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2025-01-18 | Browse: 16 | Download: 7
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2025-01-18 | Browse: 21 | Download: 0
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2025-01-18 | Browse: 12 | Download: 0
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471 items Read more >>
1
"Thanks for the joint efforts of the assistant editor, science editor, peer reviewers, editorial director, journal editor-in-chief, ..."
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"Thanks for the joint efforts of the assistant editor, science editor, peer reviewers, editorial director, journal editor-in-chief, company editor-in-chief, language editor and production editor. All the responses are prompt, meticulous, and responsible. We extend our gratitude to the editor for their meticulous review, attentive modifications to the images, and the prompt follow-up on the article. "
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Ge YY, Xia XC, Wu AQ, Ma CY, Yu LH, Zhou JY. Identifying adipocyte-derived exosomal miRNAs as potential novel prognostic markers for radiotherapy of esophageal squamous cell carcinoma. World J Gastrointest Oncol 2025; 17(2): 98808
2
"The overall quality of Journal's credibility in our opinion is high. The whole process has been conducted in a rigorous manner. The ..."
[Read more]
"The overall quality of Journal's credibility in our opinion is high. The whole process has been conducted in a rigorous manner. The peer review report was clear and very useful in order to improve the quality of the paper. The time spent for peer review process was adeguate and fast. Generally, the authors are satisfied with the publishing process. "
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Evola G, Vacante M, Evola FR. Confocal laser endomicroscopy as a new diagnostic tool for poorly differentiated gastric adenocarcinoma. World J Clin Cases 2024; 12(26): 5845-5849
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"I found the process easy to follow. The initial peer review report was helpful in enabling me to complete editing. The reviews happened ..."
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"I found the process easy to follow. The initial peer review report was helpful in enabling me to complete editing. The reviews happened whilst I was on holiday and found the team's replies and understanding in moving deadlines really helpful and reduced stress for me. Everything was done in a timely manner. "
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McGinty G, Przemioslo R. Effects of excess high-normal alanine aminotransferase levels in relation to new-onset metabolic dysfunction-associated fatty liver disease: Clinical implications. World J Gastroenterol 2024; 30(27): 3264-3267
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"Throughout this submission process, I've reaped nothing but satisfaction and joy. Right from the start, the editorial department ..."
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"Throughout this submission process, I've reaped nothing but satisfaction and joy. Right from the start, the editorial department provided a comprehensive and clear submission guide, which gave me a precise understanding of the requirements for manuscript format, thematic direction, and more. This guidance was instrumental in steering my creative process and preventing numerous potential detours. The submission system was a pleasure to use—streamlined and user-friendly, with an intuitive interface. Uploading the manuscript and filling in the necessary information were seamless tasks, making the entire process a smooth sail. During the review period, I could easily track the real-time status of my manuscript through the system. This transparent process was a source of comfort, sparing me from the anxiety that often accompanies waiting in the dark. What truly delighted me was the timely and professional feedback from the editorial team. Even though my initial draft had its shortcomings, the editors patiently pointed out the issues and offered constructive suggestions for improvement. In my communications with them, I sensed their reverence for the written word, their passion for their work, and their respect and support for authors. After revising the manuscript according to their advice and resubmitting it, it was ultimately accepted. This not only affirmed my work but also served as a testament to the efficient and fair nature of the submission process. This submission experience has allowed me to enjoy a professional, efficient, and warm service from beginning to end. It has added a bright hue to my creative journey and has me eagerly looking forward to more collaborations with this platform in the future. "
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Yang TF, Kong MW. Innovative applications and research progress of hepatic arterial infusion chemotherapy in the treatment of advanced hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(2): 99332
5
"I sincerely hope that the World Journal of Orthopedics will become better and better, publish more high-level articles, and become ..."
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"I sincerely hope that the World Journal of Orthopedics will become better and better, publish more high-level articles, and become the best journal in orthopedics in the world. I hope that this journal can invite world-class orthopedic experts to organize manuscripts on a hot topic and then publish a special issue this year, which attract more readers and thus increase the international influence of the journal. "
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Peng BG. Fundamentals of intervertebral disc degeneration and related discogenic pain. World J Orthop 2025; 16(1): 102119
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"I sincerely hope that the World Journal of Orthopedics will become better and better, publish more high-level articles, and become ..."
[Read more]
"I sincerely hope that the World Journal of Orthopedics will become better and better, publish more high-level articles, and become the best journal in orthopedics in the world. I hope that this journal will invite more world-class orthopedic experts to publish high-level review articles this year, and try not to publish case reports. "
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Peng BG, Li YC, Yang L. Role of neurogenic inflammation in intervertebral disc degeneration. World J Orthop 2025; 16(1): 102120
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"First of all, we are honored that our article has been published in your journal and we are very satisfied that your submission process ..."
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"First of all, we are honored that our article has been published in your journal and we are very satisfied that your submission process is reasonable. Secondly, we would like to express our sincere thanks to the editors and reviewers. The editors are very professional in their work and always solve our problems in time when we have doubts, and we learn a lot from the reviewers' opinions. "
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Wang L, Li ZY, Wu F, Tan GQ, Wang BL. Endoscopic retrograde cholangiopancreatography for patients aged ninety and older with choledocholithiasis: A single-center experience in south China. World J Gastrointest Endosc 2025; 17(1): 102010
8
"I extend my heartfelt gratitude to the magazine and its editors for their invaluable assistance and guidance. The editors are ..."
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"I extend my heartfelt gratitude to the magazine and its editors for their invaluable assistance and guidance. The editors are exceptionally kind, providing timely corrections to any mistakes I make. My communication with them flows effortlessly, and their instructions regarding article revisions are both clear and detailed. I eagerly anticipate the opportunity to submit my work to your esteemed magazine once again. Thank you! "
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Gong Y. Calcineurin inhibitors-related posterior reversible encephalopathy syndrome in liver transplant recipients: Three case reports and review of literature. World J Hepatol 2024; 16(9): 1297-1307
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"I am highly satisfied with the editorial and peer review process of World Journal of Clinical Cases. The submission, review, and ..."
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"I am highly satisfied with the editorial and peer review process of World Journal of Clinical Cases. The submission, review, and publication procedures were efficient and well-organized. The constructive feedback from reviewers and editors significantly contributed to the improvement of my manuscript. I appreciate the professionalism and timely communication throughout the process. Thank you for your excellent editorial support. I look forward to collaborating with WJCC again in the future. "
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Fu XP. Dual benefits of sodium-glucose cotransporter 2 inhibitors in metabolic diseases: Diabetes control and gout management. World J Clin Cases 2025; 13(14): 100262
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"There was no other comment in our team. There was no other comment in our team. There was no other comment in our team. There was ..."
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"There was no other comment in our team. There was no other comment in our team. There was no other comment in our team. There was no other comment in our team. There was no other comment in our team. There was no other comment in our team. There was no other comment in our team. "
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Li Y, Luo Y, Peng J, Fan J, Long XT. Clinical effect of operative vs nonoperative treatment on humeral shaft fractures: Systematic review and meta-analysis of clinical trials. World J Orthop 2024; 15(8): 783-795
11
"We are very delighted with the whole process from submission to publication of the paper. In general, the submission process depends ..."
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"We are very delighted with the whole process from submission to publication of the paper. In general, the submission process depends on the computer-assisted search of reviewers which was fast and confidential. From the reviewers' comments to the editor decision tool a few weeks which was very fast as well. "
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Liu WN, Dai MS, Lin F, Lin GM. Navigating the complex terrain of hepatitis B virus reactivation in the era of Bruton tyrosine kinase inhibitors. World J Gastroenterol 2024; 30(21): 2748-2750
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"Outstanding peer review processing system that operates in a timely fashion! I am very satisfied with the time spent for peer review, ..."
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"Outstanding peer review processing system that operates in a timely fashion! I am very satisfied with the time spent for peer review, period of publication and online submission system and the quality of PDF and the published article processes. Looking forward to submitting many more manuscripts in the near future. "
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Khoury KM, Jradi A, Karam K, Fiani E. Lymphogranuloma venereum proctosigmoiditis misdiagnosed as inflammatory bowel disease: A case report. World J Clin Cases 2025; 13(14): 102791
13
"As a more outstanding journal in the field of orthopedics, this journal has been praised by everyone, and this journal has a faster ..."
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"As a more outstanding journal in the field of orthopedics, this journal has been praised by everyone, and this journal has a faster review speed and pertinent review comments, which is suitable for us to publish high-quality papers in this journal.We also hope thatWe also hope that your journalWe also hope that your journal willWe hope that your journal will continue to do its best!We also hope that your journal will continue to do its best.We also hope that your journal can continue to make efforts to helpWe also hope that your journal can continue its efforts to help moreWe also hope that your journal can continue to work hard to help more people!We hope that your journal can keep up the good work and help more people to come to us.We hope that your journal can keep up the good work and help more people to publish.We hope that your journal can keep up the good work and help more people to publish high quality papers in this journal.We hope that your journal can keep up the good work and help more people to publish high quality papers.We hope that your journal can keep up the good work and help more people to publish high quality papers. "
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Qiao YJ, Song XY, Zhang LD, Li F, Zhang HQ, Zhou SH. Comparative study of a rabbit model of spinal tuberculosis using different concentrations of Mycobacterium tuberculosis. World J Orthop 2025; 16(1): 101424
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"Authors are thankful for the support provided by the Editorial Board during publication. We extend our thanks to the reviewers for ..."
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"Authors are thankful for the support provided by the Editorial Board during publication. We extend our thanks to the reviewers for their detailed and insightful feedback, which has significantly enhanced the impact of our manuscript. We look forward to continued collaboration with World Journal of Psychiatry and hope our work will contribute meaningfully to the field. "
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Dabla PK, Gupta S, Singh S, Viswas A, Yadav M, Sonkar SC, Koner BC. Sodium channel mutation SCN1A T875M, D188V and associated dysfunction with drug resistant epilepsy. World J Psychiatry 2025; 15(2): 100738
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"I am very satisfied with the process of publishing articles, the quality of editing, and the submission system. The peer review report ..."
