For: | Singh SS, Yap WN, Arfuso F, Kar S, Wang C, Cai W, Dharmarajan AM, Sethi G, Kumar AP. Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine? World J Gastroenterol 2015; 21(43): 12261-12273 [PMID: 26604635 DOI: 10.3748/wjg.v21.i43.12261] |
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URL: | https://www.wjgnet.com/1007-9327/full/v21/i43/12261.htm |
Number | Citing Articles |
1 |
Chin-Yap Loh, Jian Chai, Ting Tang, Won Wong, Gautam Sethi, Muthu Shanmugam, Pei Chong, Chung Looi. The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges. Cells 2019; 8(10): 1118 doi: 10.3390/cells8101118
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Ya-kai Huang, Wei-ming Kang, Zhi-qiang Ma, Yu-qin Liu, Li Zhou, Jian-chun Yu. NUCKS1 promotes gastric cancer cell aggressiveness by upregulating IGF-1R and subsequently activating the PI3K/Akt/mTOR signaling pathway. Carcinogenesis 2019; 40(2): 370 doi: 10.1093/carcin/bgy142
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Francesca Battaglin, Giovanni Randon, Alessandra Raimondi, Filippo Pagani, Hiroyuki Arai, Filippo Pietrantonio, Heinz-Josef Lenz. Molecular Determinants of Gastrointestinal Cancers. Advances in Oncology 2021; 1: 311 doi: 10.1016/j.yao.2021.02.026
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Zhiyuan Wang, Zijin Shen, Haibin Wang, Lin Zhang, Rong Dong. Effect of dexmedetomidine on the cognitive function of patients undergoing gastric cancer surgery by regulating the PI3K/AKT signaling pathway. Oncology Letters 2019; doi: 10.3892/ol.2019.11224
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Wei Liu, Meijin Li. The role of claudin-4 in the development of gastric cancer. Scandinavian Journal of Gastroenterology 2020; 55(9): 1072 doi: 10.1080/00365521.2020.1795923
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6 |
Runze Xu, Ran Xu, Yuanxiang Wang, Weixing Wang, Lingling Jiang, Shishun Gong, Osamah Ibrahim Khalaf. G-Protein-Coupled Receptor Kinase-Interacting Protein 1 (GIT1) Promotes Head and Neck Squamous Cell Carcinoma Metastases via Activating the PI3K/AKT/mTOR Signal Pathway. Computational and Mathematical Methods in Medicine 2022; 2022: 1 doi: 10.1155/2022/6881932
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Diana-Theodora Morgos, Constantin Stefani, Daniela Miricescu, Maria Greabu, Silviu Stanciu, Silvia Nica, Iulia-Ioana Stanescu-Spinu, Daniela Gabriela Balan, Andra-Elena Balcangiu-Stroescu, Elena-Claudia Coculescu, Dragos-Eugen Georgescu, Remus Iulian Nica. Targeting PI3K/AKT/mTOR and MAPK Signaling Pathways in Gastric Cancer. International Journal of Molecular Sciences 2024; 25(3): 1848 doi: 10.3390/ijms25031848
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Jong Hyun Lee, Chulwon Kim, Seok-Geun Lee, Woong Mo Yang, Jae-Young Um, Gautam Sethi, Kwang Seok Ahn. Ophiopogonin D modulates multiple oncogenic signaling pathways, leading to suppression of proliferation and chemosensitization of human lung cancer cells. Phytomedicine 2018; 40: 165 doi: 10.1016/j.phymed.2018.01.002
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Syedeh Elham Norollahi, Fariborz Mansour-Ghanaei, Farahnaz Joukar, Shervin Ghadarjani, Kourosh Mojtahedi, Kaveh Gharaei Nejad, Hossein Hemmati, Faeze Gharibpoor, Roya Khaksar, Ali Akbar Samadani. Therapeutic approach of Cancer stem cells (CSCs) in gastric adenocarcinoma; DNA methyltransferases enzymes in cancer targeted therapy. Biomedicine & Pharmacotherapy 2019; 115: 108958 doi: 10.1016/j.biopha.2019.108958
