How to impute study-specific standard deviations in meta-analyses of skewed continuous endpoints?

doi:10.13105/wjma.v3.i5.215

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Oct 26, 2015 (publication date) through Apr 27, 2025

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World Journal of Meta-Analysis

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2308-3840

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Meta-Analysis

World J Meta-Anal. Oct 26, 2015; 3(5): 215-224
Published online Oct 26, 2015. doi: 10.13105/wjma.v3.i5.215

Table 3 Method for imputing the study-specific standard deviation

Methodnumber	Method name	Mean imputation	Standard Deviation imputation¹
0	Reference	Mean	SD
1	Conservative SD	Median	max[(3^rd quartile - median)/0.6745; (median - 1^st quartile)/0.6745]
2	Less Conservative SD	Median	min[(3^rd quartile - median)/0.6745; (median - 1^st quartile)/0.6745]
3	Mean SD	Median	(3^rd quartile - 1^st quartile)/(2 × 0.6745)
4	IQR	Median	(3^rd quartile - 1^st quartile)

¹The 0.675 is the Z value corresponding to an area of 75% of the standard normal distribution function. IQR: Interquartile range.

Citation: Greco T, Biondi-Zoccai G, Gemma M, Guérin C, Zangrillo A, Landoni G. How to impute study-specific standard deviations in meta-analyses of skewed continuous endpoints? World J Meta-Anal 2015; 3(5): 215-224
URL: https://www.wjgnet.com/2308-3840/full/v3/i5/215.htm
DOI: https://dx.doi.org/10.13105/wjma.v3.i5.215