For: | Fidder HH, Singendonk MM, van der Have M, Oldenburg B, van Oijen MG. Low rates of adherence for tumor necrosis factor-α inhibitors in Crohn’s disease and rheumatoid arthritis: Results of a systematic review. World J Gastroenterol 2013; 19(27): 4344-4350 [PMID: 23885145 DOI: 10.3748/wjg.v19.i27.4344] |
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URL: | https://www.wjgnet.com/1007-9327/full/v19/i27/4344.htm |
Number | Citing Articles |
1 |
Dimitrios A. Pappas, Taylor Blachley, Steve Zlotnick, Jennie Best, Kelechi Emeanuru, Joel M. Kremer. Methotrexate Discontinuation and Dose Decreases After Therapy With Tocilizumab: Results From the Corrona Rheumatoid Arthritis Registry. Rheumatology and Therapy 2020; 7(2): 357 doi: 10.1007/s40744-020-00200-z
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2 |
Shuyan Li, Yan Ma, Hongling Sun, Zijun Ni, Shurong Hu, Yan Chen, Meijuan Lan. The impact of medication belief on adherence to infliximab in patients with Crohn’s disease. Frontiers in Pharmacology 2023; 14 doi: 10.3389/fphar.2023.1185026
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3 |
Christopher Ma, Vivian Huang, Darryl K. Fedorak, Karen I. Kroeker, Levinus A. Dieleman, Brendan P. Halloran, Richard N. Fedorak. Crohn's disease outpatients treated with adalimumab have an earlier secondary loss of response and requirement for dose escalation compared to infliximab: A real life cohort study. Journal of Crohn's and Colitis 2014; 8(11): 1454 doi: 10.1016/j.crohns.2014.05.007
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4 |
Ashwin N Ananthakrishnan, Gilaad G Kaplan, Charles N Bernstein, Kristin E Burke, Paul J Lochhead, Alexa N Sasson, Manasi Agrawal, Jimmy Ho Tuan Tiong, Joshua Steinberg, Wolfgang Kruis, Flavio Steinwurz, Vineet Ahuja, Siew C Ng, David T Rubin, Jean-Frederic Colombel, Richard Gearry, M Abreu, V Ahuja, M Allez, A Ananthakrishnan, W Bemelman, C Bernstein, J Braun, Y Chowers, J-F Colombel, S Danese, G D'Haens, A D'Hoore, A Dignass, I Dotan, M Dubinsky, A Ekbom, P Fleshner, C Gasche, MA Gassull, R Gearry, S Ghosh, P Gibson, A Griffiths, J Halfvarson, S Hanauer, N Harpaz, A Hart, T Hibi, M Kamm, G Kaplan, A Kaser, B Korelitz, P Kotze, I Koutroubakis, W Kruis, P Lakatos, J Lewis, J Lindsay, E Loftus, E Louis, M Lukas, F Magro, U Mahadevan, G Mantzaris, J-Y Mary, D McGovern, B Moum, P Munkholm, M Neurath, S Ng, C O'Morain, T Oresland, R Panaccione, J Panes, Y Panis, J Pemberton, L Peyrin-Biroulet, C Prantera, D Rachmilewitz, Z Ran, W Reinisch, F Remzi, J Rhodes, R Riddell, G Rogler, D Rubin, D Sachar, W Sandborn, B Sands, B Sartor, J Schoelmerich, S Schreiber, C Siegel, B Siegmund, M Silverberg, J Söderholm, A Sood, A Spinelli, E Stange, F Steinwurz, S Targan, S Travis, D Turner, C Tysk, M Vatn, S Vermeire, M Watanabe, T Yamamoto, J Yamamoto-Furusho. Lifestyle, behaviour, and environmental modification for the management of patients with inflammatory bowel diseases: an International Organization for Study of Inflammatory Bowel Diseases consensus. The Lancet Gastroenterology & Hepatology 2022; 7(7): 666 doi: 10.1016/S2468-1253(22)00021-8
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5 |
Ayse Ozkaraman, Guler Balcı Alparslan, Burcu Babadağ, Timucin Kaşifoğlu, Canan Baydemir. Effect of education and telephone counseling on adherence to treatment and challenges experienced in anti-TNF-α treatment: a pilot study. Contemporary Nurse 2018; 54(1): 108 doi: 10.1080/10376178.2017.1422776
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6 |
Esma H. San, Angelique Egberts, Caroline W. Th. van Dijck - van Boetzelaer, Rachel L. West, Erwin C. Vasbinder. High refill-adherence to adalimumab is associated with low disease activity in patients with inflammatory bowel disease. European Journal of Clinical Pharmacology 2024; 80(7): 1089 doi: 10.1007/s00228-024-03676-8
