For: | Soresi M, Giannitrapani L, D’Antona F, Florena AM, Spada EL, Terranova A, Cervello M, D’Alessandro N, Montalto G. Interleukin-6 and its soluble receptor in patients with liver cirrhosis and hepatocellular carcinoma. World J Gastroenterol 2006; 12(16): 2563-2568 [PMID: 16688802 DOI: 10.3748/wjg.v12.i16.2563] |
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URL: | https://www.wjgnet.com/1007-9327/full/v12/i16/2563.htm |
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Jiangbo Zhang, Jin Cheng, Zhenzhen Zeng, Yongfeng Wang, Xiaojun Li, Qing Xie, Junqiao Jia, Ying Yan, Zhengyang Guo, Jian Gao, Mingjie Yao, Xiangmei Chen, Fengmin Lu. Comprehensive profiling of novel microRNA-9 targets and a tumor suppressor role of microRNA-9 via targeting IGF2BP1 in hepatocellular carcinoma. Oncotarget 2015; 6(39): 42040 doi: 10.18632/oncotarget.5969
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Timo Rath, Ulrike Billmeier, Maximilian J. Waldner, Raja Atreya, Markus F. Neurath. From physiology to disease and targeted therapy: interleukin-6 in inflammation and inflammation-associated carcinogenesis. Archives of Toxicology 2015; 89(4): 541 doi: 10.1007/s00204-015-1461-5
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Helene L. Kammoun, Tamara Louise Allen, Darren Colin Henstridge, Michael James Kraakman, Lone Peijs, Stefan Rose-John, Mark Anthony Febbraio, Matias A Avila. Over-expressing the soluble gp130-Fc does not ameliorate methionine and choline deficient diet-induced non alcoholic steatohepatitis in mice. PLOS ONE 2017; 12(6): e0179099 doi: 10.1371/journal.pone.0179099
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Lamiaa N. Hammad, Sahar M. Abdelraouf, Fetouh S. Hassanein, Walid A. Mohamed, Mona F. Schaalan. Circulating IL-6, IL-17 and vitamin D in hepatocellular carcinoma: Potential biomarkers for a more favorable prognosis?. Journal of Immunotoxicology 2013; 10(4): 380 doi: 10.3109/1547691X.2012.758198
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Mohamed S. Othman, Ahmed M. Aref, Amal A. Mohamed, Wesam A. Ibrahim. Serum Levels of Interleukin-6 and Interleukin-10 as Biomarkers for Hepatocellular Carcinoma in Egyptian Patients. ISRN Hepatology 2013; 2013: 1 doi: 10.1155/2013/412317
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M. Martinez-Castillo, I. Altamirano-Mendoza, S. Sánchez-Valle, L. García-Islas, M. Sánchez-Barragán, M. Hernández-Santillán, A. Hernández-Barragán, J.L. Pérez-Hernández, F. Higuera-de la Tijera, G. Gutierrez-Reyes. Desregulación inmunológica y fisiopatología del consumo de alcohol y la enfermedad hepática alcohólica. Revista de Gastroenterología de México 2023; 88(2): 136 doi: 10.1016/j.rgmx.2023.01.002
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Masashi Narazaki, Tadamitsu Kishimoto. The Two-Faced Cytokine IL-6 in Host Defense and Diseases. International Journal of Molecular Sciences 2018; 19(11): 3528 doi: 10.3390/ijms19113528
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Alfredo Smiriglia, Nicla Lorito, Marina Serra, Andrea Perra, Andrea Morandi, Marta Anna Kowalik. Sex difference in liver diseases: How preclinical models help to dissect the sex-related mechanisms sustaining NAFLD and hepatocellular carcinoma. iScience 2023; 26(12): 108363 doi: 10.1016/j.isci.2023.108363
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Zeynep Firtina Karagonlar, Doğukan Koç, Eren Şahin, Sanem Tercan Avci, Mustafa Yilmaz, Neşe Atabey, Esra Erdal. Effect of adipocyte-secreted factors on EpCAM+/CD133+ hepatic stem cell population. Biochemical and Biophysical Research Communications 2016; 474(3): 482 doi: 10.1016/j.bbrc.2016.04.137
