Machine learning approaches using blood biomarkers in non-alcoholic fatty liver diseases

Table 1 Blood biomarker panels for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Blood biomarker panels for steatosis
Panel	Patient	Anthropometry	Blood biomarkers
FLI	-	BMI, Waist circumference	GGT and TG
HSI	Presence of DM	BMI	AST:ASL
Steatotest	Sex	BMI	ALT, GGT, TG, A2M, ApoA1, haptoglobin, bilirubin,cholesterol, and glucose
LAP	Sex	Waist circumference	TG
ION	Sex	Waist to hip ratio	ALT, TG
NAFLD LFS	Presence of DM and MS	-	AST:ALT, Insulin
Blood biomarker panels for fibrosis
Panel	Patient	Anthropometry	Blood biomarkers
APRI	-	-	Platelet count, AST
FIB-4	Age	-	Platelet count, AST, ALT
FibroTest	Age, sex	BMI	GGT, A2M, ApoA1, haptoglobin, and total bilirubin
Fibrometer	Age	Body weight	Platelet count, AST, ALT, glucose, ferritin
ELF	-	-	Hyaluronic acid, PIIINP and TIMP-1
Hepascore	Age, sex	-	GGT, Hyaluronic acid, PIIINP and TIMP-1
BARD	Presence of DM	BMI	AST:ALT
NFS	Age, sex, Presence of DM	-	Platelet count, AST:ALT, Albumin

A2M: Alpha-2-macroglobulin; ALT: alanine aminotransferase; ApoA1: Apolipoprotein A1; AST: Aspartate aminotransferase; BMI: body mass index; DM: Diabetes mellitus; GGT: gamma-glutamyl transpeptidase; MS: Metabolic syndrome; NAFLD: Nonalcoholic fatty liver disease; PIIINP: Amino-terminal propeptide of type III procollagen; TG: Triglycerides; TIMP1: tissue inhibitor of matrix metalloproteinases-1.