Baishideng Publishing Group

Nguyen Tran T, Luong TV, Nguyen NVD, Dang HNN. Complex relationship between childhood obesity and the gut microbiota. World J Clin Pediatr 2025; 14(2): 100975

"I sincerely appreciate the support and constructive feedback from the editors and reviewers, which have been invaluable in improving ..." [Read more]

Luong TV, Cao MTT, Nguyen NVD, Dang HNN, Nguyen TT. Roles of autophagy and long non-coding RNAs in gastric cancer. World J Gastroenterol 2025; 31(11): 101124

"I sincerely appreciate the opportunity to publish my article, Breaking the Cycle: Psychological and Social Dimensions of Pediatric ..." [Read more]

"I sincerely appreciate the opportunity to publish my article, Breaking the Cycle: Psychological and Social Dimensions of Pediatric Functional Gastrointestinal Disorders, in [Journal Name]. Thank you for your support, insightful feedback, and dedication to advancing pediatric research. I truly value your efforts in bringing this work to publication. Best regards, Prof. Mohammed Elbeltagi " [Collapse]

Al-Beltagi M, Saeed NK, Bediwy AS, Elbeltagi R. Breaking the cycle: Psychological and social dimensions of pediatric functional gastrointestinal disorders. World J Clin Pediatr 2025; 14(2): 103323

"I sincerely appreciate the opportunity to publish my article on the role of human milk oligosaccharides (HMOs) during breastfeeding ..." [Read more]

"I sincerely appreciate the opportunity to publish my article on the role of human milk oligosaccharides (HMOs) during breastfeeding in [Journal Name]. Thank you for your support, insightful feedback, and commitment to advancing scientific knowledge. I am grateful for your efforts in bringing this work to publication. Best regards, Prof. Mohammed Elbeltagi " [Collapse]

Al-Beltagi M. Human milk oligosaccharide secretion dynamics during breastfeeding and its antimicrobial role: A systematic review. World J Clin Pediatr 2025; 14(2): 104797

"F6 system interface is very easy to use, peer review gave adequate input, the final paper looked really good, the editors were very ..." [Read more]

"F6 system interface is very easy to use, peer review gave adequate input, the final paper looked really good, the editors were very understanding. We are happy to publish Dr. Haifa's MSc thesis, and she was very proud to see her work being recognized. Everything was in its right place. Thanks! " [Collapse]

Eldew H, Soldera J. Evaluation of biological therapies in autoimmune hepatitis: A case-based systematic review. World J Gastrointest Pathophysiol 2025; 16(1): 101481

"This journal is in-depth, of high quality, covers a wide range of fields, is rigorously scrutinized, and provides scholars with a ..." [Read more]

"This journal is in-depth, of high quality, covers a wide range of fields, is rigorously scrutinized, and provides scholars with a high-quality platform for academic exchanges, which is of great value in promoting the development of the discipline. I will use it as a reference for future submissions and publications. " [Collapse]

Yang HR, Li ZY, Zhu H, Wu H, Xie C, Wang XQ, Huang CS, Geng WJ. Mapping the current trends and hotspots of transcranial magnetic stimulation-based addiction treatment from 2001-2023: A bibliometric analysis. World J Meta-Anal 2025; 13(1): 104644

"The Baishideng publishing system will always remain on the bottom of quality ranking as long as it employes scared officers and does ..." [Read more]

"The Baishideng publishing system will always remain on the bottom of quality ranking as long as it employes scared officers and does not give them minimal degrees of independent working. Can you believe that it was IMPOSSIBLE for me to convince the envolved officers that my family name is 'Rose' and my first name is 'Klaus?' They continued to address me as Dr. Klaus. All the involved procedures and rules are good in formally presenting a peer-reviewed journal system. Anybody with experience in publishing will continue to see that most papers' quality is mediocre. Enough to contribute to enhance publication lists, but not enough to be taken seriously. In other words: enough to be OK if evaluated by brainless statisticians; not enough if you look at the quality of its contributions. Part of today's academic brave new world. " [Collapse]

Ettienne EB, Rose K. Disorders of gut-brain interaction are a new challenge of our increasingly complex society, with worldwide repercussions. World J Clin Pediatr 2025; 14(2): 103608

"I agreed to submit two editorials because this journal is listed under PubMed and because the submission would be free of charge. ..." [Read more]

"I agreed to submit two editorials because this journal is listed under PubMed and because the submission would be free of charge. During the publications, I informed the representatives of the editorial office three times that my first name is 'Klaus' and my family name is 'Rose.' I did this because they had continuously addressed me as 'Dr. Klaus.' My three comments were to no avail, and I was addressed as 'Dr. Klaus' until the very end of the publication process. I conclude from this that my counterparts either did not understand (which would be bad), or did not care (which would be as bad), or did not dare to act on an information their superiors had taken on reasons that are beyound my knowledge (which is very bad). In conclusion, an open correspondence is impossible with the editorial office. There are many rules, many procedures, many peer reviews. To achieve publication, I had to folow the procedures, which I did. At least one more paper in PubMed. In my view, all the papers by Baishideng will never achieve academic credibility (1) as long as the current editorial process remains as it is; (2) as long as the current senior employees continue to work, and (3) as long as all the other employees are too scared to work with a limited degree of independent opinion. I do not know why Baishideng is investing so much resources into its publishing system. I will always remain a publishing platform that renders publications that young academicians can use to enlarge their publication list. But is will never succeed to become part of the upper third of the quality papers. " [Collapse]

Ettienne EB, Rose K. African minors’ health challenges are comparable to those in the rest of the world. World J Clin Pediatr 2025; 14(2): 102922

"I think Baishideng Publishing Group is a very good platform for publishing articles, the review speed is fast, and the reviewers give ..." [Read more]

"I think Baishideng Publishing Group is a very good platform for publishing articles, the review speed is fast, and the reviewers give a lot of constructive comments. I think I will recommend this platform to other researchers in the future. But one shortcoming is why I can't find my articles published on the platform in PubMed? " [Collapse]

Pan WJ, Wang SF. Understanding patients’ emotional needs to strengthen therapeutic relationships: A deep insight into narrative nursing. World J Psychiatry 2025; 15(3): 103093

"It is an honor to have my manuscript published in World Journal of Diabetes. I sincerely thank you for your excellent editing work ..." [Read more]

"It is an honor to have my manuscript published in World Journal of Diabetes. I sincerely thank you for your excellent editing work and dedication. The publication process was very rewarding and took many revisions and meticulous efforts in formatting to meet the high standards of the journal. The reviewers' suggestions were very professional and the review time was reasonable. " [Collapse]

Pan CJ, Wang T, Yin RH, Tang XQ, Hu CH. Coronary imaging characteristics and risk factors in patients with type 2 diabetes mellitus with coronary heart disease complication. World J Diabetes 2025; 16(4): 99151

"I sincerely appreciate the journal’s rigorous peer-review process, where reviewers provided nuanced critiques that significantly ..." [Read more]

"I sincerely appreciate the journal’s rigorous peer-review process, where reviewers provided nuanced critiques that significantly strengthened the manuscript’s scientific rigor. The editorial team maintained exceptional transparency, offering clear timelines and prompt responses to queries throughout the submission-to-publication journey. The F6Publishing platform proved highly intuitive, with streamlined manuscript tracking and real-time status updates. I'm satisfied in every way. Thanks. " [Collapse]

Yang X, Gao YY, Xu SQ, Wang JC, Ma YJ, Jiao LH, Wang L, Wang XY, Bashir S, An CX, Wang R. Efficacy of bright light therapy for perinatal depression: A meta-analysis of a randomized controlled trial. World J Meta-Anal 2025; 13(1): 99971

"Thank you for giving us the opportunity to publish our manuscript in a prestigious journal. I would also like to express my deepest ..." [Read more]

"Thank you for giving us the opportunity to publish our manuscript in a prestigious journal. I would also like to express my deepest gratitude to the editor who handled our manuscript. The editor handled our manuscript fairly and promptly. Also, the reviewers evaluated the manuscript very fairly, and the quality of the revised manuscript improved. I will continue to submit manuscripts to this journal in the future. I would like to express my gratitude to the editor who handled our manuscript. Best regards, " [Collapse]

Okpete UE, Byeon H. When ectopic bone forms in the abdomen: The diagnostic and management challenges of heterotopic mesenteric ossification. World J Gastrointest Endosc 2025; 17(3): 100253

"Thank you for giving us the opportunity to publish our manuscript in a prestigious journal. I would also like to express my deepest ..." [Read more]

Byeon H. Can decoding the complex web of non-suicidal self-injury in adolescents pave the way for tailored interventions? World J Psychiatry 2025; 15(3): 103258

"Thank you for giving us the opportunity to publish our manuscript in a prestigious journal. I would also like to express my deepest ..." [Read more]

Byeon H. Enhancing recovery in non-small cell lung cancer patients through mindfulness training and Jinshui Liujun decoction supplementation. World J Psychiatry 2025; 15(3): 101876

"Dear Editors, I am writing to express my sincere appreciation for the exceptional submission system and review process of your journal. ..." [Read more]

"Dear Editors, I am writing to express my sincere appreciation for the exceptional submission system and review process of your journal. Recently, I had the pleasure of submitting my manuscript to your platform, and I must say, the entire experience was highly satisfactory. The submission system is user-friendly and well-organized, making it easy for authors to upload their manuscripts and track the progress. Each step of the process is clearly outlined, and the system provides timely notifications, ensuring that authors are always kept in the loop. What truly impressed me, however, was the rigorous and efficient review process. The reviewers demonstrated a high level of scientific integrity and expertise, providing thorough and constructive feedback. Their comments were not only insightful but also actionable, helping me to significantly improve the quality of my work. I was particularly pleased with the speed at which the reviews were completed without compromising on the depth and quality of the evaluation. It is evident that your journal places a strong emphasis on maintaining the highest standards of academic rigor while also valuing the time and effort of contributors. This balance is commendable and sets a fine example for scholarly publications. Thank you once again for your dedication to excellence. I look forward to continuing my association with your journal and contributing more quality research in the future. Best regards, Bin Wang " [Collapse]

Wang ZH, Lv JH, Teng Y, Michael N, Zhao YF, Xia M, Wang B. Phospholipase D2: A biomarker for stratifying disease severity in acute pancreatitis? World J Gastroenterol 2025; 31(11): 104033

"The professor is very friendly and careful. The responsible editor professor is very kind and good at communication, which is of great ..." [Read more]

"The professor is very friendly and careful. The responsible editor professor is very kind and good at communication, which is of great help to us. From submission to publication, the cycle is still very fast, and we recognize this speed. Therefore, we are very satisfied with the process and result of this submission. " [Collapse]

Liang ZC, Ouyang H, Song XJ, Liang JX, Zheng WH, Chen JJ, Yin ZG, Chen SY. Eikenella corrodens isolated from pleural effusion: A case report. World J Clin Cases 2024; 12(18): 3596-3602

"The article of the journal is generally user -friendly and the operation of the online application system is smooth. The peer ..." [Read more]