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Wim Verlinden, Sven Francque, Luisa Vonghia. Biomarkers in Liver Disease. Biomarkers in Disease: Methods, Discoveries and Applications 2017; : 581 doi: 10.1007/978-94-007-7675-3_22
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Willscott E. Naugler, Toshiharu Sakurai, Sunhwa Kim, Shin Maeda, KyoungHyun Kim, Ahmed M. Elsharkawy, Michael Karin. Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production. Science 2007; 317(5834): 121 doi: 10.1126/science.1140485
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Ken-ichi Yamada, Fumiya Mito, Yuta Matsuoka, Satsuki Ide, Kazushige Shikimachi, Ayano Fujiki, Daiki Kusakabe, Yuma Ishida, Masataka Enoki, Arisa Tada, Miyuki Ariyoshi, Toshihide Yamasaki, Mayumi Yamato. Fluorescence probes to detect lipid-derived radicals. Nature Chemical Biology 2016; 12(8): 608 doi: 10.1038/nchembio.2105
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14 |
Satish Kanhar, Sandeep Kumar Swain, Umesh Chandra Dash, Neelam Meher, Atish Kumar Sahoo. Antioxidants of commercial interest from Homalium tomentosum attenuates hepatocellular necrosis: Insights from experimental and computational studies. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2024; 322: 124741 doi: 10.1016/j.saa.2024.124741
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Justin K. Messex, Crystal J. Byrd, Geou-Yarh Liou. Signaling of Macrophages that Contours the Tumor Microenvironment for Promoting Cancer Development. Cells 2020; 9(4): 919 doi: 10.3390/cells9040919
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M. Martinez-Castillo, I. Altamirano-Mendoza, S. Sánchez-Valle, L. García-Islas, M. Sánchez-Barragán, M. Hernández-Santillán, A. Hernández-Barragán, J.L. Pérez-Hernández, F. Higuera-de la Tijera, G. Gutierrez-Reyes. Immune dysregulation and pathophysiology of alcohol consumption and alcoholic liver disease. Revista de Gastroenterología de México (English Edition) 2023; 88(2): 136 doi: 10.1016/j.rgmxen.2023.03.003
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17 |
Mayumi Ueyama, Mina Nakagawa, Naoya Sakamoto, Izumi Onozuka, Yusuke Funaoka, Takako Watanabe, Sayuri Nitta, Kei Kiyohashi, Akiko Kitazume, Miyako Murakawa, Yuki Nishimura-Sakurai, Yuko Sekine-Osajima, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Mamoru Watanabe. Serum Interleukin-6 Levels Correlate with Resistance to Treatment of Chronic Hepatitis C Infection with Pegylated-Interferon-α2B plus Ribavirin. Antiviral Therapy 2011; 16(7): 1081 doi: 10.3851/IMP1864
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Shengli Tang, Zhisu Liu, Yongxi Zhang, Yueming He, Dingyu Pan, Yuanyuan Liu, Quanyan Liu, Zhonglin Zhang, Yufeng Yuan. Rather than Rs1800796 Polymorphism, Expression of Interleukin-6 Is Associated with Disease Progression of Chronic HBV Infection in a Chinese Han Population. Disease Markers 2013; 35: 799 doi: 10.1155/2013/508023
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Jeffrey K. Lee, Ricki Bettencourt, David Brenner, Thuy-Anh Le, Elizabeth Barrett-Connor, Rohit Loomba, Christian Herder. Association between Serum Interleukin-6 Concentrations and Mortality in Older Adults: The Rancho Bernardo Study. PLoS ONE 2012; 7(4): e34218 doi: 10.1371/journal.pone.0034218
