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©The Author(s) 2017.
World J Meta-Anal. Aug 26, 2017; 5(4): 103-123
Published online Aug 26, 2017. doi: 10.13105/wjma.v5.i4.103
Published online Aug 26, 2017. doi: 10.13105/wjma.v5.i4.103
Ref. | Study | Non-adherence rates |
Antipsychotics | ||
Keck et al[142], 1996b | n = 77 on antipsychotics; duration - 6 mo; clinical interview | 32% |
Svarstad et al[52], 2001 | n = 56 on antipsychotics; duration 12 mo; retrospective claims data | 23% irregular use |
Patel et al[131], 2005 | n = 32 adolescents on antipsychotics; duration - 12 mo; clinical interviews and medical records | Treatment time without full adherence in 44% |
Sajatovic et al[143], 2006b | n = 32993 on antipsychotics; duration - 3 mo or more; retrospective claims data-MPR based | 48% partially or fully non-adherent; took antipsychotics less than 50%-80% of the time |
Sajatovic et al[144], 2007b | n = 73964 on antipsychotics; duration - 3 mo or more; retrospective claims data-MPR based | 39% among those > 60 yr and 50% in those < 60 yr took antipsychotics less than 50%-80% of the time |
Hassan and Lage[145], 2009 | n = 1973 on antipsychotics; duration - 12 mo; retrospective claims based data-MPR based | 56% took antipsychotics less than 50% of the time and 73% less than 75% of the time |
Lage and Hassan[146], 2009 | n = 7,769 on antipsychotics; duration- 12 mo; retrospective claims data-MPR based | 62% took antipsychotics less than 50% of the time and 79% less than 75% of the time |
Lang et al[147], 2011 | n = 9410 on antipsychotics; duration - 12 mo; retrospective claims data-MPR based | 60% took antipsychotics less than 80% of the time |
Rascati et al[148], 2011 | n = 2446 on SGAs; duration - 18 mo; retrospective claims data-MPR based | 42% took antipsychotics less than 80% of the time |
Berger et al[34], 2012 | n = 84 on SGAs: Duration-6 mo; retrospective claims data-MPR and CMG based | 85% took antipsychotics less than 80% of times (50% according to CMGs) |
Stephenson et al[149], 2012 | n = 162 patients with BD on SGAs and 153 physicians; duration - 12 mo; retrospective claims data and physician survey | 57% with low-moderate adherence; physicians overestimated adherence in 67% patients |
Montes et al[150], 2013 | n = 303; cross-sectional study; self-reports- DAI-10 and MMAS, CRS | 69% |
Kutzelnigg et al[151], 2014 | Olanzapine alone or in combination with mood stabilizers; n = 891 at entry; 657 at 2 yr; clinical interview | 33% at baseline; 20% at 2 yr |
Arvilommi et al[101], 2014 | n = 168 on SGAs; duration 18 mo; clinical interview | 46% fully or partially non-adherent |
Sajatovic et al[152], 2016 | n = 1114 on lurasidone; duration- 27 mo; retrospective claims data-MPR based | 67%took lurasidone less than 80% of the time |
Antidepressants | ||
Svarstad et al[52], 2001 | n = 22 on antidepressants; duration 12 mo; retrospective claims data | 27% irregular use |
Bauer et al[153], 2013b | n = 144 on antidepressants; duration - daily for 100 d; self-report | 19% (missing/changing doses) to 41% (drug holidays) |
- Citation: Chakrabarti S. Medication non-adherence in bipolar disorder: Review of rates, demographic and clinical predictors. World J Meta-Anal 2017; 5(4): 103-123
- URL: https://www.wjgnet.com/2308-3840/full/v5/i4/103.htm
- DOI: https://dx.doi.org/10.13105/wjma.v5.i4.103