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7 |
Lieven Pouillon, Peter Bossuyt, Laurent Peyrin-Biroulet. Considerations, challenges and future of anti-TNF therapy in treating inflammatory bowel disease. Expert Opinion on Biological Therapy 2016; 16(10): 1277 doi: 10.1080/14712598.2016.1203897
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8 |
Ferdinando D'Amico, Laurent Peyrin-Biroulet, Luc Vandromme, Yoram Bouhnik, Patrick Faure, Stéphane Nahon, Hervé Hagege, Xavier Hebuterne, Salim Benkhalifa, Maria Nachury. Motivation to pursue anti-TNFα treatment in patients with Crohn's disease – the SPACE motivation study. Digestive and Liver Disease 2020; 52(9): 995 doi: 10.1016/j.dld.2020.05.032
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9 |
Aniela Bonorino Xexeo Castelo BRANCO, Wilton ARGOLO, Nathalia SANTOS, Gabriela HERNANDEZ, Adriana KAKEHASI, Carlos Walter SOBRADO, Richard MELSHEIMER. ADHERENCE AND PERSISTENCE TO TREATMENT WITH INFLIXIMAB: ANALYSIS OF A PATIENT SUPPORT PROGRAM COHORT IN BRAZIL. Arquivos de Gastroenterologia 2024; 61 doi: 10.1590/s0004-2803.24612023-149
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10 |
Parvaneh Heidari, Wendy Cross, Kimberley Crawford. Do out-of-pocket costs affect medication adherence in adults with rheumatoid arthritis? A systematic review. Seminars in Arthritis and Rheumatism 2018; 48(1): 12 doi: 10.1016/j.semarthrit.2017.12.010
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11 |
J. Kirchgesner, M. Lemaitre, A. Rudnichi, A. Racine, M. Zureik, F. Carbonnel, R. Dray‐Spira. Therapeutic management of inflammatory bowel disease in real‐life practice in the current era of anti‐TNF agents: analysis of the French administrative health databases 2009–2014. Alimentary Pharmacology & Therapeutics 2017; 45(1): 37 doi: 10.1111/apt.13835
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12 |
Clarice Gomes e Souza Dabés, Alessandra Maciel Almeida, Francisco de Assis Acurcio. Não adesão à terapia biológica em pacientes com doenças reumáticas no Sistema Único de Saúde em Minas Gerais, Brasil. Cadernos de Saúde Pública 2015; 31(12): 2599 doi: 10.1590/0102-311X00169514
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13 |
Cristina Trigo-Vicente, Vicente Gimeno-Ballester, Raquel Montoiro-Allué, Alejandro López-Del Val. Cost-effectiveness analysis of infliximab, adalimumab, golimumab and vedolizumab for moderate to severe ulcerative colitis in Spain. Expert Review of Pharmacoeconomics & Outcomes Research 2018; 18(3): 321 doi: 10.1080/14737167.2018.1411193
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14 |
Adi Eindor-Abarbanel, Timna Naftali, Nahum Ruhimovich, Ariella Bar-Gil Shitrit, Fabiana Sklerovsky-Benjaminov, Fred Konikoff, Shai Matalon, Haim Shirin, Yael Milgrom, Efrat Broide. Revealing the Puzzle of Nonadherence in IBD—Assembling the Pieces. Inflammatory Bowel Diseases 2018; 24(6): 1352 doi: 10.1093/ibd/izy013
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15 |
Bart J. F. van den Bemt, Lynda Gettings, Barbara Domańska, Richard Bruggraber, Irina Mountian, Lars E. Kristensen. A portfolio of biologic self-injection devices in rheumatology: how patient involvement in device design can improve treatment experience. Drug Delivery 2019; 26(1): 384 doi: 10.1080/10717544.2019.1587043
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16 |
Akihiko Akamine, Yuya Nagasaki, Atsushi Tomizawa, Mariko Arai, Koichiro Atsuda. Risk Factors for Non-Adherence to Medications That Affect Surgery: A Retrospective Study in Japan. Patient Preference and Adherence 2022; : 1623 doi: 10.2147/PPA.S365348
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17 |
