For: | Hsu HH, Chen MC, Day CH, Lin YM, Li SY, Tu CC, Padma VV, Shih HN, Kuo WW, Huang CY. Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation. World J Gastroenterol 2017; 23(7): 1171-1179 [PMID: 28275297 DOI: 10.3748/wjg.v23.i7.1171] |
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URL: | https://www.wjgnet.com/1007-9327/full/v23/i7/1171.htm |
Number | Citing Articles |
1 |
Y. X. Wang, Y. Z. Li, Z. Y. Zhang, J. Q. Wang, J. Cui, X. L. Qian. HPV16 E6 Promotes Breast Cancer Proliferation via Upregulation of COX-2 Expression. BioMed Research International 2017; 2017: 1 doi: 10.1155/2017/2948467
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2 |
Rabea Parveen, Sradhanjali Mohapatra, Sayeed Ahmad, Syed Akhtar Husain. Amalgamation of Nanotechnology for Delivery of Bioactive Constituents in
Solid Tumors. Current Drug Delivery 2023; 20(5): 457 doi: 10.2174/1567201819666220425093102
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3 |
Fahadul Islam, Saikat Mitra, Talha Bin Emran, Zidan Khan, Nikhil Nath, Rajib Das, Rohit Sharma, Ahmed Abdullah Al Awadh, Moon Nyeo Park, Bonglee Kim. Natural Small Molecules in Gastrointestinal Tract and Associated Cancers: Molecular Insights and Targeted Therapies. Molecules 2022; 27(17): 5686 doi: 10.3390/molecules27175686
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4 |
Natalia Kurowska, Marcel Madej, Barbara Strzalka-Mrozik. Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer. Current Issues in Molecular Biology 2023; 46(1): 121 doi: 10.3390/cimb46010010
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5 |
Zakia Akter, Faiza Rafa Ahmed, Mousumi Tania, Md. Asaduzzaman Khan. Targeting Inflammatory Mediators: An Anticancer Mechanism of Thymoquinone Action. Current Medicinal Chemistry 2020; 28(1): 80 doi: 10.2174/0929867326666191011143642
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6 |
Geumi Park, Na-Young Song, Do-Hee Kim, Su-Jun Lee, Kyung-Soo Chun. Thymoquinone Suppresses Migration of Human Renal Carcinoma Caki-1 Cells through Inhibition of the PGE2-Mediated Activation of the EP2 Receptor Pathway. Biomolecules & Therapeutics 2021; 29(1): 64 doi: 10.4062/biomolther.2020.048
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7 |
Farzad Ghasemi, Amir Nili‐Ahmadabadi, Navid Omidifar, Maryam Nili‐Ahmadabadi. Protective potential of thymoquinone against cadmium, arsenic, and lead toxicity: A short review with emphasis on oxidative pathways. Journal of Applied Toxicology 2023; 43(12): 1764 doi: 10.1002/jat.4459
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8 |
Yong‑Xia Wang, Zhe‑Ying Zhang, Jian‑Qiang Wang, Xin‑Lai Qian, Jing Cui. HPV16 E7 increases COX‑2 expression and promotes the proliferation of breast cancer. Oncology Letters 2018; doi: 10.3892/ol.2018.8624
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9 |
Dali Tong, Qiuli Liu, Lin-ang Wang, Qiubo Xie, Jian Pang, Yiqiang Huang, Luofu Wang, Gaolei Liu, Dianzheng Zhang, Weihua Lan, Jun Jiang. The roles of the COX2/PGE2/EP axis in therapeutic resistance. Cancer and Metastasis Reviews 2018; 37(2-3): 355 doi: 10.1007/s10555-018-9752-y
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10 |
Qiushi Wang, Rebecca J. Morris, Ann M. Bode, Tianshun Zhang. Prostaglandin Pathways: Opportunities for Cancer Prevention and Therapy. Cancer Research 2022; 82(6): 949 doi: 10.1158/0008-5472.CAN-21-2297
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11 |
