Risk of infectious diseases and cutaneous tumours in solid organ recipients: A meta-analysis of literature

Table 5 Risk to develop non-melanoma skin cancer and clinical characteristics of the various published series

Ref.	No. of cases/	NMSC	BCC/SCC	Median age at	Median follow-	Risk factors associated
	population		ratio	transplantation	up time	with NMSC
España et al[54]	92/Heart	15.2%	1:1.5	NA	NA	Immunosuppression
						UV exposure
						Skin type
Ong et al[68]	455/Heart	31%	3:1	NA	NA	Caucasian origin
	Australia					Age at transplantation
						Duration of follow up
Hiesse et al[5]	1710/Kidney France	7.5%-8.2%	NA	35.5 yr	9 yr	Cyclosporin
Moloney et al[8]	1755/Kidney	27.7%	1:2	40 yr	5.35 yr	Age at transplantation
	Irland					Duration of immunosuppression
						Age at transplantation
Mackenzie et al[49]	384/Kidney	25%	1:1.2	41.5 yr	5.3 yr (0.01-33.4)	Male sex
	New Zeland					Cyclosporine/Azathioprine
Sandoval et al[63]	91/Kidney Chile	16%	1:1-9	NA	7.3 yr (1 mo-29 yr)	Duration of immunosuppression
Fekecs et al[52]	116/Kidney, pancreas		1:4	49.3 yr	NA	Painful sunburns
	Hungary	9.5%				Occupational UV exposure
						Cyclosporine

For each literature study has been indicated number of included patients, type of solid organ transplantation, median age at transplantation, median follow-up time after solid organ transplantation, percentage of patients affected by NMSC and BCC/SCC ratio. Risk factors significantly associated to the development of non-melanoma skin cancer in each study are indicated in the right column. NA: Data non available in the considered study; UV: Ultraviolet; NMSC: Non-melanoma skin cancer; BCC: Basal cell carcinoma; SCC: Squamous cell carcinoma.