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"I am very satisfied with the process of publishing articles, the quality of editing, and the submission system. The peer review report of my manuscript is fair and objective, and it has been of great help to my manuscript. Thank you for the work done by your magazine on my article. "
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Zhao YP, Liu WH, Zhang QC. Determinants of generalized anxiety and construction of a predictive model in patients with chronic obstructive pulmonary disease. World J Psychiatry 2025; 15(2): 98447
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"It is nice to publish at World Journal of Gastroenterology. We have always felt the support of the editors and peer-reviewers. Our ..."
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"It is nice to publish at World Journal of Gastroenterology. We have always felt the support of the editors and peer-reviewers. Our requests were always responded to very quickly. The process between the initial decision and the publication of our article moved very quickly. We believe that this journal has made great contributions to the gastroenterology community. "
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Ozbey D, Saribas S, Kocazeybek B. Gut microbiota in Crohn’s disease pathogenesis. World J Gastroenterol 2025; 31(6): 101266
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"I am extremely pleased with the smooth and professional process of publishing my paper in your esteemed journal. The experience has ..."
[Read more]
"I am extremely pleased with the smooth and professional process of publishing my paper in your esteemed journal. The experience has been highly satisfying, and I deeply appreciate the support and guidance provided throughout. In the future, I hope to have the opportunity to submit more of my work to your journal and continue contributing to its high-quality publications. Thank you once again for your efforts and dedication, which have made this experience truly rewarding. I look forward to collaborating with your journal again in the near future. "
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Sun YY, Xia Y, Zhi QN, Liu XY. Diagnosis and treatment of bipolar disorder in Phelan-McDermid syndrome: A case report and review of literature. World J Psychiatry 2025; 15(2): 101948
18
"I am grateful for your peer review report for this manuscript and appreciate your comments. It is unfortunate that it took so long ..."
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"I am grateful for your peer review report for this manuscript and appreciate your comments. It is unfortunate that it took so long from the first submission to the first peer review, but I believe that the comments were useful and helped to improve the quality of the manuscript. So, I satisfied with the manuscript editing and publishing process. "
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Kaneko T, Kida M, Kurosu T, Kitahara G, Koyama S, Nomura N, Tahara K, Kusano C. Outcomes of bile duct cannulation using a novel contrast-enhanced catheter: A single-center, retrospective cohort study. World J Gastrointest Endosc 2025; 17(1): 97840
19
"it is a useful system. WJGE accepts both solicited and unsolicited manuscripts. Articles published in WJGE are high-quality, clinical ..."
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"it is a useful system. WJGE accepts both solicited and unsolicited manuscripts. Articles published in WJGE are high-quality, clinical and basic, influential research articles by established academic authors as well as new researchers. The paramount objective of WJGE is to showcase and promote distinguished research in the field of gastrointestinal endoscopy. I will submit my manuscript to this journal again. "
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Liu YL, Liu J, Wang YT. Early esophageal cancer with mucosal bridging in the resting room: A case report. World J Gastrointest Endosc 2025; 17(1): 103404
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"It was an overall great experience and honor to be publishing with Baishideng World Journal of Gastroenterology- Thank you. The overall ..."
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"It was an overall great experience and honor to be publishing with Baishideng World Journal of Gastroenterology- Thank you. The overall publication process was very scientific, timely, seamless and updated according to required norms. The unwavering effort to find a peer reviewer for the process is highly appreciated. Hope to be publishing more articles with the journal and publisher. "
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Hazrah P. Reflux after peroral endoscopic myotomy: The dilemma and the options. World J Gastroenterol 2025; 31(6): 100510
17911 items Read more >>
1
"1. The title can include recipient extubation for clarity
2. The operating time appears to be different for both the groups. Did ..."
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"1. The title can include recipient extubation for clarity
2. The operating time appears to be different for both the groups. Did prolonged surgical time have a bearing on extubation?
3. Diffcult anatomy / reconstruction - was it given consideration during the analysis?
4. Was the surgeon factor considered across the groups - senior / junior?
5. What about the anesthesia team - was it the same across the groups?
6. Limiting factors - non randomisation / surgeon / anesthetist factors"
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Jeon S, Lim DG, Kim H, You SB, Kim HJ, Yoon JP, Yang K, Park SJ, Ri HS. Relevant clinical factors for early extubation in living-donor liver transplantation: A single-center retrospective cohort study. World J Clin Cases 2025; 13(14): 102693
2
"Unveiling expression patterns, mechanisms, and therapeutic opportunities of transmembrane protein 106C: From pan-cancers to ..."
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"Unveiling expression patterns, mechanisms, and therapeutic opportunities of transmembrane protein 106C: From pan-cancers to hepatocellular carcinoma
World J Gastrointest Oncol 2025; 17(2): 92437 [DOI:10.4251/wjgo.v17.i2.92437]
I congratulate the authors on publishing the above-titled manuscript. The authors are targeting an important research question, and they used several tools to provide an answer from the 34 cancers they tested, including hepatocellular carcinoma. I have three comments-
The title is not clear - "From pan-cancers to hepatocellular carcinoma"- it showed be instead testing 34 cancers, including hepatocellular carcinoma". We use "pan-cancer analysis", not from ..to, as stated.
These 34 cancers should be stated in the introduction or the methods. I see some mentioned in the note under Figures 1 and 2. Informing the readers about them early is crucial. also, why they were selected.
There is a bias in selecting references. Nearly most references (total 37) are by Chinese authors, may be you need to look into the broader English literature and include references from the USA, the UK, Canada, Europe, Japan, South Korea, Australia and New Zealand. Thank you."
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Li JD, He RQ, Dang YW, Huang ZG, Xiong DD, Zhang L, Du XF, Chen G. Unveiling expression patterns, mechanisms, and therapeutic opportunities of transmembrane protein 106C: From pan-cancers to hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(2): 92437
3
"Cost-effective treatment strategies for liver fibrosis/cirrhosis are limited. Many clinical trials have shown that stem cells might ..."
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"Cost-effective treatment strategies for liver fibrosis/cirrhosis are limited. Many clinical trials have shown that stem cells might be a potential therapeutic approach here. This study presented the first bibliometric analysis of stem cell therapy for liver fibrosis/cirrhosis. This is useful information for future research on problems and trends in stem cell therapy for liver fibrosis/cirrhosis.
"
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Zhu WY, Li X, Xie JL, Lu Q, Ma YJ, Zhu ZJ, Liu J. Hotspots and trends in stem cell therapy for liver fibrosis and cirrhosis: A bibliometric analysis. World J Hepatol 2025; 17(1): 96105
4
"Fecal transplantation appears to be effective for refractory Crohn's disease, but please mention the intestinal flora before and after ..."
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"Fecal transplantation appears to be effective for refractory Crohn's disease, but please mention the intestinal flora before and after the procedure, and the short-chain fatty acids lactic acid, butyric acid, and acetic acid. Also, please describe contraindications for fecal transplantation for refractory Crohn's disease.How long do the effects of fecal transplants last?"
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Ozbey D, Saribas S, Kocazeybek B. Gut microbiota in Crohn’s disease pathogenesis. World J Gastroenterol 2025; 31(6): 101266
5
"1 Ethics: Yes, the ethical approval form provided by the author that meets the requirements
2 Methods: Experimental method effective ..."
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"1 Ethics: Yes, the ethical approval form provided by the author that meets the requirements
2 Methods: Experimental method effective and well described by authors
3 Results: Yes, the results true and authentic. it is validated very well.
4 Figures and tables: Good quality and well constructive
5 Biostatistics: Yes, validated and perfect biostatistics data
6 References: Recent and relevant to the topic
7 Language: Good quality of language in article correctly, clearly and concisely without any grammatical and spelling mistakes.
8 Caveats or drawbacks: No obsvious caveats or drawbacks for the results noted"
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Ba MQ, Zheng WL, Zhang YL, Zhang LL, Chen JJ, Ma J, Huang JL. Construction of a nomogram prediction model for early postoperative stoma complications of colorectal cancer. World J Gastrointest Surg 2025; 17(1): 100547
6
"1 Ethics: Yes, the ethical approval form provided by the author that meets the requirements
2 Methods: Experimental method effective ..."
[Read more]
"1 Ethics: Yes, the ethical approval form provided by the author that meets the requirements
2 Methods: Experimental method effective and well described by authors
3 Results: Yes, the results true and authentic. it is validated very well.
4 Figures and tables: Good quality and well constructive
5 Biostatistics: Yes, validated and perfect biostatistics data
6 References: Recent and relevant to the topic
7 Language: Good quality of language in article correctly, clearly and concisely without any grammatical and spelling mistakes.
8 Caveats or drawbacks: No obsvious caveats or drawbacks for the results noted"
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Ling YT, Yao F, Li SJ, Cao CX, Chen ZW, Qiu M, Li BZ, Hu BW, Zhong SY, Hu GL, Li JH. Microbiota in patients with cefuroxime resistance and anal fistula revealed by 16S ribosomal DNA. World J Gastrointest Surg 2025; 17(1): 100790
7
"1 Ethics: Not applicable
2 Methods: Not applicable
3 Results: Not applicable
4 Figures and tables: Good quality and ..."
[Read more]
"1 Ethics: Not applicable
2 Methods: Not applicable
3 Results: Not applicable
4 Figures and tables: Good quality and constructive
5 Biostatistics: No applicable
6 References: Recent and relevant to the topic
7 Language: The language in article correctly, clearly and concisely accordingly. No obvious grammatical and spelling mistakes?
8 Caveats or drawbacks: No caveats or drawbacks"
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Li MY, Han Z, Wang H, Wang YY, Zhao ZR. Multiple jejunal diverticula with repeated gastrointestinal bleeding: A case report. World J Gastrointest Surg 2025; 17(1): 101623
8
"1. What about urine VMA / metanephrine levels?
