Post-transplant malignancy: Focusing on virus-associated etiologies, pathogenesis, evidence-based management algorithms, present status of adoptive immunotherapy and future directions

doi:10.13105/wjma.v11.i7.317

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World Journal of Meta-Analysis

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World J Meta-Anal. Dec 18, 2023; 11(7): 317-339
Published online Dec 18, 2023. doi: 10.13105/wjma.v11.i7.317

Table 2 Post-transplant malignancy meta-analysis standardized incidence ratio in relation to viral infections[2,140]

Cancers associated with post-transplant viral infections	Meta-analysis SIR
EBV-associated
Hodgkin’s lymphoma	3.89 (2.42-6.26)
NHL	8.07 (6.40-10.2)
HHV8-associated
Kaposi’s sarcoma	208 (114-369)
HBV/HCV-associated
Hepatocellular	2.13 (1.16-3.91)
HPV-associated
Cervical	2.13 (1.37-3.30)
Vulva & vagina	22.8 (15.8-32.7)
Penis	15.8 (5.79-34.4)
Anus	4.85 (1.36-17.3)
Oropharynx	3.23 (2.4-4.35)
Non-melanocytic skin cancer	28.6 (9.39-87.2)

EBV: Epstein–Barr virus; SIR: Standardized incidence ratio; NHL: Non-Hodgkin’s lymphoma; HHV8: Human herpes virus 8; HBV: Hepatitis B virus; HCV: Hepatitis C virus; HPV: Human papilloma virus.

Citation: Yadav R, El Kossi M, Belal D, Sharma A, Halawa A. Post-transplant malignancy: Focusing on virus-associated etiologies, pathogenesis, evidence-based management algorithms, present status of adoptive immunotherapy and future directions. World J Meta-Anal 2023; 11(7): 317-339
URL: https://www.wjgnet.com/2308-3840/full/v11/i7/317.htm
DOI: https://dx.doi.org/10.13105/wjma.v11.i7.317