Effect of supervised exercise on aerobic capacity in cancer survivors: Adherence and workload predict variance in effect

Table 2 Description of Included Studies

Ref.	Sample size/	Age	Gender	Intervention	Comparison	Key outcomes	Adverse
	cancer type	(SD/range)	(F/M)	group	group		events
On treatment studies/subgroups
Adamsen et al[22], 2009 Denmark	n = 117 Mixed Cancer Groups	47.2 (± 6.7) yr	F: 78 M: 39	Aerobic Training with High-intensity Intervals + Resistance Exercise + Relaxation + Massage	Usual care: allowed to freely increase physical activity	Estimated VO2max	Seizure (n = 1)
Courneya et al[26], 2007 Canada	n = 133 Breast Cancer	49 yr (26-78)	F: 133	Aerobic Training	Usual care: continue usual activities	VO2peak QoL: FACT-Anemia	Hypotension (n = 1) Dizziness (n = 1)
1Courneya et al[27], 2009b Canada	n = 54 NHL, HL	253.2 yr (18-80)	2F: 50 M: 72	Aerobic Training with High-intensity Intervals	Usual Care: continue usual activities	VO2peak QoL: FACT-B/Ac/An	Back (n = 1), hip (n = 1) and knee (n = 1) pain
Hornsby et al[29], 2013 United States	n = 20 Breast Cancer	51 (± 6) yr	F: 10	Aerobic Training with High-intensity Intervals	Control: Continue usual exercise levels	VO2peak FACT-B Adverse Events	Leg pain (n = 1)
Hwang et al[30], 2012 Taiwan	n = 24 Lung	61 (± 6.3)	F: 12 M: 12	Aerobic Training	Usual Care: general patient education	VO2peak QoL: EORTC	Not reported
Jarden et al[31], 2009 Denmark	n = 42 Mixed Cancer Groups	39.1 (12.2)	F: 16 M: 26	Aerobic Training + Resistance Exercise + Flexibility	Usual Care	Estimated VO2max QoL: EORTC, FACT-An	None
Kim et al[33], 2006 United States	n = 41 Breast Cancer	51.3 (6.7) yr	F: 41	Aerobic Training	Waitlist Control	VO2peak	Not reported
MacVicar et al[34], 1989 United States	n = 34 Breast Cancer	45.4 (10.2) yr	F: 34	Aerobic Training with High-intensity Intervals	Control: Continue normal activities	VO2max L/min	Not reported
Segal et al[38], 2001 Canada	n = 66 Breast Cancer	51 (± 8.7) yr	F: 66	Aerobic Training	Control group encouraged to exercise	Estimated VO2max QoL: SF36	Not reported
Off treatment studies/comparisons
Broderick et al[23], 2013 Ireland	n = 43 Mixed Cancer Groups	52.3 (8.3) yr	F: 37 M: 6	Aerobic training	Usual Care	Estimated VO2max QoL: FACT-G, SF36	Not reported
Burnham et al[24], 2000 United States	n = 18 Mixed Cancer Groups	54.2 (8.1) yr	F: 15 M: 3	Aerobic training	Control	VO2peak QoL: LASA	Not reported
Courneya et al[25], 2003 Canada	n = 50 Breast Cancer	59 (± 6) yr	F: 54	Aerobic training	No exercise	VO2peak QoL: FACT-Breast	Lymphedema (n = 3) Gynecological complication (n = 1)
1Courneya et al[27], 2009a Canada	n = 68 NHL, HL	2As per Courneya, 2009b	2As per Courneya, 2009b	2As per Courneya, 2009b	2As per Courneya, 2009b	2As per Courneya, 2009b	2As per Courneya, 2009b
Herrero et al[28], 2005 Spain	n = 16 Breast Cancer	51 (10) yr	F: 16	Aerobic plus Resistance Training	No Exercise	VO2peak QoL: EORTC	Not reported
Kaibori et al[32], 2013 Japan	n = 51 Liver Cancer	68 (9.1) yr	F: 15 M: 36	Aerobic Training + Stretching + Diet Intervention	Diet Intervention	VO2peak	Not reported
Mehnert et al[35], 2011 Germany	n = 58 Breast Cancer	53 (7.4) yr	F: 58	Aerobic Training + Physiotherapeutic Exercises + Relaxation	Waitlist Control	VO2max QoL: BIQ	Not reported
Naumann et al[36], 2011 Australia	n = 21 Breast Cancer	49 (10) yr	F: 21	Aerobic Training + Resistance Exercise + Flexibility	Usual Care	Estimated VO2max QoL: FACT-B	Not reported
Rahnama et al[37], 2010 Iran	n = 29 Breast Cancer	58.3 (6.3) yr	F: 29	Aerobic Training + Resistance Exercise	No exercise	Estimated VO2max	Not reported
Thorsen et al[39], 2005 Norway	n = 111 Mixed Cancer Groups	39 (8.4) yr	F: 36 M: 75	Aerobic Training + Resistance Exercise	Usual Care	Estimated VO2max QoL: EORTC	Not reported