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For: Molina-Infante J, Gisbert JP. Optimizing clarithromycin-containing therapy for Helicobacter pylori in the era of antibiotic resistance. World J Gastroenterol 2014; 20(30): 10338-10347 [PMID: 25132750 DOI: 10.3748/wjg.v20.i30.10338]
URL: https://www.wjgnet.com/1007-9327/full/v20/i30/10338.htm
Number Citing Articles
1
Liya Zhou, Jianzhong Zhang, Zhiqiang Song, Lihua He, Yanqing Li, Jiaming Qian, Peng Bai, Yan Xue, Ye Wang, Sanren Lin. Tailored versus Triple plus Bismuth or Concomitant Therapy as Initial Helicobacter pylori Treatment: A Randomized TrialHelicobacter 2016; 21(2): 91 doi: 10.1111/hel.12242
2
Adrian G. McNicholl, Javier Molina‐Infante, Alfredo J. Lucendo, José Luis Calleja, Ángeles Pérez‐Aisa, Inés Modolell, Xavier Aldeguer, Margalida Calafat, Luis Comino, Mercedes Ramas, Ángel Callejo, Carlos Badiola, Jordi Serra, Javier P. Gisbert. Probiotic supplementation with Lactobacillus plantarum and Pediococcus acidilactici for Helicobacter pylori therapy: A randomized, double‐blind, placebo‐controlled trialHelicobacter 2018; 23(5) doi: 10.1111/hel.12529
3
P Malfertheiner, F Megraud, C A O'Morain, J P Gisbert, E J Kuipers, A T Axon, F Bazzoli, A Gasbarrini, J Atherton, D Y Graham, R Hunt, P Moayyedi, T Rokkas, M Rugge, M Selgrad, S Suerbaum, K Sugano, E M El-Omar. Management ofHelicobacter pyloriinfection—the Maastricht V/Florence Consensus ReportGut 2017; 66(1): 6 doi: 10.1136/gutjnl-2016-312288
4
Ricardo S. Vieira-Pires, Patricia M. Morgan, Ankit Choraria, Chinnappan Gandhimathi, Antonysamy Michael, Tiago Ôchoa-Pires, Jafar Salimian, Sentila Rajan, Meenatchisundaram Subramani. IgY-Technology: Production and Application of Egg Yolk Antibodies2021; : 237 doi: 10.1007/978-3-030-72688-1_16
5
Saman Alhooei, Hafez Tirgar Fakheri, Vahid Hosseini, Iradj Maleki, Tarang Taghvaei, Seyed Mohammad Valizadeh, Zohreh Bari. A Comparison between Hybrid and Concomitant Regimens for Helicobacter Pylori Eradication: A Randomized Clinical TrialMiddle East Journal of Digestive Diseases 2016; 8(3): 219 doi: 10.15171/mejdd.2016.24
6
Joon Sung Kim, Sung Min Park, Byung‐Wook Kim. Sequential or concomitant therapy for eradication of Helicobacter pylori infection: A systematic review and meta‐analysisJournal of Gastroenterology and Hepatology 2015; 30(9): 1338 doi: 10.1111/jgh.12984
7
Zhiqiang Song, Liya Zhou, Jianzhong Zhang, Lihua He, Peng Bai, Yan Xue. Hybrid Therapy as First‐Line Regimen for Helicobacter pylori Eradication in Populations with High Antibiotic Resistance RatesHelicobacter 2016; 21(5): 382 doi: 10.1111/hel.12294
8
Su Young Kim, Duck Joo Choi, Jun-Won Chung. Antibiotic treatment for <italic>Helicobacter pylori</italic>: Is the end coming?World Journal of Gastrointestinal Pharmacology and Therapeutics 2015; 6(4): 183-198 doi: 10.4292/wjgpt.v6.i4.183
9
Diego Reyes, Javier Ortiz, Eduardo Fuentes-López, Sigall Budnik, Vicente Gándara, Andrea Gallardo, María Francisca Seydewitz, Roberto Candia, José Ignacio Vargas, María Paz Rollan, Javiera Godoy, Antonio Rollan, Rodrigo Mansilla, Alex Arenas, Javier Chahuán, Alberto Espino, Margarita Pizarro, Arnoldo Riquelme. Terapias cuádruples son superiores a terapia triple estándar en primera línea de erradicación de Helicobacter pylori en ChileGastroenterología y Hepatología 2022; 45(7): 515 doi: 10.1016/j.gastrohep.2021.11.010