"The article of the journal is generally user -friendly and the operation of the online application system is smooth. The peer evaluation process was completed in time and the feedback of the referees became constructive and guiding. However, it will be more useful for the authors to be more transparent and to give more detailed referee comments. The quality of the editing is satisfactory and the article is made in a professional manner to edit PDFs and full text versions. However, making shapes and tables more legible and aesthetically compatible in online format is one of the areas that require improvement. Although the broadcasting time is reasonable, more information about the process at some stages can provide authors to a better prediction of the process. The magazine exhibits meticulous work in terms of compliance with academic rules, but it would be useful to make more explanations about the content of the academic abuse report. As a result, the editorial process of the journal is professional and the peer evaluation process is thought to be fair and objective. However, making processes more transparent and informative will increase the satisfaction of the author. " [Collapse]

Yıldız GN, Çiftçi B. Narrative nursing as a holistic approach in modern healthcare: Integrating emotional and physical care. World J Psychiatry 2025; 15(3): 102956

"We greatly appreciated the journal’s efficient and transparent editorial process. The thorough yet constructive peer reviews enhanced ..." [Read more]

"We greatly appreciated the journal’s efficient and transparent editorial process. The thorough yet constructive peer reviews enhanced our manuscript significantly. The editing process was seamless, ensuring clarity and precision. Their swift communication and timely publication reflect a commitment to academic excellence. Overall, an outstanding experience with a highly professional team! " [Collapse]

Desai R, Gurram P, Mohammed AS, Salian RB, Lingamsetty SSP, Guntuku S, Medarametla RVSK, Jahan R, Muslehuddin Z, Ghantasala P. Contemporary nationwide trends in major adverse cardiovascular events in young cannabis users without concomitant tobacco, alcohol, cocaine use. World J Cardiol 2024; 16(9): 512-521

"We’d like to extend our heartfelt thanks to the editorial staff for their invaluable assistance throughout the publishing and editorial ..." [Read more]

"We’d like to extend our heartfelt thanks to the editorial staff for their invaluable assistance throughout the publishing and editorial process. Your expertise, attention to detail, and thoughtful feedback have been instrumental in refining this work. From navigating the complexities of publication to ensuring every element was polished to the highest standard, your support has made a significant difference. We truly appreciate the time and effort you dedicated to this paper. " [Collapse]

Han L, Peck EW, Teo E, See KC. Systematic review comparing the efficacy and safety of covered and uncovered self-expanding metal stents in benign airway stenosis. World J Meta-Anal 2025; 13(1): 100176

"I want to point the time to review. I submitted May 5, 2024, and no response was made for more than 3 months. First review comment ..." [Read more]

"I want to point the time to review. I submitted May 5, 2024, and no response was made for more than 3 months. First review comment was made after I claimed to the chief-editor for your idle response. After I got first response from the editorial office (judgement about my manuscript) after 4 months of my first submission, the process from review to publish is satisfactory. I think it is not good about the quality of editorial office and editor in the section of regenerative medicine. Time is very important for us, especially to deliver new insight fro the readers. I think that the so long delay of first response after my submission is very critical thing. Other things are very well. When I may think to submit other manuscript to World Journal of Stem Cells, I have to think the review process, severe delay of first response, and I may think to submit to other journal. I think the journal is worth submitting, but I want the response for authors to be considerably improved. " [Collapse]

Ohtake T, Sato T, Tsukiyama T, Muraoka S, Mitomo A, Maruyama H, Yamano M, Mochida Y, Ishioka K, Oka M, Moriya H, Hidaka S, Masuda H, Asahara T, Kobayashi S. Preliminary evidence of renal function improvement in chronic progressive kidney disease using autologous CD34⁺ cell therapy: A clinical trial. World J Stem Cells 2024; 16(12): 1012-1021

18304 items Read more >>

Article Quality Tracking-Peer-Review

"This is a nicely written article. Apart from the information presented, the authors may have added the details about Combined ..." [Read more]

"This is a nicely written article. Apart from the information presented, the authors may have added the details about Combined Multichannel Intraluminal Impedance (MMI) and pH measurement. This has been found to be better than 24 hours pH monitoring alone. Role of nuclear scan in the diagnosis of GERD may also be included whenever possible. " [Collapse]

Raza D, Mohiuddin F, Khan MH, Fawad M, Raza SM. Childhood gastroesophageal reflux disease: A comprehensive review of disease, diagnosis, and therapeutic management. World J Clin Pediatr 2025; 14(2): 101175

"Risk factors for intrahepatic bile duct cancer include not only hepatitis B, but also hepatitis C, liver cirrhosis, drinking, diabetes, ..." [Read more]

"Risk factors for intrahepatic bile duct cancer include not only hepatitis B, but also hepatitis C, liver cirrhosis, drinking, diabetes, obesity, smoking, nonalcoholic fatty liver disease, liver fluke infection, primary sclerosing cholangitis, intrahepatic stones, congenital biliary dilatation (choledochal cyst), Caroline's disease, and inflammatory bowel disease. In Japan, we often experience cases of intrahepatic stones, especially cholangiocarcinoma in the atrophic lobe. The authors include Child-Pugh score, ECOG, hepatitis B, and tumor size in TO, but what about the item for intrahepatic stones? " [Collapse]

Huang TF, Luo C, Guo LB, Liu HZ, Li JT, Lin QZ, Fan RL, Zhou WP, Li JD, Lin KC, Tang SC, Zeng YY. Preoperative prediction of textbook outcome in intrahepatic cholangiocarcinoma by interpretable machine learning: A multicenter cohort study. World J Gastroenterol 2025; 31(11): 100911

"It was with pleasure that I tracked the quality of the following article: 1 Ethics: Not applicable given manuscript type 2 Methods: ..." [Read more]

"It was with pleasure that I tracked the quality of the following article: 1 Ethics: Not applicable given manuscript type 2 Methods: Not applicable given manuscript type 3 Results: Not applicable given manuscript type 4 Figures and tables: The figures/tables add to the readability of the manuscript 5 Biostatistics: Not applicable given manuscript type 6 References: The references are appropriate and up to date 7 Language: This is a detailed/well written review 8 Caveats or drawbacks: None" [Collapse]

Kotsifa E, Saffioti F, Mavroeidis VK. Cholangiocarcinoma: The era of liquid biopsy. World J Gastroenterol 2025; 31(11): 104170

"Assessment of the Article 1. Ethics The article does not provide an explicit ethical approval form, which is understandable as it ..." [Read more]

"Assessment of the Article 1. Ethics The article does not provide an explicit ethical approval form, which is understandable as it is a mini-review rather than an empirical study involving human or animal subjects. 2. Methods As a review article, the methods section focuses on the methodology of data collection rather than experimental procedures. The authors conducted a comprehensive search of peer-reviewed articles and preclinical studies using PubMed, Scopus, and Web of Science databases, with clear inclusion criteria. The methods used to collect and analyze the data are well-described and can be repeated by fellow researchers. The references provided offer adequate textual/citation content to support the findings. 3. Results The results presented in the article are based on the findings of previously published studies. While the authors do not present new empirical data, they synthesize and interpret existing research to draw conclusions about the therapeutic potential of elafibranor in alcohol-associated liver disease. The theories and hypotheses discussed are partially validated by the cited preclinical and clinical studies. The results are true and authentic to the extent that they accurately reflect the current state of knowledge in the field. 4. Figures and Tables The article contains one figure and one table that effectively illustrate the key mechanisms of elafibranor's action in alcohol-associated liver disease. The figure is well-constructed, annotated, and easy to understand. The table provides a concise summary of elafibranor's mechanisms and their benefits in ALD, which enhances the readability and comprehensibility of the review. 5. Biostatistics As a review article, the focus is on the synthesis and interpretation of existing research rather than the presentation of new biostatistical data. The authors do not provide tables or line charts with biostatistical data. Instead, they discuss the results of previous studies and their implications for elafibranor's therapeutic potential. 6. References The authors scientifically and reasonably cite the latest references in the field of alcohol-associated liver disease and related scientific problems. The references cover a wide range of topics, including the pathogenesis of ALD, the role of macrophages, and the preclinical and clinical studies of elafibranor. The authors do not appear to self-cite, omit, mis-cite, or over-cite references. 7. Language The language in the article is clear, concise, and accurate. The information is presented in a logical and well-organized manner. The article does not contain multiple grammatical or spelling mistakes, which enhances its readability and credibility. 8. Caveats or Drawbacks While the article provides a comprehensive review of elafibranor's therapeutic potential in ALD, it is important to note that the majority of the evidence is based on preclinical studies. Clinical trials are ongoing, and the long-term safety and efficacy of elafibranor in humans remain to be established. Additionally, the heterogeneity of ALD patients and the complexity of the disease pathogenesis may limit the generalizability of the findings. These caveats should be considered when interpreting the results of the review. " [Collapse]

Farhadi S, Mohammadi S, AlKindi AY, Al-Amri IS. Therapeutic potential of elafibranor in alcohol-associated liver disease: Insights into macrophage modulation and fibrosis reduction. World J Biol Chem 2025; 16(1): 104535

"This article explores the development of both 2D and 3D osteogenic coculture models to investigate the dynamic interactions between ..." [Read more]

"This article explores the development of both 2D and 3D osteogenic coculture models to investigate the dynamic interactions between macrophages and ADSCs. It highlights possible mechanisms governing osteogenesis and immune modulation, offering valuable insights into bone tissue engineering and regenerative medicine. However, integrating novel and advanced methodologies, along with the potential for futuristic in vivo translation and a critical evaluation of existing limitations, could further clarify the significance of the findings." [Collapse]

Zhang HA, Zhang BY, Tang HB. Effects of macrophages on the osteogenic differentiation of adipose tissue-derived stem cells in two-dimensional and three-dimensional cocultures. World J Stem Cells 2025; 17(2): 99326

"It is a well-designed study that presents evidence for WDR36’s inhibitory role in the osteogenic differentiation and migration of ..." [Read more]

"It is a well-designed study that presents evidence for WDR36’s inhibitory role in the osteogenic differentiation and migration of PDLSCs. The microscopic images are of good quality and effectively illustrate the findings. However, improving the quality of western blots and providing stronger quantification would further enhance the impact and readability of the manuscript " [Collapse]

Wang Y, Zhang FQ, Fan ZP, Zhu XL, Yan WH, Zhang XL. WDR36 inhibits the osteogenic differentiation and migration of periodontal ligament stem cells. World J Stem Cells 2025; 17(2): 99132

"It is a good review with high-quality illustrations. This article describes various stem cell-based and exosome-based therapeutic ..." [Read more]

"It is a good review with high-quality illustrations. This article describes various stem cell-based and exosome-based therapeutic possibilities for skeletal muscle atrophy, highlighting their potential in regeneration and functional recovery. The comprehensive insights into emerging strategies make it a valuable resource for advancing regenerative medicine approaches in muscle disorders. However, the concluding remarks on the superiority of stem cell therapy over other treatment options remain open for further exploration." [Collapse]

Wang YJ, Chen ZH, Shen YT, Wang KX, Han YM, Zhang C, Yang XM, Chen BQ. Stem cell therapy: A promising therapeutic approach for skeletal muscle atrophy. World J Stem Cells 2025; 17(2): 98693

"It is a good article, highlighting the use of NAD⁺ to boost the viability of BM-MSCs, offering a promising therapeutic strategy for ..." [Read more]

