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For: Chen J. Roles of the PI3K/Akt pathway in Epstein-Barr virus-induced cancers and therapeutic implications. World J Virol 2012; 1(6): 154-161 [PMID: 24175221 DOI: 10.5501/wjv.v1.i6.154]
URL: https://www.wjgnet.com/1007-9327/full/v1/i6/154.htm
Number Citing Articles
1
Mikiya Fujieda, Kazushi Tsuruga, Tetsuya Sato, Hiroaki Kikuchi, Wataru Tamaki, Masayuki Ishihara, Masaki Yamamoto, Taku Oishi, Hiroshi Tanaka, Masanori Daibata. Monitoring of Epstein–Barr virus load and killer T cells in patients with juvenile idiopathic arthritis treated with methotrexate or tocilizumabModern Rheumatology 2017; 27(1): 66 doi: 10.1080/14397595.2016.1177247
2
Qiaojuan Guo, Tianzhu Lu, Yan Chen, Ying Su, Yuhong Zheng, Zeng Chen, Chao Chen, Shaojun Lin, Jianji Pan, Xianglin Yuan. Genetic variations in the PI3K-PTEN-AKT-mTOR pathway are associated with distant metastasis in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapyScientific Reports 2016; 6(1) doi: 10.1038/srep37576
3
Marisa Granato, Celeste Rizzello, Maria Anele Romeo, Shivangi Yadav, Roberta Santarelli, Gabriella D’Orazi, Alberto Faggioni, Mara Cirone. Concomitant reduction of c-Myc expression and PI3K/AKT/mTOR signaling by quercetin induces a strong cytotoxic effect against Burkitt’s lymphomaThe International Journal of Biochemistry & Cell Biology 2016; 79: 393 doi: 10.1016/j.biocel.2016.09.006
4
Mohamed Ali Maroui, Grace Akinyi Odongo, Lucia Mundo, Francesca Manara, Fabrice Mure, Floriane Fusil, Antonin Jay, Tarik Gheit, Thanos M. Michailidis, Domenico Ferrara, Lorenzo Leoncini, Paul Murray, Evelyne Manet, Théophile Ohlmann, Marthe De Boevre, Sarah De Saeger, François-Loïc Cosset, Stefano Lazzi, Rosita Accardi, Zdenko Herceg, Henri Gruffat, Rita Khoueiry. Aflatoxin B1 and Epstein–Barr virus-induced CCL22 expression stimulates B cell infectionProceedings of the National Academy of Sciences 2024; 121(16) doi: 10.1073/pnas.2314426121
5
Mahmoud Soliman, Deok-Song Kim, Jun-Gyu Park, Ji-Yun Kim, Mia Madel Alfajaro, Yeong-Bin Baek, Eun-Hyo Cho, Chul-Ho Park, Mun-Il Kang, Sang-Ik Park, Kyoung-Oh Cho, Susana López. Phosphatidylinositol 3-Kinase/Akt and MEK/ERK Signaling Pathways Facilitate Sapovirus Trafficking and Late Endosomal Acidification for Viral Uncoating in LLC-PK CellsJournal of Virology 2018; 92(24) doi: 10.1128/JVI.01674-18
6
Samana Batool, Thomson Patrick Joseph, Mushraf Hussain, Miza S. Vuai, Kavish. H. Khinsar, Syed Riaz Ud Din, Arshad Ahmed Padhiar, Mintao Zhong, Anhong Ning, Wei Zhang, Jing Cao, Min Huang. LP1 from Lentinula edodes C91-3 Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901International Journal of Molecular Sciences 2018; 19(10): 2986 doi: 10.3390/ijms19102986
7
Abdelhalim Khenchouche, Mounir M. Salem-Bekhit, Ahd A. Mansour, Mohammad N. Alomary, Xiaohui Wang, Hayat Ali Alzahrani, Ibrahim M. Al Hosiny, Ehab I. Taha, Gamal A. Shazly, Yacine Benguerba, Karim Houali. Suppression of Nasopharyngeal and Gastric Tumor Growth in a Mouse Model by Antibodies to Epstein–Barr Virus LMP1 ProteinMicroorganisms 2023; 11(7): 1712 doi: 10.3390/microorganisms11071712
