Antireflux surgery vs medical treatment for gastroesophageal reflux disease: A meta-analysis

Table 1 Description of patients at baseline from the 11 articles included in meta-analysis

Ref.	Group	No. of patients randomized	Mean age (yr)	Female/male	Mean follow-up years	No. of patients at follow-up	Country
Mahon et al[14]	LNF	109	48	1:1.9	1	106	United Kingdom
	PPIs	108	47	1:2.6		97
Mehta et al[15]	LNF	91	47	1:2.0	6.9	91	United Kingdom
	PPIs	92	47	1:2.5		38
Grant et al[16]	LF	178	46.7	1:1.9	1	145	United Kingdom
	Best medical management(mainly PPIs)	179	45.9	1:2.2		154
Grant et al[17]	LF	178	46.7	1:1.9	5	127	United Kingdom
	Best medical management(mainly PPIs)	179	45.9	1:2.2		119
Lundell et al[6]	Open antireflux surgery	155	51	1:3.2	5	79	Sweden
	omeprazole	155	55	1:3.0		104
Lundell et al[18]	Open antireflux surgery	155	51	1:3.2	12	53	Sweden
	omeprazole	155	55	1:3.0		71
Anvari et al[19]	LNF	52	42.9	1:0.7	1	48	Canada
	PPIs	52	42.1	1:1		48
Anvari et al[20]	LNF	52	42.9	1:0.7	3	49	Canada
	PPIs	52	42.1	1:1		44
Spechler et al[21]	Open Nissen fundoplication	82	58	NR	9.1	38	United States
	Antacid and ranitidin	77	58	NR	10.6	91
Lundell et al[22]	Laparoscopic antireflux surgery	288	44.8	1:2.2	3	204	11 European countries
	Esomeprazole	266	45.4	1:3.0		208
Galmiche et al[23]	Laparoscopic antireflux surgery	288	44.8	1:2.2	5	180	11 European countries
	Esomeprazole	266	45.4	1:3.0		192

In the 11 articles, Ref. [16,17] were one study of different follow-up times, so were Ref. [6,18-20,22,23]. LNF: Laparoscopic Nissen fundoplication; PPIs: Proton pump inhibitors; LF: Laparoscopic fundoplication.