Role of intestinal ultrasound in ulcerative colitis: A systematic review

Table 6 Summary of studies correlating clinical activity with intestinal ultrasound

Ref.	Study type	Number of patients	IUS predictors	Clinical score	Parameters studied
Goodsall et al[4]	Prospective	19 UC (29 paired data)	MUC	SCCAI, Mayo score	Mayo score: r = 0.307; 95%CI, 0.020-0.595; P = 0.036; SCCAI score: r = 0.04; 95%CI, −0.21 to 0.28; P = 0.768
Kinoshita et al[54]	Prospective, multi-centre	156 UC	Ultrasound severity score based on BWT, BWS, hypoechoic/hyperechoic changes in submucosa/mucosa	Rachmilewitz clinical activity index	r = 0.40, P < 0.001
Lim et al[63]	Prospective cross-sectional	29 UC, 22 CD	BWT, CDS, BWS, i-fat	Partial Mayo score	r = 0.192, P = 0.317
Maaser et al[28]	Prospective, multi-center	224 UC	BWT	SCCAI	Sigmoid colon: Baseline: r = 0.187; 12 wk: r = 0.547; descending colon: Baseline: r = 0.262; 12 wk: r = 0.5
Saleh et al[89]	Retrospective	39 UC, 108 DC	BWT, CDS, i-fat, BWS, lymph node, free fluid, haustartion, motility	Mayo score, UCAI	r = 0.016 Mayo score (P = 0.002); UCAI (P = 0.014)
de Voogd et al[2]	Prospective, single centre	16 UC, 22 CD	BWT, CDS, haustrations, BWS, fatty wrapping	SCCAI, Lichtiger index	SCCAI and BWT in the SC (r = 0.65, P < 0.0001) and DC (r = 0.59, P < 0.002). Lichtiger score and BWT SC (r = 0.65, P = 0.001) and DC (r =0.63, P = 0.001)
Yamada et al[62]	Prospective	26	SWE, SWD	UCEIS	Negative correlation with SWE (r = -0.505, P = 0.008); no correlation with (r = 0.001, P = 0.998)

CD: Crohn’s disease; UC: Ulcerative Colitis; SWE: Shear wave elastography; UCEIS: Ulcerative colitis endoscopic activity index; CDAI: Crohn’s disease activity index; BWT: Bowel wall thickness; UCAI: Ulcerative colitis activity index; MUC: Mayo ultrasound score.