Pinar Obakan Yerlikaya, Kaan Adacan, Ayse Karatug Kacar, Ajda Coker Gurkan, Elif Damla Arisan. Epibrassinolide impaired colon tumor progression and induced autophagy in SCID mouse xenograft model via acting on cell cycle progression without affecting endoplasmic reticulum stress observed in vitro. The International Journal of Biochemistry & Cell Biology 2023; 155: 106360 doi: 10.1016/j.biocel.2022.106360
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12 |
Amin F. Majdalawieh, Saud Al-Samaraie, Tala M. Terro. Molecular Mechanisms and Signaling Pathways Underlying the Therapeutic Potential of Thymoquinone Against Colorectal Cancer. Molecules 2024; 29(24): 5907 doi: 10.3390/molecules29245907
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13 |
Kathiravan M K, Swethan Babu, Chitra Vellapandian, Vigneshwaran Namasivayam, Senthilkumar Palaniappan. Systems Biomedicine Approaches in Cancer Research. 2022; : 71 doi: 10.1007/978-981-19-1953-4_4
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14 |
Ehsan Sadeghi, Mohsen Imenshahidi, Hossein Hosseinzadeh. Molecular mechanisms and signaling pathways of black cumin (Nigella sativa) and its active constituent, thymoquinone: a review. Molecular Biology Reports 2023; 50(6): 5439 doi: 10.1007/s11033-023-08363-y
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15 |
Md. Abdul Hannan, Md. Ataur Rahman, Abdullah Al Mamun Sohag, Md. Jamal Uddin, Raju Dash, Mahmudul Hasan Sikder, Md. Saidur Rahman, Binod Timalsina, Yeasmin Akter Munni, Partha Protim Sarker, Mahboob Alam, Md. Mohibbullah, Md. Nazmul Haque, Israt Jahan, Md. Tahmeed Hossain, Tania Afrin, Md. Mahbubur Rahman, Md. Tahjib-Ul-Arif, Sarmistha Mitra, Diyah Fatimah Oktaviani, Md Kawsar Khan, Ho Jin Choi, Il Soo Moon, Bonglee Kim. Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety. Nutrients 2021; 13(6): 1784 doi: 10.3390/nu13061784
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16 |
Herbal Medicine Phytochemistry. Reference Series in Phytochemistry 2023; : 1 doi: 10.1007/978-3-031-21973-3_28-1
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17 |
Rohit Singh, Raniya K. Zubair, Salil Suresh, Siddheshwar B. Lonari, Ravindra S. Phatake. Quinone-Based Compounds in Drug Discovery. 2025; : 29 doi: 10.1016/B978-0-443-24126-0.00003-2
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18 |
K. I. Kirsanov, O. A. Vlasova, T. I. Fetisov, R. G. Zenkov, E. A. Lesovaya, G. A. Belitsky, K. Gurova, M. G. Yakubovskaya. Influence of DNA-binding compounds with cancer preventive activity on the mechanisms of gene expression regulation. Advances in molecular oncology 2019; 5(4): 41 doi: 10.17650/2313-805X-2018-5-4-41-63
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19 |
Prince Ahad Mir, Roohi Mohi-ud-din, Nazia Banday, Mudasir Maqbool, Syed Naeim Raza, Saeema Farooq, Suhaib Afzal, Reyaz Hassan Mir. Anticancer Potential of Thymoquinone: A Novel Bioactive Natural Compound from
Nigella sativa L.. Anti-Cancer Agents in Medicinal Chemistry 2022; 22(20): 3401 doi: 10.2174/1871520622666220511233314
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20 |
Luyao Shen, Keke Jia, Tao Bing, Zhibao Zhang, Xiaoxiao Zhen, Xiangjun Liu, Nan Zhang, Dihua Shangguan. Detection of Circulating Tumor-Related Materials by Aptamer Capturing and Endogenous Enzyme-Signal Amplification. Analytical Chemistry 2020; 92(7): 5370 doi: 10.1021/acs.analchem.0c00051