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Yaron Meirow, Julia Kanterman, Michal Baniyash. Paving the Road to Tumor Development and Spreading: Myeloid-Derived Suppressor Cells are Ruling the Fate. Frontiers in Immunology 2015; 6 doi: 10.3389/fimmu.2015.00523
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J Gong, J-P Zhang, B Li, C Zeng, K You, M-X Chen, Y Yuan, S-M Zhuang. MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R. Oncogene 2013; 32(25): 3071 doi: 10.1038/onc.2012.318
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Dirk Schmidt-Arras, Stefan Rose-John. IL-6 pathway in the liver: From physiopathology to therapy. Journal of Hepatology 2016; 64(6): 1403 doi: 10.1016/j.jhep.2016.02.004
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23 |
Yong-Cang Wang, Ge-Liang Xu, Wei-Dong Jia, Sheng-Jin Han, Wei-Hua Ren, Wei Wang, Wen-Bin Liu, Chuan-Hai Zhang, Hao Chen. Estrogen Suppresses Metastasis in Rat Hepatocellular Carcinoma through Decreasing Interleukin-6 and Hepatocyte Growth Factor Expression. Inflammation 2012; 35(1): 143 doi: 10.1007/s10753-011-9299-3
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24 |
Xudong Ren, Yu Zhou, Yunling Luo, Chaoqun Wang, Anna Pan, Yanqin Ju, Haoting Sun, Zhifei Lin, Beiyuan Hu, Guangzheng Sun, Wenwei Zhu, Liang Hong, Zhihua Kang. IL-6 Promotes Hepatocellular Carcinoma Invasion by Releasing Exosomal miR-133a-3p. Gastroenterology Research and Practice 2022; 2022: 1 doi: 10.1155/2022/4589163
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Amany F Elkhoudary, Rehab Elmougy, Afaf Elsaid, Yahya Wahba, Abdel-Aziz F Abdel-Aziz. Genetic and biochemical studies of hepatic carcinoma in the Egyptian population. Journal of Research in Medical Sciences 2021; 26(1): 62 doi: 10.4103/jrms.JRMS_846_17
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Shanshan Yu, Lei Sun, Hua Wang, Jue Jiang, Qi Zhou. Autonomic regulation of imbalance‑induced myocardial fibrosis and its mechanism in rats with cirrhosis. Experimental and Therapeutic Medicine 2021; 22(3) doi: 10.3892/etm.2021.10472
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27 |
Florence A. Servais, Mélanie Kirchmeyer, Matthias Hamdorf, Nadège W.E. Minoungou, Stefan Rose-John, Stephanie Kreis, Claude Haan, Iris Behrmann. Modulation of the IL-6-Signaling Pathway in Liver Cells by miRNAs Targeting gp130, JAK1, and/or STAT3. Molecular Therapy - Nucleic Acids 2019; 16: 419 doi: 10.1016/j.omtn.2019.03.007
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28 |
Mao Zhang, Shun Zhang, Zhenjie Yang, Jie Hu, Weiyu Hu, Peng Sun, Liqun Wu, Bing Han. Association between the expression levels of IL‑6 and IL‑6R in the hepatocellular carcinoma microenvironment and postoperative recurrence. Oncology Letters 2018; doi: 10.3892/ol.2018.9557
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Quentin Lepiller, Manoj K Tripathy, Vincent Di Martino, Bernadette Kantelip, Georges Herbein. Increased HCMV seroprevalence in patients with hepatocellular carcinoma. Virology Journal 2011; 8(1) doi: 10.1186/1743-422X-8-485
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Nathalie Théret, Fidaa Bouezzeddine, Fida Azar, Mona Diab-Assaf, Vincent Legagneux. ADAM and ADAMTS Proteins, New Players in the Regulation of Hepatocellular Carcinoma Microenvironment. Cancers 2021; 13(7): 1563 doi: 10.3390/cancers13071563
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31 |
Paulina Kur, Agnieszka Kolasa-Wołosiuk, Kamila Misiakiewicz-Has, Barbara Wiszniewska. Sex Hormone-Dependent Physiology and Diseases of Liver. International Journal of Environmental Research and Public Health 2020; 17(8): 2620 doi: 10.3390/ijerph17082620