"It is a good article, highlighting the use of NAD⁺ to boost the viability of BM-MSCs, offering a promising therapeutic strategy for regenerative medicine and immune modulation. As this study primarily relies on in vitro models, the cost and affordability of MSC treatments, along with other cost-effective alternatives, raise important considerations for widespread clinical application." [Collapse]

Xia X, Zhou K, An LY, Zhao M, Tian BL, Zhao JY, Zhou ZG, Tong Y. Nicotinamide adenine dinucleotide rejuvenates septic bone marrow mesenchymal stem cells. World J Stem Cells 2025; 17(2): 96893

"This article reviewed the advances in the diagnosis and management of coronary microvascular dysfunction focusing on the patients ..." [Read more]

"This article reviewed the advances in the diagnosis and management of coronary microvascular dysfunction focusing on the patients who underwent PCI. I think the following two explanation could be added for this excellent review article. The authors admirably discussed the pathophysiology and metabolic risk interactions. However, the authors did not refer the (epicardial) coronary artery spasm as one of the causes of post PCI myocardial ischemia. I think epicardial coronary spasm is often associated with epicardial coronary stenosis which is physiologically significant. In these patients, chest pain occurs often even after PCI even if there is no coronary microvascular dysfunction. Coronary microvascular dysfunction might be classified into two groups. One group is recognized also before PCI, and the other occurred only after PCI in cases such as acute coronary syndrome (no reflow phenomenon). " [Collapse]

Tang N, Li KM, Li HR, Zhang QD, Hao J, Qi CM. Advances in the diagnosis and management of post-percutaneous coronary intervention coronary microvascular dysfunction: Insights into pathophysiology and metabolic risk interactions. World J Cardiol 2025; 17(2): 103950

"Indeed, TIPS is an interventional radiological procedure that significantly reduces portal pressure, prevents decompensation and ..." [Read more]

"Indeed, TIPS is an interventional radiological procedure that significantly reduces portal pressure, prevents decompensation and improves survival of cirrhotic patients. The authors provided interesting but very limited information about the TIPS as a method for the treatment of portal hypertension complications. For example, the main TIPS-related problems, namely shunt dysfunction and post-TIPS hepatic encephalopathy, have not been considered at all." [Collapse]

de Mattos AA, de Mattos AZ, Manica M, Tovo CV. Which patients benefit the most? An update on transjugular intrahepatic portosystemic shunt. World J Hepatol 2025; 17(2): 99809

"1. Ethics: The ethical approval for this study is mentioned as granted by the Ethics Committee of Xuzhou Central Hospital. 2. ..." [Read more]

"1. Ethics: The ethical approval for this study is mentioned as granted by the Ethics Committee of Xuzhou Central Hospital. 2. Methods: The study is a retrospective comparative study analyzing 123 patients treated with either microwave ablation (MWA) or laparoscopic hepatectomy (LH). The inclusion and exclusion criteria are clearly outlined. The treatment protocols for both procedures are well described, making it possible for other researchers to replicate the methods. 3. Results: The results indicate that MWA has advantages over LH, with shorter operative time, lower intraoperative bleeding, and faster recovery. The study shows statistically significant differences in postoperative complications (4.84% in the MWA group vs. 19.67% in the LH group, P = 0.012). The effective rate of treatment was also significantly higher in the MWA group (P = 0.027). However, long-term survival outcomes such as recurrence-free survival (RFS) or overall survival (OS) are expected. 4. Figures and Tables: The manuscript contains clear tables and well-labeled figures comparing perioperative indicators and postoperative outcomes. Data is systematically structured, and statistical significance is appropriately indicated (P values provided). 5. Biostatistics: The study employs basic statistical methods (t-test, χ² test) to compare continuous and categorical variables. The analysis appears appropriate, but there are no multivariate analyses to control for confounders, which is a limitation. 6. References: The references include recent and relevant studies, particularly those from Nature Reviews Gastroenterology & Hepatology, Hepatology, and World Journal of Gastrointestinal Surgery. 7. Language and Clarity: The manuscript is written in clear and professional English, with minimal grammatical errors. However, some sentences are redundant or could be more concise, particularly in the discussion. The study provides valuable short-term comparative data on MWA vs. LH for primary small liver cancer. However, the lack of long-term follow-up and absence of multivariate analysis limits the strength of its conclusions. The authors should be encouraged to include propensity score matching, long-term survival data, and quality-of-life outcomes in future studies." [Collapse]

Li HS, Zhang XF, Fu J, Yuan B. Efficacy of microwave ablation vs laparoscopic hepatectomy for primary small liver cancer: A comparative study. World J Gastrointest Surg 2025; 17(3): 101786

"1. Ethics The ethical approval process is clearly documented. 2. Methods The case report aligns with typical diagnostic and ..." [Read more]

"1. Ethics The ethical approval process is clearly documented. 2. Methods The case report aligns with typical diagnostic and therapeutic workflows for CHD and PE. However, methodological details could be improved further (e.g., specific criteria for selecting CABG over other interventions, anticoagulant dosing protocols). 3. Results Results are consistent with clinical findings (elevated D-dimer, CTPA-confirmed PE, CAG-confirmed CHD). Limitation: No long-term follow-up data beyond 2 months. 4. Figures and Tables Figures clearly demonstrate the patient’s progression and treatment response. 5. Biostatistics Not applicable to this case report, as no statistical analysis was performed. 6. References Citations include key guidelines and recent studies. References support the discussion of overlapping CHD/PE symptoms and treatment strategies. 7. Language The language is generally clear and professional. 8. Caveats or Drawbacks Relative sShort follow-up period." [Collapse]

Xu JQ, Jiang MX, Wang F, Yang KQ, Xu YJ, Wang YJ, Dong SJ. Coronary heart disease with pulmonary embolism: A case report. World J Cardiol 2025; 17(2): 101588

"The topic is of great interest. Assessment of VOCs is novel, non-ivasive approach to diagnose cardiovascular disease such as ischemic ..." [Read more]

"The topic is of great interest. Assessment of VOCs is novel, non-ivasive approach to diagnose cardiovascular disease such as ischemic heart disease and heart failure. It is also important to help secandary prevention of such diseases. However we need some more data and advanced technologies for assessement of VOCs. In this perspective, thie review is worth reading. " [Collapse]

Marzoog BA, Chomakhidze P, Gognieva D, Parunova AY, Demchuk SN, Silantyev A, Kuznetsova N, Kostikova A, Podgalo D, Nagornov E, Gadzhiakhmedova A, Kopylov P. Updates in breathomics behavior in ischemic heart disease and heart failure, mass-spectrometry. World J Cardiol 2025; 17(2): 102851

"The authors reported substantial findings regarding novel predictibe biomarler for ACS based on the calculation of RBC width to albumin ..." [Read more]

"The authors reported substantial findings regarding novel predictibe biomarler for ACS based on the calculation of RBC width to albumin ratio. The aim of the study is clear and the paper is well written. The manuscript has high relevance and adequacy of the literature presented, including recognition of gaps in knowledge, interpretation of findings and significance of other recent research on the topic, and readable conclusion. The findings are based on the relevant statistics, while the weaknes of the study was a retrospective design. However, the authors obtained promising results which are likely to be implemented in clinical practice without sufficient economic expenditure. Overall, the article scientifically sounds and contributes to the reader attractivity. I congratulate the authors on the study." [Collapse]

Wang JN, Hu ZS, Yu YW, Peng XH. Red blood cell distribution width to albumin ratio is correlated with prognosis of patients in coronary care unit. World J Cardiol 2025; 17(2): 103273

"• Echinococcosis is a parasitic disease caused by tapeworms of the genus Echinococcus. It can be transmitted to humans from animals, ..." [Read more]

"• Echinococcosis is a parasitic disease caused by tapeworms of the genus Echinococcus. It can be transmitted to humans from animals, making it a zoonotic disease. Treatment options include surgery, albendazole, and PAIR (puncture, aspiration, injection, re-aspiration).Please comment about PAIR. The diagnosis of echinococcosis relies mainly on findings by ultrasonography and/or other imaging techniques supported by positive serologic test. I ask you . What kinds of examination do you performed for　 seronegative patients with hepatic image findings compatible with echinococcosis。 " [Collapse]

Pavlidis ET, Galanis IN, Pavlidis TE. Current considerations for the management of liver echinococcosis. World J Gastroenterol 2025; 31(10): 103973

"The article discusses a novel approach to diagnosing fistula-in-ano using high-resolution hydrogen peroxide-enhanced magnetic resonance ..." [Read more]

"The article discusses a novel approach to diagnosing fistula-in-ano using high-resolution hydrogen peroxide-enhanced magnetic resonance imaging (HPMRI) fistulography. Fistula-in-ano, a chronic infection affecting the perianal region, can be caused by several factors like Crohn's disease, pelvic infections, or radiotherapy. It is more common in younger adults and often presents with symptoms such as discharge and localized pain. This study sought to compare the effectiveness of various diagnostic techniques for detecting internal openings, fistula tracks, and perianal abscesses in patients undergoing surgery. The study included 60 patients and compared methods such as physical examination, ultrasound, low-resolution MRI, and high-resolution HPMRI. The results showed that high-resolution HPMRI had the highest sensitivity and specificity for detecting these features, particularly for complex and recurrent fistulas, with Kappa values indicating almost perfect agreement between observers. Furthermore, HPMRI outperformed the other methods in terms of diagnostic accuracy, with improved image quality achieved through optimized MRI protocols and contrast agents. The study emphasizes the importance of HPMRI for preoperative assessment, especially in complex cases where other methods like ultrasound or low-resolution MRI may fall short. The high spatial resolution provided by HPMRI allowed for clearer visualization of fistula tracks and internal openings, which is crucial for accurate surgical planning and reducing recurrence rates." [Collapse]

Chang CC, Qiao LH, Zhang ZQ, Tian X, Zhang Y, Cheng WW, Wang X, Yang Q. High-resolution direct magnetic resonance imaging fistulography with hydrogen peroxide for diagnosing anorectal fistula: A preliminary retrospective study. World J Radiol 2025; 17(1): 101221

"Oral and maxillofacial diagnostic imaging plays a crucial role in dental diagnosis, treatment planning, and follow-up procedures. ..." [Read more]