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21 |
Shakir Idris, Bassem Refaat, Riyad A. Almaimani, Hussain G. Ahmed, Jawwad Ahmad, Mai Alhadrami, Mahmoud Zaki El-Readi, Mohamed E. Elzubier, Haneen A.A. Alaufi, Badriah Al-Amin, Ahmad A. Alghamdi, Fayez Bahwerth, Faisal Minshawi, Saeed M. Kabrah, Akhmed Aslam. Enhanced in vitro tumoricidal effects of 5-Fluorouracil, thymoquinone, and active vitamin D3 triple therapy against colon cancer cells by attenuating the PI3K/AKT/mTOR pathway. Life Sciences 2022; 296: 120442 doi: 10.1016/j.lfs.2022.120442
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22 |
Herbal Medicine Phytochemistry. Reference Series in Phytochemistry 2024; : 1141 doi: 10.1007/978-3-031-43199-9_28
|
23 |
P. N. Ravindran. Handbook of Spices in India: 75 Years of Research and Development. 2024; : 3101 doi: 10.1007/978-981-19-3728-6_46
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24 |
Xue Hu, Jingjing Ma, Vikash Vikash, Jiao Li, Dandan Wu, Ya Liu, Jixiang Zhang, Weiguo Dong. Thymoquinone Augments Cisplatin-Induced Apoptosis on Esophageal Carcinoma Through Mitigating the Activation of JAK2/STAT3 Pathway. Digestive Diseases and Sciences 2018; 63(1): 126 doi: 10.1007/s10620-017-4856-8
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25 |
Anas Ahmad, Mohammad Imran, Ajay Kumar, Rakesh K. Mishra, Akshay Vyawahare, Abdul Q. Khan, Syed S. Raza, Rehan Khan. Black Seeds (Nigella Sativa). 2022; : 253 doi: 10.1016/B978-0-12-824462-3.00008-1
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26 |
Sawsan Elgohary, Reda A. Eissa, Hend M. El Tayebi. Thymoquinone, a Novel Multi-Strike Inhibitor of Pro-Tumorigenic Breast Cancer (BC) Markers: CALR, NLRP3 Pathway and sPD-L1 in PBMCs of HR+ and TNBC Patients. International Journal of Molecular Sciences 2023; 24(18): 14254 doi: 10.3390/ijms241814254
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27 |
Muhammad Imran, Abdur Rauf, Imtiaz Ali Khan, Muhammad Shahbaz, Tahira Batool Qaisrani, Sri Fatmawati, Tareq Abu-Izneid, Ali Imran, Khaliq Ur Rahman, Tanweer Aslam Gondal. Thymoquinone: A novel strategy to combat cancer: A review. Biomedicine & Pharmacotherapy 2018; 106: 390 doi: 10.1016/j.biopha.2018.06.159
|
28 |
Eltayeb E. M. Eid, Amer A. Almaiman, Salah Abdalrazak Alshehade, Wardah Alsalemi, Sareh Kamran, FakhrEldin O. Suliman, Mohammed Abdullah Alshawsh. Characterization of Thymoquinone-Sulfobutylether-β-Cyclodextrin Inclusion Complex for Anticancer Applications. Molecules 2023; 28(10): 4096 doi: 10.3390/molecules28104096
|
29 |
Ali H El-Far, Taher A Salaheldin, Kavitha Godugu, Noureldien HE Darwish, Shaker A Mousa. Thymoquinone and its Nanoformulation Attenuate Colorectal and Breast Cancers and Alleviate Doxorubicin-Induced Cardiotoxicity. Nanomedicine 2021; 16(17): 1457 doi: 10.2217/nnm-2021-0103
|
30 |
Pengzhan He, Yang He, Jingjing Ma, Yinghui Liu, Chuan Liu, Yu Baoping, Weiguo Dong. Thymoquinone induces apoptosis and protective autophagy in gastric cancer cells by inhibiting the PI3K/Akt/mTOR pathway. Phytotherapy Research 2023; 37(8): 3467 doi: 10.1002/ptr.7820
|
31 |
Saleh A. Almatroodi, Ahmad Almatroudi, Mohammed A. Alsahli, Amjad A. Khan, Arshad H. Rahmani. Thymoquinone, an Active Compound of Nigella sativa: Role in Prevention and Treatment of Cancer. Current Pharmaceutical Biotechnology 2020; 21(11): 1028 doi: 10.2174/1389201021666200416092743
|
32 |
