Copyright
©The Author(s) 2021.
World J Meta-Anal. Apr 28, 2021; 9(2): 153-163
Published online Apr 28, 2021. doi: 10.13105/wjma.v9.i2.153
Published online Apr 28, 2021. doi: 10.13105/wjma.v9.i2.153
No. | Ref. | Major finding |
1 | Perng et al[36], 2020 | BCAA levels and products of BCAA catabolism were higher in males than females with comparable BMI z-score; In multivariate analyses, HOMA-IR in males correlated positively with BMI z-score and a metabolic signature containing BCAA, uric acid, and long-chain acylcarnitines and negatively with byproducts of complete fatty acid oxidation |
2 | Hosking et al[14], 2019 | In longitudinal analysis, IR was associated with reduced concentrations of BCAA, 2-ketobutyrate, citrate and 3-hydroxybutyrate, and higher concentrations of lactate and alanine |
3 | Suzuki et al[44], 2019 | HOMA-IR was positively correlated with valine, leucine, isoleucine, phenylalanine, tryptophan, methionine, threonine, lysine, alanine, tyrosine, glutamate, proline, arginine, ornithine, total free amino acids and aspartate; Blood uric acid levels were positively correlated with leucine and glutamate, and negatively correlated with serine, glycine, and asparagine |
4 | Perng et al[34], 2018 | BCAA and androgen hormone metabolite patterns are related to changes in metabolic parameters in a sex-specific manner during early adolescence |
5 | Xia et al[37], 2018 | Disrupted arginine and proline metabolism associated with phthalate exposure might contribute to the development of overweight and obesity in school-age children |
6 | Moran-Ramos et al[38], 2017 | Principal component analysis showed a serum amino acid signature composed of arginine, leucine/isoleucine, phenylalanine, tyrosine, valine and proline significantly associated with obesity and serum triglycerides |
7 | Goffredo et al[39], 2017 | A branched-chain amino acid-related metabolic signature characterizes obese adolescents with non-alcoholic fatty liver disease |
8 | Hellmuth et al[40], 2016 | Tyrosine alterations in association with insulin resistance precede alteration in BCAA metabolism |
9 | Mastrangelo et al[43], 2016 | The majority of metabolites differing between groups were lysophospholipids (15) and amino acids (17), indicating inflammation and central carbon metabolism as the most altered processes in impaired insulin signaling |
10 | Lee et al[41], 2015 | Obese children presented significantly higher levels of BCAAs and several acylcarnitines and lower levels of acyl-alkyl phosphatidylcholines; Baseline BCAAs were significantly positively correlated with both HOMA-IR and continuous metabolic risk score at the 2-year follow-up |
11 | Butte et al[42], 2015 | BCAAs and their catabolites, propionylcarnitine and butyrylcarnitine, were significantly elevated in obese children; Lower lysolipids and dicarboxylated fatty acids were seen in obese children; Steroid derivatives were markedly higher in obese children, as were markers of inflammation and oxidative stress |
12 | Perng W et al[33], 2014 | BCAA and androgen metabolites were associated with adiposity and cardiometabolic risk during mid-childhood |
13 | Newbern et al[35], 2014 | BCAA levels and byproducts of BCAA catabolism are higher in obese teenage boys than girls of comparable BMI z-score; A metabolic signature comprising BCAA and uric acid correlates positively with HOMA-IR in males and TG to HDL ratio in females and inversely with adiponectin in males but not females |
- Citation: Matsumoto S, Nakamura T, Nagamatsu F, Kido J, Sakamoto R, Nakamura K. Metabolic and biological changes in children with obesity and diabetes. World J Meta-Anal 2021; 9(2): 153-163
- URL: https://www.wjgnet.com/2308-3840/full/v9/i2/153.htm
- DOI: https://dx.doi.org/10.13105/wjma.v9.i2.153