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599 items Read more >>
1
"1. Peer Review Evaluation: The peer review process was rigorous and constructive. The reviewers provided insightful comments that ..."
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"1. Peer Review Evaluation: The peer review process was rigorous and constructive. The reviewers provided insightful comments that helped improve the quality of the manuscript. 2. Editorial Evaluation: The editorial team was professional and responsive throughout the process. Communication was clear and timely. 3. Overall Publication Experience: The overall publication experience was smooth and efficient. I appreciate the efforts of the editors and reviewers, and I would be happy to work with this journal again in the future. "
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Liu CH, Zhang HY, Wang F, Mu SS, Wen FY. Anxiety and hypertensive disorders of pregnancy: Epidemiology, mechanisms, and management strategies. World J Psychiatry 2025; 15(6): 105944
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"Due to the efforts of the assistant editor, science editor, peer reviewers, editorial director, journal editor-in-chief, company ..."
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"Due to the efforts of the assistant editor, science editor, peer reviewers, editorial director, journal editor-in-chief, company editor-in-chief, language editor and production editor,this article was successfully published.Thank you to all the editors for their relentless efforts and support, which enabled me to complete this article successfully.I will continue my research on my topic and look forward to our next collaboration. "
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Wang G, Qi R. Analysis of risk factors for post-operative infection following drug-eluting trans arterial chemo embolization in hepatocellular carcinoma: A retrospective study. World J Gastrointest Surg 2025; 17(6): 106276
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"The evaluation of the article by the reviewers was quite fast. I was very pleased that the manuscript was published in a journal with ..."
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"The evaluation of the article by the reviewers was quite fast. I was very pleased that the manuscript was published in a journal with an understanding that encourages researchers and a reward incentive as much as the number of citations. Unlike other journals, preparing a short MP3 video and confirming the statistical certificate gave me a different experience, although it was a process with a lot of details, but it was completed quickly by the editor and publisher. Thank you "
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Bulut N, Erdem GU, Kapagan T, Erol VB, Sahin T, Yakin M, Bayramgil A, Dülgar Ö. Prognostic impact of histopathological features and serum inflammatory markers in patients with gastric cancer undergoing neoadjuvant therapy. World J Gastrointest Surg 2025; 17(6): 106517
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"Your journal has a fast review speed and high efficiency, which greatly facilitates the publication of the manuscript and saves the ..."
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"Your journal has a fast review speed and high efficiency, which greatly facilitates the publication of the manuscript and saves the time of the authors. I am very happy to cooperate with your journal, and I am very glad that the manuscript can be successfully published. Thank you very much for your work！ "
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Wang DD, Du YY, Li YZ, Wang W, Ma TL, Xu XC, Mi C, Wang SY, Cui F, She YH, Wang MC, Yang HT. Treatment of giant choledochal cysts with combined surgery and percutaneous transhepatic cholangial drainage: A case report. World J Gastrointest Surg 2025; 17(6): 107351
5
"The platform is systematic and the review process is rigorous. The requirement for native speaker quality check is quite stringent ..."
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"The platform is systematic and the review process is rigorous. The requirement for native speaker quality check is quite stringent for some of the authors from certain parts of the world. Nonetheless, I must thank F6 publishing for the excellent processes that they have developed over the period of time. "
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Brar MK, Sarkar S. Refining smart healthcare care for mental health and substance use disorders: A patient-centred, evidence-based approach. World J Psychiatry 2025; 15(6): 100438
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"We extend sincere appreciation to the editorial team for their exceptional support, with special recognition to Dr. Cong Lin for his ..."
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"We extend sincere appreciation to the editorial team for their exceptional support, with special recognition to Dr. Cong Lin for his meticulous efforts in securing high-caliber peer reviewers. The constructive critiques from all reviewers—particularly their methodological refinements and data validation suggestions—significantly enhanced this work's scientific robustness and scholarly rigor. We are deeply grateful for the opportunity to publish our research in this esteemed journal, which exemplifies commitment to advancing hepatology scholarship through rigorous yet efficient editorial processing. "
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Zeng ZY, Huang ZX, Wang YR, Xie LK, Lin YP, Liang Y, Liu ZY, Li DL, Zhang XY. Anti-RPL30 as a novel biomarker for enhanced diagnosis of autoantibody-negative primary biliary cholangitis. World J Gastroenterol 2025; 31(20): 104891
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"This journal maintains high credibility through its rigorous peer review system. Notably, two field experts provided constructive, ..."
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"This journal maintains high credibility through its rigorous peer review system. Notably, two field experts provided constructive, actionable comments within just four weeks of submission, which vastly improved my manuscript's methodology and data interpretation. Editorial communication remained transparent at every stage, with no hidden fees or unexpected charges. However, I recommend accelerating the publication timeline—post-acceptance formatting and production took 10 weeks, delaying dissemination. Adopting mandatory open-data policies would further strengthen reproducibility. Overall, it remains a trustworthy venue for researchers prioritizing scholarly integrity over speed "
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Wu W, Zhang YP, Zhang YL, Qu XG, Zhang ZH, Zhang R, Peng ZY. Nonlinear association between estimated plasma volume status and acute kidney injury in acute pancreatitis patients. World J Gastroenterol 2025; 31(20): 105269
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"The journal's peer review process was exceptionally thorough and constructive. The reviewers provided insightful, detailed feedback ..."
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"The journal's peer review process was exceptionally thorough and constructive. The reviewers provided insightful, detailed feedback that genuinely strengthened the manuscript. Their expertise and thoughtful critiques demonstrated a deep engagement with the work. The editorial team was also highly professional, ensuring timely communication and clear guidance throughout. This rigorous yet supportive review process significantly elevated the quality of my research, making it a truly rewarding publishing experience "
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Hu JW, Pan YZ, Zhang XX, Li JT, Jin Y. Applications and challenges of patient-derived organoids in hepatobiliary and pancreatic cancers. World J Gastroenterol 2025; 31(20): 106747
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"As the author of a manuscript published in the World Journal of Gastrointestinal Surgery, I would like to express my sincere gratitude ..."
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"As the author of a manuscript published in the World Journal of Gastrointestinal Surgery, I would like to express my sincere gratitude to the editorial board and the entire team for their professional and efficient publication process. I highly appreciate the clarity, transparency, and timeliness throughout the peer review and editing stages. The feedback from the reviewers was very valuable and contributed significantly to improving the quality of my manuscript before publication. The communication and support from the journal’s staff were also very attentive, making it easy for me to finalize the article. The online publication system is user-friendly and convenient for authors to track the progress and download documents. The journal encourages interaction among authors, reviewers, and readers, creating an open and constructive academic environment. Overall, I am fully satisfied with the quality of service and publication process of the World Journal of Gastrointestinal Surgery and will continue to choose this journal for my future research work. "
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Le QD, Le NQ, Quach DT. Underwater vs conventional endoscopic mucosal resection for nonpedunculated colorectal neoplasms: A randomized controlled trial. World J Gastrointest Surg 2025; 17(6): 103635
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"The peer review process demonstrated exceptional rigor and constructiveness, with initial feedback provided within 6 weeks. Expert ..."
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"The peer review process demonstrated exceptional rigor and constructiveness, with initial feedback provided within 6 weeks. Expert reviewers offered actionable suggestions that substantially improved our manuscript's scientific rigor. Editorial communication remained consistently clear and supportive at all stages. This efficient and valuable scholarly experience comes with our highest recommendation to colleagues. "
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Hu JT, Cao Y, Liu LL, Wang D, Zhu P, Du X, Ji F, Peng RJ, Tian Q, Zhu F. Adolescent non-suicidal self-injury: The moderating influence of social support utilization on depression. World J Psychiatry 2025; 15(6): 106017
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"I am very pleased that the article has been published in this journal. The whole process was friendly and enjoyable. The editor ..."
