transition of Thalassaemia from a Fatal to a Chronic Disease and Challenges in Its Repurposing for Use in Non-Iron-Loaded Diseases. Pharmaceuticals 2023; 16(7): 1016 doi: 10.3390/ph16071016
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| 20 |
Yuna Horiuchi, Ryunosuke Ohkawa, Shao-Jui Lai, Shitsuko Shimano, Michio Hagihara, Shuji Tohda, Takahiro Kameda, Minoru Tozuka. Usefulness of apolipoprotein B-depleted serum in cholesterol efflux capacity assays using immobilized liposome-bound gel beads. Bioscience Reports 2019; 39(4) doi: 10.1042/BSR20190213
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| 21 |
George J. Kontoghiorghes. Ethics in Medicines: Exposing Unethical Practices and Corruption in All Sectors of Medicines Is Essential for Improving Global Public Health and Saving Patients’ Lives. Medicines 2021; 8(9): 54 doi: 10.3390/medicines8090054
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| 22 |
George J. Kontoghiorghes. Deferiprone: A Forty-Year-Old Multi-Targeting Drug with Possible Activity against COVID-19 and Diseases of Similar Symptomatology. International Journal of Molecular Sciences 2022; 23(12): 6735 doi: 10.3390/ijms23126735
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| 23 |
Gema Esteban-Bueno, Lucas Ramón Díaz-Anadón, Antonio Rodríguez González, Miguel Navarro Cabrero, Aída María Berenguel Hernández. Protocolo genético en Atención Primaria para enfermedades raras: el síndrome de Wolfram como prototipo. Atención Primaria 2022; 54(5): 102285 doi: 10.1016/j.aprim.2022.102285
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| 24 |
Jian Qian, Bradley P. Sullivan, Samuel J. Peterson, Cory Berkland. Nonabsorbable Iron Binding Polymers Prevent Dietary Iron Absorption for the Treatment of Iron Overload. ACS Macro Letters 2017; 6(4): 350 doi: 10.1021/acsmacrolett.6b00945
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| 25 |
Ghada Mohammed Abozaid, Hussain Abdulrahman Al-Omar, Abdulaziz Alrabiah, Asma AlMuaither, Amy Jayne McKnight. Towards a sustainable rare disease and orphan drug ecosystem in Saudi Arabia: policy insights from a multi-stakeholder workshop. Frontiers in Pharmacology 2025; 16 doi: 10.3389/fphar.2025.1583477
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| 26 |
George J. Kontoghiorghes, Annita Kolnagou, Christina N. Kontoghiorghe, Loukia Mourouzidis, Viktor A. Timoshnikov, Nikolay E. Polyakov. Trying to Solve the Puzzle of the Interaction of Ascorbic Acid and Iron: Redox, Chelation and Therapeutic Implications. Medicines 2020; 7(8): 45 doi: 10.3390/medicines7080045
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| 27 |
Hala A. Al-Kherbash, Ahmed Al-Awdi, Nawal S. Hasan. Pattern and clinical profile of thalassemia among pediatric patients attending the Yemeni Society Centers for Thalassemia and Genetic Blood Disorders in Yemen. The Scientific Journal of Al-Azhar Medical Faculty, Girls 2017; 1(2): 43 doi: 10.4103/sjamf.sjamf_15_17
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| 28 |
Sara Rosenberg, Björn Södergård, Jessica M. Rosenholm, Jussi-Pekka Rauha. A qualitative study on the views of experts on the social impact of the high-priced orphan drug nusinersen. Exploratory Research in Clinical and Social Pharmacy 2023; 9: 100227 doi: 10.1016/j.rcsop.2023.100227
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| 29 |
Ioannis Ioannidis, George Lefkaritis, Savvas N. Georgiades, Ioannis Pashalidis, George J. Kontoghiorghes. Towards Clinical Development of Scandium Radioisotope Complexes for Use in Nuclear Medicine: Encouraging Prospects with the Chelator 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid (DOTA) and Its Analogues. International Journal of Molecular Sciences 2024; 25(11): 5954 doi: 10.3390/ijms25115954
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| 30 |
George Kontoghiorghes, Christina Kontoghiorghe. Iron and Chelation in Biochemistry and Medicine: New Approaches to Controlling Iron Metabolism and Treating Related Diseases. Cells 2020; 9(6): 1456 doi: 10.3390/cells9061456
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| 31 |
George J Kontoghiorghes, Christina N Kontoghiorghe. Prospects for the introduction of targeted antioxidant drugs for the prevention and treatment of diseases related to free radical pathology. Expert Opinion on Investigational Drugs 2019; 28(7): 593 doi: 10.1080/13543784.2019.1631284
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| 32 |
Olga Yu. Selyutina, Maya A. Ul’yanova, Olga A. Chinak, Viktor A. Timoshnikov, Lidiya G. Fedenok, Alexander A. Stepanov, Vadim V. Yanshole, Leonid V. Kulik, Sergey F. Vasilevsky, Nikolay E. Polyakov, George J. Kontoghiorghes. Novel Anthraquinone Derivatives and Their Complexes with Metal Ions with Anticancer Activity: Structure/Redox and Chelation Activity Correlations. Pharmaceuticals 2024; 17(12): 1717 doi: 10.3390/ph17121717
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| 33 |
George J. Kontoghiorghes. Questioning Established Theories and Treatment Methods Related to Iron and Other Metal Metabolic Changes, Affecting All Major Diseases and Billions of Patients. International Journal of Molecular Sciences 2022; 23(3): 1364 doi: 10.3390/ijms23031364
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| 34 |
Annita Kolnagou, Marios Kleanthous, George J. Kontoghiorghes. Benefits and Risks in Polypathology and Polypharmacotherapy Challenges in the Era of the Transition of Thalassaemia from a Fatal to a Chronic or Curable Disease. Frontiers in Bioscience-Elite 2022; 14(3) doi: 10.31083/j.fbe1403018
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| 35 |
George J. Kontoghiorghes, Stella Fetta, Christina N. Kontoghiorghe. The need for a multi-level drug targeting strategy to curb the COVID-19 pandemic. Frontiers in Bioscience-Landmark 2021; 26(12) doi: 10.52586/5064
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| 36 |
George J. Kontoghiorghes. Deferiprone and Iron–Maltol: Forty Years since Their Discovery and Insights into Their Drug Design, Development, Clinical Use and Future Prospects. International Journal of Molecular Sciences 2023; 24(5): 4970 doi: 10.3390/ijms24054970
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| 37 |
Paloma López Villafranca. Research Anthology on Improving Health Literacy Through Patient Communication and Mass Media. 2022; : 163 doi: 10.4018/978-1-6684-2414-8.ch010
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| 38 |
Jyoti Pawar, Sanjay Sharma, Namita Hegde. Regulatory Frameworks for Approval of Orphan Drugs: A Comparative Overview Highlighting Need for Global Harmonization and Cohesive Guidelines. Current Pharmacology Reports 2025; 11(1) doi: 10.1007/s40495-025-00410-5
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