Steve Fenwick, Kunal Thakur, Duncan Munro. Nurse and Patient Perceptions and Preferences for Subcutaneous Autoinjectors for Inflammatory Joint or Bowel Disease: Findings from a European Survey. Rheumatology and Therapy 2019; 6(2): 195 doi: 10.1007/s40744-019-0144-8
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18 |
Spyros Peppas, Claudia Pansieri, Daniele Piovani, Silvio Danese, Laurent Peyrin-Biroulet, Andreas G. Tsantes, Enrico Brunetta, Argirios E. Tsantes, Stefanos Bonovas. The Brain-Gut Axis: Psychological Functioning and Inflammatory Bowel Diseases. Journal of Clinical Medicine 2021; 10(3): 377 doi: 10.3390/jcm10030377
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19 |
Parvaneh Heidari, Wendy Cross, Carolina Weller, Victoria Team, Mohammadali Nazarinia, Kimberley Crawford. Rheumatologists' insight into medication adherence in patients with rheumatoid arthritis: A qualitative study. International Journal of Rheumatic Diseases 2019; 22(9): 1695 doi: 10.1111/1756-185X.13660
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20 |
M. Péntek, L. Gulácsi, L. Herszényi, J. Banai, K. Palatka, P. L. Lakatos, V. Brodszky, F. Rencz. Subjective expectations regarding longevity and future health: a cross‐sectional survey among patients with Crohn's disease. Colorectal Disease 2021; 23(1): 105 doi: 10.1111/codi.15357
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21 |
Manish Mittal, Min Yang, Manan Shah, Wei Gao, Christopher Carley, Bruce W. Sherman. Impact of Medication Adherence on Healthcare Resource Utilization, Work Loss, and Associated Costs in a Privately Insured Employed Population Treated With Adalimumab in the United States. Journal of Occupational & Environmental Medicine 2021; 63(10): e724 doi: 10.1097/JOM.0000000000002354
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22 |
Parvaneh Heidari, Wendy Cross, Carolina Weller, Mohammadali Nazarinia, Kimberley Crawford. Medication adherence and cost‐related medication non‐adherence in patients with rheumatoid arthritis: A cross‐sectional study. International Journal of Rheumatic Diseases 2019; 22(4): 555 doi: 10.1111/1756-185X.13549
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23 |
Amanda M. Kibbons, Ryan Moore, Leena Choi, Megan Peter, Autumn D. Zuckerman. Individual and Community-Level Characteristics and Adherence to Specialty Medications. Journal of Pharmacy Practice 2024; 37(2): 279 doi: 10.1177/08971900221131933
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24 |
S Nikolaus, S Schreiber, B Siegmund, B Bokemeyer, E Bästlein, O Bachmann, D Görlich, U Hofmann, M Schwab, W Kruis. Patient Education in a 14-month Randomised Trial Fails to Improve Adherence in Ulcerative Colitis: Influence of Demographic and Clinical Parameters on Non-adherence. Journal of Crohn's and Colitis 2017; 11(9): 1052 doi: 10.1093/ecco-jcc/jjx062
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25 |
Margot L. Herman, Sunanda V. Kane. Treatment Nonadherence in Inflammatory Bowel Disease. Inflammatory Bowel Diseases 2015; 21(12): 2979 doi: 10.1097/MIB.0000000000000581
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26 |
Michael Ruberson Ribeiro da Silva, Jéssica Barreto Ribeiro dos Santos, Alessandra Maciel Almeida, Alexander Itria, Adriana Maria Kakehasi, Juliana Alvares Teodoro, Francisco de Assis Acurcio. Medication Persistence for Psoriatic Arthritis in a Brazilian Real-World Setting. Future Science OA 2019; 5(2) doi: 10.4155/fsoa-2018-0101
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27 |
Bart P. H. Pouls, Lars E. Kristensen, Marianne Petersson, B. J. F. van den Bemt, Luca Ballerini, Richard Bruggraber, Henrik Karlen, Irina Mountian, Etienne van Bracht, Susanne Wiegratz, Tanja S. Jørgensen. A pilot study examining patient preference and satisfaction for ava®, a reusable electronic injection device to administer certolizumab pegol. Expert Opinion on Drug Delivery 2020; 17(5): 705 doi: 10.1080/17425247.2020.1736552