"Oral and maxillofacial diagnostic imaging plays a crucial role in dental diagnosis, treatment planning, and follow-up procedures. X-rays, particularly intraoral periapical radiography, have been the primary imaging technique in clinical dental practice since their introduction in the early 20th century. Over time, several advanced imaging technologies have emerged, enhancing the diagnostic capabilities of dentists. Among these are various types of digital sensors, such as charge-coupled devices and complementary metal oxide semiconductors, which allow for clearer, more detailed images. However, issues like patient discomfort during imaging and positioning errors still pose challenges, affecting the quality of images. Periapical radiographs are vital for visualizing the entire crown and root of teeth, providing essential information for diagnosing common dental issues like periodontal and periapical diseases. Bite-wing radiographs, which focus on interproximal surfaces, are also used for detecting caries, periodontal disease, and restorations. While these 2D imaging techniques are useful, they have limitations in showing more complex anatomical structures and pathologies. Panoramic radiography, another common method, provides broader images by rotating the X-ray source and detector around a stationary patient. This method, though effective for evaluating both jaws, suffers from issues like unequal magnification and image distortion. Cone beam CT (CBCT), which offers three-dimensional images of the dentomaxillofacial region, is a significant advancement. It provides detailed information on complex structures and is especially useful in fields like implantology, orthodontics, and maxillofacial surgery. While CBCT offers advantages over traditional X-rays, it does have limitations in soft tissue contrast. Micro-CT, which provides extremely detailed 3D images, is another emerging tool, primarily for research purposes. It offers high resolution for assessing tooth and bone structures but is not yet feasible for routine clinical use due to its high radiation doses and costs. Ultrasonography (US) is a non-invasive alternative that doesn’t use ionizing radiation. It’s especially useful for examining superficial soft tissues, bone, and conditions like salivary gland lesions. However, it has limitations in visualizing deeper tissues like bone. Magnetic resonance imaging (MRI), another ionizing-free method, offers excellent soft tissue contrast and is becoming increasingly important for assessing temporomandibular joint (TMJ) disorders and soft tissue lesions. MRI can also be used for evaluating bone loss and inflammation. Recently, MRI technology tailored specifically for dental applications has shown promise in providing detailed views of dentomaxillofacial structures. The advent of 3D printing technology in dentistry is revolutionizing how dental procedures are planned and executed. With the help of CBCT data, 3D-printed models can be used for creating precise surgical guides, which are particularly beneficial in implantology. This technology is also being explored in fields like endodontics, periapical surgery, and maxillofacial surgery, and has the potential to improve procedural accuracy and efficiency. Artificial intelligence (AI) is another exciting development in dental imaging. AI algorithms are being explored for tasks like disease detection, image segmentation, and treatment planning, with the potential to enhance diagnostic accuracy and efficiency. However, while AI has shown promise, it is still in the research phase and needs further validation before it can be fully integrated into clinical practice. In conclusion, advancements in dental imaging technologies, such as CBCT, 3D printing, and AI, are significantly improving the diagnostic and treatment capabilities in dentistry. These innovations are expected to enhance clinical outcomes, reduce diagnostic errors, and increase efficiency. However, challenges like high costs, long scanning times, and the need for further research in AI remain. Continued exploration of these technologies will contribute to the evolution of dental care, offering new possibilities for diagnosis and treatment." [Collapse]

Kamburoğlu K. Trends in dentomaxillofacial radiology. World J Radiol 2025; 17(1): 97255

"The article compares whole-body MRI (wbMRI) with PET/CT for staging diffuse large B-cell lymphoma (DLBCL), and provides important ..." [Read more]

"The article compares whole-body MRI (wbMRI) with PET/CT for staging diffuse large B-cell lymphoma (DLBCL), and provides important insights into the potential of wbMRI as an alternative imaging modality. The study aims to evaluate the diagnostic effectiveness of both techniques in a clinical setting, using key metrics like sensitivity, specificity, and accuracy. The authors present a clear hypothesis, a solid methodological framework, and appropriate statistical analyses, which establish the credibility and reliability of the results. Despite the article’s strengths, a few issues remain that could limit its objectivity and the generalizability of the findings. One key concern is the small sample size, with only 14 patients included in the study. This raises questions about the representativeness of the sample and the external validity of the conclusions. A larger and more diverse cohort could provide more robust and widely applicable results. Additionally, the study focuses primarily on the diagnostic accuracy of wbMRI but does not delve deeply into the practical implications of implementing this modality in clinical practice. Issues like the potential for longer scan times and the lack of functional data, which PET/CT provides, are not sufficiently addressed. These factors may limit the clinical utility of wbMRI, and it would be valuable for future research to explore solutions to these limitations, such as combining wbMRI with other imaging techniques to provide more comprehensive results. The ethical approval and informed consent procedures are clearly outlined, contributing to the study’s scientific credibility. The authors also conduct appropriate statistical analyses, and the findings are statistically significant. However, the article could benefit from a more thorough examination of the real-world impact of incorporating wbMRI into routine DLBCL staging. For example, cost-effectiveness, patient comfort, and potential integration into clinical workflows were not explored in depth. These aspects are important for assessing the practical feasibility of adopting wbMRI more broadly. Furthermore, while the authors discuss the diagnostic performance of wbMRI, they do not fully consider the limitations of this imaging modality, such as longer scan times and the absence of functional data, which are key features of PET/CT. In terms of future directions, the study would benefit from larger-scale research involving more diverse patient populations. Additionally, hybrid imaging techniques, which combine the strengths of both wbMRI and functional imaging methods like PET/CT, could offer a promising avenue to enhance diagnostic accuracy. Addressing patient comfort, particularly by reducing scan duration, and incorporating cost-effectiveness analyses into future studies would further improve the practical applicability of wbMRI. By addressing these issues, future research could provide more comprehensive, clinically relevant findings that would further strengthen the case for wbMRI as a viable alternative to PET/CT in lymphoma staging. In conclusion, while the article contributes valuable insights into the potential of wbMRI in DLBCL staging, several issues remain unresolved. These include the small sample size, practical challenges related to patient comfort, and the limitations of wbMRI compared to PET/CT. By addressing these concerns in future studies, the authors could enhance the scientific quality and applicability of their research, ultimately contributing to the development of better diagnostic tools for lymphoma management." [Collapse]

Lambert L, Wagnerova M, Vodicka P, Benesova K, Zogala D, Trneny M, Burgetova A. Whole-body magnetic resonance imaging provides accurate staging of diffuse large B-cell lymphoma, but is less preferred by patients. World J Radiol 2025; 17(1): 99207

"The article "Retrospective analysis of delta hemoglobin and bleeding-related risk factors in pancreaticoduodenectomy" presents a ..." [Read more]

"The article "Retrospective analysis of delta hemoglobin and bleeding-related risk factors in pancreaticoduodenectomy" presents a well-structured and objective study with clear methodology and robust statistical analysis. The authors effectively address the limitations of visual estimation of intraoperative blood loss by introducing delta hemoglobin (ΔHb) as a more objective metric. The study's credibility is reinforced by its large sample size (n=1722) and the rigorous statistical evaluation, including univariate and multivariate regression analyses to identify independent bleeding risk factors. Key issues resolved include demonstrating a significant correlation between ΔHb and estimated blood loss (EBL), as well as identifying ASA classification IV, BMI > 24 kg/m², and preoperative total bilirubin > 200 μmol/L as independent risk factors for perioperative bleeding. However, some limitations persist, such as potential biases from a single-center retrospective design and confounding factors like fluid resuscitation affecting ΔHb values. Future research should focus on multicenter validation and prospective studies to confirm ΔHb’s predictive value across different institutions. Additionally, exploring real-time ΔHb monitoring and integrating machine learning models for individualized bleeding risk prediction could enhance clinical applicability. This study provides valuable insights that contribute to surgical safety and perioperative risk stratification." [Collapse]

Lin YM, Yu C, Xian GZ. Retrospective analysis of delta hemoglobin and bleeding-related risk factors in pancreaticoduodenectomy. World J Gastrointest Surg 2025; 17(3): 100999

"The study aimed to evaluate the efficacy of ASC-Exos cross-linked CS-αβ-GP hydrogel on treating deep burn wounds. Some papers have ..." [Read more]

"The study aimed to evaluate the efficacy of ASC-Exos cross-linked CS-αβ-GP hydrogel on treating deep burn wounds. Some papers have demostrated exosomal effects on skin wound like burning wound, however the selection of scaffold for the exosomal treatment has been still challenging. In the paper, the author used chitosan (CS)-αβ-glycerophosphate (CS-αβ-GP) hydrogel as a scaffold and that was cross-linked with adipose-derived stem cell exosomes (ASC-Exos). In results, they showed impactful anti-inflammatory effects, promotes wound healing, and facilitates the transition of M1 macrophages to M2 macrophages by blocking the NF-κB pathway. From the study, we can get an insight for using CS-αβ-GP as a scaffold for exosomal treatment." [Collapse]

Xu L, Liu D, Yun HL, Zhang W, Ren L, Li WW, Han C. Effect of adipose-derived stem cells exosomes cross-linked chitosan-αβ-glycerophosphate thermosensitive hydrogel on deep burn wounds. World J Stem Cells 2025; 17(2): 102091

15131 items Read more >>

Peer-Reviewers and Manuscript Statistics

Editorial board members: 2267

Peer-reviewers: 29426

Manuscripts received today: 5

Manuscript reviews today: 26

Unhandled manuscripts today: 144

Active peer-reviewers today: 2111

Reviewer acceptance today: 36

Reviewer refusals today: 74

Total accepted manuscripts: 35295

Total rejected manuscripts: 40825

Total peer-reviewers: 4099270

Total submissions: 33572

Baishideng Publishing Group (BPG) publishes 47 peer-reviewed, open-access journals covering a broad range of topics in clinical medicine, as well as several topics in biochemistry and molecular biology, relevant to human health today.

BPG Journals

Reference Citation Analysis

BPG E-Books

BPG Blog

All Journal Articles

Parchwani D, Singh R, Patel D. Biological and translational attributes of mitochondrial DNA copy number: Laboratory perspective to clinical relevance. World J Methodol 2025; 15(3): 102709

2025-09-20 | Browse: 647 | Download: 112

Tawheed A, Ismail A, El-Tawansy A, Maurice K, Ali A, El-Fouly A, Madkour A. Third space endoscopy pulmonary complications and chylothorax post peroral endoscopic myotomy. World J Methodol 2025; 15(3): 102703

2025-09-20 | Browse: 673 | Download: 105

Bajpai J, Saxena M, Pradhan A, Kant S. Sotatercept: A novel therapeutic approach for pulmonary arterial hypertension through transforming growth factor-β signaling modulation. World J Methodol 2025; 15(3): 102688

2025-09-20 | Browse: 650 | Download: 108

Bale BI, Zeppieri M, Idogen OS, Okechukwu CI, Ojo OE, Femi DA, Lawal AA, Adedeji SJ, Manikavasagar P, Akingbola A, Aborode AT, Musa M. Seeing the unseen: The low treatment rate of eye emergency in Africa. World J Methodol 2025; 15(3): 102477

2025-09-20 | Browse: 798 | Download: 119

Vo LT, Vu T, Pham TN, Trinh TH, Nguyen TT. Machine learning-based models for prediction of in-hospital mortality in patients with dengue shock syndrome. World J Methodol 2025; 15(3): 101837

2025-09-20 | Browse: 659 | Download: 162

Chauhan R, Padiyar N, Kaurani P, Gupta A, Chauhan S. Comparative evaluation of retentive capacity of three different attachment systems for implant retained overdentures: An in vitro study. World J Methodol 2025; 15(3): 101057

2025-09-20 | Browse: 670 | Download: 138

Shah P, Shah VM, Saravanan VR, Kumar K, Narendran S. Evaluation of macular and peripapillary structure and microvasculature with optical coherence tomography angiography in migraine in Indian population. World J Methodol 2025; 15(3): 100950

2025-09-20 | Browse: 654 | Download: 153

Drăgoi AL, Nemeș RM. “Electronic Pediatrician”, a non-machine learning prototype artificial intelligence software for pediatric computer-assisted pathophysiologic diagnosis — general presentation. World J Methodol 2025; 15(3): 100903

2025-09-20 | Browse: 582 | Download: 161

Drăgoi AL, Nemeș RM. The remarkable effects of the ionized medical water Asea® in 3 boys with Duchenne dystrophy: Three case reports. World J Methodol 2025; 15(3): 100840