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"I am very pleased that the article has been published in this journal. The whole process was friendly and enjoyable. The editor provides dedicated assistance during each manuscript revision process. The reviewer's comments are highly constructive and help us better express our opinions. Waiting for the next collaboration. I provided wholehearted assistance during the manuscript revision process. The reviewer's comments are highly constructive and help us better express our opinions. Waiting for the next collaboration. "
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Wang MY, Chen XH, He XC, Yang ZJ, Yang YW, Yang J, He HL. Application of enhanced recovery after surgery in perioperative care of infants and children with Hirschsprung disease. World J Gastrointest Surg 2025; 17(6): 105739
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"The post-peer-review process of the manuscript was handled very efficiently, and we sincerely appreciate the editorial team’s efforts. ..."
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"The post-peer-review process of the manuscript was handled very efficiently, and we sincerely appreciate the editorial team’s efforts. However, the duration of the peer review was excessively long, possibly due to a low response rate from invited reviewers. While we acknowledge that the handling editor made prompt and repeated efforts to invite multiple reviewers—an effort we genuinely appreciate—the overall review timeline remained extended. "
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Yu Y, Yamauchi S, Kaji S, Yube Y, Nasu M, Yoshimoto Y, Cheng M, Ozaki A, Watanabe T, Orita H, Ecoff K, Nojiri S, Mine S, Wu YY, Fukunaga T. Predictive model and prognostic insights into duodenal stump fistula following radical gastrectomy with Roux-en-Y reconstruction for gastric cancer. World J Gastrointest Surg 2025; 17(6): 104333
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"As corresponding author, I commend World Journal of Gastrointestinal Surgery for its vital role in translating AI-driven surgical ..."
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"As corresponding author, I commend World Journal of Gastrointestinal Surgery for its vital role in translating AI-driven surgical research into clinical practice. Our radiomic nomogram study, now rapidly accessible to clinicians, directly supports critical decisions in hernia emergencies. The editorial team demonstrated exceptional professionalism: peer reviewers provided incisive methodological refinement, science editors ensured technical precision, and the production group enabled seamless online publication. This efficient, rigorous ecosystem—where rigorous review enhances clinical applicability—exemplifies the journal’s commitment to advancing evidence-based surgery. Such collaborative excellence accelerates the adoption of technological innovations at the bedside. "
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Li DL, Zhu L, Liu SL, Wang ZB, Liu JN, Zhou XM, Hu JL, Liu RQ. Machine learning-based radiomic nomogram from unenhanced computed tomography and clinical data predicts bowel resection in incarcerated inguinal hernia. World J Gastrointest Surg 2025; 17(6): 106155
14
"I am very satisfied with the entire submission and review process of the magazine. Through the publication of my experience in treating ..."
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"I am very satisfied with the entire submission and review process of the magazine. Through the publication of my experience in treating special patients in the clinical setting by this magazine,it provides a reference for the treatment of similar patients in the future.I would like to recommend this magazine to other clinical researchers. "
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Wang J, Li J, Wei YG, Lu XX, Zhang ZH. Efficacy of electroconvulsive therapy in treating auditory verbal hallucinations in a deaf patient with schizophrenia: A case report. World J Psychiatry 2025; 15(6): 105934
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"ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ..."
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"ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k okokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokook o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k kokokokoko "
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Liu H, Gu RJ, Li C, Wang JX, Dong CS. Potential of traditional Chinese medicine in managing and preventing Helicobacter pylori infection in Chinese military. World J Gastroenterol 2025; 31(18): 103754
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"ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ..."
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"ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k okokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokook o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k kokokokoko "
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Liu H. Role of traditional Chinese medicine in supporting liver transplantation outcomes. World J Transplant 2025; 15(3): 103904
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"ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ..."
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"ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k okokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokokook o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k ok o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k o k kokokokokokokokokokokokokokokokokok "
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Liu HR. Harnessing traditional medicine and biomarker-driven approaches to counteract Trichostatin A-induced esophageal cancer progression. World J Gastroenterol 2025; 31(20): 106443
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"The time from article submission to acceptance and subsequent publication is too long and should be significantly shortened. Is it ..."
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"The time from article submission to acceptance and subsequent publication is too long and should be significantly shortened. Is it necessary to send the phonetic summary of the article? Has a study been done on how many readers ultimately make use of this facility offered by the journal? There are no other comments. The magazine, as well as the entire series, is excellent. They are an essential step for researchers in promoting and publicizing their research efforts internationally. Keep it up! "
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Triantafillidis JK. Perioperative nutritional support in patients undergoing gastrointestinal surgery: Current views with an emphasis on prehabilitation efforts. World J Gastrointest Surg 2025; 17(6): 101244
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"This was an excellent submission experience. The reviewer was particularly professional, offering many constructive suggestions to ..."
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"This was an excellent submission experience. The reviewer was particularly professional, offering many constructive suggestions to enhance my manuscript. The editorial team also processed my submission very thoroughly and efficiently.We aspire for this journal to serve as a guiding light in academia, leading cutting-edge knowledge innovation while advancing ever more impactful scholarship for its readership. "
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Yu J, Li M, Qin XZ, Gong L, Qin L, Lv ZB, Guo W, Huang B, Tian YH. Application of modified Roux-en-Y digestive tract reconstruction in total gastrectomy for patients with gastric cancer. World J Gastrointest Surg 2025; 17(6): 106009
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"Dear Editorial Office, I am overall satisfied with the manuscript editing and publishing process. The communication was clear, ..."
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"Dear Editorial Office, I am overall satisfied with the manuscript editing and publishing process. The communication was clear, timelines were respected, and the editorial team provided helpful guidance throughout. The process was professional and efficient, reflecting the journal’s commitment to quality and academic integrity. I truly appreciate the support and attention to detail provided. "
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Pejčić AV. Targeting muscarinic receptors in schizophrenia treatment: Novel antipsychotic xanomeline/trospium chloride. World J Psychiatry 2025; 15(6): 105409
18762 items Read more >>
1
"The article addresses the timely and pertinent subject of the potential of PRF in clinical applications related to wound healing and ..."
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"The article addresses the timely and pertinent subject of the potential of PRF in clinical applications related to wound healing and the immune response. The language used is clear and accessible, making complex biological concepts understandable to a wide readership. As an editorial, it effectively summarises key points without unnecessary elaboration, respecting the format's purpose.
While the editorial provides a succinct overview of the potential benefits of PRF in wound healing and immune response, incorporating recent research findings and a more detailed exploration of the underlying mechanisms would enhance it further."
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Mohammadi S. Innate immunity and wound repair: The platelet-rich fibrin advantage. World J Biol Chem 2025; 16(2): 107195
2
"This article addresses the important and timely topic of the immunomodulatory effects of chloroquine and hydroxychloroquine in ..."
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"This article addresses the important and timely topic of the immunomodulatory effects of chloroquine and hydroxychloroquine in autoimmune diseases. This topic remains highly relevant for clinical and research audiences alike. The review provides a comprehensive overview of various autoimmune conditions and the mechanisms through which these drugs exert their effects, offering readers a valuable summary of the current state of knowledge in this area. The article is organised coherently, progressing logically from drug mechanisms to clinical applications, which makes it easy for readers to understand.
However, while it discusses the immunomodulatory effects of these drugs, the article lacks a critical analysis of the results from the cited studies. There is little discussion of the strength of the evidence, the limitations of the studies, or the quality of the data presented.