10
Yong Hwan Kwon. Helicobacter pylori2016; : 459 doi: 10.1007/978-981-287-706-2_45
11
Jung Wan Choe, Sung Woo Jung, Seung Young Kim, Jong Jin Hyun, Young Kul Jung, Ja Seol Koo, Hyung Joon Yim, Sang Woo Lee. Comparative study of Helicobacter pylori eradication rates of concomitant therapy vs modified quadruple therapy comprising proton‐pump inhibitor, bismuth, amoxicillin, and metronidazole in KoreaHelicobacter 2018; 23(2) doi: 10.1111/hel.12466
12
Stella I. Smith, Christian Schulz, Rose Ugiagbe, Roland Ndip, Yakhya Dieye, Marcis Leja, Charles Onyekwere, Dennis Ndububa, Abraham Ajayi, Tolulope Funbi Jolaiya, Hyasinta Jaka, Mashiko Setshedi, Revathi Gunturu, Jesse Abiodun Otegbayo, Naima Lahbabi-Amrani, Anthony Oluwole Arigbabu, Violet Kayamba, Pueya Abdulrashid Nashidengo. <i>Helicobacter pylori</i> Diagnosis and Treatment in Africa: The First Lagos Consensus Statement of the African Helicobacter and Microbiota Study GroupDigestive Diseases 2024; 42(3): 240 doi: 10.1159/000537878
13
David Itskoviz, Doron Boltin, Haim Leibovitzh, Tsachi Tsadok Perets, Doron Comaneshter, Arnon Cohen, Yaron Niv, Zohar Levi. Smoking increases the likelihood of Helicobacter pylori treatment failureDigestive and Liver Disease 2017; 49(7): 764 doi: 10.1016/j.dld.2017.03.010
14
Teresa Fasciana, Cinzia Calà, Celestino Bonura, Enza Di Carlo, Domenica Matranga, Giuseppe Scarpulla, Michele Manganaro, Salvatore Camilleri, Anna Giammanco. Resistance to clarithromycin and genotypes in Helicobacter pylori strains isolated in Sicily Journal of Medical Microbiology 2015; 64(11): 1408 doi: 10.1099/jmm.0.000163
15
María R. Baroni, Pamela Bucci, Rita N. Giani, Antonela Giusti, Fabian A. Tedeschi, Emiliano Salvatierra, Yanina Barbaglia, Félix Jimenez, Fabian E. Zalazar. Usefulness of rapid urease test samples for molecular analysis of clarithromycin resistance in Helicobacter pyloriRevista Argentina de Microbiología 2018; 50(4): 359 doi: 10.1016/j.ram.2017.11.005
16
M. A. Derbak, Ye. E. Dankanych, O. T. Ganich. POSSIBILITY OF HELICOBACTER PYLORI ERADICATION THERAPY IN PATIENTS WITH CHRONIC HEPATITIS C Bulletin of Problems Biology and Medicine 2020; 4(1): 113 doi: 10.29254/2077-4214-2020-4-158-113-117
17
Hidekazu Suzuki, Hideki Mori. World trends for H. pylori eradication therapy and gastric cancer prevention strategy by H. pylori test-and-treatJournal of Gastroenterology 2018; 53(3): 354 doi: 10.1007/s00535-017-1407-1
18
J. Molina‐Infante, D. Y. Graham, J. P. Gisbert. Editorial: quadruple therapy for H. pylori eradication is better than triple therapy – authors' replyAlimentary Pharmacology & Therapeutics 2015; 41(7): 695 doi: 10.1111/apt.13113
19
Zhi-Qiang Song, Jian Liu, Li-Ya Zhou. Hybrid Therapy Regimen for Helicobacter Pylori EradicationChinese Medical Journal 2016; 129(8): 992 doi: 10.4103/0366-6999.179803
20
Bahare Salehi, Farukh Sharopov, Miquel Martorell, Jovana Rajkovic, Adedayo Oluwaseun Ademiluyi, Mehdi Sharifi-Rad, Patrick Valere Tsouh Fokou, Natália Martins, Marcello Iriti, Javad Sharifi-Rad. Phytochemicals in Helicobacter pylori Infections: What Are We Doing Now?International Journal of Molecular Sciences 2018; 19(8): 2361 doi: 10.3390/ijms19082361
