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May 28, 2013 (publication date) through Jul 25, 2025
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World Journal of Gastroenterology
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1007-9327
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
| For: | Grattagliano I, Diogo CV, Mastrodonato M, de Bari O, Persichella M, Wang DQ, Liquori A, Ferri D, Carratù MR, Oliveira PJ, Portincasa P. A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes. World J Gastroenterol 2013; 19(20): 3007-3017 [PMID: 23716980 DOI: 10.3748/wjg.v19.i20.3007] |
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| URL: | https://www.wjgnet.com/1007-9327/full/v19/i20/3007.htm |
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Giulia Vecchione, Elena Grasselli, Adriana Voci, Francesca Baldini, Ignazio Grattagliano, David QH Wang, Piero Portincasa, Laura Vergani. Silybin counteracts lipid excess and oxidative stress in cultured steatotic hepatic cells. World Journal of Gastroenterology 2016; 22(26): 6016-6026 doi: 10.3748/wjg.v22.i26.6016
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Hyun‐Seok Oh, Woojae Cho, Sang‐Bum Tak, Sukjoon Kim, Sun Pyo Hong, Soo‐Ok Kim. Triticum aestivum ethanolic extract improves non‐alcoholic fatty liver disease in mice fed a choline‐deficient or high‐fat diet. Journal of the Science of Food and Agriculture 2019; 99(5): 2602 doi: 10.1002/jsfa.9478
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Andrei Dumitru, Elena Matei, Georgeta Camelia Cozaru, Anca Chisoi, Luana Alexandrescu, Răzvan Cătălin Popescu, Mihaela Pundiche Butcaru, Eugen Dumitru, Sorin Rugină, Cristina Tocia. Endotoxin Inflammatory Action on Cells by Dysregulated-Immunological-Barrier-Linked ROS-Apoptosis Mechanisms in Gut–Liver Axis. International Journal of Molecular Sciences 2024; 25(5): 2472 doi: 10.3390/ijms25052472
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Aida Doostkam, Mohammad Fathalipour, Mohammad Hossein Anbardar, Azar Purkhosrow, Hossein Mirkhani, Ravindran Caspa Gokulan. Therapeutic Effects of Milk Thistle (Silybum marianum L.) and Artichoke (Cynara scolymus L.) on Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Rats. Canadian Journal of Gastroenterology and Hepatology 2022; 2022: 1 doi: 10.1155/2022/2868904
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Yichao Wang, Hang Zhao, Liying Yang, He Zhang, Xian Yu, Wenjie Fei, Yunfeng Zhen, Zhe Gao, Shuchun Chen, Luping Ren. Quantitative proteomics analysis based on tandem mass tag labeling coupled with labeling coupled with liquid chromatography-tandem mass spectrometry discovers the effect of silibinin on non-alcoholic fatty liver disease in mice. Bioengineered 2022; 13(3): 6750 doi: 10.1080/21655979.2022.2045837
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Praveen K. Pasala, Ramya K. Uppara, Mithun Rudrapal, James H. Zothantluanga, Abd. Kakhar Umar. Silybin phytosome attenuates cerebral ischemia‐reperfusion injury in rats by suppressing oxidative stress and reducing inflammatory response: In vivo and in silico approaches. Journal of Biochemical and Molecular Toxicology 2022; 36(7) doi: 10.1002/jbt.23073
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| 11 |
Bregje Van De Wier, Ger H. Koek, Aalt Bast, Guido R. M. M. Haenen. The potential of flavonoids in the treatment of non-alcoholic fatty liver disease. Critical Reviews in Food Science and Nutrition 2017; 57(4): 834 doi: 10.1080/10408398.2014.952399
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Agostino Di Ciaula, Giuseppe Calamita, Harshitha Shanmugam, Mohamad Khalil, Leonilde Bonfrate, David Q.-H. Wang, Gyorgy Baffy, Piero Portincasa. Mitochondria Matter: Systemic Aspects of Nonalcoholic Fatty Liver Disease (NAFLD) and Diagnostic Assessment of Liver Function by Stable Isotope Dynamic Breath Tests. International Journal of Molecular Sciences 2021; 22(14): 7702 doi: 10.3390/ijms22147702
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| 13 |
Sergey V. Okovityi, Karina L. Raikhelson, Veronika A. Prikhodko. Combined hepatoprotective pharmacotherapy for liver disease. Experimental and Clinical Gastroenterology 2022; (7): 5 doi: 10.31146/1682-8658-ecg-203-7-5-20
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| 14 |
Aline Maria Stolf, Cibele Campos Cardoso, Alexandra Acco. Effects of Silymarin on Diabetes Mellitus Complications: A Review. Phytotherapy Research 2017; 31(3): 366 doi: 10.1002/ptr.5768