2025-09-20 | Browse: 542 | Download: 146

Fawaz P, El Sayegh P, Vande Vannet B. Artificial intelligence in revolutionizing orthodontic practice. World J Methodol 2025; 15(3): 100598

2025-09-20 | Browse: 809 | Download: 159

Khokhar RK, Nashwan AJ. Gut virome and its emerging role in inflammatory bowel disease. World J Methodol 2025; 15(3): 100534

2025-09-20 | Browse: 520 | Download: 135

English K. Echo contrast medium: How the use of contrast echocardiography (ultrasound contrast agents) can improve patient care. World J Methodol 2025; 15(3): 100490

2025-09-20 | Browse: 544 | Download: 117

Tramontana A, Rulli M, Falegnami A, Bilotta F. Visual avatar to increase situational awareness in anaesthesia: Systematic review of recent evidence. World J Methodol 2025; 15(3): 100459

2025-09-20 | Browse: 611 | Download: 103

Li XL, Megdadi M, Quadri HS. Interaction between gut virome and microbiota on inflammatory bowel disease. World J Methodol 2025; 15(3): 100332

2025-09-20 | Browse: 476 | Download: 89

Raveendran AV. Clinical inertia in sexual medicine practice. World J Methodol 2025; 15(3): 99874

2025-09-20 | Browse: 624 | Download: 110

Tarazi A, Aburrub A, Hijah M. Use of artificial intelligence in neurological disorders diagnosis: A scientometric study. World J Methodol 2025; 15(3): 99403

2025-09-20 | Browse: 701 | Download: 125

Casu C, Inchingolo AM, Orrù G. Interleukin 10 supplement to reduce episodes of recurrent aphthous stomatitis. World J Methodol 2025; 15(3): 99176

2025-09-20 | Browse: 568 | Download: 96

Singh K, Nashwan AJ. Innovative forecasting models for nurse demand in modern healthcare systems. World J Methodol 2025; 15(3): 99162

2025-09-20 | Browse: 519 | Download: 107

Kodali R, Parasar K, Anand U, Singh BN, Kant K, Arora A, Karthikeyan V, Anwar S, Saha B, Wadaskar S. Evidence-based approach for intraabdominal drainage in pancreatic surgery: A systematic review and meta-analysis. World J Methodol 2025; 15(3): 99080

2025-09-20 | Browse: 960 | Download: 132

Al-Beltagi M. Fishing reviewing: A threat to research integrity and credibility. World J Methodol 2025; 15(3): 98795

2025-09-20 | Browse: 660 | Download: 118

57873 items Read more >>

Featured Articles

Al-Beltagi M. Human milk oligosaccharide secretion dynamics during breastfeeding and its antimicrobial role: A systematic review. World J Clin Pediatr 2025; 14(2): 104797

2025-03-18 | Browse: 4 | Download: 0

Macho V, Rodrigues R, Pinto D, Castro R, Silva CC, Silva CC, Soares SC. Importance of celiac disease oral manifestations in pediatric patients: A systematic review. World J Clin Pediatr 2025; 14(2): 102002

2025-03-18 | Browse: 6 | Download: 3

Son Y, Quiring M, Serpico S, Wu E, Wood E, Deynzer S, Olive W, Henderson B, Choudhry H, Ahmed A, Aljameey U, Terrenzio D, Dean GE. Factors and outcomes leading to postoperative emergency department visits after ureteroneocystostomy. World J Clin Pediatr 2025; 14(2): 99455

2025-03-18 | Browse: 5 | Download: 0

Faa G, Pichiri G, Coni P, Dessì A, Fraschini M, Fanos V. They will be famous: Multipotent stem cells in breast milk. World J Clin Pediatr 2025; 14(2): 101080

2025-03-18 | Browse: 4 | Download: 0

Goyal S, Tibrewal S, Ratna R, Vanita V. Genetic and environmental factors contributing to anophthalmia and microphthalmia: Current understanding and future directions. World J Clin Pediatr 2025; 14(2): 101982

2025-03-18 | Browse: 20 | Download: 0

Eldew H, Soldera J. Evaluation of biological therapies in autoimmune hepatitis: A case-based systematic review. World J Gastrointest Pathophysiol 2025; 16(1): 101481

2025-03-18 | Browse: 8 | Download: 12

Yang WL, Zhou R, Zhang XJ, Jiang WC. Bibliometric analysis of original studies on stereoelectroencephalography from 1990 to 2023. World J Meta-Anal 2025; 13(1): 102634

2025-03-14 | Browse: 35 | Download: 70

Khoo E, Gilmore R, Griffin A, Holtmann G, Begun J. Risk factors associated with the development of chronic pouchitis following ileal-pouch anal anastomosis surgery for ulcerative colitis. World J Meta-Anal 2025; 13(1): 101226

2025-03-14 | Browse: 30 | Download: 61

Santos CS, Carteri RB, Coghetto C, Czermainski J, Rosa CB. Nutritional interventions in the treatment of Hashimoto’s disease: A systematic review. World J Meta-Anal 2025; 13(1): 100523

2025-03-14 | Browse: 28 | Download: 67

2025-03-14 | Browse: 29 | Download: 58

Kar SK, Kumari B, Joseph R, Chatterjee S, Joshi M, Agrawal A. Role of transcranial magnetic stimulation in the management of trichotillomania: A systematic review. World J Meta-Anal 2025; 13(1): 98933

2025-03-14 | Browse: 31 | Download: 71

Tonishi T, Ishibashi F, Okusa K, Mochida K, Suzuki S. Effects of a training system that tracks the operator’s gaze pattern during endoscopic submucosal dissection on hemostasis. World J Gastrointest Endosc 2025; 17(3): 104315

2025-03-14 | Browse: 31 | Download: 83

Lim SXY, Ratcliffe E, Wiltshire R, Whiteway JGS, McGrath S, Sultan J, Prasad N, Assadsangabi A, Britton J, Ang YS. Long-term outcomes of endoscopic submucosal dissection for gastric dysplasia and early neoplasia in a United Kingdom Caucasian population. World J Gastrointest Endosc 2025; 17(3): 102694

2025-03-14 | Browse: 44 | Download: 78

Xiang Y, Yuan Y, Wang ZY, Zhu YM, Li WY, Ye QG, Wang YN, Sun Q, Ding XW, Longi F, Tang DH, Xu GF. Comorbidities related to metachronous recurrence for early gastric cancer in elderly patients. World J Gastrointest Endosc 2025; 17(3): 99540

2025-03-14 | Browse: 34 | Download: 91

Ballester R, Costigan C, O'Sullivan AM, Sengupta S, McNamara D. Efficacy and applications for PuraStat® use in the management of unselected gastrointestinal bleeding: A retrospective observational study. World J Gastrointest Endosc 2025; 17(3): 98021

2025-03-14 | Browse: 37 | Download: 72

Calabrese G, Sferrazza S, Ramai D, Maida M. Stricture prevention after circumferential endoscopic submucosal dissection of the esophagus: Proactive vs reactive strategies. World J Gastrointest Endosc 2025; 17(3): 101428

2025-03-14 | Browse: 33 | Download: 62

Wu Y, Xie BB, Zhang BL, Zhuang QX, Liu SW, Pan HM. Apatinib regulates the glycolysis of vascular endothelial cells through PI3K/AKT/PFKFB3 pathway in hepatocellular carcinoma. World J Gastroenterol 2025; 31(11): 102848

2025-03-13 | Browse: 47 | Download: 93

Niu YR, Xiang MD, Yang WW, Fang YT, Qian HL, Sun YK. NAD+/SIRT1 pathway regulates glycolysis to promote oxaliplatin resistance in colorectal cancer. World J Gastroenterol 2025; 31(11): 100785

2025-03-13 | Browse: 43 | Download: 71

Shi YH, Liu JL, Cheng CC, Li WL, Sun H, Zhou XL, Wei H, Fei SJ. Construction and validation of machine learning-based predictive model for colorectal polyp recurrence one year after endoscopic mucosal resection. World J Gastroenterol 2025; 31(11): 102387

2025-03-13 | Browse: 47 | Download: 95

Kotsifa E, Saffioti F, Mavroeidis VK. Cholangiocarcinoma: The era of liquid biopsy. World J Gastroenterol 2025; 31(11): 104170

2025-03-13 | Browse: 52 | Download: 68

9317 items Read more >>

Keyword Search Published Articles Processes

Case report

2852

Case report

1523

Hepatocellular carcinoma

1401

Gastric cancer

972

Colorectal cancer

952

Inflammatory bowel disease

709

COVID-19

703

Prognosis

670

Liver transplantation

611

Treatment

552

Ulcerative colitis

549

Diagnosis

517

Helicobacter pylori

509

Crohn’s disease

505

Endoscopy

478

Cirrhosis

475

Meta-analysis

454

Magnetic resonance imaging

440

Pancreatic cancer

438

Surgery

423

67662 items Read more >>

Reader Comments

"This study provides valuable insights into the effectiveness of combining three-dimensional computed tomography (3D CT) reconstruction ..." [Read more]

"This study provides valuable insights into the effectiveness of combining three-dimensional computed tomography (3D CT) reconstruction and laparoscopic techniques for accurately measuring the myopectineal orifice (MPO) in inguinal hernia repair. The research clearly demonstrates that preoperative 3D CT measurements closely match intraoperative laparoscopic findings, suggesting that CT could reliably guide surgical planning. The authors effectively highlight the clinical implications, emphasizing how precise measurement and patch placement can minimize complications such as nerve injury, recurrence, and chronic postoperative pain. Additionally, they provide a thoughtful analysis regarding demographic factors, noting significant differences in MPO measurements between sexes, while age and body mass index showed less impact. One of the strengths of this article is its detailed methodological description, which facilitates replication and further research. However, future studies might benefit from larger sample sizes and expanded demographic variability to enhance generalizability. Overall, the paper makes a significant contribution to personalized surgical approaches for inguinal hernia treatment. " [Collapse]

Zhang L, Chen J, Zhang YY, Liu L, Wang HD, Zhang YF, Sheng J, Hu QS, Liu ML, Yuan YL. Three-dimensional reconstruction under computed tomography and myopectineal orifice measurement under laparoscopy for quality control of inguinal hernia treatment. World J Gastrointest Endosc 2025; 17(3): 104966

"As this is a editorial article, it has got no sections of methods, results, tables, biostatistics, units and ethical statement to ..." [Read more]

"As this is a editorial article, it has got no sections of methods, results, tables, biostatistics, units and ethical statement to provide commentary on these sections. The editorial by Behrens and Elgafy provides an insightful analysis of factors influencing outcomes in indirect decompression through oblique and lateral lumbar interbody fusions (OLIF and LLIF). The discussion on patient selection criteria, particularly regarding preoperative spinal canal dimensions and lateral recess depth, is a valuable contribution to clinical decision-making. The emphasis on the unpredictability of outcomes in patients with severe lateral recess stenosis and the potential need for staged procedures highlights a crucial consideration for spine surgeons. However, one area that could benefit from further exploration is the long-term stability of indirect decompression compared to direct decompression, especially concerning adjacent segment disease and fusion longevity. Additionally, a deeper comparison of OLIF and LLIF in terms of specific complications and recovery trajectories would provide even greater clinical relevance. Overall, this editorial offers a comprehensive and well-referenced synthesis of the current literature on indirect decompression. It serves as a useful guide for surgeons considering minimally invasive approaches while remaining cautious about their limitations. " [Collapse]