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Hiroo Imai, Ken Saijo, Sonoko Chikamatsu, Yoshifumi Kawamura, Chikashi Ishioka. LPIN1 downregulation enhances anticancer activity of the novel HDAC/PI3K dual inhibitor FK‐A11. Cancer Science 2021; 112(2): 792 doi: 10.1111/cas.14759
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11 |
Ying Luo, Dan Zhang, Leping Hou, Nengming Lin. Vernodalin Suppresses Tumor Proliferation and Increases Apoptosis of
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MAPKs Signaling Pathways. Current Pharmaceutical Biotechnology 2023; 24(5): 708 doi: 10.2174/1389201023666220728150544
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12 |
Dongmei Fan, Baoqi Ren, Xiaojun Yang, Jia Liu, Zhengzheng Zhang. Upregulation of miR-501-5p activates the wnt/β-catenin signaling pathway and enhances stem cell-like phenotype in gastric cancer. Journal of Experimental & Clinical Cancer Research 2016; 35(1) doi: 10.1186/s13046-016-0432-x
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13 |
Nand Kishor Roy, Javadi Monisha, Ganesan Padmavathi, H. Lalhruaitluanga, Nachimuthu Senthil Kumar, Anuj Kumar Singh, Devivasha Bordoloi, Munindra Narayan Baruah, Gazi Naseem Ahmed, Imliwati Longkumar, Frank Arfuso, Alan Prem Kumar, Ajaikumar B. Kunnumakkara. Isoform-Specific Role of Akt in Oral Squamous Cell Carcinoma. Biomolecules 2019; 9(7): 253 doi: 10.3390/biom9070253
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14 |
Ali Dehshahri, Milad Ashrafizadeh, Elham Ghasemipour Afshar, Abbas Pardakhty, Ali Mandegary, Reza Mohammadinejad, Gautam Sethi. Topoisomerase inhibitors: Pharmacology and emerging nanoscale delivery systems. Pharmacological Research 2020; 151: 104551 doi: 10.1016/j.phrs.2019.104551
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15 |
Zhiguo Zhang, Yutong Sui, Liyi Luan, Bo Li, Chuan Qin. Retracted: A Novel CircRNA Circ_0095424 Regulates Proliferation, Metastasis, and Apoptosis of Osteosarcoma Cells Via the PI3K/AKT Signaling Pathway Through Targeting the miR-1238/HMGB1 Axis. Cancer Biotherapy and Radiopharmaceuticals 2020; 35(10): e802 doi: 10.1089/cbr.2020.3563
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Denisa Leonte, Daniel Ungureanu, Valentin Zaharia. Flavones and Related Compounds: Synthesis and Biological Activity. Molecules 2023; 28(18): 6528 doi: 10.3390/molecules28186528
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Hui Cai, Changqing Jing, Xusheng Chang, Dan Ding, Ting Han, Junchi Yang, Zhengmao Lu, Xuguang Hu, Zhaorui Liu, Jinshen Wang, Liang Shang, Shouxin Wu, Peng Meng, Ling Lin, Jiangman Zhao, Mingming Nie, Kai Yin. Mutational landscape of gastric cancer and clinical application of genomic profiling based on target next-generation sequencing. Journal of Translational Medicine 2019; 17(1) doi: 10.1186/s12967-019-1941-0
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Qiang Wu, Xuewei Yi. Down-regulation of Long Noncoding RNA MALAT1 Protects Hippocampal Neurons Against Excessive Autophagy and Apoptosis via the PI3K/Akt Signaling Pathway in Rats with Epilepsy. Journal of Molecular Neuroscience 2018; 65(2): 234 doi: 10.1007/s12031-018-1093-3
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Qian Chen, Lang Hu, Kaihua Chen. Construction of a Nomogram Based on a Hypoxia-Related lncRNA Signature to Improve the Prediction of Gastric Cancer Prognosis. Frontiers in Genetics 2020; 11 doi: 10.3389/fgene.2020.570325
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Xiaofen Zhou, Erjie Xia, Adheesh Bhandari, Chen Zheng, Jingjing Xiang, Yaoyao Guan, Xiaohua Zhang. LRP4 promotes proliferation, migration, and invasion in papillary thyroid cancer. Biochemical and Biophysical Research Communications 2018; 503(1): 257 doi: 10.1016/j.bbrc.2018.06.012