8
Alejandra Suares, María Victoria Medina, Omar Coso. Autophagy in Viral Development and Progression of CancerFrontiers in Oncology 2021; 11 doi: 10.3389/fonc.2021.603224
9
Dharmendra Kashyap, Samiksha Rele, Pranit Hemant Bagde, Vaishali Saini, Debi Chatterjee, Ajay Kumar Jain, Rajan Kumar Pandey, Hem Chandra Jha. Comprehensive insight into altered host cell-signaling cascades upon Helicobacter pylori and Epstein–Barr virus infections in cancerArchives of Microbiology 2023; 205(7) doi: 10.1007/s00203-023-03598-6
10
Olesea Cojohari, Megan A. Peppenelli, Gary C. Chan, K. Frueh. Human Cytomegalovirus Induces an Atypical Activation of Akt To Stimulate the Survival of Short-Lived MonocytesJournal of Virology 2016; 90(14): 6443 doi: 10.1128/JVI.00214-16
11
Mengwen Lv, Yuan Ding, Yan Zhang, Shuzhen Liu. Targeting EBV‐encoded products: Implications for drug development in EBV‐associated diseasesReviews in Medical Virology 2024; 34(1) doi: 10.1002/rmv.2487
12
Jinshun Zhu, Saidu Kamara, Danwei Cen, Wanlin Tang, Meiping Gu, Xingyuan Ci, Jun Chen, Lude Wang, Shanli Zhu, Pengfei Jiang, Shao Chen, Xiangyang Xue, Lifang Zhang. Generation of novel affibody molecules targeting the EBV LMP2A N-terminal domain with inhibiting effects on the proliferation of nasopharyngeal carcinoma cellsCell Death & Disease 2020; 11(4) doi: 10.1038/s41419-020-2410-7
13
Mariana Suaya, Gonzalo Manuel Sánchez, Antonella Vila, Analía Amante, María Cotarelo, Mercedes García Carrillo, Matías Blaustein. Live and let die: signaling AKTivation and UPRegulation dynamics in SARS-CoVs infection and cancerCell Death & Disease 2022; 13(10) doi: 10.1038/s41419-022-05250-5
14
Samantha S. Soldan, Emma M. Anderson, Drew M. Frase, Yue Zhang, Lisa B. Caruso, Yin Wang, Julianna S. Deakyne, Benjamin E. Gewurz, Italo Tempera, Paul M. Lieberman, Troy E. Messick. EBNA1 inhibitors have potent and selective antitumor activity in xenograft models of Epstein–Barr virus-associated gastric cancerGastric Cancer 2021; 24(5): 1076 doi: 10.1007/s10120-021-01193-6
15
Mathias Montenarh, Friedrich A. Grässer, Claudia Götz. Protein Kinase CK2 and Epstein–Barr VirusBiomedicines 2023; 11(2): 358 doi: 10.3390/biomedicines11020358
16
Hongli Wang. Metabolic reprogramming in the pathogenesis and progression of nasopharyngeal carcinoma: molecular mechanisms and therapeutic implicationsAmerican Journal of Cancer Research 2024; 14(8): 4049 doi: 10.62347/VYAT9271
17
Mara Cirone. Cancer cells dysregulate PI3K/AKT/mTOR pathway activation to ensure their survival and proliferation: mimicking them is a smart strategy of gammaherpesvirusesCritical Reviews in Biochemistry and Molecular Biology 2021; 56(5): 500 doi: 10.1080/10409238.2021.1934811
18
Mujeeb R Cheerathodi, David G Meckes. The Epstein–Barr Virus LMP1 Interactome: Biological Implications and Therapeutic TargetsFuture Virology 2018; 13(12): 863 doi: 10.2217/fvl-2018-0120
19
Periyannan Velu, Annamalai Vijayalakshmi, Veerasamy Vinothkumar. Retracted: Inhibiting the PI3K/Akt, NF-κB signalling pathways with syringic acid for attenuating the development of oral squamous cell carcinoma cells SCC131Journal of Pharmacy and Pharmacology 2020; 72(11): 1595 doi: 10.1111/jphp.13350