21
Xiaolin Zhang, Anmin Jiang, Guisheng Wang, Hao Yu, Banghua Qi, Youyi Xiong, Guoliang Zhou, Meisong Qin, Jinfeng Dou, Jianfei Wang. Fusion expression of the PGLa-AM1 with native structure and evaluation of its anti-Helicobacter pylori activityApplied Microbiology and Biotechnology 2017; 101(14): 5667 doi: 10.1007/s00253-017-8302-9
22
Xiaolin Zhang, Anmin Jiang, Banghua Qi, Hao Yu, Youyi Xiong, Guoliang Zhou, Meisong Qin, Jinfeng Dou, Jianfei Wang. Secretion expression of human neutrophil peptide 1 (HNP1) in Pichia pastoris and its functional analysis against antibiotic-resistant Helicobacter pyloriApplied Microbiology and Biotechnology 2018; 102(11): 4817 doi: 10.1007/s00253-018-8982-9
23
Angel Cosme, Jacobo Lizasoan, Milagrosa Montes, Esther Tamayo, Horacio Alonso, Usua Mendarte, Maider Martos, María Fernández‐Reyes, Cristina Saraqueta, Luis Bujanda. Antimicrobial Susceptibility‐Guided Therapy Versus Empirical Concomitant Therapy for Eradication of Helicobacter pylori in a Region with High Rate of Clarithromycin ResistanceHelicobacter 2016; 21(1): 29 doi: 10.1111/hel.12231
24
György Miklós Buzás. Helicobacter pylori– 2014Orvosi Hetilap 2015; 156(6): 203 doi: 10.1556/OH.2015.30097
25
Ana Campillo, Edurne Amorena, Miriam Ostiz, Marcos Kutz, Matilde LaIglesia. Triple terapia 10 días con esomeprazol 40 mg/12 h vs. cuádruple concomitante sin bismuto como tratamiento de primera línea de la infección por Helicobacter pyloriGastroenterología y Hepatología 2016; 39(9): 584 doi: 10.1016/j.gastrohep.2016.03.002
26
Yong Hwan Kwon, Nayoung Kim, Ju Yup Lee, Yoon Jin Choi, Kichul Yoon, Ryung Hee Nam, Ji Hyung Suh, Jung Won Lee, Dong Ho Lee. Comparison of the efficacy of culture-based tailored therapy forHelicobacter pylorieradication with that of the traditional second-line rescue therapy in Korean patients: a prospective single tertiary center studyScandinavian Journal of Gastroenterology 2016; 51(3): 270 doi: 10.3109/00365521.2015.1095352
27
Javier Molina-Infante, David Y. Graham. Helicobacter pylori Research2016; : 471 doi: 10.1007/978-4-431-55936-8_20
28
Javier P. Gisbert, Javier Molina-Infante, Javier Amador, Fernando Bermejo, Luis Bujanda, Xavier Calvet, Manuel Castro-Fernández, Antonio Cuadrado-Lavín, J. Ignasi Elizalde, Emili Gene, Fernando Gomollón, Ángel Lanas, Carlos Martín de Argila, Fermín Mearin, Miguel Montoro, Ángeles Pérez-Aisa, Emilio Pérez-Trallero, Adrián G. McNicholl. IV Conferencia Española de Consenso sobre el tratamiento de la infección por Helicobacter pyloriGastroenterología y Hepatología 2016; 39(10): 697 doi: 10.1016/j.gastrohep.2016.05.003
29
Diego Reyes, Javier Ortiz, Eduardo Fuentes-López, Sigall Budnik, Vicente Gándara, Andrea Gallardo, María Francisca Seydewitz, Roberto Candia, José Ignacio Vargas, María Paz Rollan, Javiera Godoy, Antonio Rollan, Rodrigo Mansilla, Alex Arenas, Javier Chahuán, Alberto Espino, Margarita Pizarro, Arnoldo Riquelme. Quadruple therapies are superior to standard triple therapy for Helicobacter pylori first-line eradication in ChileGastroenterología y Hepatología (English Edition) 2022; 45(7): 515 doi: 10.1016/j.gastre.2022.07.004
30