Furthermore, while the article cites relevant literature, it does not include the most recent studies, particularly those published within the last year. Additionally, there is little discussion of conflicting evidence or ongoing debates in the field.
While the article briefly mentions the potential side effects of chloroquine and hydroxychloroquine, it does not address the controversies surrounding their use, such as the debate over their efficacy and safety profiles in different patient populations. Including a more in-depth discussion of the limitations, controversies and areas of uncertainty surrounding the use of these drugs in autoimmune diseases would provide a more balanced perspective."
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Al-Hamadani M, Darweesh M, Mohammadi S, Al-Harrasi A. Chloroquine and hydroxychloroquine: Immunomodulatory effects in autoimmune diseases. World J Biol Chem 2025; 16(2): 107042
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"This mini-review is concise and well organised, providing a comprehensive overview of the topic. It effectively summarises the existing ..."
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"This mini-review is concise and well organised, providing a comprehensive overview of the topic. It effectively summarises the existing challenges and highlights the potential of stem cell therapy in Parkinson’s disease. To further enrich the article, it would be beneficial to include a comparative table summarising the different types of stem cells (e.g. ESCs, iPSCs and MSCs) and their respective advantages and disadvantages. Additionally, expanding upon novel technological advancements (e.g. CRISPR, organoids or biomaterials) would provide a forward-looking perspective that aligns with current research trends.
Overall, this article meets BPG's quality standards and is a valuable contribution to the field of neurodegenerative medicine.
However, the existing figures are relatively few, lack quantitative detail, and are very simple. For instance, it would be highly beneficial to include a comparative table summarising the different stem cell types, their sources, differentiation capacities, and clinical readiness. I would recommend adding at least one comprehensive table summarising and comparing therapeutic options, mechanisms or clinical trial data."
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Mokhtari YG, Varnava I, Kyrgiannis K, Ampatsidou V, Giakoumettis D. Stem cell therapy for Parkinson’s disease: A new hope for neural regeneration. World J Biol Chem 2025; 16(2): 106850
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"This is very interesting paper. I ask some questions for author. In the past, surgical necrosectomy was performed for necrotizing ..."
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"This is very interesting paper. I ask some questions for author. In the past, surgical necrosectomy was performed for necrotizing pancreatitis, but this had a high incidence of complications. In recent years, endoscopic drainage has become more effective, but should it be performed after waiting four weeks until encapsulated necrosis (WON) occurs, or if MOF or infection is difficult to control, should it be ？"
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Zeng Y, Zhang JW, Yang J. Endoscopic management of infected necrotizing pancreatitis: Advancing through standardization. World J Gastroenterol 2025; 31(20): 107451
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"The article is devoted to the search for new markers for the diagnosis of AMA-negative forms of primary biliary cholangitis (PBC), ..."
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"The article is devoted to the search for new markers for the diagnosis of AMA-negative forms of primary biliary cholangitis (PBC), which is an important problem in hepatology. The authors of the study posit that the antibodies to RPL30 that were identified may serve as such a marker. The rationale behind the authors' decision to focus on the RPL30 protein, a constituent of the 60S ribosome subunit involved in protein synthesis, remains ambiguous. The impaired protein synthesis function of the liver in PBC occurs when a patient develops signs of progressive cholestasis involving hepatocytes, both in AMA-positive and AMA-negative patients. At the same time, in the early stages of PBC, cholangiocytes lining the small (intralobular, interlobular) bile ducts are primarily damaged. Therefore, the authors' rationale for determining antibodies to RPL30 remains ambiguous. Besidesr, the article does not provide a comprehensive analysis of the relationship between the detection of antibodies against RPL30 and the data on histological signs that confirm the presence of PBC.
The results obtained by the authors on the diagnostic value of antimitochondrial antibodies for the diagnosis of PBC are questionable..
The objective of the present study is to identify novel biomarkers that can facilitate the diagnosis of AMA-negative forms of PBC, a significant area of research in the field of hepatology. However, the motives behind this study remain unclear. What was the prerequisite for the study of antibodies to ribosomal protein L30? What role can ribosomal protein L30 play in the pathogenesis of PBC?"
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Zeng ZY, Huang ZX, Wang YR, Xie LK, Lin YP, Liang Y, Liu ZY, Li DL, Zhang XY. Anti-RPL30 as a novel biomarker for enhanced diagnosis of autoantibody-negative primary biliary cholangitis. World J Gastroenterol 2025; 31(20): 104891
6
"Neuroendocrine tumors of the rectum are a relatively rare malignancy that is often diagnosed during colonoscopy. In recent years, ..."
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"Neuroendocrine tumors of the rectum are a relatively rare malignancy that is often diagnosed during colonoscopy. In recent years, its incidence has been observed to be increasing. These small tumors can be removed endoscopically using modified endoscopic submucosal resection (mEMR) or endoscopic submucosal resection. In the annotated review article, the authors discuss the indications, methods, risks, and difficulties of their endoscopic removal and propose a therapeutic algorithm to assist in making correct treatment decisions. An essential part of treating these tumors is the accurate evaluation of their endoscopic characteristics and the demonstration by means of imaging methods of any lymph node metastases or distant metastases. Also, an essential part of the correct treatment of these tumors, which is usually neglected in everyday clinical practice, is the avoidance of taking a simple biopsy. EMR with submucosal dilatation should be preferred. Patient follow-up is an essential part of proper patient management. Finally, managing these patients by a team of specialists, which includes a gastroenterologist, oncologist, and pathologist with substantial experience in diagnosing and treating these neoplasms, represents an essential element regarding the best possible management of the patients. This article contributes substantially to enriching the knowledge of gastroenterologists and oncologists about diagnosing and managing rectal neuroendocrine tumors. "
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Liu JN, Chen H, Fang N. Current status of endoscopic resection for small rectal neuroendocrine tumors. World J Gastroenterol 2025; 31(19): 106814
7
"This is a well-written and presented rarely case report about Chronic abdominal pain caused by foreign bodies in the appendix .This ..."
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"This is a well-written and presented rarely case report about Chronic abdominal pain caused by foreign bodies in the appendix .This manuscript gives additional new knowledge to the existing literature. This interesting and rare case report has certain guiding significance for clinicians.I think that this manuscript is worth to publication."
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Huang T, Li SK, Wang W, Zhang R. Chronic abdominal pain caused by foreign bodies in the appendix: A case report. World J Gastrointest Surg 2025; 17(5): 105423
8
"This is very interesting paper. In the past, obesity was said to be bad for treatment, but the current data shows that a BMI of ..."
[Read more]
"This is very interesting paper. In the past, obesity was said to be bad for treatment, but the current data shows that a BMI of >35mg/dl is said to be associated with a good prognosis.
lenvatinib and camrelizumab were good effect for obesity patient with HCC and have not yet been observed with more commonly used immunotherapy treatments for hepatocellular carcinoma, such as nivolumab, pembrolizumab, or bevacizumab.
In the past, obesity was said to be bad for treatment, but the current data shows that a BMI of >35mg/dl is said to be associated with a good prognosis.
"
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Sierra L, Abu-Hammour MN, Chatterjee A, Simons-Linares CR. Obesity paradox role in the immunosuppressive treatment of hepatocellular carcinoma. World J Gastroenterol 2025; 31(19): 105617
9
"The authors claimed that helicobacter pylori infection could promote the progression of gastric cancer by regulating the expression ..."