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Bo Sun, Haiyuan Sun, Qunying Wang, Xinhong Wang, Jingzi Quan, Dongfang Dong, Yue Lun. Circular RNA circMAN2B2 promotes growth and migration of gastric cancer cells by down‐regulation of miR‐145. Journal of Clinical Laboratory Analysis 2020; 34(6) doi: 10.1002/jcla.23215
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Moussa Ide Nasser, Muqaddas Masood, Wei Wei, Xiaochun Li, Yifa Zhou, Bao Liu, Jiang Li, Xiaomeng Li. Cordycepin induces apoptosis in SGC-7901 cells through mitochondrial extrinsic phosphorylation of PI3K/Akt by generating ROS. International Journal of Oncology 2017; 50(3): 911 doi: 10.3892/ijo.2017.3862
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Jiaxin Xu, Yunhe Chen, Rui Yang, Tong Zhou, Wei Ke, Yuan Si, Shusheng Yang, Te Zhang, Xuewen Liu, Liang Zhang, Ke Xiang, Yang Guo, Ying Liu. Cucurbitacin B inhibits gastric cancer progression by suppressing STAT3 activity. Archives of Biochemistry and Biophysics 2020; 684: 108314 doi: 10.1016/j.abb.2020.108314
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Milad Ashrafizadeh, Hui Li Ang, Ebrahim Rahmani Moghadam, Shima Mohammadi, Vahideh Zarrin, Kiavash Hushmandi, Saeed Samarghandian, Ali Zarrabi, Masoud Najafi, Reza Mohammadinejad, Alan Prem Kumar. MicroRNAs and Their Influence on the ZEB Family: Mechanistic Aspects and Therapeutic Applications in Cancer Therapy. Biomolecules 2020; 10(7): 1040 doi: 10.3390/biom10071040
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Devivasha Bordoloi, Kishore Banik, Ganesan Padmavathi, Rajesh Vikkurthi, Choudhary Harsha, Nand Kishor Roy, Anuj Kumar Singh, Javadi Monisha, Hong Wang, Alan Prem Kumar, Ajaikumar B Kunnumakkara. TIPE2 Induced the Proliferation, Survival, and Migration of Lung Cancer Cells Through Modulation of Akt/mTOR/NF-κB Signaling Cascade. Biomolecules 2019; 9(12): 836 doi: 10.3390/biom9120836
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Xiong Shu, Pan-Pan Zhan, Li-Xin Sun, Long Yu, Jun Liu, Li-Chao Sun, Zhi-Hua Yang, Yu-Liang Ran, Yue-Min Sun. BCAT1 Activates PI3K/AKT/mTOR Pathway and Contributes to the Angiogenesis and Tumorigenicity of Gastric Cancer. Frontiers in Cell and Developmental Biology 2021; 9 doi: 10.3389/fcell.2021.659260
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Juan Chen, Jingdong Kang, Shouli Yuan, Peter O’Connell, Zizhu Zhang, Lina Wang, Junying Liu, Rongfeng Chen. Exploring the Mechanisms of Traditional Chinese Herbal Therapy in Gastric Cancer: A Comprehensive Network Pharmacology Study of the Tiao-Yuan-Tong-Wei decoction. Pharmaceuticals 2024; 17(4): 414 doi: 10.3390/ph17040414
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Min Hee Yang, Seung Ho Baek, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Kwang Seok Ahn. Identification of protocatechuic acid as a novel blocker of epithelial‐to‐mesenchymal transition in lung tumor cells. Phytotherapy Research 2021; 35(4): 1953 doi: 10.1002/ptr.6938
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Alessandro Agnarelli, Viviana Vella, Mark Samuels, Panagiotis Papanastasopoulos, Georgios Giamas. Incorporating Immunotherapy in the Management of Gastric Cancer: Molecular and Clinical Implications. Cancers 2022; 14(18): 4378 doi: 10.3390/cancers14184378
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Elena Paccosi, Alessio Balzerano, Luca Proietti-De-Santis. Interfering with the Ubiquitin-Mediated Regulation of Akt as a Strategy for Cancer Treatment. International Journal of Molecular Sciences 2023; 24(3): 2809 doi: 10.3390/ijms24032809