2. What were the sonography findings?
3. What were the differential diagnosis based ..."
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"1. What about urine VMA / metanephrine levels?
2. What were the sonography findings?
3. What were the differential diagnosis based on the clinical and imaging findings?
4. Was a MIBG scan considered in the evaluation?
5. What was the Blood Pressure on examination?
6. What were the histopathology findings? The same can be described. A relevant photomicrograph can be included for better understanding and educational purpose."
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Zhou JL, Xie F. Precision en-bloc retroperitoneal paraganglioma resection performed laparoscopically: A case report. World J Clin Cases 2025; 13(12): 98721
9
"1. Did the pain abdomen relate to the food type? Was the pain increased or decreased after intake of different foods like solid / ..."
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"1. Did the pain abdomen relate to the food type? Was the pain increased or decreased after intake of different foods like solid / liquid?
2. Any ball rolling movements in the upper abdomen reported in history. On examination any visible gastric peristalsis noted? With air instillation through nasogastric tube or large bolus fluid intake examination for visible gastric peristalsis can be looked for.
3. A calibre change of the duodenum between D1 / D2 or other parts of duodenum would help in suspecting the web .
4. Differentials include stenosis / stricture / duodenal duplication / intraluminal mass"
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Chen KQ, Jiang WQ, Li XR. Diagnostic value of upper gastrointestinal imaging for duodenal webbing in adults: A case report. World J Clin Cases 2025; 13(12): 101443
10
"1. Both rehabilitation and palliation are actually two sides of the same coin in cancer care. Tailoring them to the individual needs ..."
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"1. Both rehabilitation and palliation are actually two sides of the same coin in cancer care. Tailoring them to the individual needs of the patient is not a simple task
2. Physical, mental and social issues as discussed require to be identified, evaluated by the interdisciplinary team keeping the individual needs in focus.
3. Holistic approach with integration of spiritual needs requires consideration
4. Charts / algorithms would help in better understanding"
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Swarnakar R, Yadav SL. Integration of rehabilitation and palliative care in cancer management: A futuristic model. World J Clin Cases 2025; 13(12): 102326
11
"Dear Author
The immunogenicity of the Helicobacter pylori in different serotypes, its resistance to antibiotic eradication therapy, ..."
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"Dear Author
The immunogenicity of the Helicobacter pylori in different serotypes, its resistance to antibiotic eradication therapy, early exposure to the bacteria (duration of disease), and the variable patient immune system response to the microbe are among the most important factors that influence the helicobacter pylori (both gastric and extra gastric) outcomes. In the other word to accurately identify the pathogenic bacteria, the PCR genotyping is a promising way to define the Helico species with negative outcomes."
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Li C, Nan J, Xu BT. Helicobacter pylori infection as a contributing factor to metabolic dysfunction-associated steatohepatitis: A population-based insight. World J Hepatol 2025; 17(1): 103228
12
"Dear Author
Considering the role of gut microbiome on the metabolic syndrome, the effect of Helicobacter pylori in the context of ..."
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"Dear Author
Considering the role of gut microbiome on the metabolic syndrome, the effect of Helicobacter pylori in the context of microbiomics should be studied in the future. Also the immunogenicity of the H.pylori species are variable and their relation with insulin resistance mandate further researches. Defining a probiotic to suppress he growth of H.pylori in gastric epithelium is a new concept to manipulate the gut microbiome. "
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Gou GE, Li T, Liu CR, Meng T, Li YP. Potential mechanisms and therapeutic prospects of the association between Helicobacter pylori infection and metabolic dysfunction-associated steatohepatitis. World J Hepatol 2025; 17(1): 101798
13
"Thank you for sharing this case. For more accurate diagnosis, I recommend IHC staining for Fasiola and cholangiocarcinoma in the ..."
[Read more]
"Thank you for sharing this case. For more accurate diagnosis, I recommend IHC staining for Fasiola and cholangiocarcinoma in the histologic samples. Since I am concerned about the possibility of an occult cholangiocarcinoma site arising from chronic cholangitis induced by the parasite, I suggest the longer follow up the case. "
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Le KL, Tran MQ, Pham TN, Duong NNQ, Dinh TT, Le NK. Hepatic eosinophilic pseudotumor due to Fasciola hepatica infection mimicking intrahepatic cholangiocarcinoma: A case report. World J Hepatol 2025; 17(1): 101664
14
"1 Ethics: Not applicable
2 Methods: ok
3 Results: Not applicable
4 Figures and tables: Good quality and photography is ..."
[Read more]
"1 Ethics: Not applicable
2 Methods: ok
3 Results: Not applicable
4 Figures and tables: Good quality and photography is perfect.
5 Biostatistics: Not applicable as not statistical analysis
6 References: Recent and relevant to topic/title
7 Language: Good language and no obvious grammatical and format erros
8 Caveats or drawbacks: Conclusion is too lengthy, redundant and have references that suppose not."
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Li F, Zhang YY, Li M, Chen SK. Microwave ablation for liver metastases from colorectal cancer: A comprehensive review of clinical efficacy and safety. World J Gastrointest Surg 2025; 17(1): 101162
15
"1 Ethics: Yes, approval granted
2 Methods: Effective and good quality methodology
3 Results: The results true, validate and ..."
[Read more]
"1 Ethics: Yes, approval granted
2 Methods: Effective and good quality methodology
3 Results: The results true, validate and authentic
4 Figures and tables: Good quality figures/tables
5 Biostatistics: Good and validated biostatistics data. Good chart
6 References: Recent and relevant by scientifically and reasonably cite the latest references which are important in this topic.
7 Language: The language in article correctly, clearly and concisely express the information. No obvious grammatical and spelling mistakes?
8 Caveats or drawbacks: No obsvious the caveats or drawbacks noted"
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Celotto F, Bao QR, Capelli G, Spolverato G, Gumbs AA. Machine learning and deep learning to improve prevention of anastomotic leak after rectal cancer surgery. World J Gastrointest Surg 2025; 17(1): 101772
16
"1 Ethics: Not applicable
2 Methods: ok
3 Results: Not applicable
4 Figures and tables: Good quality and photography is ..."
[Read more]
"1 Ethics: Not applicable
2 Methods: ok
3 Results: Not applicable
4 Figures and tables: Good quality and photography is perfect.
5 Biostatistics: Not applicable as not statistical analysis
6 References: Recent and relevant to topic/title
7 Language: Good language and no obvious grammatical and format erros
8 Caveats or drawbacks: Conclusion is too lengthy, redundant and have references that suppose not."
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Memis KB, Celik AS, Aydin S, Kantarci M. Rectal ameboma: A new entity in the differential diagnosis of rectal cancer. World J Gastrointest Surg 2025; 17(1): 100278
17
"1 Ethics: Yes
2 Methods: effective
3 Results: Validated and authentic.
4 Figures and tables: Good quality
5 Biostatistics: ..."
[Read more]
"1 Ethics: Yes
2 Methods: effective
3 Results: Validated and authentic.
4 Figures and tables: Good quality
5 Biostatistics: good clarify and justify by authors.
6 References: recent and relevant to topic.
7 Language:The language in article correctly, clearly and concisely express the information and no obvious grammatical and spelling mistakes noted.
8 Caveats or drawbacks: The future recommendation and limitations is mentioned by authors. "
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Ye YQ, Li PH, Ding ZW, Zhang SF, Li RQ, Cao YW. Application of DynaCT biliary soft tissue reconstruction technology in diagnosis and treatment of hepatolithiasis. World J Gastrointest Surg 2025; 17(1): 98283
18
"The paper presents a comprehensive overview of AI's role in gastrointestinal surgery, emphasizing its current uses and future ..."
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"The paper presents a comprehensive overview of AI's role in gastrointestinal surgery, emphasizing its current uses and future potential. Nonetheless, it would benefit from a deeper critique of the associated challenges, a thorough exploration of cost-effectiveness, and a more inclusive discussion of its global applicability. Incorporating these elements would result in a more balanced and insightful review, enriching its value for both academic and clinical readers."
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Shukla A, Chaudhary R, Nayyar N. Role of artificial intelligence in gastrointestinal surgery. Artif Intell Cancer 2024; 5(2): 97317
19
"Dear Sir,
Excellent letter that reviews the indications, contraindications and some of the limitations capsule endoscopy has. Even ..."
[Read more]
"Dear Sir,
Excellent letter that reviews the indications, contraindications and some of the limitations capsule endoscopy has. Even though the great help this device has, there are some pitfalls that you had pointed out and the possible solutions. Future could be promising for the capsule endoscopy, however, the indications are clear and further use could be enhance if new technologic advances could be applied to the actual one.
But right now there are several aspects that need to improve and no new indications, but limitation to the actual one are needed.
Thank you and hope to hear from you more."
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Tawheed A, Ismail A, Amer MS, Elnahas O, Mowafy T. Capsule endoscopy: Do we still need it after 24 years of clinical use? World J Gastroenterol 2025; 31(5): 102692
20
"This systematic review and meta-analysis follows the ethical standards for this type of study and is registered in the required ..."
[Read more]
"This systematic review and meta-analysis follows the ethical standards for this type of study and is registered in the required database PROSPERO.
The methods are appropriate and have been thoroughly described, so the study could be reproduced.
Results are valid and different variables have been well assessed. In addition, when quality, heterogeneity or certainty of the evidence in the included studies was considered questionable, authors have explicitly informed about it.
Tables and figures are informative and well composed.
Biostatistics are correctly reported. However, I have detected one mistake in the abstract section, when mentioning the results of CFB in eGFR, it should be p > 0.05 for all, instead of p < 0.05.
References are well chosen based on relevance about the topic and including high-impact journals.
The language is correct and clearly expresses the information.