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"The authors claimed that helicobacter pylori infection could promote the progression of gastric cancer by regulating the expression of DMBT1, however,
The “tumor progression” involves multiple aspects. In this study, it was mainly investigated through in vitro “scratch, and Transwell assays”. It is too simple. Evidently, these approaches are insufficient to comprehensively address this complex issue. Another big concern is that, cancer is a complex system, not genetic disease. In fact, merely exploring the occurrence and development of cancer from the perspective of mutation/molecules pathway is insufficient to address the complex problems such as recurrence and resistance that arise in clinical practice."
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Zhou X, Wang LQ, Song S, Xu M, Li CP. Helicobacter pylori infection promotes the progression of gastric cancer by regulating the expression of DMBT1. World J Clin Oncol 2025; 16(5): 105322
10
"This study proposed that “HOXC6 may influence the cellular functions of BLCA by regulating the expression of the target gene TIMELESS,” ..."
[Read more]
"This study proposed that “HOXC6 may influence the cellular functions of BLCA by regulating the expression of the target gene TIMELESS,” yet no direct evidence was provided to substantiate this claim.
Another major concern is that cancer represents a complex system rather than merely a genetic disease. Indeed, focusing solely on mutations and molecular mechanisms to explore the occurrence and progression of cancer is insufficient to address the intricate challenges, such as recurrence and resistance, encountered in clinical practice.
Overall, this research is seriously lacking both in terms of its content and significance"
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Lu DJ, Wang HR, Xu YS, Huang HB, Zhong QG, Luo YN, Qi JF, Wu HC, Pei JY, Zhang K, Xu CX, Wang TX, Zhang W, Zhou YH, Huang ZG, Wang FB. Homeobox C6 plays an oncogenic role in bladder cancer. World J Clin Oncol 2025; 16(5): 103830
11
"This systematic review highlighted the growing role of hydroxyapatite, β-tricalcium phosphate, and fibrin-based products in bone ..."
[Read more]
"This systematic review highlighted the growing role of hydroxyapatite, β-tricalcium phosphate, and fibrin-based products in bone regeneration. However, this article contains few diagrams and the references are quite outdated. Although this literature provides a detailed account of the application of synthetic biomaterials combined with fibrin derivatives in bone regeneration medicine, there is still a significant lack of research at the molecular level."
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Pagani BT, Rosso MPO, Moscatel MBM, Trazzi BFM, da Cunha MR, Issa JPM, Buchaim DV, Buchaim RL. Update on synthetic biomaterials combined with fibrin derivatives for regenerative medicine: Applications in bone defect treatment: Systematic review. World J Orthop 2025; 16(5): 106181
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"This review is rich in illustrations and graphics, with appropriate methods and reliable results. Therefore, this article is highly ..."
[Read more]
"This review is rich in illustrations and graphics, with appropriate methods and reliable results. Therefore, this article is highly scientific and innovative. The author elaborated in detail on the formation mechanism and progress of neutrophil extracellular traps in common osteoarticular diseases. However, the mechanism of interaction between neutrophil extracellular traps and other cells in osteoarticular diseases has not been fully elucidated, and this should be a direction for future research."
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Sun GJ, Xu F, Jiao XY, Yin Y. Advances in research of neutrophil extracellular trap formation in osteoarticular diseases. World J Orthop 2025; 16(5): 106377
13
"In this manuscript, the authors analyzed the prevalence and incidence of ulcerative colitis and Crohn's disease using large medical ..."
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"In this manuscript, the authors analyzed the prevalence and incidence of ulcerative colitis and Crohn's disease using large medical record databases from three regions: Hong Kong, Japan, and the United States. In the results, substantial differences were identified among regions in absolute prevalence/incidence, temporal trends, and disease characteristics. Although the authors discussed various potential factors contributing to these differences, it is difficult to accept several explanations, such as the difference in NO2 exposure leading to the different prevalence and incidence of Crohn's disease between Japan and the USA. NO2 exposure at the time point may not differ between Japan and the USA with the magnitude reflected in the different prevalence/incidence of Crohn's disease. It would be ideal for the authors to include a discussion that proposes possible solutions to reduce the prevalence and incidence of inflammatory bowel diseases in each society."
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Zhang Y, Chung H, Fang QW, Xu YR, Zhang YJ, Nakajo K, Wong ICK, Leung WK, Qiu H, Li X. Current and forecasted 10-year prevalence and incidence of inflammatory bowel disease in Hong Kong, Japan, and the United States. World J Gastroenterol 2025; 31(18): 105472
14
"This manuscript employs a bibliometric analysis to map the field of spondylolisthesis research. Using the Web of Science database, ..."
[Read more]
"This manuscript employs a bibliometric analysis to map the field of spondylolisthesis research. Using the Web of Science database, the authors identified 1831 relevant articles. The study reveals a dramatic increase in publications post-2010, with the United States leading in contributions. The University of California, San Francisco, emerges as the most prolific institution. Spine is identified as the top journal publishing in this area. Keyword analysis highlights themes in clinical presentation, diagnosis, and treatment. The authors conclude that this work provides a methodological framework to synthesize historical and current trends in spondylolisthesis studies, but the authors acknowledge limitations due to dependence on the web of science collection database."
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Xu JN, Li Y, Zhao TX, Wu WY, Yang XW, Zhang HW, Chen Q, Xia C, Zhang J. Mapping the field of spondylolisthesis: A bibliometric analysis. World J Clin Cases 2025; 13(22): 99221
15
"This editorial critically analyzes a study by Maranhão et al. investigating pleural adenosine deaminase (P-ADA) as a biomarker for ..."
[Read more]
"This editorial critically analyzes a study by Maranhão et al. investigating pleural adenosine deaminase (P-ADA) as a biomarker for inflammatory pleural effusions. The editorial highlights the clinical relevance of the study, which established a cutoff value for P-ADA to differentiate between inflammatory and non-inflammatory pleural effusions. It emphasizes the study's novelty in providing a standardized P-ADA threshold in a Brazilian population, addressing inconsistencies found in previous studies. The editorial further explores the pathophysiological mechanisms underlying elevated P-ADA, linking it to purinergic signaling pathways and immune cell activation. The editorial acknowledges that using P-ADA leads to early diagnosis, improved treatment stratification and reduction in cost. The limitation is that the cutoff value requires validation across diverse population and the data is retrospective. Overall, the editorial positions P-ADA as a non-invasive, cost-effective biomarker with potential to streamline diagnostics, particularly in resource-limited settings, and calls for future research to prioritize global validation and explore integration with other biomarkers."
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Shi DD, Tian J, Ding J. Adenosine deaminase in pleural effusion: Bridging diagnosis and the pathophysiology of inflammation. World J Clin Cases 2025; 13(22): 106925
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Tasneem AA, Luck NH, Mubarak M. Mediastinal lymphadenopathy: Causes, symptoms and factors predicting good yield of endoscopic ultrasound-guided biopsy. World J Clin Cases 2025; 13(22): 105596
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Kucukakcali Z, Akbulut S. Role of immature granulocyte and blood biomarkers in predicting perforated acute appendicitis using machine learning model. World J Clin Cases 2025; 13(22): 104379
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Abdishakur AE, Ahmed MAA. Adult ileo cecal intussusception as a manifestation of colon carcinoma: A case report. World J Clin Cases 2025; 13(22): 104352
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Inoue Y, Yata Y, Yokota Y, Li ZL, Kawabata K. Acute pancreatitis after total aortic arch replacement leading to walled-off necrosis: A case report and review of literature. World J Clin Cases 2025; 13(22): 104165
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"This manuscript describes a rare case of walled-off necrosis (WON) after acute pancreatitis following total aortic arch replacement ..."