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Yong Xia, Zhihao Liu, Yong Huang, Xiaojun Huang, Mengya Liao, Yiwen Zhang, Xuelei Ma. A validated chiral LC method for the enantiomeric separation of AT13148 on polysaccharide-based chiral stationary phase. Journal of the Iranian Chemical Society 2018; 15(3): 711 doi: 10.1007/s13738-017-1270-2
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Identification of a novel 1,2 oxazine that can induce apoptosis by targeting NF-κB in hepatocellular carcinoma cells. Biotechnology Reports 2020; 25: e00438 doi: 10.1016/j.btre.2020.e00438
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47 |
Yaashini Rajasegaran, Adam Azlan, Aliaa Arina Rosli, Mot Yee Yik, Khor Kang Zi, Narazah Mohd Yusoff, Emmanuel Jairaj Moses. Footprints of microRNAs in Cancer Biology. Biomedicines 2021; 9(10): 1494 doi: 10.3390/biomedicines9101494
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48 |
Jeong-Hyeon Ko, Gautam Sethi, Jae-Young Um, Muthu K Shanmugam, Frank Arfuso, Alan Prem Kumar, Anupam Bishayee, Kwang Seok Ahn. The Role of Resveratrol in Cancer Therapy. International Journal of Molecular Sciences 2017; 18(12): 2589 doi: 10.3390/ijms18122589
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49 |
Honglei Wang, Yongjie Zhao, Lei Cao, Judong Zhang, Yu Wang, Min Xu. Metastasis suppressor protein 1 regulated by PTEN suppresses invasion, migration, and EMT of gastric carcinoma by inactivating PI3K/AKT signaling. Journal of Cellular Biochemistry 2019; 120(3): 3447 doi: 10.1002/jcb.27618
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50 |
Mitsuro Kanda, Dai Shimizu, Koichi Sawaki, Shunsuke Nakamura, Shinichi Umeda, Takashi Miwa, Haruyoshi Tanaka, Chie Tanaka, Masamichi Hayashi, Yohei Iguchi, Suguru Yamada, Masahisa Katsuno, Yasuhiro Kodera. Therapeutic monoclonal antibody targeting of neuronal pentraxin receptor to control metastasis in gastric cancer. Molecular Cancer 2020; 19(1) doi: 10.1186/s12943-020-01251-0
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51 |
Shuwen Jiang, Xiangkun Li, Weifang Xue, Sumei Xia, Jian Wang, Yang Sai, Guangxiu Dai, Weiguo Su. Preclinical pharmacokinetic characterization of amdizalisib, a novel PI3Kδ inhibitor for the treatment of hematological malignancies. Frontiers in Pharmacology 2024; 15 doi: 10.3389/fphar.2024.1392209
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52 |
Masahiro Sasahara, Mitsuro Kanda, Chie Tanaka, Dai Shimizu, Shinichi Umeda, Hideki Takami, Yoshikuni Inokawa, Norifumi Hattori, Masamichi Hayashi, Goro Nakayama, Yasuhiro Kodera. Therapeutic antibody targeting natriuretic peptide receptor 1 inhibits gastric cancer growth viaBCL‐2‐mediated intrinsic apoptosis. International Journal of Cancer 2024; 154(7): 1272 doi: 10.1002/ijc.34831
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53 |
Atena Soleimani, Farzad Rahmani, Gordon A. Ferns, Mikhail Ryzhikov, Amir Avan, Seyed Mahdi Hassanian. Role of Regulatory Oncogenic or Tumor Suppressor miRNAs of PI3K/AKT Signaling Axis in the Pathogenesis of Colorectal Cancer. Current Pharmaceutical Design 2019; 24(39): 4605 doi: 10.2174/1381612825666190110151957
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54 |
Milad Ashrafizadeh, Ali Zarrabi, Kiavash Hushmandi, Mahshad Kalantari, Reza Mohammadinejad, Tahereh Javaheri, Gautam Sethi. Association of the Epithelial–Mesenchymal Transition (EMT) with Cisplatin Resistance. International Journal of Molecular Sciences 2020; 21(11): 4002 doi: 10.3390/ijms21114002
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55 |