20
Wei Sang, Dongyun Tu, Meng Zhang, Yuanyuan Qin, Wenjing Yin, Xuguang Song, Cai Sun, Dongmei Yan, Xiangmin Wang, Lingyu Zeng, Zhenyu Li, Kailin Xu, Linyan Xu. l‐Asparaginase synergizes with etoposide via the PI3K/Akt/mTOR pathway in Epstein−Barr virus‐positive Burkitt lymphomaJournal of Biochemical and Molecular Toxicology 2022; 36(8) doi: 10.1002/jbt.23117
21
XueQiao Liu, Jeffrey I. Cohen. The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedsideVirology 2015; : 568 doi: 10.1016/j.virol.2015.02.040
22
QI-FU BO, XIU-MEI SUN, JIN LIU, XIAO-MEI SUI, GUI-XIN LI. Antitumor action of the peroxisome proliferator-activated receptor-γ agonist rosiglitazone in hepatocellular carcinomaOncology Letters 2015; 10(4): 1979 doi: 10.3892/ol.2015.3554
23
Yilong Yao, Yixue Xue, Jun Ma, Chao Shang, Ping Wang, Libo Liu, Wenjing Liu, Zhen Li, Shengtao Qu, Zhiqing Li, Yunhui Liu, Jin Q. Cheng. MiR-330-Mediated Regulation of SH3GL2 Expression Enhances Malignant Behaviors of Glioblastoma Stem Cells by Activating ERK and PI3K/AKT Signaling PathwaysPLoS ONE 2014; 9(4): e95060 doi: 10.1371/journal.pone.0095060
24
Zhiwei Wu, Qing Ye, Yimei Huang, Yating Lin, Mengmeng Zheng, Xiaoyan Wang, Shusen Xie, Juqiang Lin. Real-time detection of LMP1/LMP1 interaction in MβCD-induced apoptosis of nasopharyngeal carcinoma cells using FRET methodJournal of Innovative Optical Health Sciences 2019; 12(06) doi: 10.1142/S1793545819500196
25
Wen Liu, Ying-ying Song, Jia-yi Wang, Hua Xiao, Yan Zhang, Bing Luo. Dysregulation of FOXO transcription factors in Epstein-Barr virus-associated gastric carcinomaVirus Research 2020; 276: 197808 doi: 10.1016/j.virusres.2019.197808
26
Timmy Richardo, Pongphol Prattapong, Chawalit Ngernsombat, Nurulfitri Wisetyaningsih, Hisashi Iizasa, Hironori Yoshiyama, Tavan Janvilisri. Epstein-Barr Virus Mediated Signaling in Nasopharyngeal Carcinoma CarcinogenesisCancers 2020; 12(9): 2441 doi: 10.3390/cancers12092441
27
Robert J. Visalli, Adam M. Schwartz, Shivam Patel, Melissa A. Visalli. Identification of the Epstein Barr Virus portalVirology 2019; 529: 152 doi: 10.1016/j.virol.2019.01.003
28
Uyen Mui, Christopher Haley, Stephen Tyring. Viral Oncology: Molecular Biology and PathogenesisJournal of Clinical Medicine 2017; 6(12): 111 doi: 10.3390/jcm6120111
29
Oren Shechter, Daniel G. Sausen, Elisa S. Gallo, Harel Dahari, Ronen Borenstein. Epstein–Barr Virus (EBV) Epithelial Associated Malignancies: Exploring Pathologies and Current TreatmentsInternational Journal of Molecular Sciences 2022; 23(22): 14389 doi: 10.3390/ijms232214389
30
Xuesong Zhang, Shan Li, Mingxue Zheng, Li Zhang, Rui Bai, Ruiqi Li, Siyuan Hao, Bing Bai, Huixin Kang. Effects of the PI3K/Akt signaling pathway on the apoptosis of early host cells infected with Eimeria tenellaParasitology Research 2020; 119(8): 2549 doi: 10.1007/s00436-020-06738-9
31
Yuanyuan Jiang, Yuan Ding, Shuzhen Liu, Bing Luo. The Role of Epstein–Barr virus-encoded Latent Membrane Proteins in Host Immune EscapeFuture Virology 2021; 16(8): 565 doi: 10.2217/fvl-2020-0320