[Read more]
"This manuscript describes a rare case of walled-off necrosis (WON) after acute pancreatitis following total aortic arch replacement in a 67-year-old man. The case was successfully managed with the endoscopic ultrasound (EUS)-guided drainage of the peripancreatic fluid collection (PFC). The manuscript underscores the feasibility and safety of this endoscopic intervention in this clinical scenario, even though large prospective studies are certainly needed to draw conclusions in this direction."
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Inoue Y, Yata Y, Yokota Y, Li ZL, Kawabata K. Acute pancreatitis after total aortic arch replacement leading to walled-off necrosis: A case report and review of literature. World J Clin Cases 2025; 13(22): 104165
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Peer-Reviewers and Manuscript Statistics
- Editorial board members
- 2266
- Peer-reviewers
- 31305
- Manuscripts received today
- 2
- Manuscript reviews today
- 10
- Unhandled manuscripts today
- 164
- Active peer-reviewers today
- 340
- Reviewer acceptance today
- 13
- Reviewer refusals today
- 12
- Total accepted manuscripts
- 36244
- Total rejected manuscripts
- 41849
- Total peer-reviewers
- 4233731
- Total submissions
- 34467
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1
"This study presents significant findings regarding the metabolic effects of esophagectomy with gastric conduit reconstruction, ..."
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"This study presents significant findings regarding the metabolic effects of esophagectomy with gastric conduit reconstruction, particularly in T2D patients. Although the observed remission rate is modest compared to bariatric surgery outcomes, it opens up a new avenue for exploring the potential benefits of esophagectomy on metabolic health, especially in patients with comorbid diabetes. The study provides evidence that the use of a narrow gastric tube during esophagectomy might contribute to better diabetes outcomes, offering a potential modification to surgical practice that could improve patient care and prognosis. "
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Xing HJ, Hu MY, Jiang YQ, Li XH, Zhu B, Wang ZQ. Remission of type 2 diabetes one year after esophagectomy with gastric conduit reconstruction: A prospective cohort study. World J Gastrointest Surg 2025; 17(6): 105514
2
"The topic of perioperative nutritional support is highly relevant, particularly in the context of enhancing patient recovery and ..."
[Read more]
"The topic of perioperative nutritional support is highly relevant, particularly in the context of enhancing patient recovery and reducing postoperative complications. Given the increasing focus on improving surgical outcomes through preoperative interventions, this manuscript addresses a critical aspect of patient care. This paper underscores the importance of perioperative nutritional interventions and their potential to significantly improve postoperative outcomes, including reduced complications, shorter hospital stays, and faster recovery. Given the high rates of malnutrition and postoperative complications in gastrointestinal surgery patients, this review is highly significant for improving clinical practice. While the article touches on prehabilitation, the section could delve deeper into the specific methods of implementation and the practical challenges faced in clinical settings. A more detailed discussion of how to integrate prehabilitation into routine clinical practice, especially in less resource-rich environments, would add value for practitioners looking to apply these strategies. "
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Triantafillidis JK. Perioperative nutritional support in patients undergoing gastrointestinal surgery: Current views with an emphasis on prehabilitation efforts. World J Gastrointest Surg 2025; 17(6): 101244
3
"This review article is a really helpful and up-to-date look at how PET/CT scans using FDG are used for bile duct cancer (BTC). The ..."
[Read more]
"This review article is a really helpful and up-to-date look at how PET/CT scans using FDG are used for bile duct cancer (BTC). The authors do a great job pulling together the latest research, especially focusing on the past three years. They carefully examine how well PET/CT works for the different types of BTC – like cancers inside the liver (ICC), near the liver's exit (PCC), further down the bile duct (DCC), and gallbladder cancer (GBC). This breakdown is important because each type behaves differently. A key point the review makes is comparing PET/CT to standard scans like CT or MRI. PET/CT is generally better at finding cancer spread to lymph nodes, even if they aren't enlarged, and at spotting distant cancer spread elsewhere in the body. This can be crucial for planning treatment and avoiding unnecessary surgeries. However, the review honestly points out that PET/CT isn't perfect. It can sometimes miss smaller bile duct cancers (especially PCC) or cancers that produce a lot of mucus. It can also give "false alarms" due to inflammation, infection, or the presence of stents. The article highlights a significant shift happening: moving beyond just looking at the pictures to actually measuring things from the scan. Measurements like how "hot" the cancer appears (SUVmax) or the total amount of active cancer (MTV, TLG) can help doctors predict how aggressive the cancer might be and how long patients might live. Even more exciting is brand new research showing these PET/CT measurements might give clues about the cancer's genetics (like KRAS mutations in ICC) without needing a new biopsy. The review also covers advanced computer analysis of the scans (radiomics and AI), which shows promise in predicting things like how likely the cancer is to invade blood vessels or come back after surgery, especially for ICC. The authors also touch on the potential of combining PET with MRI (PET/MRI). This newer technology might offer better pictures of the soft tissues around the bile ducts and gallbladder, which could be useful for seeing exactly where the cancer is locally or if it has come back. However, more studies are needed, particularly for gallbladder cancer. Overall, this is a very valuable summary. It clearly explains where PET/CT is most useful right now for BTC patients – mainly in accurate staging to find hidden spread and guide treatment choices. It also effectively shows where the field is heading: using the scan data more precisely to understand the cancer's biology and predict outcomes, paving the way for more personalized care. The balanced view of both the strengths and weaknesses of PET/CT makes this review practical for doctors and informative for researchers looking at the future of imaging for these difficult cancers. "
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Yin JX, Fan X, Chen QL, Chen J, He J. Progress in the application of fludeoxyglucose positron emission tomography computed tomography in biliary tract cancer. World J Hepatol 2025; 17(5): 105446
4
"This bibliometric study systematically examines artificial intelligence applications in hepatobiliary surgery from 2014-2024, offering ..."
[Read more]
"This bibliometric study systematically examines artificial intelligence applications in hepatobiliary surgery from 2014-2024, offering a quantitative perspective on this evolving field. The research effectively maps global publication patterns, collaborative networks, and research priorities. The title accurately defines the scope, while the abstract concisely summarizes objectives, methodology, and key findings. Keywords demonstrate appropriate thematic alignment, and the background section adequately contextualizes AI's integration into hepatobiliary practice, noting its clinical relevance for diagnostic and therapeutic applications. Methodologically, the study employs Web of Science data with visualization tools (CiteSpace/VOSviewer) to analyze authorship, institutional contributions, national productivity, and keyword evolution. However, the search strategy shows limitations through its predominant focus on "CNN" (Convolutional Neural Networks), overlooking emerging architectures like Transformer models that are gaining prominence in medical AI research. Results clearly demonstrate China's leadership in publication volume alongside the United States' influence in citation impact, with network visualizations effectively illustrating these geographical patterns. The discussion reasonably outlines AI's role in imaging diagnostics and tumor segmentation, though greater analytical depth regarding clinical implementation challenges - such as model validation requirements and integration with surgical workflows - would strengthen its practical relevance. Presentation issues require attention as Figure 3 suffers from resolution limitations affecting text legibility, while Figures 10-11 contain non-essential graphical elements that reduce interpretive clarity. Strategic labeling could enhance data communication in these visualizations. Statistical approaches are appropriately applied for bibliometric analysis, and referenced literature shows generally authoritative coverage. Minor language issues exist, including inconsistent quotation usage in the abstract (e.g., "classification", "CT and "diagnosis") and occasional terminology variations, though these do not substantially hinder comprehension. Collectively, this work provides a structured, data-informed overview of AI research in hepatobiliary surgery during the specified decade. It documents the field's development trajectory, identifies primary research themes and key contributors, and establishes baseline patterns of international collaboration. The analysis offers researchers a useful reference point for understanding current research landscapes and potential partnership opportunities. With refinements addressing methodological scope, analytical depth, and visual presentation, the study could serve as a more comprehensive benchmark for future investigations in this domain. "
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Zheng RJ, Li DL, Lin HM, Wang JF, Luo YM, Tang Y, Li F, Hu Y, Su S. Bibliometrics of artificial intelligence applications in hepatobiliary surgery from 2014 to 2024. World J Gastrointest Surg 2025; 17(5): 104728
5
"The he article is well-written, and the research methodology is scientifically rigorous. The article holds significant scientific ..."