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| 15 |
Gerardo Bosco, Alessandra Vezzoli, Andrea Brizzolari, Matteo Paganini, Tommaso Antonio Giacon, Fabio Savini, Maristella Gussoni, Michela Montorsi, Cinzia Dellanoce, Simona Mrakic-Sposta. Consumption of Sylimarin, Pyrroloquinoline Quinone Sodium Salt and Myricetin: Effects on Alcohol Levels and Markers of Oxidative Stress—A Pilot Study. Nutrients 2024; 16(17): 2965 doi: 10.3390/nu16172965
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| 16 |
Chun-Xue Cui, Jing-Na Deng, Li Yan, Yu-Ying Liu, Jing-Yu Fan, Hong-Na Mu, Hao-Yu Sun, Ying-Hong Wang, Jing-Yan Han. Silibinin Capsules improves high fat diet-induced nonalcoholic fatty liver disease in hamsters through modifying hepatic de novo lipogenesis and fatty acid oxidation. Journal of Ethnopharmacology 2017; 208: 24 doi: 10.1016/j.jep.2017.06.030
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| 17 |
Francesca Baldini, Piero Portincasa, Elena Grasselli, Gianluca Damonte, Annalisa Salis, Michela Bonomo, Marilina Florio, Nadia Serale, Adriana Voci, Patrizia Gena, Laura Vergani, Giuseppe Calamita. Aquaporin-9 is involved in the lipid-lowering activity of the nutraceutical silybin on hepatocytes through modulation of autophagy and lipid droplets composition. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2020; 1865(3): 158586 doi: 10.1016/j.bbalip.2019.158586
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| 18 |
Mohammad H. Pourhanifeh, Reza Mottaghi, Zahra S. Razavi, Alimohammad Shafiee, Sarah Hajighadimi, Hamed Mirzaei. Therapeutic Applications of Curcumin and its Novel Formulations in the Treatment of Bladder Cancer: A Review of Current Evidence. Anti-Cancer Agents in Medicinal Chemistry 2021; 21(5): 587 doi: 10.2174/1871520620666200807223832
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| 19 |
Hamed Mirzaei, Abolfazl Shakeri, Bahman Rashidi, Amin Jalili, Zarrin Banikazemi, Amirhossein Sahebkar. Phytosomal curcumin: A review of pharmacokinetic, experimental and clinical studies. Biomedicine & Pharmacotherapy 2017; 85: 102 doi: 10.1016/j.biopha.2016.11.098
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| 20 |
Alessandro Federico, Marcello Dallio, Carmelina Loguercio. Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years. Molecules 2017; 22(2): 191 doi: 10.3390/molecules22020191
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| 21 |
Jingqi Xu, Jiayan Shen, Ruolan Yuan, Bona Jia, Yiwen Zhang, Sijian Wang, Yi Zhang, Mengyang Liu, Tao Wang. Mitochondrial Targeting Therapeutics: Promising Role of Natural Products in Non-alcoholic Fatty Liver Disease. Frontiers in Pharmacology 2021; 12 doi: 10.3389/fphar.2021.796207
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| 22 |
Piero Portincasa, Leonilde Bonfrate, Mohamad Khalil, Maria De Angelis, Francesco Maria Calabrese, Mauro D’Amato, David Q.-H. Wang, Agostino Di Ciaula. Intestinal Barrier and Permeability in Health, Obesity and NAFLD. Biomedicines 2021; 10(1): 83 doi: 10.3390/biomedicines10010083
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| 23 |
Peter Surai. Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives. Antioxidants 2015; 4(1): 204 doi: 10.3390/antiox4010204
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Ignazio Grattagliano, Liliana P. Montezinho, Paulo J. Oliveira, Gema Frühbeck, Javier Gómez-Ambrosi, Fabrizio Montecucco, Federico Carbone, Mariusz R. Wieckowski, David Q.-H. Wang, Piero Portincasa. Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease. Biochemical Pharmacology 2019; 160: 34 doi: 10.1016/j.bcp.2018.11.020
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| 25 |
Gaetano Serviddio, Francesco Bellanti, Eleonora Stanca, Paola Lunetti, Maria Blonda, Rosanna Tamborra, Luisa Siculella, Gianluigi Vendemiale, Loredana Capobianco, Anna Maria Giudetti. Silybin exerts antioxidant effects and induces mitochondrial biogenesis in liver of rat with secondary biliary cirrhosis. Free Radical Biology and Medicine 2014; 73: 117 doi: 10.1016/j.freeradbiomed.2014.05.002
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Anna Egresi, Krisztina Süle, Klára Szentmihályi, Anna Blázovics, Erzsébet Fehér, Krisztina Hagymási, Hedvig Fébel. Impact of milk thistle (Silybum marianum) on the mycotoxin caused redox-homeostasis imbalance of ducks liver. Toxicon 2020; 187: 181 doi: 10.1016/j.toxicon.2020.09.002
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