32
Fengchao Lang, Yonggang Pei, Zachary L. Lamplugh, Erle S. Robertson. HIV/AIDS-Associated Viral OncogenesisCancer Treatment and Research 2019; 177: 81 doi: 10.1007/978-3-030-03502-0_4
33
Wen‐Liang Fang, Yuan‐Tzu Lan, Kuo‐Hung Huang, Chien‐An Liu, Yi‐Ping Hung, Chien‐Hsing Lin, Fang‐Yu Jhang, Shih‐Ching Chang, Ming‐Huang Chen, Yee Chao, Wen‐Chang Lin, Su‐Shun Lo, Anna Fen‐Yau Li, Chew‐Wun Wu, Shih‐Hwa Chiou, Yi‐Ming Shyr. Clinical significance of circulating plasma DNA in gastric cancerInternational Journal of Cancer 2016; 138(12): 2974 doi: 10.1002/ijc.30018
34
Chenxi Wang, Chenyang Huang, Jiali Wang, Jianfeng Ye, Zhiqiang Xue, Jian Zhang, Yuke Ren. Ginsenoside Rg5 attenuates hypoxia‐induced cardiomyocyte apoptosis via regulating the Akt pathwayChemical Biology & Drug Design 2023; 101(6): 1348 doi: 10.1111/cbdd.14217
35
Qingqing Cai, Kailin Chen, Ken H Young. Epstein–Barr virus-positive T/NK-cell lymphoproliferative disordersExperimental & Molecular Medicine 2015; 47(1): e133 doi: 10.1038/emm.2014.105
36
Hiroyuki Abe, Atsushi Kaneda, Masashi Fukayama. Epstein-Barr Virus-Associated Gastric Carcinoma: Use of Host Cell Machineries and Somatic Gene MutationsPathobiology 2015; 82(5): 212 doi: 10.1159/000434683
37
Syed Riaz Ud Din, Muhammad Azhar Nisar, Muhammad Noman Ramzan, Muhammad Zubair Saleem, Hassan Ghayas, Bashir Ahmad, Samana Batool, Kashif Kifayat, Xiaorong Guo, Min Huang, Mintao Zhong. Latcripin-7A from Lentinula edodes C91-3 induces apoptosis, autophagy, and cell cycle arrest at G1 phase in human gastric cancer cells via inhibiting PI3K/Akt/mTOR signalingEuropean Journal of Pharmacology 2021; 907: 174305 doi: 10.1016/j.ejphar.2021.174305
38
Beatrice Rivalta, Donato Amodio, Cinzia Milito, Maria Chiriaco, Silvia Di Cesare, Carmela Giancotta, Francesca Conti, Veronica Santilli, Lucia Pacillo, Cristina Cifaldi, Maria Giovanna Desimio, Margherita Doria, Isabella Quinti, Rita De Vito, Gigliola Di Matteo, Andrea Finocchi, Paolo Palma, Antonino Trizzino, Alberto Tommasini, Caterina Cancrini. Case Report: EBV Chronic Infection and Lymphoproliferation in Four APDS Patients: The Challenge of Proper Characterization, Therapy, and Follow-UpFrontiers in Pediatrics 2021; 9 doi: 10.3389/fped.2021.703853
39
Elham Patrad, Solmaz Khalighfard, Taghi Amiriani, Vahid Khori, Ali Mohammad Alizadeh. Molecular mechanisms underlying the action of carcinogens in gastric cancer with a glimpse into targeted therapyCellular Oncology 2022; 45(6): 1073 doi: 10.1007/s13402-022-00715-3
40
C-F Yang, G-D Yang, T-J Huang, R Li, Q-Q Chu, L Xu, M-S Wang, M-D Cai, L Zhong, H-J Wei, H-B Huang, J-L Huang, C-N Qian, B-J Huang. EB-virus latent membrane protein 1 potentiates the stemness of nasopharyngeal carcinoma via preferential activation of PI3K/AKT pathway by a positive feedback loopOncogene 2016; 35(26): 3419 doi: 10.1038/onc.2015.402
41
Hyun Jin Kwun, Masahiro Shuda, Carlos J. Camacho, Armin M. Gamper, Mamie Thant, Yuan Chang, Patrick S. Moore, M. J. Imperiale. Restricted Protein Phosphatase 2A Targeting by Merkel Cell Polyomavirus Small T AntigenJournal of Virology 2015; 89(8): 4191 doi: 10.1128/JVI.00157-15
