Association between SHBG (TAAAA)n and AR (CAG)n polymorphisms and PCOS risk: A meta-analysis

Table 1 Characteristics of studies on (TAAAA)n sex hormone-binding globulin polymorphism and polycystic ovarian syndrome

Ref.	Year	Country	Race	PCOS	Controls	PCOS alleles (2 n)		Controls alleles (2 n)		PCOS women genotype			Controls genotype			PCOS diagnostic
				women		S (< 8 repeats)	L (≥8 repeats)	S (< 8 repeats)	L (≥8 repeats)	SS	SL	LL	SS	SL	LL	criteria
Xita et al[10]	2003	Greece	Caucasian	185	324	230	140	446	202	NR	NR	NR	NR	NR	NR	A
Zhao et al[24]	2005	China	Asian	157	156	180	134	175	137	48	84	25	48	79	29	B
Ferk et al[26]	2007	Slovenia	Caucasian	123	110	155	91	151	69	54	48	21	52	47	11	C
Liu et al[27]	2008	China	Asian	187	176	216	158	210	142	59	96	32	66	78	32	C
Díaz et al[25]	2010	Spain	Caucasian	70	107	102	38	139	75	NR	NR	NR	NR	NR	NR	D

A: The 1990 National Institutes of Health–National Institute of Child Health and Human Development conference on PCOS; B: (1) Amenorrhoea or oligomenorrhoea; (2) LH/FSH ≥ 2.5 or T ≥ 1.56; (3) More than 10 follicles measuring 2-8 mm in diameter at least in one ovary; and (4) Exclusion of congenital adrenal hyperplasia, Cushing’s syndrome, androgen-secreting tumor, hyperprolactinaemia and thyroid dysfunction; C: The criteria of Rotterdam Revised 2003 (two of three) diagnosis; D: (1) Hirsutism; (2) Amenorrhoea or oligomenorrhoea; (3) Increased serum T and/or androstenedione and 17OH-P hyperresponse to GnRH agonist; and (4) Hyperinsulinaemia during an oral glucose tolerance test. PCOS: Polycystic ovarian syndrome; S: Short alleles; L: Long alleles; SS: Short-short genotype; SL: Short-long genotype; LL: Long-long genotype; NR: Non-reported.