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Copyright ©The Author(s) 2021.
Artif Intell Cancer. Jun 28, 2021; 2(3): 25-41
Published online Jun 28, 2021. doi: 10.35713/aic.v2.i3.25
Table 1 Selected list of tumor vaccine under recruitment in clinical trials
Vaccine typeDiseaseCombinationPhaseNCT ID
Tumor cell vaccineGVAXNeuroblastoma. Pediatric Solid TumorNivolumab. IpilimumabPhase INCT04239040
Locally Advanced Pancreatic Ductal AdenocarcinomaNivolumab CCR2/CCR5 dual antagonistPhase I; Phase IINCT03767582
Metastatic Pancreatic AdenocarcinomaEpacadostat. Pembrolizumab CRS-207 CYPhase IINCT03006302
Colorectal CancerPhase INCT01952730
GVAX Pancreas VaccinePancreatic CancerCyclophosphamide NivolumabPhase IINCT03161379
Pancreatic CancerCyclophosphamide Nivolumab UrelumabPhase I; Phase IINCT02451982
GM-CSF vaccineMultiple MyelomaLenalidomide Prevnar13Phase IINCT03376477
DC VaccineAST-VAC2NSCLC in the Advanced and Adjuvant SettingsPhase INCT03371485
MIDRIXNEONSCLCAntigen-specific DTH. Control DTHPhase INCT04078269
Autologous Dendritic Cell-Adenovirus CCL21 VaccineNSCLC Stage IV, IVA, IVB Lung Cancer AJCC v8PembrolizumabPhase INCT03546361
Autologous DCs: MESOVAXMesothelioma. Malignant PD-L1 Negative Advanced Cancer Progressive DiseasePembrolizumab. Interleukin-2Phase INCT03546426
PEP-DC vaccinePancreatic AdenocarcinomaPhase INCT04627246
ME TARP vaccineProstate CancerPhase IINCT02362451
DC/AML Fusion VaccineAcute Myelogenous LeukemiaDecitabinePhase INCT03679650
Acute Myelogenous LeukemiaPhase IINCT03059485
mDC3/8-KRAS VaccinePancreatic Ductal AdenocarcinomaPhase INCT03592888
Autologous DC vaccine: RaC-AdHead Neck Tumors, Neuroendocrine Tumors, Soft Tissue Sarcoma Rare CancerInterleukin-2Phase IINCT04166006
COREVAX-1Stage IV Colorectal Cancer Curative ResectionInterleukin-2Phase IINCT02919644
Autologous DCs + Prevnar 13Stage III, IIIA, IIIB, IV, IVA, IVB Hepatocellular Carcinoma AJCC v8, Stage III, IIIA, IIIB, IV Intrahepatic Cholangiocarcinoma AJCC v8, Unresectable Hepatocellular Carcinoma, Unresectable Intrahepatic CholangiocarcinomaRadiation: External Beam Radiation TherapyEarly Phase INCT03942328
DC Tumor Cell Lysate Vaccine: ATL-DCRecurrent GlioblastomaPembrolizumab poly-ICLCPhase INCT04201873
Dendritic Cell/Tumor Fusion VaccineGlioblastoma, Neuroectodermal TumorsInterleukin-12 TemozolomidePhase I; Phase IINCT04388033
DC1 Vaccine+ WOKVAC VaccineFemale Breast Cancer, Male Breast Cancer, Stage I, II, III Breast Cancer, HER2-positive Breast CancerPhase IINCT03384914
neoantigen-primed DC vaccineGastric Cancer, Hepatocellular Carcinoma, NSCLC, Colon Rectal CancerPhase INCT04147078
MG-7-DC vaccineLater stage of gastric cancerSintilimabPhase I; Phase IINCT04567069
IKKb matured, RNA-loaded DC vaccineMelanoma, Uveal MetastaticPhase IINCT04335890
Peptide vaccineUCPVax: VolATILSquamous Cell Carcinoma of the Head and Neck, Anal Canal Cancer, Cervical CancerAtezolizumabPhase IINCT03946358
UCPVax-GlioGlioblastomaPhase I; Phase IINCT04280848
UCPVaxMetastatic NSCLCPhase I; Phase IINCT02818426
MUC1NSCLCPolyICLCPhase I; Phase IINCT01720836
SVN53-67/M57-KLHLung Atypical Carcinoid Tumor, Lung Typical Carcinoid Tumor, Metastatic Pancreatic Neuroendocrine TumorIncomplete Freund's Adjuvant Octreotide Acetate SargramostimPhase INCT03879694
NSABP FB-14/AE37Triple-negative Breast CancerPembrolizumabPhase IINCT04024800
KRAS peptide vaccineColorectal Cancer, Pancreatic CancerNivolumab IpilimumabPhase INCT04117087
da VINc/OTSGC-A24Gastric CancerNivolumab IpilimumabPhase INCT03784040
ARG1-18, 19, 20NSCLC, Urothelial Carcinoma, Malignant Melanoma, Ovarian Cancer, Colorectal Cancer, Breast Cancer, Squamous Cell Carcinoma of the Head and Neck, Metastatic CancerPhase INCT03689192
Personalized peptide vaccineStage IV, IVA, IVB Colorectal Cancer AJCC v7, Stage IV Pancreatic Cancer AJCC v6 and v7Imiquimod PembrolizumabPhase INCT02600949
WT1/NY-ESO-1Ovarian Cancer, Fallopian Tube Primary Peritoneal Cancer, Recurrent Ovarian CancerNivolumabPhase INCT02737787
IMU-131/HER-VaxxGastrointestinal Neoplasms, AdenocarcinomaCisplatin and either Fluorouracil (5-FU) or Capecitabine or Oxaliplatin and capecitabinePhase I; Phase IINCT02795988
ESR1Breast CancerPhase INCT04270149
DNAJB1-PRKACAFibrolamellar, Hepatocellular CarcinomaNivolumab IpilimumabPhase INCT04248569
H3.3K27MDiffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-MutantNivolumabPhase I; Phase IINCT02960230
H2NVACDuctal Breast Carcinoma In SituGranulocyte Macrophage Colony Stimulating FatorPhase INCT04144023
IDH1R132H/AMPLIFY-NEOVACMalignant GliomaAvelumabPhase INCT03893903
DNA VaccinepTVG-HP/pTVG-ARCRPC, Metastatic CancerPembrolizumab rhGM-CSFPhase IINCT04090528
Mammaglobin-ABreast CancerPhase INCT02204098
pTVG-HPProstate CancerNivolumab GM-CSFPhase IINCT03600350
pNGVL4a-Sig/E7(detox)/HSP70Cervical Cancer, Precancerous Condition, HPV Disease, Human Papilom-virusImiquimodPhase INCT00788164
Salmonella oral vaccineRelapsed NeuroblastomaLenalidomideEarly Phase INCT04049864