42
Isabel Huang-Doran, Patsy Tomlinson, Felicity Payne, Alexandra Gast, Alison Sleigh, William Bottomley, Julie Harris, Allan Daly, Nuno Rocha, Simon Rudge, Jonathan Clark, Albert Kwok, Stefano Romeo, Emma McCann, Barbara Müksch, Mehul Dattani, Stefano Zucchini, Michael Wakelam, Lazaros C. Foukas, David B. Savage, Rinki Murphy, Stephen O’Rahilly, Inês Barroso, Robert K. Semple. Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutationsJCI Insight 2016; 1(17) doi: 10.1172/jci.insight.88766
43
Hem C. Jha, Yonggang Pei, Erle S. Robertson. Epstein–Barr Virus: Diseases Linked to Infection and TransformationFrontiers in Microbiology 2016; 7 doi: 10.3389/fmicb.2016.01602
44
Caiyan Yuan, Shuangyan Chang, Chong Zhang, Dirong Dong, Jiahui Ding, Ali Reza Mahdavian, Zheng Hu, Lili Sun, Songwei Tan. Post cross-linked ROS-responsive poly(β-amino ester)-plasmid polyplex NPs for gene therapy of EBV-associated nasopharyngeal carcinomaJournal of Materials Chemistry B 2024; 12(12): 3129 doi: 10.1039/D3TB02926C
45
Lu Shi, Yijun Tu, Yu Xia, Siqi Ye, Chaozhi Ma, Yanwen Liu, Pengtao You. TEEG Induced A549 Cell Autophagy by Regulating the PI3K/AKT/mTOR Signaling PathwayAnalytical Cellular Pathology 2019; 2019: 1 doi: 10.1155/2019/7697610
46
Prankur Awasthi, Manish Dwivedi, Dhruv Kumar, Saba Hasan. Insights into intricacies of the Latent Membrane Protein-1 (LMP-1) in EBV-associated cancersLife Sciences 2023; 313: 121261 doi: 10.1016/j.lfs.2022.121261
47
Cigdem Irkkan, Serdar Balci, Gaye Güler Tezel, Bülent Akinci, Bülent Yalcin, Gülnur Güler. Comparison of Clinicopathologic Parameters and Survivals Between Epstein-Barr Virus–positive and Her2-positive Gastric CancersApplied Immunohistochemistry & Molecular Morphology 2017; 25(9): 609 doi: 10.1097/PAI.0000000000000353
48
Binnari Kim, Kyoung-Mee Kim. Role of Exosomes and Their Potential as Biomarkers in Epstein-Barr Virus-Associated Gastric CancerCancers 2023; 15(2): 469 doi: 10.3390/cancers15020469
49
Valli De Re, Giulia Brisotto, Ombretta Repetto, Mariangela De Zorzi, Laura Caggiari, Stefania Zanussi, Lara Alessandrini, Vincenzo Canzonieri, Gianmaria Miolo, Fabio Puglisi, Claudio Belluco, Agostino Steffan, Renato Cannizzaro. Overview of Epstein–Barr-Virus-Associated Gastric Cancer Correlated with Prognostic Classification and Development of Therapeutic OptionsInternational Journal of Molecular Sciences 2020; 21(24): 9400 doi: 10.3390/ijms21249400
50
Anna Shestakova, Narina Grove, Jonathan Said, Sophie Song, Fabiola Quintero-Rivera. Trisomy 3, a sole recurrent cytogenetic abnormality in pediatric polymorphic post-transplant lymphoproliferative disorder (PTLD)Cancer Genetics 2020; : 39 doi: 10.1016/j.cancergen.2020.09.006
51
Yu Sunakawa, Heinz-Josef Lenz. Molecular Classification of Gastric Adenocarcinoma: Translating New Insights from The Cancer Genome Atlas Research NetworkCurrent Treatment Options in Oncology 2015; 16(4) doi: 10.1007/s11864-015-0331-y
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Marco Pizzi, Elizabeth Margolskee, Giorgio Inghirami. Pathogenesis of Peripheral T Cell LymphomaAnnual Review of Pathology: Mechanisms of Disease 2018; 13(1): 293 doi: 10.1146/annurev-pathol-020117-043821