[Read more]
"The he article is well-written, and the research methodology is scientifically rigorous. The article holds significant scientific value and clinical relevance in the research of stem cell therapies for retinal pigment epithelium (RPE) cells. I hope the authors will address the current challenges in future studies, advancing the application of stem cell therapies in the treatment of RPE-related diseases. Thank you once again for your outstanding contributions to this field. "
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Sorrentino FS, Parmeggiani F, Gardini L, Fontana L, Musa M, Gagliano C, Zeppieri M. Stem cell therapy for retinal pigment epithelium disorders. World J Stem Cells 2025; 17(5): 103100
6
"Title: A Critical Appraisal of Dissociative Psychosis and Dissociative Schizophrenia as Distinct Entities Body: Having reviewed the ..."
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"Title: A Critical Appraisal of Dissociative Psychosis and Dissociative Schizophrenia as Distinct Entities Body: Having reviewed the article titled "Are dissociative psychosis and dissociative schizophrenia reality?" by H. Belli, I am compelled to offer a commentary that reflects on the conceptualization and clinical significance of these conditions. The article presents a comprehensive analysis of dissociative phenomena within the context of psychotic disorders, challenging readers to reconsider the boundaries between dissociative and schizophrenic experiences. Belli's work prompts a reevaluation of the diagnostic criteria and the potential overlap between dissociative symptoms and schizophrenia. The discussion on the role of childhood trauma as a precipitating factor for dissociative experiences that may manifest as psychotic symptoms is particularly noteworthy. It suggests a bio-psycho-social model that could enhance our understanding of the etiology and comorbidity of these disorders. The article also underscores the importance of psychometric testing in identifying dissociative features in individuals with psychotic disorders. This approach could potentially lead to more personalized and effective treatment strategies, emphasizing the need for a trauma-informed care framework. In conclusion, Belli's article contributes to a growing body of research that questions the traditional dichotomy between dissociative and psychotic disorders. It advocates for a more integrated view that recognizes the complexity of mental health conditions and the impact of early life experiences on later psychiatric outcomes. I look forward to future studies that build on these insights and further explore the implications for clinical practice and mental health policy. Reviewer: Lu Hou "
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Belli H. Are dissociative psychosis and dissociative schizophrenia reality? World J Psychiatry 2025; 15(4): 102008
7
"This study by Wang et al. presents a compelling advancement in the noninvasive prediction of variceal bleeding risk in Budd-Chiari ..."
[Read more]
"This study by Wang et al. presents a compelling advancement in the noninvasive prediction of variceal bleeding risk in Budd-Chiari syndrome (BCS) patients using a combined radiomics and clinical model (R+C model). The integration of high-dimensional radiomics features with clinical parameters to stratify bleeding risk is both innovative and clinically relevant. The authors should be commended for conducting a multicenter study with an external validation cohort, which strengthens the generalizability of their findings. Strengths of the Study: Innovative Use of Radiomics: The application of radiomics in BCS—a relatively rare and under-studied condition—represents a novel contribution. The extraction of hepatic and splenic texture features from CT images enhances the predictive capability beyond conventional clinical models. Robust Methodology: The use of LASSO Cox regression for feature selection and validation of the model using an external cohort adds credibility. The model’s performance metrics, such as the C-index (0.906 for training and 0.859 for validation), demonstrate excellent discriminative ability. Clinical Utility: The development of an accessible online tool for individualized risk prediction (https://bcsvh.shinyapps.io/BCS_Variceal_Bleeding_Risk_Tool/) is a practical step towards clinical translation, potentially aiding in decision-making for prophylactic interventions. Risk Stratification: The ability to categorize patients into low-, medium-, and high-risk groups offers a framework for personalized management strategies, which could reduce unnecessary interventions in low-risk patients and prioritize high-risk individuals for aggressive preventive therapies. Limitations and Areas for Improvement: Retrospective Design: As with all retrospective studies, the potential for selection bias and unmeasured confounding exists. Prospective validation in diverse populations, including Western cohorts where thrombophilic etiologies of BCS predominate, is necessary. Limited Radiomics Scope: The use of single-slice regions of interest (ROIs) for liver and spleen may not capture the full heterogeneity of these organs. A volumetric or multi-slice approach could improve robustness. Generalizability: The study population is entirely Chinese, with BCS cases predominantly due to membranous obstruction—an etiology not common in other geographic regions. Thus, external validation in populations with differing BCS etiologies is crucial. Anticoagulation Risk Interpretation: While anticoagulation was found to be an independent risk factor for bleeding, the model does not differentiate between anticoagulant types or dosing strategies. Given the importance of anticoagulation in BCS, further work is needed to clarify safe therapeutic windows. Manual Segmentation: The reliance on manual ROI delineation is resource-intensive and may limit scalability. Incorporating semi-automated or AI-driven segmentation could enhance reproducibility and feasibility in routine clinical settings "
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Wang ZD, Nan HJ, Li SX, Li LH, Liu ZC, Guo HH, Li L, Liu SY, Li H, Bai YL, Dang XW. Development and validation of a radiomics-based prediction model for variceal bleeding in patients with Budd-Chiari syndrome-related gastroesophageal varices. World J Gastroenterol 2025; 31(19): 104563
8
"I read a very interesting manuscript. The authors propose to use Hericium erinaceus to regress gastric mucosal atrophy. The authors ..."
[Read more]
"I read a very interesting manuscript. The authors propose to use Hericium erinaceus to regress gastric mucosal atrophy. The authors present convincing evidence of the effectiveness of this medicine. Prevention of gastric cancer has several successive stages of implementation (detection of precancerous diseases and precancerous changes in the gastric mucosa, implementation of screening, diagnostics, verification of diagnosis by morphological methods and treatment). Preventive treatment of precancerous lesions has a very limited number of means and methods. I believe that it is necessary to continue studying and using Hericium erinaceus. Perhaps Hericium erinaceus will be an effective drug for the prevention of gastric cancer. "
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Pellegrino R, Gravina AG. Potential of traditional Chinese medicine in gastrointestinal disorders: Hericium erinaceus in chronic atrophic gastritis. World J Gastroenterol 2025; 31(20): 106615
9
"This paper systematically analyzes the etiology of the two major subtypes of inflammatory bowel disease (IBD): Crohn’s disease and ..."
[Read more]
"This paper systematically analyzes the etiology of the two major subtypes of inflammatory bowel disease (IBD): Crohn’s disease and ulcerative colitis. It is highly comprehensive and commendable. It examines the etiology broadly, focusing on immune responses and considering genetic changes, gut microbiota, and social and environmental factors. On the other hand, further discussion is needed regarding how concretely these theoretical insights into etiology are linked to the development of therapeutic approaches. Additionally, genetic factors and changes in gut microbiota can vary by region, making universal evaluation difficult. "
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Yang QH, Zhang CN. Comparative study on the pathogenesis of Crohn’s disease and ulcerative colitis. World J Gastroenterol 2025; 31(19): 106406
10
"This minireview article provides a systematic comparison of the pathogenic mechanisms of Crohn’s disease and ulcerative colitis. It ..."