Mohammed M Mehanna, Rana Sarieddine, Jana K Alwattar, Racha Chouaib, Hala Gali-Muhtasib. <p>Anticancer Activity of Thymoquinone Cubic Phase Nanoparticles Against Human Breast Cancer: Formulation, Cytotoxicity and Subcellular Localization</p>. International Journal of Nanomedicine 2020; : 9557 doi: 10.2147/IJN.S263797
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33 |
Vildan Betul Yenigun, Abdurrahim Kocyigit, Ebru Kanimdan, Ezgi Balkan, Ayse Zehra Gul. Copper (II) increases anti-Proliferative activity of thymoquinone in colon cancer cells by increasing genotoxic, apoptotic, and reactive oxygen species generating effects. Toxicon 2024; 250: 108103 doi: 10.1016/j.toxicon.2024.108103
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34 |
Julia Huei‐Mei Chang, Chih‐Hsueh Lin, Marthandam Asokan Shibu, Yung‐Chen Chou, Jer‐Yuh Liu, Yen‐Hong Chou, Chia‐Yao Shen, Yu‐Lan Yeh, Vijaya Padma Viswanadha, Chih‐Yang Huang. Cryptotanshinone (Dsh‐003) from Salvia miltiorrhiza Bunge inhibits prostaglandin E2‐induced survival and invasion effects in HA22T hepatocellular carcinoma cells. Environmental Toxicology 2018; 33(12): 1254 doi: 10.1002/tox.22633
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35 |
Muthu K. Shanmugam, Frank Arfuso, Alan Prem Kumar, Lingzhi Wang, Boon Cher Goh, Kwang Seok Ahn, Anupam Bishayee, Gautam Sethi. Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn. Pharmacological Research 2018; 129: 357 doi: 10.1016/j.phrs.2017.11.023
|
36 |
Marta Ribeiro, Manuel Simões. Health Consequences of Microbial Interactions with Hydrocarbons, Oils, and Lipids. 2020; : 335 doi: 10.1007/978-3-030-15147-8_28
|
37 |
Anas Ahmad, Rakesh Kumar Mishra, Akshay Vyawahare, Ajay Kumar, Muneeb U. Rehman, Wajhul Qamar, Abdul Quaiyoom Khan, Rehan Khan. Thymoquinone (2-Isopropyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: Chemistry and biological effects. Saudi Pharmaceutical Journal 2019; 27(8): 1113 doi: 10.1016/j.jsps.2019.09.008
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38 |
Manzar Alam, Gulam Mustafa Hasan, Md Meraj Ansari, Rishi Sharma, Dharmendra Kumar Yadav, Md Imtaiyaz Hassan. Therapeutic implications and clinical manifestations of thymoquinone. Phytochemistry 2022; 200: 113213 doi: 10.1016/j.phytochem.2022.113213
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39 |
Belal Almajali, Hamid Ali Nagi Al-Jamal, Wan Rohani Wan Taib, Imilia Ismail, Muhammad Farid Johan, Abd Almonem Doolaanea, Wisam Nabeel Ibrahim. Thymoquinone, as a Novel Therapeutic Candidate of Cancers. Pharmaceuticals 2021; 14(4): 369 doi: 10.3390/ph14040369
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40 |
Samar Al Bitar, Farah Ballout, Alissar Monzer, Mariam Kanso, Nour Saheb, Deborah Mukherji, Walid Faraj, Ayman Tawil, Samer Doughan, Maher Hussein, Wassim Abou-Kheir, Hala Gali-Muhtasib. Thymoquinone Radiosensitizes Human Colorectal Cancer Cells in 2D and 3D Culture Models. Cancers 2022; 14(6): 1363 doi: 10.3390/cancers14061363
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41 |
Junfang Liang, Liyang Lian, Xiaoli Wang, Liang Li. Thymoquinone, extract from Nigella sativa seeds, protects human skin keratinocytes against UVA-irradiated oxidative stress, inflammation and mitochondrial dysfunction. Molecular Immunology 2021; 135: 21 doi: 10.1016/j.molimm.2021.03.015
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42 |