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Jie Liu, Wei Huang, Caiping Ren, Qiuyuan Wen, Weidong Liu, Xuyu Yang, Lei Wang, Bin Zhu, Liang Zeng, Xiangling Feng, Chang Zhang, Huan Chen, Wei Jia, Lihua Zhang, Xiaomeng Xia, Yuxiang Chen. Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathwaysScientific Reports 2015; 5(1) doi: 10.1038/srep11614
54
Gonzalo Carrasco-Avino, Ismael Riquelme, Oslando Padilla, Miguel Villaseca, Francisco R. Aguayo, Alejandro H. Corvalan. The conundrum of the Epstein-Barr virus-associated gastric carcinoma in the AmericasOncotarget 2017; 8(43): 75687 doi: 10.18632/oncotarget.18497
55
Zhili Ni, Jingmei Yi. Oxymatrine induces nasopharyngeal cancer cell death through inhibition of PI3K/AKT and NF-κB pathwaysMolecular Medicine Reports 2017; 16(6): 9701 doi: 10.3892/mmr.2017.7822
56
Sadegh Fattahi, Fatemeh Amjadi-Moheb, Reza Tabaripour, Gholam Hossein Ashrafi, Haleh Akhavan-Niaki. PI3K/AKT/mTOR signaling in gastric cancer: Epigenetics and beyondLife Sciences 2020; 262: 118513 doi: 10.1016/j.lfs.2020.118513
57
Feng Su, Lan Zhao, Shaoheng Zhang, Jiahong Wang, Nannan Chen, Qunlin Gong, Jinhui Tang, Hao Wang, Jianhua Yao, Qin Wang, Ming Zhong, Jian Yan. Cardioprotection by PI3K-mediated signaling is required for anti-arrhythmia and myocardial repair in response to ischemic preconditioning in infarcted pig heartsLaboratory Investigation 2015; 95(8): 860 doi: 10.1038/labinvest.2015.64
58
Marc L Ooft, Weibel W Braunius, Paulien Heus, Inge Stegeman, Paul J van Diest, Wilko Grolman, Charlotte I Zuur, Stefan M Willems. Prognostic Significance of the EGFR Pathway in Nasopharyngeal Carcinoma: A Systematic Review and Meta-AnalysisBiomarkers in Medicine 2015; 9(10): 997 doi: 10.2217/bmm.15.68
59
Euno Choi, Sun-ju Byeon, Soo Hee Kim, Hyun Ju Lee, Hyeong Ju Kwon, HyeSeong Ahn, Dong Ha Kim, Mee Soo Chang, Joseph S Pagano. Implication of Leptin-Signaling Proteins and Epstein-Barr Virus in Gastric CarcinomasPLOS ONE 2015; 10(7): e0130839 doi: 10.1371/journal.pone.0130839
60
Yunchang Cao, Hongbo Wen, Chaoqun Leng, Shaolong Feng. MiR‐29a mediates the apoptotic effects of TNF‐α on endothelial cells through inhibiting PI3K/AKT/BCL‐2 axisJournal of Biochemical and Molecular Toxicology 2024; 38(1) doi: 10.1002/jbt.23598
61
Alexandra Koumpouli, Paulina Karavida, Vasileios Zisis, Athanasios Poulopoulos, Dimitrios Andreadis. Epstein-Barr virus: Ubiquitous virus with multifarious implication in oral diseases material and methods resultsBalkan Journal of Dental Medicine 2024; 28(1): 1 doi: 10.5937/bjdm2401001K
62
Lyla J. Stanland, Micah A. Luftig. The Role of EBV-Induced Hypermethylation in Gastric Cancer TumorigenesisViruses 2020; 12(11): 1222 doi: 10.3390/v12111222
63
Huimin Li, Jiaojiao Zhu, Minyi He, Qiong Luo, Fan Liu, Ruiai Chen. Marek’s Disease Virus Activates the PI3K/Akt Pathway Through Interaction of Its Protein Meq With the P85 Subunit of PI3K to Promote Viral ReplicationFrontiers in Microbiology 2018; 9 doi: 10.3389/fmicb.2018.02547