M Behrens KM, Elgafy H. Factors affecting outcomes of indirect decompression after oblique and lateral lumbar interbody fusions. World J Orthop 2025; 16(3): 100772

"The clinical significance of this study lies in its innovative approach to predicting colorectal polyp recurrence using machine ..." [Read more]

"The clinical significance of this study lies in its innovative approach to predicting colorectal polyp recurrence using machine learning (ML), specifically the eXtreme Gradient Boosting (XGBoost) model. Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, largely preventable through early detection and effective management of precancerous polyps. Endoscopic mucosal resection (EMR) is widely utilized for the removal of colorectal polyps, yet it carries a considerable risk of recurrence, highlighting the need for accurate predictive tools to guide postoperative surveillance. This study identifies critical independent risk factors for polyp recurrence one year post-EMR, such as age, family history, smoking habits, diarrhea, Helicobacter pylori infection, polyp size, number of polyps, and hazard classification. By leveraging ML algorithms, particularly XGBoost, the researchers have developed a model with superior predictive performance, evidenced by high Area Under the Curve (AUC) values exceeding 0.90 across multiple validation cohorts, including a prospective validation set, indicating robust predictive accuracy and clinical utility. Clinically, the XGBoost model offers substantial advantages. Its high sensitivity, specificity, accuracy, precision, and F1 scores suggest that it effectively stratifies patients based on recurrence risk. Such a model significantly enhances personalized patient management by informing more accurate follow-up intervals, potentially improving patient outcomes through timely interventions and reducing unnecessary colonoscopies in low-risk individuals. Additionally, the authors' development of an accessible online web calculator based on this predictive model further underscores its practical utility in routine clinical practice. Clinicians can conveniently input patient-specific clinical parameters to obtain immediate, individualized risk predictions, facilitating shared decision-making between physicians and patients. Decision Curve Analysis further underscores the practical value of this tool, demonstrating that using the XGBoost model provides superior clinical net benefit compared to standard follow-up strategies. This methodical approach not only advances clinical decision-making but also optimizes healthcare resources by prioritizing surveillance for those most at risk. Finally, the interpretability of the model via SHapley Additive exPlanations (SHAP) analysis significantly mitigates concerns about the "black box" nature commonly associated with ML models, thus increasing clinician trust and acceptability. In conclusion, this ML-based predictive model represents a critical advancement in clinical gastroenterology, providing robust, data-driven support for clinicians in making individualized recommendations for colorectal polyp surveillance and potentially reducing colorectal cancer incidence through targeted early intervention. " [Collapse]

"The author has shown that knocking out SERPINB5 not only inhibits the proliferation and metastasis of cancer cells but also suppresses ..." [Read more]

"The author has shown that knocking out SERPINB5 not only inhibits the proliferation and metastasis of cancer cells but also suppresses tumor growth in xenograft mice, effectively reducing tumor progression. This suggests that SERPINB5 could potentially serve as an important target for tumor treatment. We sincerely appreciate the author's dedication and hard work. The quality of this article is truly outstanding, and we eagerly look forward to your next research contribution. " [Collapse]

Meng ZS, Hu JT, Wu H, Li BK. Inhibition of the SERPINB5/HSP90AA1 axis restrains the proliferation and invasion of rectal cancer. World J Gastroenterol 2025; 31(11): 103412

"This study provides valuable data specifically focused on endoscopic resection (ER) of esophageal GISTs. Thorough evaluation of the ..." [Read more]

"This study provides valuable data specifically focused on endoscopic resection (ER) of esophageal GISTs. Thorough evaluation of the ER technique, complications, and resection margin status enhances our understanding of ER safety and effectiveness. Furthermore, the study presented a relatively large case series of 32 patients, which increases the statistical reliability of the findings for esophageal GIST research. By presenting long-term follow-up results, it assessed the long-term prognosis after ER and suggested potential benefits for future treatment strategy development. " [Collapse]

Xu EP, Qi ZP, Zhang JW, Li B, Ren Z, Cai MY, Cai SL, Lv ZT, Chen ZH, Liu JY, Zhong YS, Zhou PH, Shi Q. Endoscopic treatment outcome of oesophageal gastrointestinal stromal tumours. World J Gastroenterol 2025; 31(10): 102393

"We greatly appreciate the authors and their team for their in-depth study on treatment strategies for rectal neuroendocrine neoplasms ..." [Read more]

"We greatly appreciate the authors and their team for their in-depth study on treatment strategies for rectal neuroendocrine neoplasms (R-NENs). This retrospective analysis compares the efficacy of endoscopic full-thickness resection (EFTR) and endoscopic submucosal dissection (ESD) in the treatment of R-NENs, demonstrating the superior R0 resection rate of EFTR while maintaining comparable short-term safety with ESD. This study provides critical clinical evidence supporting the use of EFTR in R-NENs and contributes to the refinement of function-preserving surgical approaches. However, we would like to offer some constructive suggestions to enhance the clinical applicability and long-term evaluation of this study. First, some terminology and definitions in the study are somewhat ambiguous, which may affect the interpretability of the results. For instance, the study mentions that some patients had "severe comorbidities" but does not specify the types of comorbidities or the inclusion/exclusion criteria applied. Certain comorbidities, such as diabetes or chronic kidney disease, may impact postoperative healing, and failing to differentiate them could introduce confounding among patients with varying risk profiles. Additionally, the description of lesion morphology is inherently subjective, and the study does not clarify whether standardized imaging assessments, such as endoscopic ultrasound (EUS), were used to measure lesion size and invasion depth. Inconsistencies in preoperative evaluation criteria could lead to bias in treatment selection. For example, was EFTR preferentially chosen for lesions with specific morphological characteristics? Future studies should adopt more detailed imaging assessment criteria and pathological grading methods to improve reproducibility and the interpretability of results. Second, the study does not assess the impact of the learning curve for EFTR and ESD on surgical outcomes. As a relatively novel technique, EFTR may require a longer period of experience accumulation to achieve stable performance. The study does not clarify whether operator experience was comparable between the EFTR and ESD groups or whether surgical success rates varied with increasing experience. If EFTR procedures were performed by highly experienced endoscopists while ESD procedures involved a broader range of operators, the results could be biased in favor of EFTR. Additionally, since EFTR has a steeper learning curve, factors such as procedure time and complication rates may decrease with increased experience, but the study does not conduct a dynamic analysis of these trends. Future studies should incorporate learning curve analyses to evaluate the influence of experience on surgical outcomes, ensuring a fair comparison between the two techniques. Furthermore, EFTR may cause greater bowel wall injury than ESD, potentially affecting postoperative bowel function, yet this study focuses primarily on R0 resection rates and short-term complications without assessing long-term functional outcomes. As a full-thickness resection technique, EFTR may alter rectal compliance, bowel movement frequency, and gut motility. However, the study does not provide data on postoperative bowel function changes, alterations in defecation patterns, bloating, or incontinence. If EFTR improves R0 resection rates but increases the risk of postoperative functional impairment, its clinical utility must be considered more cautiously. Future research should incorporate patient-reported outcomes (PROs) and quality of life (QoL) assessments and include long-term functional evaluations such as anorectal manometry and bowel dysfunction scoring to comprehensively assess the impact of EFTR on patient prognosis. " [Collapse]

Zhang XL, Jiang YY, Chang YY, Sun YL, Zhou Y, Wang YH, Dou XT, Guo HM, Ling TS. Endoscopic full-thickness resection: A definitive solution for local complete resection of small rectal neuroendocrine neoplasms. World J Gastroenterol 2025; 31(10): 100444

"This is a well-constructed and well-written review, which gives readers with a general bioscience background updated information about ..." [Read more]

"This is a well-constructed and well-written review, which gives readers with a general bioscience background updated information about the stem cell application in liver diseases (fatty liver diseases and steatohepatitis). The language is fluent, and the references are up to date. It will be easier for readers to understand the concepts if the authors provide a table to compare the 2D model with the 3D model. It will be helpful to include the abbreviation for each key word. " [Collapse]

Silva B, Bragança J. Induced pluripotent stem cell-derived mesenchymal stem cells for modeling and treating metabolic associated fatty liver disease and metabolic associated steatohepatitis: Challenges and opportunities. World J Stem Cells 2025; 17(2): 99331

"The authors should provide adequate legends for each figure. Some parts of the paper are just a listing of facts and are poorly ..." [Read more]

"The authors should provide adequate legends for each figure. Some parts of the paper are just a listing of facts and are poorly organized or discussed. The table in the paper is well organized and suited. A table to compare the pros and cons of different kinds of stem cells for muscle atrophy therapy will be helpful. " [Collapse]

Wang YJ, Chen ZH, Shen YT, Wang KX, Han YM, Zhang C, Yang XM, Chen BQ. Stem cell therapy: A promising therapeutic approach for skeletal muscle atrophy. World J Stem Cells 2025; 17(2): 98693

"Stem Cell Therapy: A New Hope for Patients with Skeletal Muscle Atrophy? Skeletal muscle atrophy refers to the reduction or loss of ..." [Read more]