As authors have highlighted, several caveats arise from the results, including the low or very low certainty of the evidence in most of the analyses or the limited follow-up period in the RCTs. Unfortunately, the novelty of this review is limited, since a similar report has been published in 2024. As authors have acknowledged, there are some differences between the two systematic reviews and meta-analyses. However, the additional aspects addressed in the current review are not strongly remarkable. Despite these concerns, the study paves the way for future design of RCTs evaluating the long-term benefits of the use of tirzepatide, particularly for renal disease."
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Kamrul-Hasan A, Patra S, Dutta D, Nagendra L, Muntahi-Reza A, Borozan S, Pappachan JM. Renal effects and safety of tirzepatide in subjects with and without diabetes: A systematic review and meta-analysis. World J Diabetes 2025; 16(2): 101282
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Peer-Reviewers and Manuscript Statistics
- Editorial board members
- 2775
- Peer-reviewers
- 27865
- Manuscripts received today
- 1
- Manuscript reviews today
- 11
- Unhandled manuscripts today
- 138
- Active peer-reviewers today
- 0
- Reviewer acceptance today
- 5
- Reviewer refusals today
- 6
- Total accepted manuscripts
- 34629
- Total rejected manuscripts
- 40212
- Total peer-reviewers
- 3912023
- Total submissions
- 32881
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1
"This is an excellent and insightful article. The authors have provided a comprehensive overview of the most impactful studies in the ..."
[Read more]
"This is an excellent and insightful article. The authors have provided a comprehensive overview of the most impactful studies in the field of gastrointestinal endoscopy. It has greatly enhanced my understanding of the current research landscape and has inspired me to define more focused and meaningful directions for my own research in this area. "
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Sui J, Luo JS, Xiong C, Tang CY, Peng YH, Zhou R. Bibliometric analysis on the top one hundred cited studies on gastrointestinal endoscopy. World J Gastrointest Endosc 2025; 17(1): 100219
2
"This paper examines the differences in proficiency of AI tools for IBD patients and is considered a critical study for the inevitable ..."
[Read more]
"This paper examines the differences in proficiency of AI tools for IBD patients and is considered a critical study for the inevitable future utilization of large language models in healthcare. However, it is merely a comparative study of large language models, and it remains unclear whether it contributes to improving IBD patients' literacy. Regarding patient education, Crohn's disease and ulcerative colitis belong to different categories, making it challenging to evaluate IBD as a whole comprehensively. Separate evaluations for ulcerative colitis and Crohn's disease patients would be preferable. Furthermore, large language models alone are insufficient for shared decision-making that considers patients' social backgrounds for treatment selection, including biological agents (especially for Crohn's disease). Simply improving knowledge on several items through large language models may not be enough for clinical application. Future evaluations using large language models should address these points. "
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Zhang Y, Wan XH, Kong QZ, Liu H, Liu J, Guo J, Yang XY, Zuo XL, Li YQ. Evaluating large language models as patient education tools for inflammatory bowel disease: A comparative study. World J Gastroenterol 2025; 31(6): 102090
3
"Dear editor, this is a review that summarizes the most recent evidence focused on the safety of the peroral endoscopic myotomy (POEM). ..."
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"Dear editor, this is a review that summarizes the most recent evidence focused on the safety of the peroral endoscopic myotomy (POEM). The manuscript is well written. However, I found some inaccuracies in the background. The style, language and grammar are appropriate. Since there are no figures or tables in the paper I answered no to the dedicated questions. Although the safety of POEM is well explained, superficial informations were provided on the precision and the post-procedural management. Therefore, I would focus the article mainly on the safety, explaining better the post-procedural management. "
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Christodoulidis G, Tsagkidou K, Koumarelas KE, Kouliou MN. Advances and challenges in peroral endoscopic myotomy: Safety, precision, and post-procedure management. World J Gastroenterol 2025; 31(5): 97574
4
"This case is an extensively worked-up and well-written report. Best regards to the team. Stroke is not a clear-cut biophysics in ..."
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"This case is an extensively worked-up and well-written report. Best regards to the team. Stroke is not a clear-cut biophysics in neurology, with challenges in the clinical-radiological correlation encountered so often in clinical practice. As in this case, the work-up in SPECT could not convincingly determine theexact biomechanism of the clinical phenomena. However, it opened up information for future scopes of research into lacunar strokes. DSA, functional MRI, and Perfusion mismatch studies can also help in this type of situations. In contrast, the treatment is fairly less complicated in lacunar stroke. "
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Tsai YH, Chen YH, Chao TC, Lin LF, Chang ST. New type of lacunar stroke presenting in brain perfusion images: A case report. World J Neurol 2024; 10(1): 98672
5
"Fu et al.'s recent study published in the World Journal of Psychiatry examines a complex connection between parenting stress, various ..."
[Read more]
"Fu et al.'s recent study published in the World Journal of Psychiatry examines a complex connection between parenting stress, various family parenting styles, and the behavioral and emotional challenges that children experience. This study highlights the need for appropriate emotional management during the preschool years, demonstrating how differences in parental stress may have a significant impact on children's early emotional health. The analytical strength of this study is really impressive. The authors use structural equation modeling (SEM) to give a detailed examination of how different parenting styles mediate the relationships between these factors. Moreover, comprehensive questionnaire data collection contributes to a better understanding of family dynamics in a variety of environments. According to the findings, parents report high levels of stress, which suggests that they face constant challenges. The study discovers a link between "hostile/coercive" parenting and problem behaviors in children, revealing the deleterious effects of negative strategies for parenting. This conclusion is consistent with previous research, which emphasizes the importance of understanding how inadequate parenting may lead to behavioral problems in children. Conversely, the negative connection with "supportive/engaged" parenting implies that positive approaches might provide large protective benefits, emphasizing the importance of specific treatments. Besides, this study emphasizes how parenting styles serve as mediators in the relationship between parental stress and children's emotional health. The data show a 28.99% mediation impact, indicating that how parents handle stress influences the behaviors of their kids through their strategies for parenting. This finding not only strengthens the foundation for designing personalized therapies, but it also emphasizes the important need to improve parental practices. Also, the study points out the importance of providing parents with evidence-based strategies for managing their emotional health, with a focus on both parental and child well-being. The study aims to establish a caring environment for preschoolers by giving practical ways to reduce stress and promoting positive parenting behaviors. It focuses on the broader impacts of various parenting styles, implying that investing in parental support systems is important for enhancing children's mental health and promoting total family happiness. This perspective is consistent with current trends in mental health initiatives and requires a comprehensive effort to address families' emotional needs, supplying the framework for future research in this important area. Although Fu et al.'s work contributes significantly to our understanding of the link between parental stress and children's behavior, future research might profit from using a longitudinal strategy. Such an approach might allow researchers to investigate the changing dynamics of parental stress and child behavior over time, leading to a more comprehensive explanation of their causal relationships. Longitudinal studies may track how changes in parental stress affect the growth path of children's behavior by following the same set of participants at different points in time. This method not only gives a more in-depth understanding of these dynamics, but it also identifies potential mediators and moderators, offering light on the underlying reasons of the connections. Finally, this strategy may help us understand how the family environment affects children's developmental achievement. "
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Fu ZW, Li YJ, Yu R, Guo RQ, Gao LX, Zhao SX. Relationship between parenting stress and behavioral and emotional problems in preschool children: A mediation effect analysis. World J Psychiatry 2025; 15(1): 100068
6
"There is a need for non-invasive methods of evaluating mucosal healing in the small bowel. This study applies the principles of ..."
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"There is a need for non-invasive methods of evaluating mucosal healing in the small bowel. This study applies the principles of radiomics using small bowel CTE to develop a predictive normogram capable of predicting mucosal healing. Despite the study's stated limitations, it adds to the current literature, and extends the emerging field of radiomics in Crohn's disease. "
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Ding H, Fang YY, Fan WJ, Zhang CY, Wang SF, Hu J, Han W, Mei Q. Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease. World J Gastroenterol 2025; 31(3): 102283
7
"The article presents a strong case for the use of endoscopic ultrasound-guided gastroenterostomy (EUS-GE) in managing gastric outlet ..."
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"The article presents a strong case for the use of endoscopic ultrasound-guided gastroenterostomy (EUS-GE) in managing gastric outlet obstruction (GOO). However, a few points could be clarified to strengthen its conclusions. Specifically, it would be helpful to elaborate on the inclusion or exclusion criteria for patient selection, as well as provide data on long-term outcomes like stent patency and recurrence rates. Additionally, discussing the learning curve associated with EUS-GE and the level of expertise required for its successful implementation would offer valuable insight for broader clinical adoption. "
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Jagielski M. Endoscopic ultrasound guided-gastroenterostomy is the best choice in the treatment of gastric outlet obstruction. World J Gastrointest Endosc 2024; 16(12): 691-693
8
"The manuscript is very interesting. Global burden of human disorders caused by parasites is high. The topic is hot in selected areas. ..."
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"The manuscript is very interesting. Global burden of human disorders caused by parasites is high. The topic is hot in selected areas. Those areas include not only Asia or Africa, but some parts of Eastern and Central Europe. I recommend to read the article for specialists in Hepatology, Liver surgery, including liver transplantation, Epademiology and Infectious Diuseases. "
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Shahid Y, Emman B, Abid S. Liver parasites: A global endemic and journey from infestation to intervention. World J Gastroenterol 2025; 31(1): 101360
9
"This editorial pointed out the connection between adipose tissue and intestinal bacteria in Crohn's disease (CD). It is an interesting ..."
