MicroRNAs as prognostic biomarkers for survival outcome in osteosarcoma: A meta-analysis

Table 3 Subgroup analyses of the relationship between microRNA expression and overall survival.

years

Subgroup	Number of datasets	Heterogeneity		Pooled HR (95%CI)	P value
		I2 (%)	P value
Overall	60	89.0%	0.000	2.92 (2.43–3.41)	0.000
Expression
High	27	91.4%	0.000	3.56 (2. 59–4.54)	0.000
Low	33	74.5%	0.000	2.23 (1. 74–2.72)	0.000
Specimen
Tissue	26	92.1%	0.000	3.20 (2.16–4.23)	0.000
Serum	28	77.1%	0.000	3.04 (2.37–3.71)	0.000
Plasma	6	53.7%	0.055	0.94 (0.36–1.51)	0.001
Survival analysis
U	6	0.0%	0.569	2.36 (1.67–3.04)	0.000
M	30	76.9%	0.000	3.29 (2.52–4.07)	0.000
U/M	24	93.9%	0.000	2.73 (1.95–3.50)	0.000
Source of HR
Reported	35	92.6%	0.000	3.00 (2.21–3.79)	0.000
K-M curve	25	65.6%	0.000	2.48 (1.92–3.04)	0.000
Follow-up
≤ 5 years	40	76.2%	0.000	3.08 (2.44–3.71)	0.000
	> 5	20	94.8%	0.000	2.75 (1.88–3.63)	0.000
Country
China	58	89.0%	0.000	3.05 (2.52–3.57)	0.000
Non-China	2	44.9%	0.178	1.24 (0.59–3.07)	0.183

OS: Overall survival; M: Multivariate analysis; U: Univariate analysis; HR: Hazard ratio; CI: Confidence interval.