Sawsan Elgohary, Aya A. Elkhodiry, Nada S. Amin, Ulrike Stein, Hend M. El Tayebi. Thymoquinone: A Tie-Breaker in SARS-CoV2-Infected Cancer Patients?. Cells 2021; 10(2): 302 doi: 10.3390/cells10020302
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43 |
Roohi Mohi-ud-din, Reyaz Hassan Mir, Saba Sabreen, Rafia Jan, Faheem Hyder Pottoo, Inder Pal Singh. Recent Insights into Therapeutic Potential of Plant-Derived Flavonoids against
Cancer. Anti-Cancer Agents in Medicinal Chemistry 2022; 22(20): 3343 doi: 10.2174/1871520622666220421094055
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44 |
Naila Hassan Alkefai. Optimization and Evaluation of Thymoquinone-Loaded Transniosome in situ Gel for Intranasal Treatment of Parkinson's Disease. Journal of Drug Delivery Science and Technology 2024; : 106565 doi: 10.1016/j.jddst.2024.106565
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45 |
Johura Ansary, Francesca Giampieri, Tamara Y. Forbes-Hernandez, Lucia Regolo, Denise Quinzi, Santos Gracia Villar, Eduardo Garcia Villena, Kilian Tutusaus Pifarre, José M. Alvarez-Suarez, Maurizio Battino, Danila Cianciosi. Nutritional Value and Preventive Role of Nigella sativa L. and Its Main Component Thymoquinone in Cancer: An Evidenced-Based Review of Preclinical and Clinical Studies. Molecules 2021; 26(8): 2108 doi: 10.3390/molecules26082108
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46 |
Wei-Chung Hsu, Samiraj Ramesh, Marthandam Asokan Shibu, Ming-Cheng Chen, Tso-Fu Wang, Cecilia Hsuan Day, Ray-Jade Chen, V. Vijaya Padma, Chi-Cheng Li, Yu-Chen Tseng, Chih-Yang Huang. Platycodin D reverses histone deacetylase inhibitor resistance in hepatocellular carcinoma cells by repressing ERK1/2-mediated cofilin-1 phosphorylation. Phytomedicine 2021; 82: 153442 doi: 10.1016/j.phymed.2020.153442
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47 |
Ming-Chang Tsai, Ching-Chun Chen, Tsui-Hwa Tseng, Yun-Ching Chang, Yi-Jie Lin, I-Ning Tsai, Chi-Chih Wang, Chau-Jong Wang. Hibiscus Anthocyanins Extracts Induce Apoptosis by Activating AMP-Activated Protein Kinase in Human Colorectal Cancer Cells. Nutrients 2023; 15(18): 3972 doi: 10.3390/nu15183972
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48 |
Maria Camilla Bergonzi, Marzia Vasarri, Giulia Marroncini, Emanuela Barletta, Donatella Degl’Innocenti. Thymoquinone-Loaded Soluplus®-Solutol® HS15 Mixed Micelles: Preparation, In Vitro Characterization, and Effect on the SH-SY5Y Cell Migration. Molecules 2020; 25(20): 4707 doi: 10.3390/molecules25204707
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49 |
Farah Ballout, Alissar Monzer, Maamoun Fatfat, Hala El Ouweini, Miran A. Jaffa, Rana Abdel-Samad, Nadine Darwiche, Wassim Abou-Kheir, Hala Gali-Muhtasib. Thymoquinone induces apoptosis and DNA damage in 5-Fluorouracil-resistant colorectal cancer stem/progenitor cells. Oncotarget 2020; 11(31): 2959 doi: 10.18632/oncotarget.27426
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50 |
Ravi Raj Pal, Vasundhara Rajpal, Priya Singh, Shubhini A. Saraf. Recent Findings on Thymoquinone and Its Applications as a Nanocarrier for the Treatment of Cancer and Rheumatoid Arthritis. Pharmaceutics 2021; 13(6): 775 doi: 10.3390/pharmaceutics13060775
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51 |