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"This editorial pointed out the connection between adipose tissue and intestinal bacteria in Crohn's disease (CD). It is an interesting paper. The authors found that Clostridium innocuum migrates to adjacent adipose tissue and remains "trapped" in the fat. As a result, immune cell migration and macrophage differentiation increase, leading to fibrosis, narrowing, and, eventually, the formation of creeping fat. Although the main cytokine release is mainly TNFα and IL-6 in adipocytes, the cytokine profile changes over time, especially in fibrosis, may be related to IL-17, and the dominant cytokines will change from IL-12 to IL-23, as previously pointed out. It is interesting to evaluate the aging adipose tissue in CD. However, it is difficult to determine the actual time of onset in patients with CD, and it is challenging to evaluate this issue. "
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Quaglio AE, Magro DO, Imbrizi M, De Oliveira EC, Di Stasi LC, Sassaki LY. Creeping fat and gut microbiota in Crohn’s disease. World J Gastroenterol 2025; 31(1): 102042
10
"The authors provide evidence supporting the efficacy of serum-free cultured human umbilical cord mesenchymal stem cells (N-hUCMSCs) ..."
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"The authors provide evidence supporting the efficacy of serum-free cultured human umbilical cord mesenchymal stem cells (N-hUCMSCs) in treating knee osteoarthritis (OA). However, as the results indicate that the therapeutic effects of N-hUCMSCs, serum-cultured hUCMSCs (S-hUCMSCs), and hyaluronic acid (HA) are comparable, the rationale for prioritizing N-hUCMSCs warrants further exploration, particularly in comparison to the well-established use of HA. There are also issues with data quality and clarity 1.The study administered three injections (at 2, 4, and 6 weeks after model establishment). However, the rationale for this dosing schedule is not provided. HA dosing is not described in the manuscript. 2.The source of the N-hUCMSCs and S-hUCMSCs should be disclosed. Were these cells derived from the same donor? If not, what were the baseline characteristics of each donor (e.g., age, health status)? Such details are critical, as MSC functionality can vary significantly based on donor conditions. 3.Some results, such as those described in Figure 1 and the observation that “Uneven chondrocyte thickness, disorganized cartilage structure, and increased clefts were more pronounced in the model control group than in the blank control group,” are inappropriately placed in the methods section. These descriptions should be moved to the results section. 4. Figure 3c and 3d: Both graphs have the same y-axis label, but according to the results section, one should represent IL-6 and the other IL-1β. Figure 4a and 4b: These panels illustrate hematoxylin-eosin (HE) staining for the model and control groups. However, the HE results for the treatment groups (N-hUCMSCs, S-hUCMSCs, and HA) are missing. Including these results would provide a clearer comparison of treatment effects. 5.Figure 4d: The manuscript mentions that “The Mankin scores were significantly lower in the experimental group than in the model control group (P < 0.05),” but this result is not adequately represented in the figure. "
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Xiao KZ, Liao G, Huang GY, Huang YL, Gu RH. Efficacy of serum-free cultured human umbilical cord mesenchymal stem cells in the treatment of knee osteoarthritis in mice. World J Stem Cells 2024; 16(11): 944-955
11
"he significant impact of surgical approaches on male sexual dysfunction after rectal cancer surgery is highlighted by both this letter ..."
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"he significant impact of surgical approaches on male sexual dysfunction after rectal cancer surgery is highlighted by both this letter to the editor and the latest study by Numata et al. published in Annals of Surgery1). Damage to the autonomic nervous system during rectal cancer surgery is a major cause of sexual dysfunction, with problems such as ejaculatory dysfunction, erectile dysfunction, and sexual dysfunction commonly reported. These complications are particularly common with open surgery, and previous research has also shown that the incidence of sexual dysfunction following surgery is high. However, advances in surgical techniques such as robotic surgery are expected to reduce these complications. The LANDMARC Study provided convincing evidence that robotic surgery significantly reduces the incidence of postoperative sexual dysfunction compared to laparoscopic surgery. The incidence of ejaculatory dysfunction at 12 months postoperatively was 25% in robotic surgery patients compared to 40.9% in laparoscopic surgery patients. The incidence of sexual dysfunction was 17.8% and 29%, respectively. This letter to editor alos emphasized the importance of accurate surgical technique and knowledge of pelvic nerve anatomy. It also discussed the benefits of new techniques such as robotic surgery and transanal total mesorectal excision (Ta-TME), as well as the use of intraoperative pelvic nerve monitoring. These advances enhance nerve preservation, reduce complications, and improve patients' postoperative quality of life. These findings highlight the need to adapt innovative surgical techniques in rectal cancer treatment to minimize adverse effects on sexual health while maintaining oncologic effectiveness. 1) Numata, Masakatsu, et al. "Prospective Multicenter Comprehensive Survey on Male Sexual Dysfunction following Laparoscopic, Robotic, and Transanal Approaches for Rectal Cancer (the LANDMARC Study)." Annals of Surgery: 10-1097 "
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Kolokotronis T, Pantelis D. Urinary and sexual dysfunction after rectal cancer surgery: A surgical challenge. World J Gastroenterol 2024; 30(47): 5081-5085
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"since the patient also had general anesthesia, it should be clairifed to whihc degree analgesics given for the procedure prevented ..."
[Read more]
"since the patient also had general anesthesia, it should be clairifed to whihc degree analgesics given for the procedure prevented the patient from experienceing severe pain xxxx xx x x x x x x x x x x x x x x x x x x x x x x xx x x x x x xx "
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Chen KH, Kang MY, Chang YT, Huang SY, Wu YS. Enhancing postoperative pain control by surgically-initiated rectus sheath block in abdominal aortic aneurysm open repair: A case report. World J Clin Cases 2025; 13(6): 100673
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"The novelty of the topic is very important, suitable for fine rather than too broad content. The interpretation of statistical results ..."
[Read more]
"The novelty of the topic is very important, suitable for fine rather than too broad content. The interpretation of statistical results needs to be rigorous, correlation does not mean causation, and the HR presented may be inaccurate. The discussion needs to be tightly focused on the results and not extend to other unwarranted conclusions. "
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Chen DQ, Wu YX, Zhang YX, Yang HL, Huang HH, Lv JY, Xiao Q. Sarcopenia-associated factors and their bone mineral density levels in middle-aged and elderly male type 2 diabetes patients. World J Diabetes 2024; 15(12): 2285-2292
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"I would like to commend the authors for their comprehensive analysis of the complex interplay between gut microbiota, mesenteric ..."
[Read more]
"I would like to commend the authors for their comprehensive analysis of the complex interplay between gut microbiota, mesenteric adipose tissue (MAT), and creeping fat (CF) in the context of Crohn’s disease (CD). The manuscript provides a valuable contribution to the field. The article meticulously elucidates the profound clinical significance of the interplay between the gut microbiota and MAT/CF. The authors have not only reviewed the current body of knowledge but have also contributed novel insights into the role of MAT and CF in shaping CD phenotypes and treatment strategies.The structure of the letter is well-organized, making it easy to follow the authors' line of reasoning. The abstract succinctly captures the essence of the study, and the core tip effectively highlights the main takeaways for the reader.The exploration of fecal microbiota transplantation (FMT) as a therapeutic strategy is both timely and relevant. The authors have successfully linked the current understanding of microbial imbalances to potential clinical applications, which could influence future treatment protocols for CD. In conclusion, Hasnaoui et al. have provided a thought-provoking analysis of the role of gut microbiota and MAT/CF in CD. Their work not only advances our understanding of the disease but also offers promising avenues for therapeutic intervention. "
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Hasnaoui A, Trigui R, Giuffrida M. Gut microbiota and mesenteric adipose tissue interactions in shaping phenotypes and treatment strategies for Crohn’s disease. World J Gastroenterol 2024; 30(46): 4969-4976
15
"The author suggests to use in all diabetic patients an interesting technique, the” body surface gastric mapping” (BSGM), to detect ..."
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"The author suggests to use in all diabetic patients an interesting technique, the” body surface gastric mapping” (BSGM), to detect the onset of gastric dysmotility precursor of gastroparesis, instead of invasive procedures, as gastroscopy, manometry, emptying of radiopaque markers or radioactive bolus and breath tests . The idea is interesting , but there are some observations to make. First of all the author forgot a simple, not invasive, physiologic and reliable method to measure gastric emptying, that is real-time ultrasonography, which allows the use of a normal solid–liquid meal and gives an immediate result (1). Furthermore the author did not take into account the fact that, as indicated in figure 1 of ref. 4, the cause of delayed gastric emptying in gastroparesis may be also due, not only to antral dysmotility detectable with BSGM, but also to impaired pyloric relaxation upon arrival of antral peristalsis (pylorospasm) and, sometimes, to dysmotility of duodenum, which does not accept the bolus coming from the stomach. The pylorospasm, which was observed in 14 of 24 diabetics, by Mearin et al (2) forms part of the widespread disruption of gut motility that affects some patients with diabetes. Unfortunately these pyloric and duodenal motor abnormalities are not detected by the technique of BSGM, which could find a normal antral motility, giving the impression that everything is OK, while the gastric emptying is already delayed. Therefore I would suggest to monitor the diabetic patients with the real-time ultrasonography, which is able to detect also a minimal delay in gastric emptying harbinger of gastroparesis, and, if the gastric emptying is delayed, then perform the BSGM, to see if the cause of the slowing is due to antral dysmotility. If the latter examination is negative, then the cause of delayed gastric emptying shoul be pylorospasm or duodenal dysmotility. REFERENCES 1) Bolondi L, Bortolotti M, Santi V, Calletti T, Gaiani S, Labò G. Measurement of gastric emptying time by real-time ultrasonography. Gastroenterology. 1985 Oct; 89(4):752-9.PMID:3896910. 2) Mearin F, Camilleri M, Malagelada JR. Pyloric dysfunction in diabetics with recurrent nausea and vomiting. Gastroenterology. 1986 Jun;90(6):1919-25. doi: 10.1016/0016-5085(86)90262-3. PMID: 3699409 "
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Mori H. Early detection and intervention in diabetic gastroparesis: Role of body surface gastric mapping. World J Gastroenterol 2024; 30(45): 4836-4838
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"This article presents a case report of air embolism occurring during endoscopic retrograde cholangiopancreatography (ERCP), ..."