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28 |
Diana Brixner, David T. Rubin, Philip Mease, Manish Mittal, Harry Liu, Matthew Davis, Arijit Ganguli, A. Mark Fendrick. Patient Support Program Increased Medication Adherence with Lower Total Health Care Costs Despite Increased Drug Spending. Journal of Managed Care & Specialty Pharmacy 2019; 25(7): 770 doi: 10.18553/jmcp.2019.18443
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29 |
Juul M.P.A. van den Reek, Philippe A.R.R. Pijls, Marcia Tummers, Piet C.L.M. van Riel, Wietske Kievit, Frank Hoentjen, Elke M.G.J. de Jong. Adalimumab drug survival in patients with psoriasis, Crohn's disease, and rheumatoid arthritis: Relevant differences using the same treatment. Journal of the American Academy of Dermatology 2016; 74(1): 177 doi: 10.1016/j.jaad.2015.08.010
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30 |
Jéssica Barreto Ribeiro dos Santos, Augusto Afonso Guerra Junior, Michael Ruberson Ribeiro da Silva, Alessandra Maciel Almeida, Francisco de Assis Acurcio, Juliana Alvares-Teodoro. First line of biological drugs in rheumatoid arthritis: a medication persistence analysis. Expert Review of Clinical Pharmacology 2019; 12(4): 363 doi: 10.1080/17512433.2019.1586533
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31 |
Kai Sun, Jackie Szymonifka, Henghe Tian, Yaju Chang, Jennifer C. Leng, Lisa A. Mandl. Association of Traditional Chinese Medicine Use With Adherence to Prescribed Western Rheumatic Medications Among Chinese American Patients: A Cross‐Sectional Survey. Arthritis Care & Research 2020; 72(10): 1474 doi: 10.1002/acr.24031
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32 |
Maria Lia Scribano, Flavio Caprioli, Andrea Michielan, Antonella Contaldo, Antonino Carlo Privitera, Rosa Maria Bozzi, Emma Calabrese, Fabiana Castiglione, Antonio Francesco Ciccaglione, Gianfranco Delle Fave, Giorgia Bodini, Giuseppe Costantino, Robert Horne, Silvia Saettone, Paolo Usai, Piero Vernia, Sara Di Fino, Giuliana Gualberti, Michela di Fonzo, Rocco Merolla, Ambrogio Orlando. Translation and initial validation of the Medication Adherence Report Scale (MARS) in Italian patients with Crohn’s Disease. Digestive and Liver Disease 2019; 51(5): 640 doi: 10.1016/j.dld.2018.09.026
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33 |
Mohammed A Omair, Maha M. Alshehri, Nouf Altokhais, Ghada A Aljanobi, Maha I El Dessougi, Amal AlHarthi, Maha A Omair, Suzan M Attar, Sami M Bahlas, Abdullah S Alfurayj, Mansour Alazmi, Alhussain M Asiri, Mohammed M AlOmair, Lobna Al Juffali, Haya M Almalag. Exploring Factors Influencing Medication Compliance in Saudi Rheumatoid Arthritis Patients: A Nationwide Cross-Sectional Survey – Results from the COPARA Study. Patient Preference and Adherence 2022; : 1105 doi: 10.2147/PPA.S363477
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34 |
Nashwa Eltantawy, Islam Abd El-Hamid El-Zayyadi, Ahmed A. Elberry, Layla M. Salah, Mohamed E. A. Abdelrahim, Amira B. Kassem. A review article of inflammatory bowel disease treatment and pharmacogenomics. Beni-Suef University Journal of Basic and Applied Sciences 2023; 12(1) doi: 10.1186/s43088-023-00361-0
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35 |
Thomas Wilke, Sabrina Mueller, Sze Chim Lee, Istvan Majer, Marieke Heisen. Drug survival of second biological DMARD therapy in patients with rheumatoid arthritis: a retrospective non-interventional cohort analysis. BMC Musculoskeletal Disorders 2017; 18(1) doi: 10.1186/s12891-017-1684-0
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36 |