[Read more]
"This minireview article provides a systematic comparison of the pathogenic mechanisms of Crohn’s disease and ulcerative colitis. It outlines six shared mechanisms—including immune dysregulation, genetics, microbiota imbalance, and infections—and identifies 14 key differences between the two diseases. The article is well-structured, comprehensive in scope, and supported by clear diagrams, offering strong academic value and clinical relevance. While its originality and depth of mechanistic insight could be further improved and the discussion on clinical translation is somewhat limited, it remains a well-organized and information-rich review suitable for researchers and clinicians alike. "
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Yang QH, Zhang CN. Comparative study on the pathogenesis of Crohn’s disease and ulcerative colitis. World J Gastroenterol 2025; 31(19): 106406
11
"This article explores the role of the "obesity paradox" in immunotherapy for hepatocellular carcinoma (HCC), suggesting that obese ..."
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"This article explores the role of the "obesity paradox" in immunotherapy for hepatocellular carcinoma (HCC), suggesting that obese patients may experience better survival outcomes when treated with immune checkpoint inhibitors such as lenvatinib and camrelizumab. Based on recent clinical findings, the authors discuss leptin-mediated immune modulation as a possible mechanism, noting that obesity may enhance the efficacy of anti-PD-1 therapies but potentially reduce the effectiveness of anti-VEGF treatments. While the topic is novel and clinically relevant, the current evidence remains limited and the mechanistic explanation could be more detailed. Overall, the article provides a valuable perspective on the dual role of obesity in HCC immunotherapy and highlights the need for further research in this area. "
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Sierra L, Abu-Hammour MN, Chatterjee A, Simons-Linares CR. Obesity paradox role in the immunosuppressive treatment of hepatocellular carcinoma. World J Gastroenterol 2025; 31(19): 105617
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"Reader′s comments: We are delighted to read the interesting article by Hu et al entitled: "Pescadillo ribosomal biogenesis factor ..."
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"Reader′s comments: We are delighted to read the interesting article by Hu et al entitled: "Pescadillo ribosomal biogenesis factor 1 and programmed death-ligand 1 in gastric and head and neck squamous cell carcinoma"it is an interesting study, but we have some comments: In section of patients selection: exclusion criteria: it is not clear what was meant by pathological condition????? I think it is better to represent demographic , clinical data of enrolled patients. Result section: it is better to clear if difference between positive and negative patients is significant or not. What about expression of the studied markers in adjacent non tumor tissues???????? "
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Hu XN, Li CF, Huang SM, Nie CL, Pang R. Pescadillo ribosomal biogenesis factor 1 and programmed death-ligand 1 in gastric and head and neck squamous cell carcinoma. World J Gastroenterol 2025; 31(19): 106644
13
"Shukla et al.'s comprehensive review on remnant pancreatic carcinoma (RPC) brings much-needed attention to a rare but clinically ..."
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"Shukla et al.'s comprehensive review on remnant pancreatic carcinoma (RPC) brings much-needed attention to a rare but clinically formidable entity increasingly recognized in the era of improved surgical outcomes and long-term survival following partial pancreatectomy. Their work, titled "Remnant Pancreatic Carcinoma: The Current Status", outlines the epidemiology, risk factors, surveillance strategies, and therapeutic challenges of RPC, providing a valuable clinical framework for a condition historically relegated to case reports and small series. The authors astutely emphasize the evolving landscape of RPC, shaped by the growing volume of patients undergoing distal or proximal pancreatectomy for benign or malignant lesions. The incidence of RPC is likely underestimated, given limited long-term follow-up in most cohorts. As such, the article's call for structured postoperative surveillance protocols is particularly timely. Importantly, Shukla et al. underscore that remnant pancreatic malignancies may arise de novo or as recurrences, and often present with more aggressive histological and molecular profiles, reinforcing the need for tailored risk stratification. A notable strength of this review is its discussion on the putative mechanisms underlying RPC, including genetic predisposition, field cancerization, and chronic inflammation of the residual gland. These insights are crucial for identifying high-risk patients who may benefit from enhanced surveillance or prophylactic strategies. However, while the authors reference KRAS and TP53 mutations, a more extensive exploration of genomic drivers and their potential as surveillance biomarkers would have added translational depth. Surgically, re-resection remains the mainstay of curative intent in selected patients with adequate functional reserve. The article appropriately highlights the technical and oncological complexities of completion pancreatectomy. Nonetheless, future perspectives might benefit from the integration of evolving minimally invasive approaches and neoadjuvant strategies tailored to RPC biology. One of the article’s understated yet significant contributions is its implication that RPC represents a failure of current surveillance paradigms. Given the shift towards parenchyma-sparing resections and increased survivorship, integrating longitudinal imaging and biomarker monitoring—such as circulating tumor DNA (ctDNA) or CA 19-9 kinetics—may optimize early detection. Moreover, data on long-term outcomes post-remnant resection remain sparse, and prospective registries are needed to define survival benchmarks and refine selection criteria. In conclusion, Shukla et al. succeed in framing RPC not merely as a post-surgical curiosity, but as a distinct oncological entity warranting multidisciplinary attention. Their review lays the foundation for future clinical and translational studies in a domain poised to grow in relevance. Establishing consensus on definitions, risk stratification algorithms, and surveillance protocols will be essential to improving outcomes in this uniquely challenging subset of pancreatic cancer. "
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Shukla A, Kalayarasan R, Sai Krishna P, Pottakkat B. Remnant pancreatic carcinoma: The current status. World J Clin Oncol 2025; 16(5): 107039
14
"The “obesity paradox” in hepatocellular carcinoma suggests better outcomes in patients with obesity undergoing immunotherapy, ..."
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"The “obesity paradox” in hepatocellular carcinoma suggests better outcomes in patients with obesity undergoing immunotherapy, potentially due to leptin-driven immune modulation and enhanced nutritional reserves. While promising, these findings have only been demonstrated with lenvatinib and camrelizumab, and have not yet been observed with more commonly used immunotherapy treatments for hepatocellular carcinoma, such as nivolumab, pembrolizumab, or bevacizumab. Although intriguing, this phenomenon remains limited by the scope of current studies "
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Sierra L, Abu-Hammour MN, Chatterjee A, Simons-Linares CR. Obesity paradox role in the immunosuppressive treatment of hepatocellular carcinoma. World J Gastroenterol 2025; 31(19): 105617
15
"Six common and fourteen unique aspects of the pathogenesis of inflammatory bowel disease, primarily Crohn’s disease and ulcerative ..."
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"Six common and fourteen unique aspects of the pathogenesis of inflammatory bowel disease, primarily Crohn’s disease and ulcerative colitis, illustrate the causes and beneficial factors of resistance to inflammatory bowel disease, providing critical insights for the targeted treatment of Crohn’s disease and ulcerative colitis. Utilizing the main contents of this paper allows for the development of comprehensive interventions that reduce harmful influences, enhance protective factors and use an integrative approach to address the diseases for the benefit of the human being "
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Yang QH, Zhang CN. Comparative study on the pathogenesis of Crohn’s disease and ulcerative colitis. World J Gastroenterol 2025; 31(19): 106406
16
"The article is devoted to the problem of introducing narrative medicine into primary health care systems. This process is part of ..."