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"This article presents a case report of air embolism occurring during endoscopic retrograde cholangiopancreatography (ERCP), emphasizing the necessity for gastroenterologists to maintain a high level of vigilance regarding this potential complication during such procedures. While ERCP is a widely used and effective diagnostic and therapeutic technique, air embolism represents a serious complication that can significantly jeopardize patient health. Consequently, this article not only reviews pertinent cases and analyzes the mechanisms, clinical manifestations, and countermeasures associated with air embolism but also underscores the importance of preventive measures that medical staff should implement to minimize the incidence of such complications during ERCP. The aim of this article is to provide a comprehensive overview of relevant knowledge, thereby enabling medical professionals to better understand and address this issue, ultimately enhancing the safety and effectiveness of clinical operations. "
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Li JH, Luo ZK, Zhang Y, Lu TT, Deng Y, Shu RT, Yu H. Systemic air embolism associated with endoscopic retrograde cholangiopancreatography: A case report. World J Gastrointest Endosc 2024; 16(11): 617-622
17
"Exercise during pregnancy improve organ development in offspring with gestational diabetes mellitus Shengju Chen, Hangming Fan, Yu ..."
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"Exercise during pregnancy improve organ development in offspring with gestational diabetes mellitus Shengju Chen, Hangming Fan, Yu Chen Abstract In this commentary, we discuss the study by Tang et al., “Effect of exercise during pregnancy on offspring development through ameliorating high glucose and hypoxia in gestational diabetes mellitus”. Gestational diabetes mellitus (GDM), defined as ‘glucose intolerance with onset or first recognition during pregnancy’, impacts millions of women worldwide and poses significant health risks. Exercise during pregnancy has been shown to improve offspring health outcomes in obese mothers, potentially reducing epigenetic changes associated with maternal high-fat diets and minimizing abnormalities in lipid and glucose metabolism. However, while prenatal exercise’s impact on metabolic disorders in GDM offspring has been explored, its effects on organ growth remain insufficiently understood. Tang et al. identified GLUT1 and HIF1 as key regulators influencing the development of the heart, liver, and kidney in GDM offspring. Their study demonstrates that exercise during pregnancy supports organ development by inhibiting placental GLUT1 and HIF1 expression in GDM. This work contributes to understanding the role of GLUT1 and HIF1 in moderating the effects of prenatal exercise on organ development in GDM-affected offspring, supporting the idea that maternal exercise is an important intervention for improving offspring outcomes in GDM pregnancies and warrants further investigation in future epigenetic research. Introduction Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications, affecting approximately 20.9 million pregnant women and their newborns worldwide as of 2020. GDM is associated with a range of adverse pregnancy outcomes, including preeclampsia, polyhydramnios, and fetal organomegaly (Pettitt et al., 1980). Additionally, GDM poses several short-term risks to offspring, such as neonatal respiratory distress, metabolic complications (Ferrara et al., 2007), and increased perinatal mortality rates. The GDM quintet management model recommends five core interventions to mitigate these risks, exercise, dietary regulation, maternal education, pharmacological treatment, and fetal health evaluation (Association, 2003). Pathophysiologically, GDM is characterized by hyperglycemia, glucose intolerance, and insulin resistance, typically manifesting in the late second to early third trimester of pregnancy (Buchanan et al., 2012, Jovanovic and Pettitt, 2001, Pereira et al., 2015). Several mechanisms have been proposed to explain these outcomes, including chronic fetal hyperinsulinemia, impaired oxygenation due to elevated metabolic rates, and metabolic acidosis (Freinkel, 1980). In this commentary, we discuss the article by Tang et al., recently published in the recent issue of the World Journal of Diabetes, which explores the impact of maternal exercise during pregnancy on organ development in offspring of mothers with GDM. Risks and complications associated with GDM In a healthy pregnancy, insulin sensitivity decreases to allow more glucose availability for the fetus; however, normoglycemia is typically maintained through increased insulin production by pancreatic β-cells. In cases of GDM, the pancreas may fail to produce sufficient insulin, resulting in elevated blood glucose levels and the onset of GDM (Freinkel, 1980). GDM pregnancies can lead to additional complications that negatively impact maternal and fetal health (Poston et al., 2011). Immediate complications in offspring of overweight women with GDM include macrosomia, the most severe of which is shoulder dystocia; other neonatal complications such as hypoglycemia and hyperbilirubinemia have also been reported (Kaaja and Rönnemaa, 2008, Lecomte et al., 2017). Long-term exposure to GDM increases the risk of obesity, type 2 diabetes, and cardiovascular diseases (CVD) as offspring age (Capobianco et al., 2016). Epigenetic studies indicate that the intrauterine environment significantly influences offspring organ development, and exposure to elevated maternal blood levels can impair fetal health. Maintaining a healthy uterine environment is thus essential to promoting favorable health outcomes in offspring. Exercise, as a non-pharmacological intervention without side effects, is widely used in diabetes prevention and management. Given that pregnancy is a period when non-pharmacological interventions are especially favored by medical staff and patients, exercise is particularly promising for managing GDM. Benefits of exercise during pregnancy Eight national guidelines on exercise during pregnancy recommend 60-150 minutes of aerobic exercise per week for healthy pregnant women (Savvaki et al., 2018). The benefits of exercise for pregnant women include improved overall health, better weight management, reduced risk of GDM and gestational hypertension (Davenport et al., 2018, Yu et al., 2018). For women with GDM, moderate aerobic or combined exercise has been shown to enhance postprandial blood glucose control (Walter and Klaus, 2014), although the optimal duration and intensity remain unclear. Moderate exercise during pregnancy can improve maternal insulin sensitivity, reduce placental lipid accumulation in both male and female fetuses, and alleviate hypoxia, positively influencing the intrauterine environment and fetal growth (Laker et al., 2014). Exercise during pregnancy also promotes healthier liver glucose production, helps maintain liver triglycerides levels, and prevents the expression of liver enzymes and genes in offspring caused by maternal high-fat diet, thereby improving the offspring’s metabolic profile. These findings suggest that maternal exercise can mitigate modifications linked to a high-fat diet, protecting offspring from future metabolic diseases. Regulation of GLUT1 by maternal exercise and offspring health outcomes in GDM The placenta is responsible for transporting essential nutrients and oxygen from maternal to fetal circulation, as fetal gluconeogenesis is minimal (Kalhan and Parimi, 2000). GDM disrupts placental function, leading to various morphological (Treesh and Khair, 2015) and vascular changes (Aldahmash et al., 2022, El Sawy et al., 2018) and including fetal vascular changes and DNA methylation (Song et al., 2022). Placental transport proteins, such as glucose transporters, facilitate nutrient transfer from the mother to the fetus. Glucose is the primary energy source for both placental and fetal growth (Stanirowski et al., 2017), with GLUT1 and GLUT3 serving as the main placental glucose transport proteins in humans. GLUT1 is expressed in syncytiotrophoblast microvilli and the basal membrane, as well as in vascular endothelium and cell layers (Brown et al., 2011, Jansson et al., 1993). Research on GDM in humans and mice shows increased placental GLUT1 expression, likely due to increased glucose availability in maternal circulation, which enhances placental glucose consumption (Muralimanoharan et al., 2016). This increase in GLUT1 may contribute to the higher rates of macrosomia observed in GDM pregnancies (Stanirowski et al., 2022). Moreover, GDM leads to placental hypoxia, elevated hypoxia-inducible (HIF) levels, and glial cell missing 1 degradation, inhibiting trophoblast migration and invasion. Exercise during pregnancy can significantly reduce placental GLUT1 expression and alleviate hypoxia. Silencing GLUT1 can partially counteract the reduced trophoblast migration caused by hyperglycemia and hypoxia. Beyond energy metabolism, GLUT1 is also related to the development of the heart, liver, and kidneys. Zhang et al. investigated the relationship between GLUT1 expression in these organs and their structural and pathological changes, examining how exercise influences growth and development in offspring with GDM. In a neonatal GLUT1 transgenic heart model, increased glucose metabolism can stimulate hyperplastic growth after cardiac injury (Fajardo et al., 2021). Maternal exercise during pregnancy has been shown to lower hepatic GLUT1 expression, reduce inflammatory infiltration, and decrease the risk of liver disease in adult offspring (Baker and Friedman, 2018). In the kidney, GLUT1 functions vary by cell type; elevated GLUT1 in mesangial cells can