Hepatitis B reactivation in patients with hepatitis B core antibody positive and surface antigen negative on immunosuppressants

Table 2 Risk factors determining risk of hepatitis B reactivation in HBsAg negative, anti-HBc positive patients. Hepatitis B chemoprophylaxis can be considered in patients with 2 or more high risk factors for hepatitis B reactivation

Category	Risk factor
Virological factors	(1) High baseline HBV DNA; (2) Absence of anti-HBs antibody; (3) Presence of Hepatitis B core-related antigen
Patient factors	(1) Male gender; (2) Liver cirrhosis; (3) Immunosuppression required because of hematological malignancy
Type of immunosuppressive regime	High risk: B-cell depleting therapies
	Medium risk: Anthracycline derivatives, high dose corticosteroids, systemic cancer chemotherapy, cytokine-based therapies, immunophilin inhibitors, tyrosine-kinase inhibitors, protease inhibitors
	Low risk: Immune checkpoint inhibitors, low-moderate dose corticosteroids, antimetabolite therapies