"Stem Cell Therapy: A New Hope for Patients with Skeletal Muscle Atrophy? Skeletal muscle atrophy refers to the reduction or loss of muscle fibers due to nutritional deficiencies or diseases, leading to a decline in muscle mass. Current studies indicate that skeletal muscle atrophy is closely associated with an imbalance between protein synthesis and degradation, driven by multiple factors such as inflammation, oxidative stress, autophagy, and apoptosis [1-3]. Due to the complexity of its molecular mechanisms, effective therapeutic strategies are lacking, and traditional approaches like rehabilitation training and pharmacological interventions show limited efficacy. Therefore, exploring more effective treatments is imperative. Stem cell therapy, with its unique regenerative potential and immunomodulatory properties, offers a promising avenue for treating this condition. In the current issue of the World Journal of Stem Cells, Ying-Jie Wang and colleagues published a review titled "Stem Cell Therapy: A Promising Therapeutic Approach for Skeletal Muscle Atrophy." The article summarizes the molecular mechanisms of muscle atrophy and highlights the applications of mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), and their derivatives (e.g., exosomes) in treating skeletal muscle atrophy. These stem cells exert therapeutic effects by modulating inflammation, promoting angiogenesis, suppressing oxidative stress, and facilitating muscle regeneration. The authors also address challenges in clinical translation, including immune rejection, tumorigenic risks, inefficient stem cell homing, and the absence of standardized protocols. Despite these hurdles, the review expresses optimism about the future of stem cell therapy, particularly emphasizing the superior potential of stem cell-derived acellular therapies (e.g., exosomes) over traditional cell transplantation. We maintain a cautiously optimistic view regarding the prospects of stem cell therapy for skeletal muscle atrophy. While stem cell-based approaches, especially MSC- and exosome-based strategies, demonstrate promising safety and efficacy [4, 5], several issues must be resolved. These include addressing heterogeneity in stem cell sources, ensuring long-term safety, and establishing standardized protocols for clinical translation. Although iPSCs circumvent ethical concerns, their differentiation and purification techniques require optimization, and potential genetic mutations remain a concern. Exosomes, as acellular therapeutics, may reduce immune reactions; however, challenges in large-scale production and quality control persist. Therapeutic Potential of Stem Cells Stem cell therapy exhibits multidimensional potential in treating muscle atrophy. First, its mechanisms are highly synergistic: MSCs and iPSCs improve the muscle microenvironment by regulating inflammatory cytokines (e.g., suppressing IL-6 and TNF-α), promoting angiogenesis, inhibiting oxidative stress, and enhancing autophagy. Exosomes further amplify therapeutic effects by delivering functional miRNAs (e.g., miR-132-3p/FoxO3 axis) to delay protein degradation and stimulate regeneration [4, 6]. Second, exosomes as acellular carriers broaden clinical applicability: MSC-derived exosomes (e.g., hUC-MSC-Exos, ADSC-Exos) avoid immune rejection and tumorigenic risks associated with live cell transplantation. Their high biocompatibility and cargo of bioactive molecules (e.g., circHIPK3, AMPK/ULK1 regulators) enable targeted intervention in diabetes- or neuropathy-related atrophy, positioning them as pivotal tools for clinical translation [6, 7]. Third, iPSCs hold exceptional promise for personalized medicine. Their ability to differentiate into myogenic progenitor cells (MPCs) or motor neurons facilitates the reconstruction of neuromuscular junctions, offering precise repair for genetic atrophy (e.g., facioscapulohumeral muscular dystrophy, FSHD). While autologous iPSCs mitigate immune rejection, clinical application demands improved differentiation efficiency and safety [8, 9]. Current Challenges and Solutions Clinical translation of stem cell therapy faces multiple challenges requiring innovative solutions. First, heterogeneity and standardization: MSC efficacy varies with donor age, tissue source (e.g., bone marrow, adipose, umbilical cord), and culture conditions [10]. Establishing unified quality control standards—via surface marker screening, secretome profiling, and single-cell sequencing—is critical to identify functional subpopulations and enable precision manufacturing [11]. Second, genetic instability and differentiation inefficiency hinder iPSC applications: reprogramming-induced mutations and inconsistent differentiation protocols (transgene-dependent or -independent) limit reliability [12]. Integrating non-integrative methods (e.g., mRNA reprogramming) and 3D organoid culture systems may optimize differentiation pathways [8]. Third, exosome scalability and targeting: natural exosomes suffer from low bioactive content and short half-lives. Engineering strategies (e.g., ligand modification or drug loading) can enhance tissue-specific delivery [13, 14], while microfluidic-nanocarrier systems may resolve production bottlenecks. Finally, accelerating clinical translation: preclinical studies predominantly rely on animal models; multicenter trials are needed to validate long-term safety (e.g., tumorigenicity, immune tolerance) [15, 16]. Combining stem cell therapy with anti-inflammatory agents (e.g., IL-1β inhibitors), rehabilitation, or gene editing (e.g., CRISPR-Cas9) may synergistically enhance efficacy [17, 18]. Future Directions Future research should prioritize interdisciplinary integration and precision strategies. First, mechanistic insights: single-cell and spatial transcriptomics can unravel dynamic interactions between stem cells and the muscle microenvironment (e.g., satellite cells, macrophages), identifying key regulatory nodes (e.g., Wnt/β-catenin, PI3K/Akt pathways) [3, 19]. Second, biomaterial innovations: smart hydrogels or electroconductive scaffolds combined with localized stem cell/exosome delivery systems could enhance homing efficiency and functional persistence [20, 21]. Third, personalized approaches: tailored therapies based on disease-specific etiologies (e.g., ALS, diabetic atrophy) and molecular subtypes (e.g., inflammatory signatures) are essential. For instance, AMPK-activated umbilical cord MSCs may rectify metabolic dysregulation in diabetic atrophy [22, 23]. Lastly, ethical and regulatory frameworks: international guidelines must standardize stem cell therapies and clarify regulatory classifications (e.g., exosomes as "drugs") to accelerate clinical translation. Stem cell therapy for skeletal muscle atrophy is transitioning from bench to bedside, yet critical hurdles—standardization, safety, and efficacy validation—remain. Integrating multidisciplinary technologies (e.g., synthetic biology, bioinformatics) and advancing translational research will bridge the gap between "laboratory breakthroughs" and "patient benefits." References: 1. Zhang, H., et al., Oxidative stress: Roles in skeletal muscle atrophy. Biochem Pharmacol, 2023. 214: p. 115664. 2. Ji, Y., et al., Inflammation: Roles in Skeletal Muscle Atrophy. Antioxidants (Basel), 2022. 11(9). 3. Liang, W., et al., Epigenetic control of skeletal muscle atrophy. Cell Mol Biol Lett, 2024. 29(1): p. 99. 4. Huang, Z., et al., Skeletal Muscle Atrophy Was Alleviated by Salidroside Through Suppressing Oxidative Stress and Inflammation During Denervation. Front Pharmacol, 2019. 10: p. 997. 5. Song, J., et al., Mesenchymal stromal cells ameliorate diabetes-induced muscle atrophy through exosomes by enhancing AMPK/ULK1-mediated autophagy. J Cachexia Sarcopenia Muscle, 2023. 14(2): p. 915-929. 6. Archacka, K., et al., Hypoxia preconditioned bone marrow-derived mesenchymal stromal/stem cells enhance myoblast fusion and skeletal muscle regeneration. Stem Cell Res Ther, 2021. 12(1): p. 448. 7. Leong, J., et al., Surface Tethering of Inflammation-Modulatory Nanostimulators to Stem Cells for Ischemic Muscle Repair. ACS Nano, 2020. 14(5): p. 5298-5313. 8. Kim, H., et al., Genomic Safe Harbor Expression of PAX7 for the Generation of Engraftable Myogenic Progenitors. Stem Cell Reports, 2021. 16(1): p. 10-19. 9. Azzag, K., et al., Transplantation of PSC-derived myogenic progenitors counteracts disease phenotypes in FSHD mice. NPJ Regen Med, 2022. 7(1): p. 43. 10. Li, J., et al., The heterogeneity of mesenchymal stem cells: an important issue to be addressed in cell therapy. Stem Cell Res Ther, 2023. 14(1): p. 381. 11. Oguma, Y., et al., Single-cell RNA sequencing reveals different signatures of mesenchymal stromal cell pluripotent-like and multipotent populations. iScience, 2022. 25(11): p. 105395. 12. Shamsian, A., et al., Cancer cells as a new source of induced pluripotent stem cells. Stem Cell Res Ther, 2022. 13(1): p. 459. 13. Rezaie, J., et al., Mesenchymal stem cells derived extracellular vesicles: A promising nanomedicine for drug delivery system. Biochem Pharmacol, 2022. 203: p. 115167. 14. Yang, Q., et al., Exosomes-loaded electroconductive nerve dressing for nerve regeneration and pain relief against diabetic peripheral nerve injury. Bioact Mater, 2023. 26: p. 194-215. 15. Drela, K., et al., Experimental Strategies of Mesenchymal Stem Cell Propagation: Adverse Events and Potential Risk of Functional Changes. Stem Cells Int, 2019. 2019: p. 7012692. 16. Deuse, T., et al., Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients. Nat Biotechnol, 2019. 37(3): p. 252-258. 17. Iyer, S.R., et al., Exosomes Isolated From Platelet-Rich Plasma and Mesenchymal Stem Cells Promote Recovery of Function After Muscle Injury. Am J Sports Med, 2020. 48(9): p. 2277-2286. 18. Chang, M., et al., Duchenne muscular dystrophy: pathogenesis and promising therapies. J Neurol, 2023. 270(8): p. 3733-3749. 19. Sartori, R., V. Romanello, and M. Sandri, Mechanisms of muscle atrophy and hypertrophy: implications in health and disease. Nat Commun, 2021. 12(1): p. 330. 20. Luo, W., et al., Biomaterials-Based Technologies in Skeletal Muscle Tissue Engineering. Adv Healthc Mater, 2024. 13(18): p. e2304196. 21. Shan, Y., et al., Pharmacokinetic characteristics of mesenchymal stem cells in translational challenges. Signal Transduct Target Ther, 2024. 9(1): p. 242. 22. Shen, Y., et al., Diabetic Muscular Atrophy: Molecular Mechanisms and Promising Therapies. Front Endocrinol (Lausanne), 2022. 13: p. 917113. 23. Yeo, C.J.J., E.F. Tizzano, and B.T. Darras, Challenges and opportunities in spinal muscular atrophy therapeutics. Lancet Neurol, 2024. 23(2): p. 205-218. " [Collapse]

Wang YJ, Chen ZH, Shen YT, Wang KX, Han YM, Zhang C, Yang XM, Chen BQ. Stem cell therapy: A promising therapeutic approach for skeletal muscle atrophy. World J Stem Cells 2025; 17(2): 98693

"Top-down therapy for Crohn's disease (CD) involves starting with the most potent medications, such as biologics and immunomodulators, ..." [Read more]

"Top-down therapy for Crohn's disease (CD) involves starting with the most potent medications, such as biologics and immunomodulators, immediately after early diagnosis. This strategy may lead to rapid induction of remission, promotion of mucosal healing, prevention of complications, and reduced need for surgery. However, the background factors influencing this top-down therapy have not been sufficiently examined. A recent report on a Japanese cohort found that factors significantly associated with the recent top-down treatment approach were male gender, perianal lesions, no immunomodulators, and anti-tumor necrosis factor therapy. (Miyoshi J, Yoon A, Matsuura M, Hisamatsu T. Real-world use of biologics during the first year of treatment for newly diagnosed Crohn's disease in Japan: a claims analysis from 2010 to 2021. Intest Res. 2025 [PMID: 39848334 DOI: 10.5217/ir.2024.00082]) Top-down therapy for CD should be considered case-by-case, weighing potential benefits against risks and costs. As the authors suggest, identifying patients with a high genetic predisposition for CD may help predict their response to medications, the risk of side effects, and the cost-effectiveness. Further investigation in this area is desirable. " [Collapse]

Fan YH, Wang MW, Gao YN, Li WM, Jiao Y. Genetic and environmental factors influencing Crohn’s disease. World J Gastrointest Surg 2025; 17(3): 98526

"Suggested Title:From Weakness to Wellness: The Role of Stem Cells in Muscle Atrophy Recovery A. Clarity and Conciseness • Some ..." [Read more]

Wang YJ, Chen ZH, Shen YT, Wang KX, Han YM, Zhang C, Yang XM, Chen BQ. Stem cell therapy: A promising therapeutic approach for skeletal muscle atrophy. World J Stem Cells 2025; 17(2): 98693

"This review presents a comprehensive analysis of the role of Traditional Chinese Medicine (TCM) in the treatment of chronic atrophic ..." [Read more]

"This review presents a comprehensive analysis of the role of Traditional Chinese Medicine (TCM) in the treatment of chronic atrophic gastritis (CAG), highlighting its multi-targeted therapeutic effects, including gastric mucosal protection, modulation of inflammatory responses, and improvement of microcirculation. The discussion is well-supported by clinical studies and meta-analyses, underscoring the potential benefits of specific herbal compounds such as berberine, morroniside, and notoginsenoside R1. However, the review also acknowledges a key challenge—the lack of standardized research methodologies and evaluation criteria, which limits the broader clinical application of TCM. While the evidence presented suggests promising therapeutic effects, future research should focus on large-scale randomized controlled trials to further validate these findings and establish consistent guidelines for integrating TCM into mainstream gastroenterology practice. Additionally, a more detailed discussion on potential interactions between TCM and conventional Western therapies would strengthen the clinical relevance of this review. Overall, this article makes a valuable contribution to the understanding of CAG management and provides a strong foundation for future research in this field. " [Collapse]