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Yan Deng, Meng Li, Jian Wang, Li Xie, Taijie Li, Yu He, Qinghua Lu, Ruolin Li, Aihua Tan, Xue Qin, Shan Li. Susceptibility to hepatocellular carcinoma in the Chinese population—associations with interleukin-6 receptor polymorphism. Tumor Biology 2014; 35(7): 6383 doi: 10.1007/s13277-014-1863-7
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Bon-Wook Koo, Dae-Jin Lim, Ah-Young Oh, Hyo-Seok Na. Retrospective Comparison between the Effects of Propofol and Inhalation Anesthetics on Postoperative Recurrence of Early- and Intermediate-Stage Hepatocellular Carcinoma. Medical Principles and Practice 2020; 29(5): 422 doi: 10.1159/000506637
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Mohamed Balaha, Samah Kandeel, Waleed Barakat. Carvedilol suppresses circulating and hepatic IL-6 responsible for hepatocarcinogenesis of chronically damaged liver in rats. Toxicology and Applied Pharmacology 2016; 311: 1 doi: 10.1016/j.taap.2016.10.012
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Jordi Ribera, Juan Rodríguez-Vita, Bernat Cordoba, Irene Portolés, Gregori Casals, Eudald Casals, Wladimiro Jiménez, Victor Puntes, Manuel Morales-Ruiz, Matias A. Avila. Functionalized cerium oxide nanoparticles mitigate the oxidative stress and pro-inflammatory activity associated to the portal vein endothelium of cirrhotic rats. PLOS ONE 2019; 14(6): e0218716 doi: 10.1371/journal.pone.0218716
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36 |
Christa Buechler, Elisabeth Haberl, Lisa Rein-Fischboeck, Charalampos Aslanidis. Adipokines in Liver Cirrhosis. International Journal of Molecular Sciences 2017; 18(7): 1392 doi: 10.3390/ijms18071392
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Sylvia S. W. Ng, Hong Zhang, Lisa Wang, Deborah Citrin, Laura A. Dawson. Association of pro-inflammatory soluble cytokine receptors early during hepatocellular carcinoma stereotactic radiotherapy with liver toxicity. npj Precision Oncology 2020; 4(1) doi: 10.1038/s41698-020-0124-z
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Lara Kern, Melanie Mittenbühler, Anna Vesting, Anna Ostermann, Claudia Wunderlich, F. Wunderlich. Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between Obesity and Inflammation—Driven Liver and Colorectal Cancers. Cancers 2018; 11(1): 24 doi: 10.3390/cancers11010024
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Neele Schumacher, Stefan Rose-John, Dirk Schmidt-Arras. ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation. International Journal of Molecular Sciences 2020; 21(14): 5133 doi: 10.3390/ijms21145133
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Jeong Won Jang, Byong Sun Oh, Jung Hyun Kwon, Chan Ran You, Kyu Won Chung, Chul Seung Kay, Hyun Suk Jung. Serum interleukin-6 and C-reactive protein as a prognostic indicator in hepatocellular carcinoma. Cytokine 2012; 60(3): 686 doi: 10.1016/j.cyto.2012.07.017
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Hongfang Ma, Na Xing, Lin Hou, Jianhua Wu, Ziyue Sha, Fujun Wang, Xiaohui Ji, Zhanjun Guo. Dicer Inhibits Hepatocellular Carcinoma by Inhibiting the Interleukin 6 Pathway. Hepatitis Monthly 2023; 23(1) doi: 10.5812/hepatmon-134381