Asal Jalal Abadi, Ali Zarrabi, Mohammad Hossein Gholami, Sepideh Mirzaei, Farid Hashemi, Amirhossein Zabolian, Maliheh Entezari, Kiavash Hushmandi, Milad Ashrafizadeh, Haroon Khan, Alan Prem Kumar. Small in Size, but Large in Action: microRNAs as Potential Modulators of PTEN in Breast and Lung Cancers. Biomolecules 2021; 11(2): 304 doi: 10.3390/biom11020304
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56 |
So-Hee Han, Jae-Han Lee, Joong-Seok Woo, Gi-Hwan Jung, Soo-Hyun Jung, Eun-Ji Han, Bumseok Kim, Sung Dae Cho, Jeong Seok Nam, Jeong Hwan Che, Ji-Youn Jung. Myricetin induces apoptosis and autophagy in human gastric cancer cells through inhibition of the PI3K/Akt/mTOR pathway. Heliyon 2022; 8(5): e09309 doi: 10.1016/j.heliyon.2022.e09309
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57 |
Chie Ito, Satoshi S. Nishizuka, Kazuyuki Ishida, Noriyuki Uesugi, Tamotsu Sugai, Gen Tamura, Keisuke Koeda, Akira Sasaki. Analysis of PIK3CA mutations and PI3K pathway proteins in advanced gastric cancer. Journal of Surgical Research 2017; 212: 195 doi: 10.1016/j.jss.2017.01.018
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58 |
Mihaela Chivu-Economescu, Lilia Matei, Laura G Necula, Denisa L Dragu, Coralia Bleotu, Carmen C Diaconu. New therapeutic options opened by the molecular classification of gastric cancer. World Journal of Gastroenterology 2018; 24(18): 1942-1961 doi: 10.3748/wjg.v24.i18.1942
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59 |
Bethsebie Lalduhsaki Sailo, Kishore Banik, Sosmitha Girisa, Devivasha Bordoloi, Lu Fan, Clarissa Esmeralda Halim, Hong Wang, Alan Prem Kumar, Dali Zheng, Xinliang Mao, Gautam Sethi, Ajaikumar Bahulayan Kunnumakkara. FBXW7 in Cancer: What Has Been Unraveled Thus Far?. Cancers 2019; 11(2): 246 doi: 10.3390/cancers11020246
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60 |
Yuqin Li, Xiaolan Lu, Peiying Tian, Kai Wang, Jianping Shi. Procyanidin B2 induces apoptosis and autophagy in gastric cancer cells by inhibiting Akt/mTOR signaling pathway. BMC Complementary Medicine and Therapies 2021; 21(1) doi: 10.1186/s12906-021-03225-1
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Man You, Junmin Fu, Xingzhi Lv, Lan Wang, Hongwei Wang, Ruifang Li. Saikosaponin b2 inhibits tumor angiogenesis in liver cancer via down‑regulation of VEGF/ERK/HIF‑1α signaling. Oncology Reports 2023; 50(1) doi: 10.3892/or.2023.8573
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Muhammad Abbas, Alessia Faggian, Dahiru Nasiru Sintali, Ghulam Jilany Khan, Shagufta Naeem, Meiqi Shi, Chen Dingding. Current and future biomarkers in gastric cancer. Biomedicine & Pharmacotherapy 2018; 103: 1688 doi: 10.1016/j.biopha.2018.04.178
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Xinjie Yao, Dongyan Liu, Linyan Zhou, Ying Xie, Yan Li. FAM60A, increased by Helicobacter pylori, promotes proliferation and suppresses apoptosis of gastric cancer cells by targeting the PI3K/AKT pathway. Biochemical and Biophysical Research Communications 2020; 521(4): 1003 doi: 10.1016/j.bbrc.2019.11.029
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Xiaohui Su, Jianjun Zhang, Wei Yang, Yanqing Liu, Yang Liu, Zexing Shan, Wentao Wang. Identification of the Prognosis-Related lncRNAs and Genes in Gastric Cancer. Frontiers in Genetics 2020; 11 doi: 10.3389/fgene.2020.00027
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Brusatol, a Nrf2 Inhibitor Targets STAT3 Signaling Cascade in Head and Neck Squamous Cell Carcinoma. Biomolecules 2019; 9(10): 550 doi: 10.3390/biom9100550
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66 |