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"The article is devoted to the problem of introducing narrative medicine into primary health care systems. This process is part of the enriching the humanistic dimensions of medical care and, in general, of a systemic approach to maintaining public health. The relevance of this problem has significantly increased recently due to the increasing role of instrumental component of the medical industry and some dehumanization associated primarily with the crisis of individualizing clinical approach and increasing standardization in the provision of medical services. It is expected that the development of narrative medicine can improve the comfort of doctor-patient interaction, provide a personalized approach with improved diagnostic efficiency and quality of treatment. The authors analyze the main problems of the widespread introduction of narrative medicine in primary health care, namely, the strengthening of the humanitarian component in the educational programs of medical professionals, increasing the burden on the staff, the need to allocate additional funds, the peculiarities of the national health care system of China. The article discusses possible solutions to some of these problems, such as the involvement of volunteers, application of artificial intelligence, optimization of equipment operation mode in order to save money. Feedback mechanisms, telemedicine methods, etc. are built into the implementation system proposed by the authors. However, it seems that the proposed schemes need experimental validation, which requires the creation of interdisciplinary research groups in which doctors and humanities can interact. Given the peculiarities of the humanitarian environment of Chinese society, it would be appropriate to include representatives of different schools of psychology and even philosophy in such groups. In general, given the novelty of the problem and its relevance, the quality of the article is quite high. "
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Lei NJ, Vaishnani DK, Shaheen M, Pisheh H, Zeng J, Ying FR, Yang QQ, Wang CY, Ma J, Pan JY, Hou NJ. Embedding narrative medicine in primary healthcare: Exploration and practice from a medical humanities perspective. World J Clin Cases 2025; 13(22): 105684
17
"The studied groups were not homogeneous by age and gender proportion. Research does not achieve the objectives of the experiment. ..."
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"The studied groups were not homogeneous by age and gender proportion. Research does not achieve the objectives of the experiment. The results are unreliable and cannot be considered to be a meaningful contribution to research progress in this field. Furthermore, the comorbidity was not reported: this represents a further limit that could affect the results. "
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Buterin A, Vuckovic M, Spanja Prpic S, Zaharija V, Nonkovic M, Prpic T. Comparison of functional recovery of the knee following total knee arthroplasty in patients with and without ankle symptoms. World J Orthop 2025; 16(5): 106004
18
"This prospective study rightly identifies a significant problem i.e.,preoperative ankle pain might effect the early functional outcome ..."
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"This prospective study rightly identifies a significant problem i.e.,preoperative ankle pain might effect the early functional outcome in patients undergoing total knee arthroplasty for primary Osteoarthritis knee.It is often overlooked but the deformity at the level of knee definitely impacts the biomechanics alignment of the entire lower limb and also at the ankle. The key finding was patients exhibited significantly lower KOOS scores and extension recovery at 3 months postoperatively, even after adjusting for demographic confounders. This reiterates the necessity for a complete lower limb assessment and managing preoperatively any hip/ankle symptoms preoperatively to optimize TKA outcomes. The methodology, protocol, grouping of patients was all good. The authors could have given a detailed radiographic alignment of the patient's lowerliimbs that were operated to substantiate the preoperative status and the results postoperatively. Even though AOFAS score, is an appropriate tool for assessing the ankle symptoms and pathologies, a detailed radiographic assessment of the ankle including ankle hind foot assessment, weight bearing alignment could have been added/ mentioned. Incorporating pre- and postoperative radiographs would have allowed the authors to better delineate whether the observed differences in KOOS and knee extension were attributable to underlying mechanical misalignment or simply symptomatic variation. A gait analysis of the patients can also be included to add objective assessment to the data. That would tell us whether the results are an outcome of any malalignment or just symptomatic variation. A longer followup would also suggest us whether the symptoms are resolving over time or still persisting. "
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Buterin A, Vuckovic M, Spanja Prpic S, Zaharija V, Nonkovic M, Prpic T. Comparison of functional recovery of the knee following total knee arthroplasty in patients with and without ankle symptoms. World J Orthop 2025; 16(5): 106004
19
"This study addresses the deficit of medical humanities in China’s resource-limited primary healthcare (PHC) system by systematically ..."
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"This study addresses the deficit of medical humanities in China’s resource-limited primary healthcare (PHC) system by systematically exploring pathways to integrate narrative medicine (NM) into grassroots care. Situated within the Healthy China 2030 policy framework, the research proposes actionable strategies for humanizing PHC through theoretical analysis and practical innovations, such as the One-Minute Patient Narrative and 11253 Family Doctor Service Model. Key contributions include: (1) revealing tensions between policy mandates and on-the-ground realities, emphasizing NM’s localization to regional disparities; (2) enhancing care efficiency via AI-mediated narrative analysis (e.g., a 25% increase in treatment adherence); and (3) offering scalable models to ensure PHC sustainability. However, three critical gaps require further exploration. First, cultural dynamics—such as patients’ traditional deference to medical authority and healthcare commercialization—demand culturally adaptive interventions (e.g., competency training for clinicians, redefining relational medicine values). Current analyses lack actionable steps to operationalize these strategies across diverse contexts. Second, sustainability challenges—including the feasibility of urban NM models in high-demand rural settings and volunteer system stability in under-resourced areas—are underexamined. Systemic inequities (e.g., funding gaps, workforce shortages) further constrain implementation. Third, while short-term metrics like patient satisfaction are prioritized, long-term systemic issues—health equity, clinician burnout, and bureaucratic barriers to PDCA (Plan-Do-Check-Act) cycles—remain unaddressed. Future studies must adopt mixed-method evaluations to bridge these gaps and enable NM’s transition from pilot projects to systemic reform. To further this agenda, this study presents a three-pillar framework. Firstly, by fostering interdisciplinary collaboration, we aim to integrate public health experts, community advocates, and policymakers. Together, they will devise NM interventions, such as narrative-driven public health campaigns. This approach will transform patient stories into effective social governance tools, thereby enhancing the inclusivity of medical decision-making. Secondly, we propose establishing an ethical AI governance system. This system will ensure that AI-driven narrative data processing aligns with China's data security regulations. We plan to adopt encryption technology and an informed consent mechanism to bolster privacy protections. Additionally, we will systematically mitigate technical biases through algorithm fairness audits and transparent training protocols, including the use of open dataset sources. Finally, we advocate for a global localization adaptation strategy, drawing inspiration from international practices like the Indian Asha worker model. While respecting the universal principle of patient autonomy, we intend to devise localized solutions, such as a health narrative literacy improvement project tailored for rural areas. This will facilitate the effective integration of medical humanistic values within diverse social and cultural contexts. Ultimately, this framework aims to shift healthcare paradigms from fragmented, biomarker-centric models to holistic, humanistic systems. By empowering patients and frontline workers as NM co-designers through participatory research, localized innovations can catalyze structural reforms, ensuring medical services prioritize humanistic care over purely biomedical metrics. "
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Lei NJ, Vaishnani DK, Shaheen M, Pisheh H, Zeng J, Ying FR, Yang QQ, Wang CY, Ma J, Pan JY, Hou NJ. Embedding narrative medicine in primary healthcare: Exploration and practice from a medical humanities perspective. World J Clin Cases 2025; 13(22): 105684
20
"Endoscopic gastroplasty treatments were significantly better in reducing total body weight, excessive weight, and average weight among ..."
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"Endoscopic gastroplasty treatments were significantly better in reducing total body weight, excessive weight, and average weight among obese population. No significant difference between endoscopic transoral outlet reduction and full-thickness suturing plus argon plasma mucosal coagulation. Lack of comparative, long-term follow-up and randomized studies, reporting and selection bias, high level of heterogeneity were the major limitations in the currently available meta-analyses. "
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Abdulla M, Mohammed N, AlQamish J, Arau RT. Efficacy and safety of endoscopic gastroplasty for treatment of obesity: An overview of comparative meta-analyses. World J Gastrointest Endosc 2025; 17(5): 105158
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