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Hayato Nakagawa, Shin Maeda, Haruhiko Yoshida, Ryosuke Tateishi, Ryota Masuzaki, Takamasa Ohki, Yoku Hayakawa, Hiroto Kinoshita, Minoru Yamakado, Naoya Kato, Shuichiro Shiina, Masao Omata. Serum IL‐6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients: An analysis based on gender differences. International Journal of Cancer 2009; 125(10): 2264 doi: 10.1002/ijc.24720
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Juri Bergmann, Miryam Müller, Niklas Baumann, Manuel Reichert, Carola Heneweer, Julia Bolik, Karsten Lücke, Sabine Gruber, Antonella Carambia, Susanne Boretius, Ivo Leuschner, Thomas Becker, Björn Rabe, Johannes Herkel, F. Thomas Wunderlich, Hans‐Willi Mittrücker, Stefan Rose‐John, Dirk Schmidt‐Arras. IL‐6 trans‐signaling is essential for the development of hepatocellular carcinoma in mice. Hepatology 2017; 65(1): 89 doi: 10.1002/hep.28874
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Lichao Yang, Chunmeng Wei, Yasi Li, Xiao He, Min He. Mir-224 Is An Early-Stage Biomarker of Hepatocellular Carcinoma with Mir-224 and Mir-125B As Prognostic Biomarkers. Biomarkers in Medicine 2020; 14(15): 1485 doi: 10.2217/bmm-2020-0099
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Reza Rahbari, Lisa Zhang, Electron Kebebew. Thyroid Cancer Gender Disparity. Future Oncology 2010; 6(11): 1771 doi: 10.2217/fon.10.127
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Melchiorre Cervello, James A. McCubrey, Antonella Cusimano, Nadia Lampiasi, Antonina Azzolina, Giuseppe Montalto. Targeted therapy for hepatocellular carcinoma: novel agents on the horizon. Oncotarget 2012; 3(3): 236 doi: 10.18632/oncotarget.466
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Hyunjung Park, Sangjik Lee, Jaehun Lee, Hyuk Moon, Simon Weonsang Ro. Exploring the JAK/STAT Signaling Pathway in Hepatocellular Carcinoma: Unraveling Signaling Complexity and Therapeutic Implications. International Journal of Molecular Sciences 2023; 24(18): 13764 doi: 10.3390/ijms241813764
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Ssu-Chuan Lai, Yu-Ting Su, Ching-Chi Chi, Yung-Che Kuo, Kam-Fai Lee, Yu-Chih Wu, Pei-Chi Lan, Muh-Hwa Yang, Te-Sheng Chang, Yen-Hua Huang. DNMT3b/OCT4 expression confers sorafenib resistance and poor prognosis of hepatocellular carcinoma through IL-6/STAT3 regulation. Journal of Experimental & Clinical Cancer Research 2019; 38(1) doi: 10.1186/s13046-019-1442-2
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Takao Nagashima, Akihito Maruyama, Yasuyuki Kamata, Seiji Minota. Unchanged serum viral load and liver function during tocilizumab treatment in a patient with rheumatoid arthritis and hepatitis C virus infection. Rheumatology International 2012; 32(7): 2231 doi: 10.1007/s00296-011-2060-2
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Antonia Mourtzikou, Maria Alepaki, Marilena Stamouli, Abraham Pouliakis, Anastasios Skliris, Petros Karakitsos. Evaluation of serum levels of IL-6, TNF-α, IL-10, IL-2 and IL-4 in patients with chronic hepatitis. Inmunología 2014; 33(2): 41 doi: 10.1016/j.inmuno.2014.01.001
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Qiongyao He, Wu He, Hui Dong, Yujin Guo, Gang Yuan, Xiaoli Shi, Dingkun Wang, Fuer Lu. Role of liver sinusoidal endothelial cell in metabolic dysfunction-associated fatty liver disease. Cell Communication and Signaling 2024; 22(1) doi: 10.1186/s12964-024-01720-9
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Wim Verlinden, Sven Francque, Luisa Vonghia. Biomarkers in Liver Disease. Biomarkers in Disease: Methods, Discoveries and Applications 2016; : 1 doi: 10.1007/978-94-007-7742-2_22-1