impair kidney structure, while in podocytes, it may reduce mesangial expansion and fibronectin accumulation (Chen et al., 2024). Future research is recommended to clarify the specific mechanisms by which exercise benefits renal structure and function in GDM offspring. Directions for future studies The specific mechanisms by which maternal exercise during pregnancy improves health outcomes in diabetic offspring remain under investigation, with multiple synergistic pathways likely involved. Given its role in glucose metabolism, GLUT1 is of particular interest as a regulatory factor in mitigating adverse outcomes in offspring of mothers with GDM through exercise. This underscores the significant influence of exercise on glucose metabolism, which enhances the intrauterine environment and supports offspring health. Improved placental GLUT1 expression appears to regulate the GLUT1 levels in offspring organs, positively impacting organ development. These findings extend our understanding of exercise-related epigenetics modifications, yet further research is essential to clarify the pathways through which maternal exercise regulates placental GLUT1, thereby promoting healthy organ development in offspring and underscoring the benefits of prenatal exercise. Conclusion GDM can lead to adverse outcomes for both the mother and their offspring. Maternal exercise during pregnancy improves the intrauterine environment and enhances offspring health. Elevated maternal blood glucose can cause fetal hyperinsulinemia, hypoxia, and metabolic acidosis. Exercise enhances glucose metabolism, reduces high blood sugar levels, and supports a healthier intrauterine environment, thereby decreasing the risk of metabolic diseases in offspring. The study by Tang et al. confirms the association between elevated placental GLUT1 expression in GDM and abnormal offspring organ development related to hypoxia. Their research demonstrates that exercise during pregnancy can improve placental glucose transport and reduce hypoxia, mitigating adverse developmental outcomes in offspring organs at various stages. These findings validate, across human, animal, and cellular models, the molecular mechanisms through which maternal exercise enhances organ development in offspring affected by GDM. This contributes to clinical application and emphasizes the role of epigenetics in promoting offspring health. As research in epigenetic progresses, the pathways through exercise benefits GDM-affected offspring will become clearer, with GLUT1 as a central regulator of glucose metabolism. Further investigation into these mechanisms will advance our understanding of how maternal exercise supports healthier outcomes for GDM offspring. Aldahmash, W.M., Alwasel, S.H., Aljerian, K., 2022. Gestational diabetes mellitus induces placental vasculopathies. Environ Sci Pollut Res Int 29 (13), 19860-19868. Association, A.D., 2003. Gestational diabetes mellitus. Diabetes Care 26 Suppl 1, S103-105. Baker, P.R., 2nd, Friedman, J.E., 2018. Mitochondrial role in the neonatal predisposition to developing nonalcoholic fatty liver disease. J Clin Invest 128 (9), 3692-3703. Brown, K., Heller, D.S., Zamudio, S., Illsley, N.P., 2011. Glucose transporter 3 (GLUT3) protein expression in human placenta across gestation. Placenta 32 (12), 1041-1049. Buchanan, T.A., Xiang, A.H., Page, K.A., 2012. Gestational diabetes mellitus: risks and management during and after pregnancy. Nat Rev Endocrinol 8 (11), 639-649. Capobianco, E., Fornes, D., Linenberg, I., Powell, T.L., Jansson, T., Jawerbaum, A., 2016. A novel rat model of gestational diabetes induced by intrauterine programming is associated with alterations in placental signaling and fetal overgrowth. Mol Cell Endocrinol 422, 221-232. Chen, Y., Bai, X., Chen, J., Huang, M., Hong, Q., Ouyang, Q., Sun, X., Zhang, Y., Liu, J., Wang, X., Wu, L., Chen, X., 2024. Pyruvate kinase M2 regulates kidney fibrosis through pericyte glycolysis during the progression from acute kidney injury to chronic kidney disease. Cell Prolif 57 (2), e13548. Davenport, M.H., Ruchat, S.M., Poitras, V.J., Jaramillo Garcia, A., Gray, C.E., Barrowman, N., Skow, R.J., Meah, V.L., Riske, L., Sobierajski, F., James, M., Kathol, A.J., Nuspl, M., Marchand, A.A., Nagpal, T.S., Slater, L.G., Weeks, A., Adamo, K.B., Davies, G.A., Barakat, R., Mottola, M.F., 2018. Prenatal exercise for the prevention of gestational diabetes mellitus and hypertensive disorders of pregnancy: a systematic review and meta-analysis. Br J Sports Med 52 (21), 1367-1375. El Sawy, N.A., Iqbal, M.S., Alkushi, A.G., EL Sawy, N., Iqbal, M., Alkushi, A., 2018. Histomorphological study of placenta in gestational diabetes mellitus. Int. J. Morphol 36 (2), 687-692. Fajardo, V.M., Feng, I., Chen, B.Y., Perez-Ramirez, C.A., Shi, B., Clark, P., Tian, R., Lien, C.L., Pellegrini, M., Christofk, H., Nakano, H., Nakano, A., 2021. GLUT1 overexpression enhances glucose metabolism and promotes neonatal heart regeneration. Sci Rep 11 (1), 8669. Ferrara, A., Weiss, N.S., Hedderson, M.M., Quesenberry, C.P., Jr., Selby, J.V., Ergas, I.J., Peng, T., Escobar, G.J., Pettitt, D.J., Sacks, D.A., 2007. Pregnancy plasma glucose levels exceeding the American Diabetes Association thresholds, but below the National Diabetes Data Group thresholds for gestational diabetes mellitus, are related to the risk of neonatal macrosomia, hypoglycaemia and hyperbilirubinaemia. Diabetologia 50 (2), 298-306. Freinkel, N., 1980. Banting Lecture 1980. Of pregnancy and progeny. Diabetes 29 (12), 1023-1035. Jansson, T., Wennergren, M., Illsley, N.P., 1993. Glucose transporter protein expression in human placenta throughout gestation and in intrauterine growth retardation. J Clin Endocrinol Metab 77 (6), 1554-1562. Jovanovic, L., Pettitt, D.J., 2001. Gestational diabetes mellitus. Jama 286 (20), 2516-2518. Kaaja, R., Rönnemaa, T., 2008. Gestational diabetes: pathogenesis and consequences to mother and offspring. Rev Diabet Stud 5 (4), 194-202. Kalhan, S., Parimi, P., 2000. Gluconeogenesis in the fetus and neonate. Semin Perinatol 24 (2), 94-106. Laker, R.C., Lillard, T.S., Okutsu, M., Zhang, M., Hoehn, K.L., Connelly, J.J., Yan, Z., 2014. Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring. Diabetes 63 (5), 1605-1611. Lecomte, V., Maloney, C.A., Wang, K.W., Morris, M.J., 2017. Effects of paternal obesity on growth and adiposity of male rat offspring. Am J Physiol Endocrinol Metab 312 (2), E117-e125. Muralimanoharan, S., Maloyan, A., Myatt, L., 2016. Mitochondrial function and glucose metabolism in the placenta with gestational diabetes mellitus: role of miR-143. Clin Sci (Lond) 130 (11), 931-941. Pereira, T.J., Moyce, B.L., Kereliuk, S.M., Dolinsky, V.W., 2015. Influence of maternal overnutrition and gestational diabetes on the programming of metabolic health outcomes in the offspring: experimental evidence. Biochem Cell Biol 93 (5), 438-451. Pettitt, D.J., Knowler, W.C., Baird, H.R., Bennett, P.H., 1980. Gestational diabetes: infant and maternal complications of pregnancy in relation to third-trimester glucose tolerance in the Pima Indians. Diabetes Care 3 (3), 458-464. Poston, L., Harthoorn, L.F., Van Der Beek, E.M., 2011. Obesity in pregnancy: implications for the mother and lifelong health of the child. A consensus statement. Pediatr Res 69 (2), 175-180. Savvaki, D., Taousani, E., Goulis, D.G., Tsirou, E., Voziki, E., Douda, H., Nikolettos, N., Tokmakidis, S.P., 2018. Guidelines for exercise during normal pregnancy and gestational diabetes: a review of international recommendations. Hormones (Athens) 17 (4), 521-529. Song, J.Y., Lee, K.E., Byeon, E.J., Choi, J., Kim, S.J., Shin, J.E., 2022. Maternal Gestational Diabetes Influences DNA Methylation in the Serotonin System in the Human Placenta. Life (Basel) 12 (11). Stanirowski, P.J., Szukiewicz, D., Majewska, A., Wątroba, M., Pyzlak, M., Bomba-Opoń, D., Wielgoś, M., 2022. Placental expression of glucose transporters GLUT-1, GLUT-3, GLUT-8 and GLUT-12 in pregnancies complicated by gestational and type 1 diabetes mellitus. J Diabetes Investig 13 (3), 560-570. Stanirowski, P.J., Szukiewicz, D., Pyzlak, M., Abdalla, N., Sawicki, W., Cendrowski, K., 2017. Impact of pre-gestational and gestational diabetes mellitus on the expression of glucose transporters GLUT-1, GLUT-4 and GLUT-9 in human term placenta. Endocrine 55 (3), 799-808. Treesh, S.A., Khair, N.S.B., 2015. Histological Changes of the Human Placenta in Pregnancies Complicated with Diabetes. Journal of Cytology and Histology 6, 1-7. Walter, I., Klaus, S., 2014. Maternal high-fat diet consumption impairs exercise performance in offspring. J Nutr Sci 3, e61. Yu, Y., Xie, R., Shen, C., Shu, L., 2018. Effect of exercise during pregnancy to prevent gestational diabetes mellitus: a systematic review and meta-analysis. J Matern Fetal Neonatal Med 31 (12), 1632-1637. "
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Tang YB, Wang LS, Wu YH, Zhang LX, Hu LY, Wu Q, Zhou ML, Liang ZX. Effect of exercise during pregnancy on offspring development through ameliorating high glucose and hypoxia in gestational diabetes mellitus. World J Diabetes 2024; 15(11): 2203-2219
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Jiang L, Chen XP. Treatment of choice for malignant gastric outlet obstruction: More than clearing the road. World J Gastrointest Endosc 2024; 16(11): 587-594
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Li JH, Luo ZK, Zhang Y, Lu TT, Deng Y, Shu RT, Yu H. Systemic air embolism associated with endoscopic retrograde cholangiopancreatography: A case report. World J Gastrointest Endosc 2024; 16(11): 617-622
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"Re-evaluating the clinical impact of functional regulatory variants Ying Ming, Yun-Ling Du, Meng-Na Zhang Ying Ming, Molecular ..."