Bojan Tepes, Marko Kastelic, Miroslav Vujasinovic, Polona Lampic, Maja Seruga, Natasa Brglez Jurecic, Olga P. Nyssen, Maria G. Donday, Colm O’Morain, Francis Megraud, Adrian G McNicholl, Javier P. Gisbert. Helicobacter pylori treatment results in Slovenia in the period 2013-2015 as a part of European Registry on Helicobacter pylori ManagementRadiology and Oncology 2017; 52(1): 1 doi: 10.1515/raon-2017-0055
31
Antonio Cuadrado-Lavín, J. Ramón Salcines-Caviedes, Ainhoa Diaz-Perez, Miguel F. Carrascosa, María Ochagavía, José Luis Fernandez-Forcelledo, Marta Cobo, Pedro Fernández-Gil, Blanca Ayestarán, Blanca Sánchez, Cristina Campo, Javier Llorca, Silvia Lorenzo, Aitziber Illaro. First-line eradication rates comparing two shortened non-bismuth quadruple regimens againstHelicobacter pylori: an open-label, randomized, multicentre clinical trialJournal of Antimicrobial Chemotherapy 2015; 70(8): 2376 doi: 10.1093/jac/dkv089
32
Javier P. Gisbert, Javier Alcedo, Javier Amador, Luis Bujanda, Xavier Calvet, Manuel Castro-Fernández, Luis Fernández-Salazar, Emili Gené, Ángel Lanas, Alfredo Lucendo, Javier Molina-Infante, Olga P. Nyssen, A. Pérez-Aisa, Ignasi Puig. V Spanish Consensus Conference on Helicobacter pylori infection treatmentGastroenterología y Hepatología (English Edition) 2022; 45(5): 392 doi: 10.1016/j.gastre.2021.07.001
33
Jing Yu, Peng Yang, Xiangrong Qin, Chunjian Li, Yiming Lv, Xiaoyong Wang. Impact of smoking on the eradication of Helicobacter pyloriHelicobacter 2022; 27(1) doi: 10.1111/hel.12860
34
Todor Asenov Angelov, Mila Dimitrova Kovacheva-Slavova, Hristo Ilianov Iliev, Hristo Yankov Valkov, Borislav Georgiev Vladimirov. Gastritis - New Approaches and Treatments2019;  doi: 10.5772/intechopen.86963
35
Mercedes Ramas, Maria G. Donday, Adrian G. McNicholl, Javier P. Gisbert. Efficacy and safety of rifaximin associated with standard triple therapy (omeprazole, clarithromycin and amoxicillin) for H. pylori eradication: A phase IV pilot clinical trialGastroenterología y Hepatología (English Edition) 2017; 40(10): 658 doi: 10.1016/j.gastre.2017.05.010
36
Yun Duk Jung, Yeon-Ji Kim, Woo Chul Chung. A Pilot Study ofHelicobacter pyloriEradication Using a Polymerase Chain Reaction-based Test for Clarithromycin ResistanceThe Korean Journal of Helicobacter and Upper Gastrointestinal Research 2017; 17(4): 200 doi: 10.7704/kjhugr.2017.17.4.200
37
Zifang Shang, Siew Yin Chan, Qing Song, Peng Li, Wei Huang. The Strategies of Pathogen-Oriented Therapy on Circumventing Antimicrobial ResistanceResearch 2020; 2020 doi: 10.34133/2020/2016201
38
Fazia Djennane-Hadibi, Mohamed Bachtarzi, Karim Layaida, Nassima Ali Arous, Mhamed Nakmouche, Berkane Saadi, Mohamed Tazir, Nadjia Ramdani-Bouguessa, Christophe Burucoa. High-Level Primary Clarithromycin Resistance ofHelicobacter pyloriin Algiers, Algeria: A Prospective Multicenter Molecular StudyMicrobial Drug Resistance 2016; 22(3): 223 doi: 10.1089/mdr.2015.0209
39
Ran Han, Hong Lu, Ming-Wan Jiang, Ke-Wen Tan, Zhong Peng, Jia-Li Hu, Dian-Chun Fang, Chun-Hui Lan, Xiao-Ling Wu. Multicenter Study of Antibiotic Resistance Profile ofH. pyloriand Distribution of CYP2C19 Gene Polymorphism in Rural Population of Chongqing, ChinaGastroenterology Research and Practice 2016; 2016: 1 doi: 10.1155/2016/8547686
