Efficacy, safety, and dose comparison of degarelix for the treatment of prostate cancer: A systematic review and meta-analysis

Table 1 Baseline characteristics of included studies

Ref.	Study arms (dose, Initial dose (mg)/monthly maintenance dosage (mg)	Regimen	Sample	Age (yr)	BMI (kg/m2)	T stage		Tumour stage				Gleason score			ECOG ( ≤ 2)	Duration (mo)
						T1/2	T3/4	Localized	Locally advanced	Metastatic	Not classifiable	2-6	7	8-10
Axcrona et al[14]	Degarelix (240/80)	Monthly	82	71.9 ± 7.7	26.8 ± 4.1	35	47	24	30	22	6	17	24	41	82	3
	Goserelin (3.6)	Goserelin 12 wk + 50 mg/d bicalutamide during the initial 28 d	97	73.0 ± 7.1	26.5 ± 3.7	42	55	32	23	31	11	16	31	50	96
Anderson et al[15]	Degarelix (240/80)	240 mg for 1 mo, 80 mg/mo	27	68 (53-87)	NR	5	21	NR				2	25		27	3
	Goserelin (3.6)	3.6 mg/mo goserelin + 50 mg/d bicalutamide	13	72 (57-85)	NR	2	11					0	13		13
Mason et al[16]	Degarelix (240/80)	240 mg day 0 + 80 mg day 28 and 56	180	70.6 ± 6.37	27.8 ± 3.99	116	64	111	63	NR	6	41	97	42	180	3
	Goserelin (3.6)	Goserelin 3.6 mg day 3, 31 and 59	64	70.8 ± 5.96	26.8 ± 3.69	42	21	41	20	NR	3	12	42	10	64
Klotz L et al[11]	Degarelix (240/80, 240/160)	240 mg for 1 mo + 80/160 mg monthly	207	72 (51-89)	26.7 ± 4.2	69	64	69	64	37	37	88	63	56	195	12
	Leuprolide (7.5)	Leuprolide 7.5 mg/mo	201	74 (50-88)	26.9 ± 3.9	63	52	63	52	47	39	87	62	51	190
Ozono et al[10]	Degarelix (240/80)	240 mg/dose + 80 mg/mo	136	74.7 ± 6.76	NR	61	42	61	42	33	0	19	117		NR	12
	Degarelix (240/160)	240 mg/dose + 160 mg/mo	137	74.2 ± 7.19	NR	64	41	64	41	31	1	23	114		NR
Van Poppel et al[12]	Degarelix (240/80)	240 mg/dose + 80 mg/mo	30	70 (57-88)	26 (18-41)	5	12	5	12	5	8	19	11		NR	12
	Degarelix (240/160)	240 mg/dose + 160 mg/mo	30	73 (52-82)	25 (20-30)	5	10	5	10	7	8	15	15		NR

BMI: Body mass index; ECOG: European Cooperative Oncology Group; NR: Not reported.