Jiahui Xu, Deying Liu, Huilin Niu, Guifang Zhu, Yangwei Xu, Danli Ye, Jian Li, Qingling Zhang. Resveratrol reverses Doxorubicin resistance by inhibiting epithelial-mesenchymal transition (EMT) through modulating PTEN/Akt signaling pathway in gastric cancer. Journal of Experimental & Clinical Cancer Research 2017; 36(1) doi: 10.1186/s13046-016-0487-8
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67 |
Milad Ashrafizadeh, Masoud Najafi, Hui Li Ang, Ebrahim Rahmani Moghadam, Mahmood Khaksary Mahabady, Amirhossein Zabolian, Leila Jafaripour, Atefe Kazemzade Bejandi, Kiavash Hushmandi, Hossein Saleki, Ali Zarrabi, Alan Prem Kumar. PTEN, a Barrier for Proliferation and Metastasis of Gastric Cancer Cells: From Molecular Pathways to Targeting and Regulation. Biomedicines 2020; 8(8): 264 doi: 10.3390/biomedicines8080264
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Yufei Han, Ye Tian, Ruxin Wang, Siyu Fu, Jia Jiang, Jiawen Dong, Mingze Qin, Yunlei Hou, Yanfang Zhao. Design, synthesis and biological evaluation of thieno[3,2-d]pyrimidine derivatives containing aroyl hydrazone or aryl hydrazide moieties for PI3K and mTOR dual inhibition. Bioorganic Chemistry 2020; 104: 104197 doi: 10.1016/j.bioorg.2020.104197
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Mengjiao Han, Dongjun Dai, Neelum Aziz Yousafzai, Faliang Wang, Hanying Wang, Qiying Zhou, Haiqi Lu, Wenxia Xu, Lifeng Feng, Hongchuan Jin, Xian Wang. CXXC4 activates apoptosis through up-regulating GDF15 in gastric cancer. Oncotarget 2017; 8(61): 103557 doi: 10.18632/oncotarget.21581
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Ou Li, Cheng Zhao, Jian Zhang, Feng-Nan Li, Zi-Yi Yang, Shi-Lei Liu, Chen Cai, Zi-Yao Jia, Wei Gong, Yi-Jun Shu, Ping Dong. UBAP2L promotes gastric cancer metastasis by activating NF-κB through PI3K/AKT pathway. Cell Death Discovery 2022; 8(1) doi: 10.1038/s41420-022-00916-7
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Jeong‐Hyeon Ko, Jae‐Young Um, Seok‐Geun Lee, Woong Mo Yang, Gautam Sethi, Kwang Seok Ahn. Conditioned media from adipocytes promote proliferation, migration, and invasion in melanoma and colorectal cancer cells. Journal of Cellular Physiology 2019; 234(10): 18249 doi: 10.1002/jcp.28456
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72 |
Irum Naz, Shanaya Ramchandani, Muhammad Rashid Khan, Min Hee Yang, Kwang Seok Ahn. Anticancer Potential of Raddeanin A, a Natural Triterpenoid Isolated from Anemone raddeana Regel. Molecules 2020; 25(5): 1035 doi: 10.3390/molecules25051035
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73 |
Jeong-Hyeon Ko, Seok-Geun Lee, Woong Yang, Jae-Young Um, Gautam Sethi, Srishti Mishra, Muthu Shanmugam, Kwang Ahn. The Application of Embelin for Cancer Prevention and Therapy. Molecules 2018; 23(3): 621 doi: 10.3390/molecules23030621
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74 |
Fengliang Wang, Jun Li, Rong Li, Guohua Pan, Mingxia Bai, Qiang Huang. Angelicin inhibits liver cancer growth in vitro and in vivo. Molecular Medicine Reports 2017; 16(4): 5441 doi: 10.3892/mmr.2017.7219
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Sepideh Mirzaei, Mahshid Deldar Abad Paskeh, Yalda Saghari, Ali Zarrabi, Michael R. Hamblin, Maliheh Entezari, Mehrdad Hashemi, Amir Reza Aref, Kiavash Hushmandi, Alan Prem Kumar, Navid Rabiee, Milad Ashrafizadeh, Saeed Samarghandian. Transforming growth factor-beta (TGF-β) in prostate cancer: A dual function mediator?. International Journal of Biological Macromolecules 2022; 206: 435 doi: 10.1016/j.ijbiomac.2022.02.094
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