Significance of multivisceral resections in oncologic surgery: A systematic review of the literature

Table 5 Patient- and treatment- associated parameters after multivisceral resection for gastric cancer

Study	Resection margin (R0 vs R1)	Most common resected organs	Lymph node involvement	Age	Blood transfusion	Complications (AI) (Re-OP)	Other prognostic factors
Carboni et al[39], 2005	R0 61.5%; R1 27.7%; R2 10.8%	Spleen: 48%; Pancreas: 43%; Colon: 25%	86.2%	61	NR	(1.5%) (1.5%)	Lymph-node involvement and metastatic disease
Colen et al[37], 2004	NR	Spleen: 62%; Pancreas 57%; Colon: 24%	NR	67.5	NR	0% (NR)	NR
D'Amato et al[38], 2004	R0: 69%	Pancreas: 62%; Colon: 12%	NR	NR	NR	(0%) (NR)	NR
Jeong et al[43], 2009	R0: 78.3%; R+: 21.7%	Spleen: 47%; Pancreas: 61%; Colon: 24%	N+: 90.1%	59	NR	(6.7%) (11%)	Lymph-node and lymphovascular involvement
Kim et al[35], 2009	R0: 43%; R1: 15%; R2: 74%	Spleen: 38%; Pancreas: 29%; Colon: 56%	NR	NR	NR	(2.9%) (0%)	histologic type, M stage, peritoneal metastasis, curability and treatment groups
Martin et al[36], 2002	R0: 100%	Spleen: 67%; Pancreas: 19%; Colon: 6%; Liver: 4% Gallbladder: 7%	N0: 35% N+: 65%	66	NR	(NR) (NR)	Lymph-node involvement and > pT3
Oñate-Ocaña et al[32], 2008	R0: 58.1%; R1: 18.9%; R2: 23%	Spleen: 68%; Pancreas: 26%; Colon: 12%; Liver: 9%	NR	NR	NR	(NR) (NR)	NR
Ozer et al[44], 2009	NR	Pancreas: 54%; Colon: 32%; Liver: 18%	NR	58	NR	(8.9%) (NR)	Advanced age, lymph node involvement, and resection of more than 1 additional organ were significant prognostic factors for survival.
Persiani et al[46], 2008	R0: 320; R1: 39; R2: 29%	Spleen: 84%; Pancreas: 25%; Colon: 10%	NR	63.4	NR	(NR) (NR)	Splenectomy, D2 lymphadenectomy, and age greater than 64 yr were the only factors predictive of overall morbidity
Shchepotin et al[33], 1998	NR	Spleen: 43%; Pancreas: 69%; Colon: 45% Liver: 29%	N+: 38.8%	NR	NR	(3.7%) (NR)	NR
Isozaki et al[45], 2000	NR	Pancreas + Spleen: 36%; Pancreatoduodenectomy: 7%	N0 = 13%; N1 = 36%; N2 = 25%; N3 = 12%	NR	NR	(NR) (NR)	Location of the tumor, lymph node metastasis, histological depth of invasion, and extent of lymph node dissection
Molina et al[40], 2019	R0: 94%	Pancreas (49%); Spleen (34%) Liver (29%).	N+: 80%	64,5	NR	(NR) (NR)	Lymph-node involvement and R1-status
Mita et al[42], 2017	R0: 82.5%; R1: 17.5%	Spleen 29.1%; Pancreas: 46.6%; Colon: 13.6%; Liver: 11.7%	N+: 84.5%	70	NR	(NR) (NR)	Resection status
Vladov et al[38], 2015	R0: 75%	Spleen: 76.7%; Pancreas:40%; Colon: 18.3%; Liver 15%	NR	NR	NR	(NR) (NR)	NR
Tran et al[31], 2015	R1: 15.5	Spleen: 48%; Pancreas:27% Liver 14% Colon: 13%	N0: 34.5%	64	NR	(11.5%) (13.8%)	MVR with pancreatectomy, was significantly associated with decreased survival, along with T-stage, N stage, perineural invasion, and
Pacelli et al[34], 2013	R0: 38.4%	Pancreas 46; Colon 43	N+: 89.3%	NR	NR	(7%) (NR)	Lymph-node involvement and incomplete resection

MVR: Multivisceral resection; NR: Not reported; AI: Anastomotic insufficiency.