40
Adrian G. McNicholl, Dmitry S. Bordin, Alfredo Lucendo, Galina Fadeenko, Manuel Castro Fernandez, Irina Voynovan, Natalia Valerievna Zakharova, Aiman Silkanovna Sarsenbaeva, Luis Bujanda, Ángeles Perez-Aisa, Liudmila Vologzhanina, Oleg Zaytsev, Tatiana Ilchishina, Cristobal de la Coba, Jorge Perez Lasala, Sergey Alekseenko, Ines Modolell, Javier Molina-Infante, Rafael Ruiz-Zorrilla Lopez, Horacio Alonso-Galan, Nuria Fernandez Moreno, Jen Hinojosa, Inmaculada Santaella, Pilar Varela, Pedro Luis Gonzalez-Cordero, Jesus Barrio, Jose Luis Dominguez-Jimenez, Oscar Nuñez, Javier Alcedo, Olga P. Nyssen, Maria Caldas, Maria G. Donday, Oleg Shvetz, Francis Megraud, Colm O'Morain, Javier P. Gisbert. Combination of Bismuth and Standard Triple Therapy Eradicates Helicobacter pylori Infection in More than 90% of PatientsClinical Gastroenterology and Hepatology 2020; 18(1): 89 doi: 10.1016/j.cgh.2019.03.048
41
Najat Bouihat, Christophe Burucoa, Ahmed Benkirane, Hassan Seddik, Sara Sentissi, Abderrahmane Al Bouzidi, Mustapha Elouennas, Amina Benouda. Helicobacter pylori Primary Antibiotic Resistance in 2015 in Morocco: A Phenotypic and Genotypic Prospective and Multicenter StudyMicrobial Drug Resistance 2017; 23(6): 727 doi: 10.1089/mdr.2016.0264
42
Amir Hossein Miri, Mojtaba Kamankesh, Antoni Llopis-Lorente, Chenguang Liu, Matthias G. Wacker, Ismaeil Haririan, Hamid Asadzadeh Aghdaei, Michael R. Hamblin, Abbas Yadegar, Mazda Rad-Malekshahi, Mohammad Reza Zali. The Potential Use of Antibiotics Against Helicobacter pylori Infection: Biopharmaceutical ImplicationsFrontiers in Pharmacology 2022; 13 doi: 10.3389/fphar.2022.917184
43
Angel Cosme, Milagrosa Montes, Begoña Ibarra, Esther Tamayo, Horacio Alonso, Usua Mendarte, Jacobo Lizasoan, Marta Herreros-Villanueva, Luis Bujanda. Antimicrobial susceptibility testing before first-line treatment for <i>Helicobacter pylori</i> infection in patients with dual or triple antibiotic resistanceWorld Journal of Gastroenterology 2017; 23(18): 3367-3373 doi: 10.3748/wjg.v23.i18.3367
44
Gamal M. El-Sherbiny, Mahmoud K. M. Elbestawy. A review – plant essential oils active againstHelicobacter pyloriJournal of Essential Oil Research 2022; 34(3): 203 doi: 10.1080/10412905.2022.2025464
45
Javier P. Gisbert, Adrian G. McNicholl. Optimization strategies aimed to increase the efficacy of H. pylori eradication therapiesHelicobacter 2017; 22(4) doi: 10.1111/hel.12392
46
Javier P. Gisbert, Javier Alcedo, Javier Amador, Luis Bujanda, Xavier Calvet, Manuel Castro-Fernández, Luis Fernández-Salazar, Emili Gené, Ángel Lanas, Alfredo J. Lucendo, Javier Molina-Infante, Olga P. Nyssen, A. Pérez-Aisa, Ignasi Puig. V Conferencia Española de Consenso sobre el tratamiento de la infección por Helicobacter pyloriGastroenterología y Hepatología 2022; 45(5): 392 doi: 10.1016/j.gastrohep.2021.07.011
47
Jing Yu, Chen Cui, Kai Ma, Peng Yang, Yizhou Jiang, Xiaoyong Wang. Effectiveness and safety of vonoprazan and amoxicillin dual regimen with Saccharomyces boulardii supplements on eradication of Helicobacter pyloriBMC Gastroenterology 2024; 24(1) doi: 10.1186/s12876-024-03524-0
48