Wang L, Lian YJ, Dong JS, Liu MK, Liu HL, Cao ZM, Wang QN, Lyu WL, Bai YN. Traditional Chinese medicine for chronic atrophic gastritis: Efficacy, mechanisms and targets. World J Gastroenterol 2025; 31(9): 102053

"The study by Real Martinez et al. provides valuable insights into the role of circulating myokines such as irisin and FGF21 in MASLD, ..." [Read more]

"The study by Real Martinez et al. provides valuable insights into the role of circulating myokines such as irisin and FGF21 in MASLD, particularly their association with severe steatosis and advanced liver fibrosis. However, the absence of a relationship between skeletal muscle alterations (SMAs) and liver fibrosis stages raises intriguing questions. Could the lack of association be attributed to the heterogeneity of the cohort, or might it suggest that SMAs play a more indirect role in MASLD progression? Additionally, how might other metabolic or inflammatory pathways, not directly evaluated in this study, influence the interplay between muscle health and liver disease? Further studies exploring these aspects, especially in longitudinal designs or larger cohorts, would be invaluable in clarifying these relationships and their implications for clinical practice. " [Collapse]

Real Martinez Y, Fernandez-Garcia CE, Fuertes-Yebra E, Calvo Soto M, Berlana A, Barrios V, Caldas M, Gonzalez Moreno L, Garcia-Buey L, Molina Baena B, Sampedro-Nuñez M, Beceiro MJ, García-Monzón C, González-Rodríguez Á. Assessment of skeletal muscle alterations and circulating myokines in metabolic dysfunction-associated steatotic liver disease: A cross-sectional study. World J Gastroenterol 2025; 31(7): 100039

"I congratulate the authors for the publication of their write up. It is well written with practical points. The information on greater ..." [Read more]

"I congratulate the authors for the publication of their write up. It is well written with practical points. The information on greater likelihood of antibody generation with premixed insulins was new to me, although I believe it would have been partly due to the highly prevalent use of this form of insulin. I would like the authors to understand this point as well while promoting the advantages of the newer insulins. In the international guidelines, at diagnosis of diabetes if the blood glucose levels are above 300 mg/dl and/or glycosylated hemoglobin level is more than 10 %, it is suggested to start the patient on insulin to reduce the glucotoxicity. Once the blood glucose levels reduce, say after 2-3 weeks, the patient may be switched to oral anti-diabetic agents. Such a guideline recommended practice is regularly followed in developing countries such as ours. In such a situation I have observed that the acceptance rate of premixed insulin which involves two pricks, is a lot better than that of multiple short acting insulin doses along with basal insulin. Since the duration of premixed insulin therapy in this context is short, the possible side effects of anti-insulin antibody generation as well as lipodystrophy are less likely. " [Collapse]

Xia Y, Hu Y, Ma JH. Premixed insulin: Advantages, disadvantages, and future. World J Diabetes 2025; 16(3): 102526

"This study presents an evaluation of a novel contrast-enhanced catheter with a chamfered tip. Achieving selective biliary cannulation ..." [Read more]

"This study presents an evaluation of a novel contrast-enhanced catheter with a chamfered tip. Achieving selective biliary cannulation is one of the most challenging endoscopic maneuver. We congratulate the authors on demonstrating in this paper that a novel device granted higher rates of biliary cannulation when retrospectively compared to a standard sphincterotome. However, a few points warrant further discussion: 1. Generalizability: As a single-center retrospective study, the external validity of these findings could be enhanced with multicenter randomized trials. Variations in patient populations, procedural techniques, and institutional expertise might influence outcomes. 2. Non-expert outcomes: The results indicate a lack of significant improvement in outcomes among non-experts or trainees using the novel catheter. This suggests the device's utility may be contingent on the operator's skill. We also noticed that the expert performed procedure percentage was slightly higher (57% vs 50%) in the novel cathether group, and, although not statistically significant, this could explain the lower use of advanced or rescue cannulation techniques. 3. Adverse Events (AEs): While the overall AE rates were low and comparable between groups, the trend toward fewer cases of PEP with the novel catheter merits closer scrutiny in larger cohorts as this could be an advantage in patients at risk for PEP. On the other hand, the non-statistically significant difference between the two groups in PEP incidence suggests us that the device used to achieve initial selective cannulation maybe isn’t that relevant in increasing PEP risk or incidence, but this should be confirmed in larger studies. 4. Cost-effectiveness: Although not discussed, evaluating the cost implications of adopting this catheter, including potential savings from reduced reliance on rescue techniques and decreased procedural times, would be beneficial for broader clinical adoption. We should also think of the negative aspects: for example, like stone clearance, achieving cannulation with a catheter would require a subsequent switch to a sphincterotome, increasing procedure length and costs, as you would be using two devices instead of one to achieve cannulation. 5. Papilla characteristics: we noticed that in the baseline characteristics intradiverticular papillas and oral oriented papillas were less represented in the catheter group. These types of papilla could benefit of the angling capabilities of a sphincterotome, so this could be a bias that needs to be furthermore cleared. In our experience the angling capabilities of a sphincterotome are crucial in achieving bile duct cannulation in difficult situations. 6. Malignant disease: we do know that malignant diseases (e.g. pancreatic cancer) affecting the ampullar area negatively affect rates of cannulation and increase the need for rescue or advanced techniques of cannulation. This point could have been furthermore discussed by making a distinction between cannulation failures in the setting of benign vs. malignant disease in both groups. In conclusion, this study gives us valuable insights into advancing ERCP outcomes through innovative device design. We must experiment with more designs to compare results and finally choose the best device for cannulation in unexpected and difficult anatomies. " [Collapse]

Kaneko T, Kida M, Kurosu T, Kitahara G, Koyama S, Nomura N, Tahara K, Kusano C. Outcomes of bile duct cannulation using a novel contrast-enhanced catheter: A single-center, retrospective cohort study. World J Gastrointest Endosc 2025; 17(1): 97840

"As a colorectal surgeon interested in colorectal cancer and the microbiome, I found this study highly relevant. The authors ..." [Read more]

"As a colorectal surgeon interested in colorectal cancer and the microbiome, I found this study highly relevant. The authors effectively highlight differences in mucosa-associated colonic microbiota between colorectal cancer (CRC) and non-CRC patients in Indonesia. A key strength is the focus on mucosal rather than fecal microbiota, providing a clearer picture of the tumor microenvironment. The use of 16S rRNA sequencing with Oxford Nanopore Technologies enables detailed bacterial diversity analysis at the genus and species levels. The study confirms the increased presence of Fusobacterium nucleatum and Bacteroides fragilis in CRC patients, supporting the link between microbial dysbiosis and carcinogenesis. The diagnostic potential of these bacterial markers is particularly noteworthy. Further research with larger sample sizes and functional analyses, such as metagenomics or metabolomics, would enhance understanding of microbiota’s role in CRC. Additionally, while this study offers important insights for Asia, global research is needed to assess regional differences and their impact on CRC diagnostics and treatment. " [Collapse]

Darnindro N, Abdullah M, Sukartini N, Rumende CM, Pitarini A, Nursyirwan SA, Fauzi A, Makmun D, Nelwan EJ, Shatri H, Rinaldi I, Tanadi C. Differences in diversity and composition of mucosa-associated colonic microbiota in colorectal cancer and non-colorectal cancer in Indonesia. World J Gastroenterol 2025; 31(7): 100051

"The manuscript is very clinically relevant. Here's a suggestion. Authors should provide the data on patients undergoing colonoscopy ..." [Read more]

"The manuscript is very clinically relevant. Here's a suggestion. Authors should provide the data on patients undergoing colonoscopy prior to capsule endoscopy examination. The retention rate of capsule endoscopy at 72 hours was 42.2%, which is still relatively high.It helps to reduce capsule retention in the colon after colonoscopy examination. " [Collapse]

O'Hara FJ, Costigan C, McNamara D. Extended 72-hour patency capsule protocol improves functional patency rates in high-risk patients undergoing capsule endoscopy. World J Gastrointest Endosc 2024; 16(12): 661-667

"This case report highlights the importance of en-bloc resection without fragmentation during endoscopic procedures and the challenges ..." [Read more]

"This case report highlights the importance of en-bloc resection without fragmentation during endoscopic procedures and the challenges of endoscopic treatment for anal canal cancer. Traditionally, anal lesions have been primarily managed by surgeons, but ESD-related technique is performed mainly by the gastrointestinal endoscopists of internal medicine. Future collaboration between internal medicine and surgery departments will be crucial. Surgery for anal cancer can significantly decrease patients' quality of life, which is why the authors' dedication to endoscopic treatment and follow-up is commendable. Anal canal cancer is rare, and it will be essential to determine which cases are suitable for endoscopic therapy in the future. With the increasing prevalence of inflammatory bowel diseases in Asian regions, a rise in anal cancer cases associated with conditions like Crohn's disease is anticipated. Further case reports in this field are desirable. " [Collapse]

Kinoshita M, Maruyama T, Hike S, Hirosuna T, Kainuma S, Kinoshita K, Nakano A, Ohira G, Uesato M, Matsubara H. Complete resection of recurrent anal canal cancer using endoscopic submucosal dissection and transanal resection: A case report. World J Gastrointest Endosc 2025; 17(1): 101119

"This is an excellent and insightful article. The authors have provided a comprehensive overview of the most impactful studies in the ..." [Read more]

"This is an excellent and insightful article. The authors have provided a comprehensive overview of the most impactful studies in the field of gastrointestinal endoscopy. It has greatly enhanced my understanding of the current research landscape and has inspired me to define more focused and meaningful directions for my own research in this area. " [Collapse]

Sui J, Luo JS, Xiong C, Tang CY, Peng YH, Zhou R. Bibliometric analysis on the top one hundred cited studies on gastrointestinal endoscopy. World J Gastrointest Endosc 2025; 17(1): 100219

"This paper examines the differences in proficiency of AI tools for IBD patients and is considered a critical study for the inevitable ..." [Read more]

"This paper examines the differences in proficiency of AI tools for IBD patients and is considered a critical study for the inevitable future utilization of large language models in healthcare. However, it is merely a comparative study of large language models, and it remains unclear whether it contributes to improving IBD patients' literacy. Regarding patient education, Crohn's disease and ulcerative colitis belong to different categories, making it challenging to evaluate IBD as a whole comprehensively. Separate evaluations for ulcerative colitis and Crohn's disease patients would be preferable. Furthermore, large language models alone are insufficient for shared decision-making that considers patients' social backgrounds for treatment selection, including biological agents (especially for Crohn's disease). Simply improving knowledge on several items through large language models may not be enough for clinical application. Future evaluations using large language models should address these points. " [Collapse]

Zhang Y, Wan XH, Kong QZ, Liu H, Liu J, Guo J, Yang XY, Zuo XL, Li YQ. Evaluating large language models as patient education tools for inflammatory bowel disease: A comparative study. World J Gastroenterol 2025; 31(6): 102090

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