Mohammed A Omair, Fatima Al Suwayeh, Alanoud Almashaan, Eman Alqurtas, Mohammed K Bedaiwi, Ibrahim Almaghlouth, Abdulaziz Alkahalaf, Haya M Almalaq. Cross-Cultural Validation of the 5-Item Compliance Questionnaire for Rheumatology to the Arabic Language in Patients with Rheumatoid Arthritis. Patient Preference and Adherence 2021; : 1461 doi: 10.2147/PPA.S316263
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37 |
Eun Sil Kim, Ben Kang. Infliximab <i>vs</i> adalimumab: Points to consider when selecting anti-tumor necrosis factor agents in pediatric patients with Crohn’s disease. World Journal of Gastroenterology 2023; 29(18): 2784-2797 doi: 10.3748/wjg.v29.i18.2784
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38 |
Zoltán Pethő, Mark R. Tanner, Rajeev B. Tajhya, Redwan Huq, Teresina Laragione, Gyorgy Panyi, Pércio S. Gulko, Christine Beeton. Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes. Arthritis Research & Therapy 2016; 18(1) doi: 10.1186/s13075-016-1003-4
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39 |
Pierre Michetti, John Weinman, Ulrich Mrowietz, Josef Smolen, Laurent Peyrin-Biroulet, Edouard Louis, Dieter Schremmer, Namita Tundia, Pascal Nurwakagari, Nicole Selenko-Gebauer. Impact of Treatment-Related Beliefs on Medication Adherence in Immune-Mediated Inflammatory Diseases: Results of the Global ALIGN Study. Advances in Therapy 2017; 34(1): 91 doi: 10.1007/s12325-016-0441-3
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40 |
Fabrizio Cantini, Laura Niccoli, Carlotta Nannini, Emanuele Cassarà, Olga Kaloudi, Ennio Giulio Favalli, Andrea Becciolini, Martina Biggioggero, Maurizio Benucci, Francesca Li Gobbi, Valentina Grossi, Maria Infantino, Francesca Meacci, Mariangela Manfredi, Serena Guiducci, Silvia Bellando-Randone, Marco Matucci-Cerinic, Rosario Foti, Marcella Di Gangi, Marta Mosca, Chiara Tani, Fabrizio Palmieri, Delia Goletti. Tailored first-line biologic therapy in patients with rheumatoid arthritis, spondyloarthritis, and psoriatic arthritis. Seminars in Arthritis and Rheumatism 2016; 45(5): 519 doi: 10.1016/j.semarthrit.2015.10.001
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41 |
Jennifer L. Barton, Laura Trupin, Dean Schillinger, Gina Evans‐Young, John Imboden, Victor M. Montori, Edward Yelin. Use of Low‐Literacy Decision Aid to Enhance Knowledge and Reduce Decisional Conflict Among a Diverse Population of Adults With Rheumatoid Arthritis: Results of a Pilot Study. Arthritis Care & Research 2016; 68(7): 889 doi: 10.1002/acr.22801
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42 |
Yuqing Wang, Duolong Zhu, Laura C. Ortiz-Velez, Jacob L. Perry, Michael W. Pennington, Joseph M. Hyser, Robert A. Britton, Christine Beeton. A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis. Proceedings of the National Academy of Sciences 2023; 120(2) doi: 10.1073/pnas.2211977120
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43 |
Christian Rhudy, Courtney Perry, Michael Wesley, David Fardo, Cody Bumgardner, Syed Hassan, Terrence Barrett, Jeffery Talbert. Applying Machine Learning Models Derived From Administrative Claims Data to Predict Medication Nonadherence in Patients Self-Administering Biologic Medications for Inflammatory Bowel Disease. Crohn's & Colitis 360 2024; 6(3) doi: 10.1093/crocol/otae039
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44 |
Laurence Goffin, Stefania Fagagnini, Alain Vicari, Céline Mamie, Hassan Melhem, Bruce Weder, Christian Lutz, Silvia Lang, Michael Scharl, Gerhard Rogler, Yolande Chvatchko, Martin Hausmann. Anti-MMP-9 Antibody. Inflammatory Bowel Diseases 2016; 22(9): 2041 doi: 10.1097/MIB.0000000000000863
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45 |
Einav Srulovici, Vishvas Garg, Adi Ghilai, Becca Feldman, Moshe Hoshen, Ran D. Balicer, Martha Skup, Maya Leventer-Roberts. Is Patient Support Program Participation Associated with Longer Persistence and Improved Adherence Among New Users of Adalimumab? A Retrospective Cohort Study. Advances in Therapy 2018; 35(5): 655 doi: 10.1007/s12325-018-0706-0
