Meta-analysis of lymph node metastasis in Siewert type I and II T1 adenocarcinomas

Table 4 Univariate and multivariate analysis of potential risk factors for lymph node metastasis

Statistical test	OR	Lower 95%CI	Upper 95%CI	P value
Univariate analysis
Age (< 70 or ≥ 70 yr)	0.32	0.03	1.75	0.19
Sex (male or female)	1.04	0.18	11	1
Location of tumor center (Siewert type I or II)	2.1	0.31	10.8	0.37
Depth of invasion (M or SM)	2.3	0.28	108.3	0.67
Depth of invasion (≥ 500 μm or < 500 μm)	4.89	0.58	40.8	0.14
Differentiation (undifferentiated or differentiated)	6.6	1.29	33.7	0.01
Tumor size (< 30 mm or ≥ 30 mm)	3.1	0.72	14.8	0.08
Macroscopic tumor type (elevated or depressed)	1.43	0.31	9.1	0.74
Ulceration (yes or no)	1.91	0.44	8.7	0.33
Barrett’s esophageal adenocarcinoma (yes or no)	0.79	0.17	3.42	0.75
Lymphovascular invasion (yes or no)	5.1	1.04	25.1	0.02
Multivariate analysis
Differentiation (undifferentiated or differentiated)	6.08	1.4	26.4	0.01
Lymphovascular invasion (yes or no)	4.66	1.09	19.9	0.03

M: Mucosal; SM: Submucosal; OR: Odds ratio.