Zhi-Qiang Song, Li-Ya Zhou. Hybrid, sequential and concomitant therapies for <i>Helicobacter pylori</i> eradication: A systematic review and meta-analysisWorld Journal of Gastroenterology 2016; 22(19): 4766-4775 doi: 10.3748/wjg.v22.i19.4766
49
Nidhi Gupta, Shweta Maurya, Harshvardhan Verma, Vijay K. Verma. Unraveling the factors and mechanism involved in persistence: Host‐pathogen interactions in Helicobacter pyloriJournal of Cellular Biochemistry 2019; 120(11): 18572 doi: 10.1002/jcb.29201
50
Marjan Mokhtare, Mohammad Ebrahimian, Abolfazl Namazi, Amir M. Sadeghian, Hani Talaee, Mohsen Masoodi, Jiong Yu. The Efficacy of Paraprobiotic, Probiotic, and Mineral Supplementation on the Eradication Rate of Helicobacter pylori in Patients with Dyspepsia: A Randomized Clinical TrialAdvanced Gut & Microbiome Research 2024; 2024: 1 doi: 10.1155/2024/9936691
51
Skander Hathroubi, Stephanie L. Servetas, Ian Windham, D. Scott Merrell, Karen M. Ottemann. Helicobacter pylori Biofilm Formation and Its Potential Role in PathogenesisMicrobiology and Molecular Biology Reviews 2018; 82(2) doi: 10.1128/MMBR.00001-18
52
Javier P. Gisbert, Javier Molina-Infante, Javier Amador, Fernando Bermejo, Luis Bujanda, Xavier Calvet, Manuel Castro-Fernández, Antonio Cuadrado-Lavín, J. Ignasi Elizalde, Emili Gene, Fernando Gomollón, Ángel Lanas, Carlos Martín de Argila, Fermín Mearin, Miguel Montoro, Ángeles Pérez-Aisa, Emilio Pérez-Trallero, Adrián G. McNicholl. IV Spanish Consensus Conference on Helicobacter pylori infection treatmentGastroenterología y Hepatología (English Edition) 2016; 39(10): 697 doi: 10.1016/j.gastre.2016.11.007
53
Frank J Senatore, Jonathan Wilmot, John W Birk. Helicobacter pyloritreatment: Still a work in progressPostgraduate Medicine 2016; 128(1): 152 doi: 10.1080/00325481.2016.1103194
54
Ana Campillo, Edurne Amorena, Miriam Ostiz, Marcos Kutz, Matilde LaIglesia. 10-day triple therapy with esomeprazole 40mg/12h vs. quadruple concomitant non-bismuth therapy as first line treatment for Helicobacter pylori infectionGastroenterología y Hepatología (English Edition) 2016; 39(9): 584 doi: 10.1016/j.gastre.2016.10.007
55
Francisco Buitrago Ramírez, Cristina Gato Núñez, Manuel Tejero Mas, Nuria Rivera Jiménez, Francisco Luis Pérez Caballero. Criterios para la erradicación de Helicobacter pyloriFMC - Formación Médica Continuada en Atención Primaria 2018; 25(1): 43 doi: 10.1016/j.fmc.2017.03.009
56
Cláudia Sousa, Rute Ferreira, Nuno F. Azevedo, Mónica Oleastro, Joana Azeredo, Ceu Figueiredo, Luís D. R. Melo. Helicobacter pylori infection: from standard to alternative treatment strategiesCritical Reviews in Microbiology 2022; 48(3): 376 doi: 10.1080/1040841X.2021.1975643
57
Mercedes Ramas, Maria G. Donday, Adrian G. McNicholl, Javier P. Gisbert. Efficacy and safety of rifaximin associated with standard triple therapy (omeprazole, clarithromycin and amoxicillin) for H. pylori eradication: A phase IV pilot clinical trialGastroenterología y Hepatología 2017; 40(10): 658 doi: 10.1016/j.gastrohep.2017.05.017
58
Javier Molina-Infante. Helicobacter pylori2016; : 237 doi: 10.1007/978-4-431-55705-0_15
59
Javier Molina-Infante, Akiko Shiotani. Practical Aspects in Choosing a Helicobacter pylori TherapyGastroenterology Clinics of North America 2015; 44(3): 519 doi: 10.1016/j.gtc.2015.05.004