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46 |
Marina Sáez Belló, Pilar Llopis Salvia, Juan José Alegre Sancho, José María Paredes Arquiola, M. del Carmen Asencio Muñoz, Mónica Climente Martí. Utilidad de las concentraciones séricas de adalimumab como predictores de adherencia al tratamiento. Reumatología Clínica 2020; 16(1): 32 doi: 10.1016/j.reuma.2018.01.004
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47 |
Johannes P. D. Schultheiss, Sandra Altena, Max R. Clevers, Dominique Baas, Bindia Jharap, Herma H. Fidder. Adherence to Adalimumab Was Not Improved by a Reminder-Based Intervention with an Electronic Needle Container. Digestive Diseases and Sciences 2021; 66(5): 1477 doi: 10.1007/s10620-020-06395-z
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48 |
James Harnett, Robert Gerber, David Gruben, Andrew S. Koenig, Connie Chen. Evaluation of Real-World Experience with Tofacitinib Compared with Adalimumab, Etanercept, and Abatacept in RA Patients with 1 Previous Biologic DMARD: Data from a U.S. Administrative Claims Database. Journal of Managed Care & Specialty Pharmacy 2016; 22(12): 1457 doi: 10.18553/jmcp.2016.22.12.1457
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49 |
Machaon Bonafede, Barbara H. Johnson, Derek H. Tang, Neel Shah, David J. Harrison, David H. Collier. Etanercept‐Methotrexate Combination Therapy Initiators Have Greater Adherence and Persistence Than Triple Therapy Initiators With Rheumatoid Arthritis. Arthritis Care & Research 2015; 67(12): 1656 doi: 10.1002/acr.22638
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50 |
Pauline Cavagna, Julien Hubert, Cécile Bottois, Clementina Lopez-Medina, Christian Roux, Ornella Conort, Maxime Dougados. Validation of the French version of the Compliance Questionnaire for Rheumatology (CQR-5), a self-reporting questionnaire specific to patients with chronic inflammatory rheumatic disease. Joint Bone Spine 2022; 89(6): 105449 doi: 10.1016/j.jbspin.2022.105449
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51 |
Melanie J. Cozad, Lisa C. Lindley, Kaitlyn Crosby, Noor Alshareef, Ann Blair Kennedy, Gulzar Merchant, Pam Evans, Ronnie D. Horner. Patient Goals for Living with Rheumatoid Arthritis: A Qualitative Study. Clinical Nursing Research 2023; 32(1): 40 doi: 10.1177/10547738221075784
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52 |
Holly F Hope, James Bluett, Anne Barton, Kimme L Hyrich, Lis Cordingley, Suzanne M M Verstappen. Psychological factors predict adherence to methotrexate in rheumatoid arthritis; findings from a systematic review of rates, predictors and associations with patient-reported and clinical outcomes. RMD Open 2016; 2(1): e000171 doi: 10.1136/rmdopen-2015-000171
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53 |
Marina Sáez Belló, Pilar Llopis Salvia, Juan José Alegre Sancho, José María Paredes Arquiola, M. del Carmen Asencio Muñoz, Mónica Climente Martí. Clinical utility of serum concentrations of adalimumab as predictor of treatment adherence. Reumatología Clínica (English Edition) 2020; 16(1): 32 doi: 10.1016/j.reumae.2018.01.003
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54 |
Mike van der Have, Bas Oldenburg, Ad A. Kaptein, Jeroen M. Jansen, Robert C. H. Scheffer, Bas A. van Tuyl, Andrea E. van der Meulen-de Jong, Marieke Pierik, Peter D. Siersema, Martijn G. H. van Oijen, Herma H. Fidder. Non-adherence to Anti-TNF Therapy is Associated with Illness Perceptions and Clinical Outcomes in Outpatients with Inflammatory Bowel Disease: Results from a Prospective Multicentre Study. Journal of Crohn's and Colitis 2016; 10(5): 549 doi: 10.1093/ecco-jcc/jjw002
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