Single-balloon and spiral enteroscopy may have similar diagnostic and therapeutic yields to double-balloon enteroscopy: Results from a meta-analysis of randomized controlled trials and prospective studies

Table 1 Study characteristics

Ref.	Country	Study design	Intervention	No. of patients	Male/Female	Age	Indications (OGIB/others)
Moran et al[7], 2018	United States	RCT	SBE	17	3/14	55.8 ± 20.3	8/9
			SE	13	10/3	53.1 ± 18.3	7/6
Oka et al[8], 2015	Japan	RCT	DBE	10	6/4	63.9 ± 12.8	0/10
			SE	10	6/4	63.9 ± 12.8	0/10
Despott et al[9], 2015	United Kingdom	Prospective	DBE	15	5/10	51.4 ± 5.4	0/15
			SE	15	5/10	51.4 ± 5.4	0/15
Messer et al[2], 2013	Germany	RCT	DBE	13	6/7	47.6 ± 20/7	7/6
			SE	13	7/6	61.2 ± 18.6	12/1
Rahmi et al[10], 2013	France	Prospective	DBE	191	76/115	59.0 ± 15.9	151/40
			SE	50	25/25	58.4 ± 14.3	43/7
May et al[11], 2011	Germany	RCT	DBE	10	6/4	69 ± 12	10/0
			SE	10	6/4	69 ± 12	10/0
Frieling et al[12], 2010	Germany	Prospective	DBE	17	7/10	61 ± 17	14/3
			SE	18	10/8	58 ± 25	11/7
Efthymiou et al[3], 2012	Australia	RCT	DBE	57	24/33	61 (49-68)1	44/13
			SBE	50	19/31	67 (51-72)1	40/10
Domagk et al[6], 2011	Germany	RCT	DBE	65	32/33	52 (18-84)2	29/36
			SBE	65	35/30	53 (21-80)2	26/39
Takano et al[5], 2011	Japan	RCT	DBE	20	15/5	62.7 ± 16.1	13/7
			SBE	18	13/5	64.9 ± 14.7	10/8
Ren et al[4], 2011	China	RCT	DBE	50	35/15	42.3	25/25
			SBE

¹Median (IQR).

²Median (range). RCT: Randomized controlled trial; SBE: Single-balloon enteroscopy; SE: Spiral enteroscopy; DBE: Double-balloon enteroscopy; OGIB: Obscure gastrointestinal bleeding.