Vahid Karpisheh, Afshin Nikkhoo, Mohammad Hojjat-Farsangi, Afshin Namdar, Gholamreza Azizi, Ghasem Ghalamfarsa, Gholamabas Sabz, Mehdi Yousefi, Bahman Yousefi, Farhad Jadidi-Niaragh. Prostaglandin E2 as a potent therapeutic target for treatment of colon cancer. Prostaglandins & Other Lipid Mediators 2019; 144: 106338 doi: 10.1016/j.prostaglandins.2019.106338
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52 |
Mengzhao Zhang, Hongxia Du, Lu Wang, Yangyang Yue, Pu Zhang, Zhixin Huang, Wei Lv, Jianbin Ma, Qiuya Shao, Minghai Ma, Xiao Liang, Tao Yang, Weiyi Wang, Jin Zeng, Guanqiu Chen, Xinyang Wang, Jinhai Fan. Thymoquinone suppresses invasion and metastasis in bladder cancer cells by reversing EMT through the Wnt/β-catenin signaling pathway. Chemico-Biological Interactions 2020; 320: 109022 doi: 10.1016/j.cbi.2020.109022
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53 |
Chiara Tupini, Matteo Zurlo, Jessica Gasparello, Irene Lodi, Alessia Finotti, Thomas Scattolin, Fabiano Visentin, Roberto Gambari, Ilaria Lampronti. Combined Treatment of Cancer Cells Using Allyl Palladium Complexes Bearing Purine-Based NHC Ligands and Molecules Targeting MicroRNAs miR-221-3p and miR-222-3p: Synergistic Effects on Apoptosis. Pharmaceutics 2023; 15(5): 1332 doi: 10.3390/pharmaceutics15051332
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54 |
Yi-Sheng Liu, Yu-Chun Chang, Wei-Wen Kuo, Ming-Cheng Chen, Hsi-Hsien Hsu, Chuan-Chou Tu, Yu-Lan Yeh, Vijaya Padma Viswanadha, Po-Hsiang Liao, Chih-Yang Huang. Inhibition of Protein Phosphatase 1 Stimulates Noncanonical ER Stress eIF2α Activation to Enhance Fisetin-induced Chemosensitivity in HDAC Inhibitor-resistant Hepatocellular Carcinoma Cells. Cancers 2019; 11(7): 918 doi: 10.3390/cancers11070918
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55 |
Xiaoting Sun, Qi Li. Prostaglandin EP2 receptor: Novel therapeutic target for human cancers (Review). International Journal of Molecular Medicine 2018; doi: 10.3892/ijmm.2018.3744
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56 |
Monireh Shahbodi, Seyed Ahmad Emami, Behjat Javadi, Zahra Tayarani-Najaran. Effects of Thymoquinone on Adipocyte Differentiation in Human Adipose-Derived Stem Cells. Cell Biochemistry and Biophysics 2022; 80(4): 771 doi: 10.1007/s12013-022-01095-z
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57 |
Chi-Cheng Li, Marthandam Asokan Shibu, Wei-Wen Kuo, Yueh-Hsiung Kuo, Yun-Peng Chao, Chun-Hsu Yao, Da-Tian Bau, Pei-Jei Lio, Chung-Jen Chiang, Chih-Yang Huang. Nuclear translocation of β-catenin and migration of arecoline-induced oral cancer cells reduced by Taiwanin E via p-GSK3β downregulation. Molecular & Cellular Toxicology 2024; doi: 10.1007/s13273-024-00464-4
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58 |
Farhad Sheikhnia, Vahid Rashidi, Hossein Maghsoudi, Maryam Majidinia. Potential anticancer properties and mechanisms of thymoquinone in colorectal cancer. Cancer Cell International 2023; 23(1) doi: 10.1186/s12935-023-03174-4
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59 |
Marta Ribeiro, Manuel Simões. Health Consequences of Microbial Interactions with Hydrocarbons, Oils, and Lipids. 2019; : 1 doi: 10.1007/978-3-319-72473-7_28-1
|
60 |
Md. Junaid, Yeasmin Akter, Syeda Samira Afrose, Mousumi Tania, Md. Asaduzzaman Khan. Biological Role of AKT and Regulation of AKT Signaling Pathway by Thymoquinone: Perspectives in Cancer Therapeutics. Mini-Reviews in Medicinal Chemistry 2021; 21(3): 288 doi: 10.2174/1389557520666201005143818
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