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Rashmi R Shah, Robert L Smith. Inflammation-Induced Phenoconversion of Polymorphic Drug Metabolizing Enzymes: Hypothesis with Implications for Personalized Medicine. Drug Metabolism and Disposition 2015; 43(3): 400 doi: 10.1124/dmd.114.061093
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K Yuan, Y Lei, H-N Chen, Y Chen, T Zhang, K Li, N Xie, K Wang, X Feng, Q Pu, W Yang, M Wu, R Xiang, E C Nice, Y Wei, C Huang. HBV-induced ROS accumulation promotes hepatocarcinogenesis through Snail-mediated epigenetic silencing of SOCS3. Cell Death & Differentiation 2016; 23(4): 616 doi: 10.1038/cdd.2015.129
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Chun-I Wang, Pei-Ming Chu, Yi-Li Chen, Yang-Hsiang Lin, Cheng-Yi Chen. Chemotherapeutic Drug-Regulated Cytokines Might Influence Therapeutic Efficacy in HCC. International Journal of Molecular Sciences 2021; 22(24): 13627 doi: 10.3390/ijms222413627
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Yan Liu, Aiguo Liu, Huameng Li, Chenglong Li, Jiayuh Lin. Celecoxib Inhibits Interleukin-6/Interleukin-6 Receptor–Induced JAK2/STAT3 Phosphorylation in Human Hepatocellular Carcinoma Cells. Cancer Prevention Research 2011; 4(8): 1296 doi: 10.1158/1940-6207.CAPR-10-0317
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Hwan Hee Lee, Hyojung Kang, Hyosun Cho. Role of Interleukin(IL)-6 in NK Activity to Hypoxic-Induced Highly Invasive Hepatocellular Carcinoma(HCC) Cells. Journal of Microbiology and Biotechnology 2023; 33(7): 864 doi: 10.4014/jmb.2304.04023
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Fatemeh Hosseinpour-Soleimani, Zahra Salmasi, Younes Ghasemi, Amir Tajbakhsh, Amir Savardashtaki. MicroRNAs and proteolytic cleavage of receptors in cancers: A comprehensive review of regulatory interactions and therapeutic implications. Heliyon 2024; 10(7): e28167 doi: 10.1016/j.heliyon.2024.e28167
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YANG WANG, XUEQUN REN, CHAOYANG DENG, LU YANG, ERFU YAN, TAO GUO, YANMIN LI, MARVIN XUEJUN XU. Mechanism of the inhibition of the STAT3 signaling pathway by EGCG. Oncology Reports 2013; 30(6): 2691 doi: 10.3892/or.2013.2743
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Bijun Qiu, Junqi Wang, Yingxue Yu, Chao Zhen, Jinyang Gu, Wenjun Liu, Yankai Wen, Lili Chen, Yueqiu Gao, Qiang Xia, Xiaoni Kong. DJ-1 promotes development of DEN-induced hepatocellular carcinoma and proliferation of liver cancer cells. Oncotarget 2017; 8(5): 8499 doi: 10.18632/oncotarget.14293
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Carlos Martínez-Pérez, Charlene Kay, James Meehan, Mark Gray, J. Michael Dixon, Arran K. Turnbull. The IL6-like Cytokine Family: Role and Biomarker Potential in Breast Cancer. Journal of Personalized Medicine 2021; 11(11): 1073 doi: 10.3390/jpm11111073
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Meenakshi Vachher, Savita Bansal, Bhupender Kumar, Sandeep Yadav, Taruna Arora, Nalini Moza Wali, Archana Burman. Contribution of organokines in the development of NAFLD/NASH associated hepatocellular carcinoma. Journal of Cellular Biochemistry 2022; 123(10): 1553 doi: 10.1002/jcb.30252
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Koji Taniguchi, Michael Karin. IL-6 and related cytokines as the critical lynchpins between inflammation and cancer. Seminars in Immunology 2014; 26(1): 54 doi: 10.1016/j.smim.2014.01.001
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