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"Re-evaluating the clinical impact of functional regulatory variants Ying Ming, Yun-Ling Du, Meng-Na Zhang Ying Ming, Molecular Diagnosis Center,The Affiliated Hospital of Chengde Medical University, Chengde, 067000, China Yun-Ling Du, Molecular Diagnosis Center,The Affiliated Hospital of Chengde Medical University, Chengde, 067000, China Meng-Na Zhang, Molecular Diagnosis Center,The Affiliated Hospital of Chengde Medical University, Chengde, 067000, China Meng-Na Zhang, Hebei Key Laboratory of Panvascular Diseases, Chengde, 067000, China ORCID number: Ying Ming (0009-0006-2161-8207) , Yun-Ling Du (0000-0001-7624-3226) , Meng-Na Zhang (0000-0001-7624-3226) Author contributions: Ying Ming contributed to the initial drafting of the work; Yun-Ling Du contributed to the drafting process; Meng-Na Zhang contributed to the initial drafting and provided overall supervision to the drafting process; All authors have read and approved the final version of the manuscript. Conflict-of-interest statement: The authors declare that they have no conflict of interest. Corresponding author: Meng-Na Zhang, Molecular Diagnosis Center,The Affiliated Hospital of Chengde Medical University, Chengde, China zhangmengna2014@sina.com Abstract Serotonin 1A receptor polymorphism (5-HTR1A) C-1019G polymorphism (rs6295) is a functional regulatory variants reported to be related with multiple phenotypes including major depression, suicidal behavior and antidepressant response. However, clinical studies investigating this variant and its potential phenotypes had incongruous findings. Molecular studies on this variant showed it does regulate HTR1A expression but meta-analysis showed it had negative relationship with antidepressant drug response in major depressive disorder (MDD), as reported by Wu et al. in the lasted issue of the World Journal of Psychiatry. This suggested the importance of re-evaluating the clinical impact of functional regulatory variants. Key words: regulatory variants, snp-meta, snp-phenotype association Core Tip: Functional regulatory variants might have negative relationship with putative phenotypes even it do regulate gene expression. Single nucleotide polymorphism (SNP) meta analysis helps to identify a more robust SNP-phenotype relationship. We carefully read the article titled “Association between 5-HTR1A gene C-1019G polymorphism and antidepressant response in patients with major depressive disorder: A meta-analysis” published in the World Journal of Psychiatry by Wu et al.[1]. In this study the authors reviewed 11 clinical studies about serotonin 1A receptor polymorphism (5-HTR1A) C-1019G polymorphism (rs6295) and antidepressant response. Though reported to be related with major depression[2], suicidal behavior[3] and antidepressant response[4], rs6295 did not show significant association with antidepressant drug response in major depressive disorder (MDD) in this meta-analysis. Genome-wide association studies (GWAS) show to be a useful tool to investigate the effect of polymorphism on clinical phenotypes. Most disease-associated variants are non-coding variants. Researchers have developed multiple methods to identify functional regulatory variants from putative regulatory regions and their cis-regulated genes, like massively parallel reporter assays (MPRAs) and expression quantitative trait loci (eQTL)[5,6]. The 5-HTR1A C-1019G polymorphism (rs6295) reviewed by Wu et al. [1] is a functional upstream variant that affects HTR1A expression but not associates with antidepressant response in patients with MDD, though the 5-HT1A receptor is a primary target for most antidepressant drugs. This variant has been reported to influence HTR1A expression in numerous molecular studies. The C-allele of this variant is capable of interacting with transcription factors (TFs) such as Hes1, Hes5, and Deaf1, whereas the G-allele fails to bind these TFs [7]. Although these three TFs are typically regarded as repressors, the activity of Deaf1 at the 5-HT1A promoter exhibits opposing effects in presynaptic versus postsynaptic neuronal cells [7]. In the human prefrontal cortex, the G-allele demonstrates a lower expression level compared to the C-allele; however, this pattern does not hold true for the midbrain and hippocampus [8]. In a humanized mouse model, subjects with GG genotype exhibited higher levels of HTR1A mRNA and protein than those with CC genotype in a line-dependent manner [9]. Furthermore, in 5-HT1A-expressing neuronal cells, the G-allele was found to downregulate 5-HT1A expression [10]. These showed the complexity of regulatory variant function. Clinical researches on rs6295 had incongruous findings, raising the need for a SNP-based meta analysis. A single variant approach is a classical method to ascertain the relationship between a variant and putative phenotypes. Selective serotonin re-uptake Inhibitors (SSRIs) like fluoxetine, paroxetine, sertraline, citalopram, and fluvoxamine were included in this meta analysis, however, the result showed no significant correlation between this variation and antidepressant drug efficacy in MDD in the dominant model (CG vs CC), recessive model (GG vs CC), and combined dominant model (CG+GG vs CC). The 11 clinical studies collected in their meta analysis included multiple populations from over 10 countries with low to moderate heterogeneity and were scored 7-9 according to the Newcastle-Ottawa Scale (NOS), suggesting a result with higher confidence. The negative correlation might due to gene-gene interactions or gene-environment interactions in MDD and its treatment. A genome-wide linkage analysis for MDD showed that association of LHPP SNPs to MDD were depended on HTR1A -1019G allele [11]. Single variant approaches are limited by lower statistical detection power because most phenotypes result from the influence of many genetic variants in many genes and pathways[12]. This limitation is particularly pronounced in pharmacogenetics and multigenic diseases like MDD. Large-scale meta-analysis of GWAS might overcome this disadvantage. However, phenotype analysis involving rs6295 through GWAS is inherently limited due to its ambiguous nature (C/G). It is challenging to distinguish which complementary allele serves as the effect allele. Furthermore, the minor allele frequency (MAF) of rs6295 is G=0.483 in gnomAD and C=0.458 in 1000G, making it impossible to solve the problem by allele frequency. Ambiguous SNPs with allele frequencies close to 0.5 are usually removed in GWAS [13]. Therefore, a SNP meta-analysis remains a viable option for investigating rs6295. The clinical impacts of regulatory variants in monogenic Mendelian diseases have also been noticed. Many bioinformatic tools were developed to predict TF binding of regulatory variants like SNEEP [14]. Many of them use eQTL datasets as training and validation sets. In rs6295’s case, the variant had different functions in different brain regions, and showed negative significance to putative related phenotype. This suggested a limitation of using these tools to predict clinical candidate variants. However, there are few clinical curated regulatory variants databases available. There are only hundreds of regulatory variants in Clinvar database classified as pathogenic/likely pathogenic/benign/likely benign (data not shown). That’s not enough to feed a complex model. Overall, the negative relationship between the functional regulatory variant rs6295 and antidepressant response underscores the importance of re-evaluating the clinical significance of functional regulatory variants. Both positive and negative meta-analyses are essential for establishing robust relationships between polymorphisms and phenotypes. References [1] Wu HN, Zhu SY, Zhang LN, Shen BH, Xu LL. Association between 5-HTR1A gene C-1019G polymorphism and antidepressant response in patients with major depressive disorder: A meta-analysis. World J Psychiatry 2024; 14(10): 1573-1582 [2]Lemonde S, Turecki G, Bakish D, Du L, Hrdina PD, Bown CD, Sequeira A, Kushwaha N, Morris SJ, Basak A, Ou XM, Albert PR. Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J Neurosci. 2003 Sep 24;23(25):8788-99 [3]Hernández-Díaz, Y., Tovilla-Zárate, C. A., Castillo-Avila, R. G., Juárez-Rojop, I. E., Genis-Mendoza, A. D., López-Narváez, M. L., Villar-Juárez, G. E., & González-Castro, T. B. (2023). Association between the HTR1A rs6295 gene polymorphism and suicidal behavior: an updated meta-analysis. European archives of psychiatry and clinical neuroscience, 273(1), 5–14 [4]Lemonde S, Du L, Bakish D, Hrdina P, Albert PR. Association of the C(-1019)G 5-HT1A functional promoter polymorphism with antidepressant response. Int J Neuropsychopharmacol. 2004 Dec;7(4):501-6 [5]Abell NS, DeGorter MK, Gloudemans MJ, Greenwald E, Smith KS, He Z, Montgomery SB. Multiple causal variants underlie genetic associations in humans. Science. 2022 Mar 18;375(6586):1247-1254 [6]Umans BD, Battle A, Gilad Y. Where Are the Disease-Associated eQTLs? Trends Genet. 2021 Feb;37(2):109-124 [7]Czesak M, Lemonde S, Peterson EA, Rogaeva A, Albert PR. Cell-specific repressor or enhancer activities of Deaf-1 at a serotonin 1A receptor gene polymorphism. J Neurosci. 2006 Feb 8;26(6):1864-71 [8]Donaldson ZR, le Francois B, Santos TL, Almli LM, Boldrini M, Champagne FA, Arango V, Mann JJ, Stockmeier CA, Galfalvy H, Albert PR, Ressler KJ, Hen R. The functional serotonin 1a receptor promoter polymorphism, rs6295, is associated with psychiatric illness and differences in transcription. Transl Psychiatry. 2016 Mar 1;6(3):e746 [9]Cunningham AM, Santos TL, Gutzeit VA, Hamilton H, Hen R, Donaldson ZR. Functional Interrogation of a Depression-Related Serotonergic Single Nucleotide Polymorphism, rs6295, Using a Humanized Mouse Model. ACS Chem Neurosci. 2019 Jul 17;10(7):3197-3206 [10]Czesak M, Lemonde S, Peterson EA, Rogaeva A, Albert PR. Cell-specific repressor or enhancer activities of Deaf-1 at a serotonin 1A receptor gene polymorphism. J Neurosci. 2006 Feb 8;26(6):1864-71 [11]Neff CD, Abkevich V, Packer JC, Chen Y, Potter J, Riley R, Davenport C, DeGrado Warren J, Jammulapati S, Bhathena A, Choi WS, Kroeger PE, Metzger RE, Gutin A, Skolnick MH, Shattuck D, Katz DA. Evidence for HTR1A and LHPP as interacting genetic risk factors in major depression. Mol Psychiatry. 2009 Jun;14(6):621-30 [12]Defo J, Awany D, Ramesar R. From SNP to pathway-based GWAS meta-analysis: do current meta-analysis approaches resolve power and replication in genetic association studies? Brief Bioinform. 2023 Jan 19;24(1):bbac600 [13]Ndong Sima, C.A.A., Step, K., Swart, Y. et al. Methodologies underpinning polygenic risk scores estimation: a comprehensive overview. Hum. Genet. 143, 1265–1280 (2024) [14]Baumgarten N, Rumpf L, Kessler T, Schulz MH. A statistical approach for identifying single nucleotide variants that affect transcription factor binding. iScience. 2024 Apr 18;27(5):109765 "
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Wu HN, Zhu SY, Zhang LN, Shen BH, Xu LL. Association between 5-HTR1A gene C-1019G polymorphism and antidepressant response in patients with major depressive disorder: A meta-analysis. World J Psychiatry 2024; 14(10): 1573-1582
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